Last update
2/24/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Zinc (as zinc glycinate amino acid chelate†)
22 mg
200%
Top Medical Research Studies
9.5
We evaluated the effectiveness of a nitric-zinc complex solution (NZCS) for treating palmoplantar and periungual warts in children. Over a series of sessions, we found that 83.9% of warts completely resolved, with 87.5% success in periungual cases. The treatment was painless and easy, requiring only biweekly applications.
Additionally, the results were esthetically pleasing, with no significant side effects reported. This study highlights NZCS as a promising option for wart management in pediatric patients, making it easier for both children and their guardians.
Additionally, the results were esthetically pleasing, with no significant side effects reported. This study highlights NZCS as a promising option for wart management in pediatric patients, making it easier for both children and their guardians.
Read More
9.5
We explored the use of a novel nitric-zinc complex (NZC) solution for treating external ano-genital warts, a common issue caused by the human papillomavirus. In this study, 100 patients underwent up to four treatments, showing a remarkable 92% cure rate after the sessions. The findings also indicated that patients with fewer warts achieved better results. While relapses occurred in some cases, most tolerated the treatment well. This study suggests that earlier diagnosis and treatment lead to a more favorable outcome against these warts.
Read More
9
Zinc treatment comparable to cryotherapy
We analyzed how effective a zinc-based solution (Nitrizinc® Complex) is compared to cryotherapy in treating anogenital warts. In our study, 120 participants received either treatment and were monitored for up to four sessions.
Our findings indicated that the zinc solution was as effective as cryotherapy for smaller warts and was generally more tolerable. Participants experienced a lower recurrence rate, making Nitrizinc a promising alternative to traditional cryotherapy for managing these warts.
Our findings indicated that the zinc solution was as effective as cryotherapy for smaller warts and was generally more tolerable. Participants experienced a lower recurrence rate, making Nitrizinc a promising alternative to traditional cryotherapy for managing these warts.
Read More
Most Useful Reviews
9
Increased fertility
4 people found this helpful
Baby making pills. It seems to have resolved these cursed plantar warts on my feet while unexpectedly increasing my fertility, leading to significant changes for me in the coming months.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
- All Researches
9.5
We evaluated the effectiveness of a nitric-zinc complex solution (NZCS) for treating palmoplantar and periungual warts in children. Over a series of sessions, we found that 83.9% of warts completely resolved, with 87.5% success in periungual cases. The treatment was painless and easy, requiring only biweekly applications.
Additionally, the results were esthetically pleasing, with no significant side effects reported. This study highlights NZCS as a promising option for wart management in pediatric patients, making it easier for both children and their guardians.
Additionally, the results were esthetically pleasing, with no significant side effects reported. This study highlights NZCS as a promising option for wart management in pediatric patients, making it easier for both children and their guardians.
Read More
9.5
We explored the use of a novel nitric-zinc complex (NZC) solution for treating external ano-genital warts, a common issue caused by the human papillomavirus. In this study, 100 patients underwent up to four treatments, showing a remarkable 92% cure rate after the sessions. The findings also indicated that patients with fewer warts achieved better results. While relapses occurred in some cases, most tolerated the treatment well. This study suggests that earlier diagnosis and treatment lead to a more favorable outcome against these warts.
Read More
9
Zinc treatment comparable to cryotherapy
We analyzed how effective a zinc-based solution (Nitrizinc® Complex) is compared to cryotherapy in treating anogenital warts. In our study, 120 participants received either treatment and were monitored for up to four sessions.
Our findings indicated that the zinc solution was as effective as cryotherapy for smaller warts and was generally more tolerable. Participants experienced a lower recurrence rate, making Nitrizinc a promising alternative to traditional cryotherapy for managing these warts.
Our findings indicated that the zinc solution was as effective as cryotherapy for smaller warts and was generally more tolerable. Participants experienced a lower recurrence rate, making Nitrizinc a promising alternative to traditional cryotherapy for managing these warts.
Read More
9
We explored the effectiveness of a nitric-zinc complex solution (NZCS) in treating hard-to-handle warts caused by HPV. In a multicenter study involving 14 Italian dermatologists, 83 out of 106 responses reported using NZCS. Impressively, 84.1% of patients saw significant improvement with this treatment, much higher than the 44.8% success rate observed with past therapies. Not only did NZCS demonstrate superior efficacy, but it also provided better tolerability compared to previously used treatment methods.
Read More
8
We explored various intralesional treatments for plantar warts by analyzing 26 studies published between January 2012 and January 2021. Among the treatments assessed, zinc sulfate showed a decent median cure rate of 70%.
However, while it was better than some options, it didn't outperform intralesional vitamin D3, which had an impressive 80% cure rate. Overall, treatments like bleomycin and Candida antigen also showed effectiveness, but vitamin D3 stands as a promising first-line choice.
This study suggests ongoing consideration of different approaches for those struggling with stubborn plantar warts.
