' 
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.8
USERS' SCORE
Good
Based on 1 Review
8.6
Supplement Facts
Serving Size: 5 Tablets
Amount Per Serving
%DV
Vitamin D3 (as cholecalciferol)
10 mcg (400 IU)
50%
Calcium (as calcium citrate)
1,000 mg
77%
Magnesium (as magnesium oxide, magnesium citrate)
500 mg
119%
Sodium
20 mg
<1%
Top Medical Research Studies
9
Vitamin D3 aids migraine relief
Vitamin D3 might improve headache characteristics and protect against inflammation in migraine: a randomized clinical trial.
Directly examines vitamin D3 effects
We conducted a rigorous study to explore how vitamin D3 supplementation might influence headaches in people suffering from migraines. By utilizing a well-structured, placebo-controlled, double-blind design, we included 80 participants with episodic migraines, assigning them either a daily dose of vitamin D3 or a placebo for 12 weeks.
After the study, we observed significant improvements in those receiving vitamin D3. Participants reported fewer headache days each month, shorter headache durations, and less severe pain overall. They also used fewer pain relievers compared to those on placebo, showcasing the potential benefit of vitamin D3 in managing migraine symptoms.
Our findings suggest that vitamin D3 not only aids in reducing headache frequency but may also play a role in addressing inflammation, as evidenced by reduced levels of certain inflammatory markers in the blood. This highlights its possible therapeutic value for migraine sufferers, indicating that a daily dose could make a meaningful difference in their lives.
After the study, we observed significant improvements in those receiving vitamin D3. Participants reported fewer headache days each month, shorter headache durations, and less severe pain overall. They also used fewer pain relievers compared to those on placebo, showcasing the potential benefit of vitamin D3 in managing migraine symptoms.
Our findings suggest that vitamin D3 not only aids in reducing headache frequency but may also play a role in addressing inflammation, as evidenced by reduced levels of certain inflammatory markers in the blood. This highlights its possible therapeutic value for migraine sufferers, indicating that a daily dose could make a meaningful difference in their lives.
Read More
8
Vitamin D3 reduces migraine frequency
A randomized, double-blinded, placebo-controlled, parallel trial of vitamin D supplementation in adult patients with migraine.
Direct study on vitamin D3 effect.
We conducted a rigorous study to determine whether vitamin D3 supplementation could help improve the lives of adults suffering from migraines. Our approach involved a well-structured, randomized, double-blinded, placebo-controlled trial, which included 36 women and 12 men, aged between 18 to 65 years.
Participants underwent a 4-week baseline period before being randomly assigned to receive either 100 μg/day of D3 vitamin or a placebo for 24 weeks. Throughout the study, we kept track of migraine attacks and various symptoms through self-reported diaries, logging important details like the frequency and severity of their migraines.
Our findings were quite promising. Those taking D3 vitamin experienced fewer migraine days compared to those on the placebo, suggesting that vitamin D3 could serve as an effective preventative treatment for migraine management. However, we noted that further studies with larger sample sizes would be beneficial to solidify these claims and fully understand the potential role of vitamin D3 in migraine prevention.
Participants underwent a 4-week baseline period before being randomly assigned to receive either 100 μg/day of D3 vitamin or a placebo for 24 weeks. Throughout the study, we kept track of migraine attacks and various symptoms through self-reported diaries, logging important details like the frequency and severity of their migraines.
Our findings were quite promising. Those taking D3 vitamin experienced fewer migraine days compared to those on the placebo, suggesting that vitamin D3 could serve as an effective preventative treatment for migraine management. However, we noted that further studies with larger sample sizes would be beneficial to solidify these claims and fully understand the potential role of vitamin D3 in migraine prevention.
Read More
9
We explored the impact of magnesium on migraine headaches, focusing on its potential benefits based on various studies. Magnesium deficiency is quite common and can arise from different factors, such as not consuming enough through diet or losing more through bodily systems.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
Read More
Most Useful Reviews
9.5
Migraine relief
Helps with migraines. A nutritionist recommended this brand primarily for migraines, and I've found it beneficial. I take three a day and notice they help in keeping headaches at bay without causing nausea like many other vitamins.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.8
9.5
Simvastatin plus vitamin D3 reduces migraines
Simvastatin and vitamin D for migraine prevention: A randomized, controlled trial.
