Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.5
USERS' SCORE
Medium or Average
Based on 8 Reviews
6.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Zinc (as zinc glycinate amino acid chelate†)
22 mg
200%
Top Medical Research Studies
9
Zinc supplementation benefits MS models
We explored how dietary zinc levels influence spinal cord damage and gene expressions associated with Multiple Sclerosis (MS) using a cuprizone-induced rat model. The study included 46 adult male Wistar rats divided into five groups, with some receiving zinc supplementation while others followed a zinc-deficient diet.
After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.
Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.
After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.
Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.
9
We aimed to understand how dietary zinc intake influences the risk of developing osteopenia and osteoporosis in patients with rheumatoid arthritis (RA). Our study relied on data collected from the National Health and Nutrition Examination Survey, spanning several years. Through careful analysis using univariate and multivariate logistic regression models, we were able to uncover significant associations between dietary zinc levels and bone health in this population.
What we found was encouraging: higher zinc intake appeared to lower the chances of these serious bone conditions among RA patients. Our research also went further by examining various factors such as age, body mass index (BMI), and pre-existing health issues like diabetes and hypertension. This comprehensive approach led us to conclude that adequate dietary zinc is crucial for maintaining bone health in individuals with RA, though we noted the need for more extensive long-term studies to corroborate these findings and delve deeper into the underlying mechanisms at play.
What we found was encouraging: higher zinc intake appeared to lower the chances of these serious bone conditions among RA patients. Our research also went further by examining various factors such as age, body mass index (BMI), and pre-existing health issues like diabetes and hypertension. This comprehensive approach led us to conclude that adequate dietary zinc is crucial for maintaining bone health in individuals with RA, though we noted the need for more extensive long-term studies to corroborate these findings and delve deeper into the underlying mechanisms at play.
8
We identified an important link between zinc transport and autoimmune disorders, specifically focusing on the protein SLC39A10 and its role in T cells. Through our study, we discovered that two specific genetic variations in the SLC39A10 gene are associated with inflammatory bowel disease (IBD). To further explore this connection, we created genetically modified mice with a targeted deletion of the Slc39a10 gene in T cells.
Our findings revealed that the loss of SLC39A10 significantly protects against the progression of both IBD and experimental autoimmune encephalomyelitis (EAE). Notably, we also observed that the absence of this transporter led to increased cell death, independent of common pathways usually associated with apoptosis. This indicates that SLC39A10 plays a crucial role in maintaining the health of T cells by facilitating zinc import, which is essential for DNA replication when T cells are activated.
Our research contributes to a deeper understanding of how zinc homeostasis impacts immune function. The insights gained from this study suggest that targeting zinc transport could present new therapeutic options for managing T cell-related autoimmune diseases.
Our findings revealed that the loss of SLC39A10 significantly protects against the progression of both IBD and experimental autoimmune encephalomyelitis (EAE). Notably, we also observed that the absence of this transporter led to increased cell death, independent of common pathways usually associated with apoptosis. This indicates that SLC39A10 plays a crucial role in maintaining the health of T cells by facilitating zinc import, which is essential for DNA replication when T cells are activated.
Our research contributes to a deeper understanding of how zinc homeostasis impacts immune function. The insights gained from this study suggest that targeting zinc transport could present new therapeutic options for managing T cell-related autoimmune diseases.
Most Useful Reviews
9
Normalisation after COVID
1 people found this helpful
After experiencing severe post-COVID fatigue, my doctor suggested zinc and vitamin D. I ordered it online and took it daily with my husband, and gradually my strength returned. The convenient dosage of one tablet daily worked well for us.
9
Thyroid function improvement
1 people found this helpful
I have autoimmune thyroiditis and my endocrinologist recommended daily zinc and selenium. I chose the chelated form for better absorption. My TSH levels returned to normal after a few months, and I suspect it contributed positively, though I take a variety of supplements as well. I find this product convenient and effective.