However, while it was better than some options, it didn't outperform intralesional vitamin D3, which had an impressive 80% cure rate. Overall, treatments like bleomycin and Candida antigen also showed effectiveness, but vitamin D3 stands as a promising first-line choice.
This study suggests ongoing consideration of different approaches for those struggling with stubborn plantar warts.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Increased fertility
4 people found this helpful
Baby making pills. It seems to have resolved these cursed plantar warts on my feet while unexpectedly increasing my fertility, leading to significant changes for me in the coming months.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Rayo Pérez AM, Juárez Jiménez JM, Rayo Rosado R, García de la Peña R. The Effectiveness of Topical Treatment for Plantar Warts: A Retrospective Cohort Study. Infect Dis Rep. 2024;16:1108. 10.3390/idr16060090
- Garcia-Oreja S, Alvaro-Afonso FJ, Vigara-Aranda P, Paramio-Rodriguez G, Leon-Herce D, et al. Treatment of Plantar Warts with a Nitric-Zinc Complex Solution: A Review of 72 Cases. Viruses. 2024;16. 10.3390/v16081307
- García-Oreja S, Álvaro-Afonso FJ, García-Madrid M, López-Moral M, García-Álvarez Y, et al. Cryotherapy versus topical nitric-zinc complex solution for the treatment of plantar warts: A randomized controlled trial. J Med Virol. 2023;95:e29212. 10.1002/jmv.29212
- Youssef EMK, Eissa MAA, Bakr RM. Intralesional Candida albicans antigen versus intralesional zinc sulfate in treatment of cutaneous warts. Arch Dermatol Res. 2023;315:1305. 10.1007/s00403-022-02499-w
- Martin A, Thatiparthi A, Nourmohammadi N, Nguyen C, Sung C, et al. Emerging Intralesional Treatments for Plantar Warts: A Systematic Review. J Drugs Dermatol. 2022;21:1322. 10.36849/JDD.6735
- Awad A, Ismael AF, Sallam M, Abdelgaber S. Intralesional purified protein derivative versus zinc sulfate 2% in the treatment of pediatric warts: Clinical and dermoscopic evaluation. J Cosmet Dermatol. 2022;21:4637. 10.1111/jocd.14876
- Song D, Pan L, Zhang M, Wang S. Clinical use of zinc in viral warts: a systematic review of the clinical trials. J Dermatolog Treat. 2022;33:1878. 10.1080/09546634.2021.1942420
- Pontini P, Mastorino L, Gaspari V, Granger C, Ramoni S, et al. A Multicentre, Randomised Clinical Trial to Compare a Topical Nitrizinc Complex Solution Versus Cryotherapy for the Treatment of Anogenital Warts. Dermatol Ther (Heidelb). 2020;10:1063. 10.1007/s13555-020-00430-7
- Nofal A, Albalat W, Ismail A, Khattab FM. Immunotherapeutic modalities for the treatment of recalcitrant plantar warts: a comparative study. J Dermatolog Treat. 2022;33:922. 10.1080/09546634.2020.1789540
- El Sayed MH, Sayed FS, Afify AA. Intralesional zinc sulfate 2% vs intralesional vitamin D in plantar warts: A clinicodermoscopic study. Dermatol Ther. 2020;33:e13308. 10.1111/dth.13308
- Songsantiphap C, Asawanonda P. Topical 15% Zinc Oxide Ointment Significantly Reduces the Size of Common Warts After Four Weeks: A Randomized, Triple-blinded, Placebo-controlled Trial. J Clin Aesthet Dermatol. 2019;12:26.
- Giacaman A, Granger C, Aladren S, Bauzá A, Alomar Torrens B, et al. Use of Topical Nitric-Zinc Complex Solution to Treat Palmoplantar and Periungual Warts in a Pediatric Population. Dermatol Ther (Heidelb). 2019;9:755. 10.1007/s13555-019-00330-5
- Abd El-Magid WM, Nada EEA, Mossa RA. Intralesional injection of vitamin D3 versus zinc sulfate 2% in treatment of plantar warts: a comparative study. J Dermatolog Treat. 2021;32:355. 10.1080/09546634.2019.1656326
- Ciccarese G, Drago F, Granger C, Parodi A. Efficacy Assessment of a Topically Applied Nitric-Zinc Complex Solution for the Treatment of External Ano-genital Warts in 100 Patients. Dermatol Ther (Heidelb). 2019;9:327. 10.1007/s13555-019-0300-7
- Puviani M, Manfredini M, Eisendle K. The SILVER study. Efficacy of topical nitric-zinc complex solution in the treatment of resistant warts: A postmarketing evaluation. Dermatol Ther. 2019;32:e12940. 10.1111/dth.12940
- El Taweel AA, Salem R, Allam A. Intralesional 2% zinc sulfate solution for plane warts: A case report. Dermatol Ther. 2019;32:e12761. 10.1111/dth.12761
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