Moderate relevance due to combination
We conducted a study to explore the effectiveness of simvastatin combined with vitamin D3 in preventing headaches for adults suffering from episodic migraines. The study involved 57 participants who were randomly assigned either the active treatment or a placebo for 24 weeks, following a 12-week baseline period.
Our findings revealed that those taking simvastatin and vitamin D3 experienced a meaningful reduction in the number of migraine days compared to those on the placebo. In fact, participants on the active treatment saw their migraine days decrease by an average of 8 days during the first 12 weeks, and 9 days during the subsequent weeks, with a statistically significant difference that supports the treatment's effectiveness.
It's also worth mentioning that 25% of the participants on simvastatin and vitamin D3 achieved at least a 50% reduction in migraine days at 12 weeks, which increased to 29% by 24 weeks. This is in stark contrast to just 3% of participants in the placebo group. Importantly, the occurrence of side effects was similar between the groups, suggesting that the treatment was well-tolerated.
Overall, we observed a promising potential for simvastatin and vitamin D3 as a preventative option for those grappling with chronic migraines, while also considering the broader health implications regarding vascular health.
Our findings revealed that those taking simvastatin and vitamin D3 experienced a meaningful reduction in the number of migraine days compared to those on the placebo. In fact, participants on the active treatment saw their migraine days decrease by an average of 8 days during the first 12 weeks, and 9 days during the subsequent weeks, with a statistically significant difference that supports the treatment's effectiveness.
It's also worth mentioning that 25% of the participants on simvastatin and vitamin D3 achieved at least a 50% reduction in migraine days at 12 weeks, which increased to 29% by 24 weeks. This is in stark contrast to just 3% of participants in the placebo group. Importantly, the occurrence of side effects was similar between the groups, suggesting that the treatment was well-tolerated.
Overall, we observed a promising potential for simvastatin and vitamin D3 as a preventative option for those grappling with chronic migraines, while also considering the broader health implications regarding vascular health.
Read More
9.5
Calcium's uncertain headache impact
Reversible Cerebral Vasoconstriction Syndrome Secondary to Escitalopram.
Study raises questions on effectiveness
We explored the connection between calcium treatment and headaches, particularly in patients with reversible cerebral vasoconstriction syndrome (RCVS). In this case, we observed a healthy young woman who had been using escitalopram for a long time. She presented with bilateral neurological deficits, and after treatment with intra-arterial calcium channel blockers, her symptoms improved significantly.
However, it’s important to note that while calcium channel blockers were administered, the study does not specifically isolate calcium’s effects on headache relief. This combination of treatments makes it challenging to understand how much calcium alone contributes to alleviating headache symptoms, if at all.
As we considered the overall findings, it became clear that while calcium channel blockers can lead to symptom improvement in RCVS, the direct impact of calcium on headaches remains uncertain. Therefore, individuals experiencing thunderclap headaches, especially those on selective serotonin reuptake inhibitors, should consider RCVS as a possible diagnosis, but we cannot definitively conclude that calcium treatment is effective for headaches based on this case alone.
However, it’s important to note that while calcium channel blockers were administered, the study does not specifically isolate calcium’s effects on headache relief. This combination of treatments makes it challenging to understand how much calcium alone contributes to alleviating headache symptoms, if at all.
As we considered the overall findings, it became clear that while calcium channel blockers can lead to symptom improvement in RCVS, the direct impact of calcium on headaches remains uncertain. Therefore, individuals experiencing thunderclap headaches, especially those on selective serotonin reuptake inhibitors, should consider RCVS as a possible diagnosis, but we cannot definitively conclude that calcium treatment is effective for headaches based on this case alone.
Read More
9
Pediatric migraine treatment effectiveness
The Impact of Vitamin D Supplementation to Topiramate Therapy on Pediatric Migraine Prophylaxis.
Limited vitamin D isolation effects
We aimed to explore the effects of vitamin D3 supplementation on headaches in children undergoing treatment with topiramate for migraines. In a carefully designed double-blind clinical trial, we involved children aged 5 to 14 years who were experiencing migraines. Participants were randomly divided into two groups: one received topiramate with vitamin D3 supplements, while the other received topiramate along with a placebo.