2
Disappointing result
15 people found this helpful
I switched from zinc sulphate to this chelated form, hoping for better results. Unfortunately, I felt no improvements in my skin condition after a month. Disappointed, I consider it a waste of money.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.5
- All Researches
9
Zinc supplementation benefits MS models
We explored how dietary zinc levels influence spinal cord damage and gene expressions associated with Multiple Sclerosis (MS) using a cuprizone-induced rat model. The study included 46 adult male Wistar rats divided into five groups, with some receiving zinc supplementation while others followed a zinc-deficient diet.
After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.
Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.
After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.
Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.
9
We aimed to understand how dietary zinc intake influences the risk of developing osteopenia and osteoporosis in patients with rheumatoid arthritis (RA). Our study relied on data collected from the National Health and Nutrition Examination Survey, spanning several years. Through careful analysis using univariate and multivariate logistic regression models, we were able to uncover significant associations between dietary zinc levels and bone health in this population.
What we found was encouraging: higher zinc intake appeared to lower the chances of these serious bone conditions among RA patients. Our research also went further by examining various factors such as age, body mass index (BMI), and pre-existing health issues like diabetes and hypertension. This comprehensive approach led us to conclude that adequate dietary zinc is crucial for maintaining bone health in individuals with RA, though we noted the need for more extensive long-term studies to corroborate these findings and delve deeper into the underlying mechanisms at play.
What we found was encouraging: higher zinc intake appeared to lower the chances of these serious bone conditions among RA patients. Our research also went further by examining various factors such as age, body mass index (BMI), and pre-existing health issues like diabetes and hypertension. This comprehensive approach led us to conclude that adequate dietary zinc is crucial for maintaining bone health in individuals with RA, though we noted the need for more extensive long-term studies to corroborate these findings and delve deeper into the underlying mechanisms at play.
8
We identified an important link between zinc transport and autoimmune disorders, specifically focusing on the protein SLC39A10 and its role in T cells. Through our study, we discovered that two specific genetic variations in the SLC39A10 gene are associated with inflammatory bowel disease (IBD). To further explore this connection, we created genetically modified mice with a targeted deletion of the Slc39a10 gene in T cells.
Our findings revealed that the loss of SLC39A10 significantly protects against the progression of both IBD and experimental autoimmune encephalomyelitis (EAE). Notably, we also observed that the absence of this transporter led to increased cell death, independent of common pathways usually associated with apoptosis. This indicates that SLC39A10 plays a crucial role in maintaining the health of T cells by facilitating zinc import, which is essential for DNA replication when T cells are activated.
Our research contributes to a deeper understanding of how zinc homeostasis impacts immune function. The insights gained from this study suggest that targeting zinc transport could present new therapeutic options for managing T cell-related autoimmune diseases.
Our findings revealed that the loss of SLC39A10 significantly protects against the progression of both IBD and experimental autoimmune encephalomyelitis (EAE). Notably, we also observed that the absence of this transporter led to increased cell death, independent of common pathways usually associated with apoptosis. This indicates that SLC39A10 plays a crucial role in maintaining the health of T cells by facilitating zinc import, which is essential for DNA replication when T cells are activated.
Our research contributes to a deeper understanding of how zinc homeostasis impacts immune function. The insights gained from this study suggest that targeting zinc transport could present new therapeutic options for managing T cell-related autoimmune diseases.
8
We analyzed how zinc levels in the body relate to alopecia areata (AA), an autoimmune disorder that affects hair loss. Our research involved a systematic review of 34 studies, gathering data from nearly 5,000 participants across 16 countries. By examining various studies, we sought to understand if zinc supplementation could be beneficial for those suffering from AA.
The results were striking. We found that individuals with alopecia areata had significantly lower levels of zinc and vitamin D compared to healthy individuals. Specifically, the data indicated that those with vitamin D deficiency faced a heightened risk of developing AA. This suggests that replenishing these nutrients might help manage the disease.
Importantly, we didn't find a significant difference in copper levels between AA patients and healthy controls, indicating that not all trace elements play the same role in this condition. Overall, our findings highlight the potential of zinc and vitamin D as targeted treatments for alopecia areata, offering new hope for those affected by this condition.
The results were striking. We found that individuals with alopecia areata had significantly lower levels of zinc and vitamin D compared to healthy individuals. Specifically, the data indicated that those with vitamin D deficiency faced a heightened risk of developing AA. This suggests that replenishing these nutrients might help manage the disease.
Importantly, we didn't find a significant difference in copper levels between AA patients and healthy controls, indicating that not all trace elements play the same role in this condition. Overall, our findings highlight the potential of zinc and vitamin D as targeted treatments for alopecia areata, offering new hope for those affected by this condition.
7
We aimed to explore how zinc supplementation might influence immune responses, particularly focusing on neutrophil activity in the context of autoimmune diseases. To do this, we simulated inflammatory conditions typically seen in such disorders using specific cytokines, interleukin-17 (IL-17) and tumor necrosis factor (TNF)-α.
Our findings indicated that elevating zinc levels significantly reduced the formation of neutrophil extracellular traps (NETs), which are often implicated in tissue damage during autoimmune flare-ups. We also discovered that zinc supplementation lowered the expression of a protein called peptidyl arginine deiminase 4 (PAD4), which is associated with NET formation.
Interestingly, zinc not only decreased harmful neutrophil activity but also boosted the production of beneficial proteins like interleukin-1 receptor antagonist (IL-1RA) and IL-8 in the activated cells. Overall, maintaining adequate zinc levels seems crucial for preserving healthy immune function and preventing the harmful overactivity of neutrophils, suggesting its potential as an adjunct treatment in managing autoimmune conditions.
Our findings indicated that elevating zinc levels significantly reduced the formation of neutrophil extracellular traps (NETs), which are often implicated in tissue damage during autoimmune flare-ups. We also discovered that zinc supplementation lowered the expression of a protein called peptidyl arginine deiminase 4 (PAD4), which is associated with NET formation.
Interestingly, zinc not only decreased harmful neutrophil activity but also boosted the production of beneficial proteins like interleukin-1 receptor antagonist (IL-1RA) and IL-8 in the activated cells. Overall, maintaining adequate zinc levels seems crucial for preserving healthy immune function and preventing the harmful overactivity of neutrophils, suggesting its potential as an adjunct treatment in managing autoimmune conditions.
User Reviews
USERS' SCORE
Medium or Average
Based on 8 Reviews
6.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Normalisation after COVID
1 people found this helpful
After experiencing severe post-COVID fatigue, my doctor suggested zinc and vitamin D. I ordered it online and took it daily with my husband, and gradually my strength returned. The convenient dosage of one tablet daily worked well for us.
9
Thyroid function improvement
1 people found this helpful
I have autoimmune thyroiditis and my endocrinologist recommended daily zinc and selenium. I chose the chelated form for better absorption. My TSH levels returned to normal after a few months, and I suspect it contributed positively, though I take a variety of supplements as well. I find this product convenient and effective.
2
Disappointing result
15 people found this helpful
I switched from zinc sulphate to this chelated form, hoping for better results. Unfortunately, I felt no improvements in my skin condition after a month. Disappointed, I consider it a waste of money.
7.5
Health improvement observed
11 people found this helpful
I purchased this zinc in June 2021 while recovering from COVID-19. Taking it alongside vitamin C improved my health significantly within three days, and it also helped stop my hair loss and reduce facial rashes. My mother experienced similar benefits when she took zinc for a viral infection. Overall, it was gentle on my stomach, and I found it effective for health support.
6
Effective immune support
2 people found this helpful
This zinc in a highly absorbable chelate form worked wonderfully for me without side effects. My hair loss reduced, which I directly attribute to its effects. I take it during cold prevention and at the onset of respiratory infections to bolster my immune system.