Over four months, we noted significant enhancements in the group taking vitamin D3. Specifically, this group showed a greater reduction in the frequency of headache attacks and overall migraine disability compared to the placebo group. We observed that 76% of children in the vitamin D3 group reported good responses to the treatment, compared to only 54% in the placebo group.
Importantly, while both groups experienced side effects, those in the vitamin D3 group reported fewer issues. Thus, we found vitamin D3 supplementation to be a well-tolerated and effective addition to topiramate therapy for managing pediatric migraines.
Over four months, we noted significant enhancements in the group taking vitamin D3. Specifically, this group showed a greater reduction in the frequency of headache attacks and overall migraine disability compared to the placebo group. We observed that 76% of children in the vitamin D3 group reported good responses to the treatment, compared to only 54% in the placebo group.
Importantly, while both groups experienced side effects, those in the vitamin D3 group reported fewer issues. Thus, we found vitamin D3 supplementation to be a well-tolerated and effective addition to topiramate therapy for managing pediatric migraines.
Read More
9
Giant Cell Arteritis Treatment Insights
A Case Report of Post COVID19 Giant Cell Arteritis and Polymyalgia Rheumatica With Visual Loss.
Moderate relevance to headache treatment
In exploring the treatment for headaches associated with post-COVID-19 giant cell arteritis and polymyalgia rheumatica, we observed that vitamin D3 was included alongside more traditional therapies. This was part of a comprehensive treatment approach that also involved pulse methylprednisolone and perineural injection therapy.
While the main focus of treatment appeared to be on corticosteroids and pain management strategies, the exact effect of vitamin D3 on headache relief remains unclear. Since the headaches notably persisted through early treatment stages and improved significantly after additional intervention, we can't conclusively state the efficacy of vitamin D3 in alleviating headache symptoms from this case alone.
It's worth noting that individual responses to treatments can vary widely, and further dedicated studies would be necessary to understand vitamin D3's specific role in headache management. For now, combining it with other treatments was part of a broader strategy to achieve recovery.
While the main focus of treatment appeared to be on corticosteroids and pain management strategies, the exact effect of vitamin D3 on headache relief remains unclear. Since the headaches notably persisted through early treatment stages and improved significantly after additional intervention, we can't conclusively state the efficacy of vitamin D3 in alleviating headache symptoms from this case alone.
It's worth noting that individual responses to treatments can vary widely, and further dedicated studies would be necessary to understand vitamin D3's specific role in headache management. For now, combining it with other treatments was part of a broader strategy to achieve recovery.
Read More
9
Atorvastatin aids migraine control
Does atorvastatin have augmentative effects with sodium valproate in prevention of migraine with aura attacks? A triple-blind controlled clinical trial.
Vitamin D3's effect unclear
We explored the relationship between vitamin D3 levels and migraine management in a study involving 68 patients suffering from migraine with aura. Before treatment, participants underwent vitamin D3 level evaluations, and those found to be deficient received vitamin D supplementation. However, while we investigated the effectiveness of adding atorvastatin to sodium valproate for better control of migraine symptoms, the specific effects of vitamin D3 alone on headache were not isolated in this study.
The results indicated that incorporating atorvastatin significantly reduced the severity of pain and the number of attacks. Participants in the atorvastatin group also reported higher satisfaction with their treatment compared to those receiving a placebo. Nonetheless, since the detailed effects of vitamin D3 on headaches were not independently assessed, we can’t conclude anything definitive about its role in headache management from this study alone.
Overall, while statins like atorvastatin show promise in treating migraine, our study did not directly evaluate the benefits of vitamin D3 on headache relief. Further research is needed to clarify vitamin D3's impact in this area.
The results indicated that incorporating atorvastatin significantly reduced the severity of pain and the number of attacks. Participants in the atorvastatin group also reported higher satisfaction with their treatment compared to those receiving a placebo. Nonetheless, since the detailed effects of vitamin D3 on headaches were not independently assessed, we can’t conclude anything definitive about its role in headache management from this study alone.
Overall, while statins like atorvastatin show promise in treating migraine, our study did not directly evaluate the benefits of vitamin D3 on headache relief. Further research is needed to clarify vitamin D3's impact in this area.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Migraine relief
Helps with migraines. A nutritionist recommended this brand primarily for migraines, and I've found it beneficial. I take three a day and notice they help in keeping headaches at bay without causing nausea like many other vitamins.