Frequently Asked Questions
7.5
Health improvement observed
11 people found this helpful
I purchased this zinc in June 2021 while recovering from COVID-19. Taking it alongside vitamin C improved my health significantly within three days, and it also helped stop my hair loss and reduce facial rashes. My mother experienced similar benefits when she took zinc for a viral infection. Overall, it was gentle on my stomach, and I found it effective for health support.
9
Thyroid function improvement
1 people found this helpful
I have autoimmune thyroiditis and my endocrinologist recommended daily zinc and selenium. I chose the chelated form for better absorption. My TSH levels returned to normal after a few months, and I suspect it contributed positively, though I take a variety of supplements as well. I find this product convenient and effective.
2
Poor personal results
42 people found this helpful
After two weeks of taking this chelated zinc, I noticed no effects at all. I had hoped for improvement but found it lacking when compared to other products.
2
Disappointing result
15 people found this helpful
I switched from zinc sulphate to this chelated form, hoping for better results. Unfortunately, I felt no improvements in my skin condition after a month. Disappointed, I consider it a waste of money.
9
Normalisation after COVID
1 people found this helpful
After experiencing severe post-COVID fatigue, my doctor suggested zinc and vitamin D. I ordered it online and took it daily with my husband, and gradually my strength returned. The convenient dosage of one tablet daily worked well for us.
8
We identified an important link between zinc transport and autoimmune disorders, specifically focusing on the protein SLC39A10 and its role in T cells. Through our study, we discovered that two specific genetic variations in the SLC39A10 gene are associated with inflammatory bowel disease (IBD). To further explore this connection, we created genetically modified mice with a targeted deletion of the Slc39a10 gene in T cells.
Our findings revealed that the loss of SLC39A10 significantly protects against the progression of both IBD and experimental autoimmune encephalomyelitis (EAE). Notably, we also observed that the absence of this transporter led to increased cell death, independent of common pathways usually associated with apoptosis. This indicates that SLC39A10 plays a crucial role in maintaining the health of T cells by facilitating zinc import, which is essential for DNA replication when T cells are activated.
Our research contributes to a deeper understanding of how zinc homeostasis impacts immune function. The insights gained from this study suggest that targeting zinc transport could present new therapeutic options for managing T cell-related autoimmune diseases.
Our findings revealed that the loss of SLC39A10 significantly protects against the progression of both IBD and experimental autoimmune encephalomyelitis (EAE). Notably, we also observed that the absence of this transporter led to increased cell death, independent of common pathways usually associated with apoptosis. This indicates that SLC39A10 plays a crucial role in maintaining the health of T cells by facilitating zinc import, which is essential for DNA replication when T cells are activated.
Our research contributes to a deeper understanding of how zinc homeostasis impacts immune function. The insights gained from this study suggest that targeting zinc transport could present new therapeutic options for managing T cell-related autoimmune diseases.
9
Zinc supplementation benefits MS models
We explored how dietary zinc levels influence spinal cord damage and gene expressions associated with Multiple Sclerosis (MS) using a cuprizone-induced rat model. The study included 46 adult male Wistar rats divided into five groups, with some receiving zinc supplementation while others followed a zinc-deficient diet.
After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.
Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.
After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.
Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.
4
We examined the connection between dietary zinc intake and the risk of autoimmune thyroiditis (AIT), particularly focusing on Hashimoto's thyroiditis. The study analyzed data from the 2007-2008 National Health and Nutrition Examination Survey, including nearly 5,500 participants—273 with AIT and 5,194 without it.
Our findings revealed that higher dietary zinc intake is associated with an increased risk of AIT, acting as an independent risk factor. This is concerning, as excessive zinc could disrupt our immune balance, potentially leading to other autoimmune disorders.
While it’s clear that zinc plays a role in thyroid health, we must be cautious about how much we consume. The study suggests that dietary zinc should be carefully monitored in those at risk for AIT, and it highlights the need for further research to establish safe consumption levels.
Our findings revealed that higher dietary zinc intake is associated with an increased risk of AIT, acting as an independent risk factor. This is concerning, as excessive zinc could disrupt our immune balance, potentially leading to other autoimmune disorders.
While it’s clear that zinc plays a role in thyroid health, we must be cautious about how much we consume. The study suggests that dietary zinc should be carefully monitored in those at risk for AIT, and it highlights the need for further research to establish safe consumption levels.
7
We aimed to explore how zinc supplementation might influence immune responses, particularly focusing on neutrophil activity in the context of autoimmune diseases. To do this, we simulated inflammatory conditions typically seen in such disorders using specific cytokines, interleukin-17 (IL-17) and tumor necrosis factor (TNF)-α.
Our findings indicated that elevating zinc levels significantly reduced the formation of neutrophil extracellular traps (NETs), which are often implicated in tissue damage during autoimmune flare-ups. We also discovered that zinc supplementation lowered the expression of a protein called peptidyl arginine deiminase 4 (PAD4), which is associated with NET formation.
Interestingly, zinc not only decreased harmful neutrophil activity but also boosted the production of beneficial proteins like interleukin-1 receptor antagonist (IL-1RA) and IL-8 in the activated cells. Overall, maintaining adequate zinc levels seems crucial for preserving healthy immune function and preventing the harmful overactivity of neutrophils, suggesting its potential as an adjunct treatment in managing autoimmune conditions.
Our findings indicated that elevating zinc levels significantly reduced the formation of neutrophil extracellular traps (NETs), which are often implicated in tissue damage during autoimmune flare-ups. We also discovered that zinc supplementation lowered the expression of a protein called peptidyl arginine deiminase 4 (PAD4), which is associated with NET formation.
Interestingly, zinc not only decreased harmful neutrophil activity but also boosted the production of beneficial proteins like interleukin-1 receptor antagonist (IL-1RA) and IL-8 in the activated cells. Overall, maintaining adequate zinc levels seems crucial for preserving healthy immune function and preventing the harmful overactivity of neutrophils, suggesting its potential as an adjunct treatment in managing autoimmune conditions.
References
- Shao Y, Mu Q, Wang R, Luo H, Song Z, et al. SLC39A10 is a key zinc transporter in T cells and its loss mitigates autoimmune disease. Sci China Life Sci. 2025. doi:10.1007/s11427-024-2817-y
- Chen L, Yan C, Huang C, Jiang Z, Lin R, et al. Higher dietary zinc intake increases the risk of autoimmune thyroiditis. Postgrad Med J. 2025. doi:10.1093/postmj/qgae202
- Wu R, Li Y, Peng H, Yang Z, Wang Y, et al. Association Between Serum Trace Elements Level and Alopecia Areata: A Systematic Review and Meta-Analysis. J Cosmet Dermatol. 2025;24:e16740. doi:10.1111/jocd.16740
- Bayiroglu AF, Acar G, Gulbahce-Mutlu E, Baltaci SB, Mogulkoc R, et al. Dietary zinc status is associated with ZnT3 (SLC30A3), IL-6 gene expressions and spinal cord tissue damage in spinal cord tissue in a cuprizone-induced rat Multiple Sclerosis model. J Trace Elem Med Biol. 2024;86:127540. doi:10.1016/j.jtemb.2024.127540
- Fang D, Jiang D, Shi G, Song Y. The association between dietary zinc intake and osteopenia, osteoporosis in patients with rheumatoid arthritis. BMC Musculoskelet Disord. 2024;25:710. doi:10.1186/s12891-024-07768-5
- Cheng J, Rink L, Wessels I. Zinc Supplementation Reduces the Formation of Neutrophil Extracellular Traps by Decreasing the Expression of Peptidyl Arginine Deiminase 4. Mol Nutr Food Res. 2024;68:e2400013. doi:10.1002/mnfr.202400013
