' 
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 2 Vegetable Capsules
Amount Per Serving
%DV
Choline (as choline bitartrate)
500 mg
91%
Inositol
500 mg
**
Top Medical Research Studies
9
D-Pinitol shows promise in Alzheimer's
Therapeutic Efficacy of the Inositol D-Pinitol as a Multi-Faceted Disease Modifier in the 5×FAD Humanized Mouse Model of Alzheimer's Amyloidosis.
Addresses multifaceted Alzheimer treatment.
We explored the potential of D-Pinitol (DPIN), a compound derived from carob pods, as a game-changing treatment for Alzheimer's disease (AD). With AD being a leading cause of dementia and lacking effective long-term solutions, we sought to evaluate how DPIN could alter the course of this debilitating condition.
Our research focused on the 5×FAD mouse model, which closely mimics the Alzheimer-like symptoms in humans. Through chronic oral administration of DPIN at a dosage of 200 mg/kg/day, we observed various promising effects. Notably, DPIN improved cognitive performance in the mice, reduced harmful amyloid beta and tau protein levels, and even enhanced the expression of insulin-degrading enzymes that could help regulate insulin in the system.
Additionally, DPIN seemed to support gut health, countering chronic inflammation and restoring the balance of gut microbiota. This is significant because gut issues are increasingly recognized as a contributing factor to Alzheimer's. The compound not only helped repair intestinal barriers but also reduced inflammation markers associated with a leaky gut.
Overall, these findings suggest that D-Pinitol could serve as a multifaceted approach to modify the progression of Alzheimer's in its early stages, potentially shifting the landscape of how we treat this serious condition.
Our research focused on the 5×FAD mouse model, which closely mimics the Alzheimer-like symptoms in humans. Through chronic oral administration of DPIN at a dosage of 200 mg/kg/day, we observed various promising effects. Notably, DPIN improved cognitive performance in the mice, reduced harmful amyloid beta and tau protein levels, and even enhanced the expression of insulin-degrading enzymes that could help regulate insulin in the system.
Additionally, DPIN seemed to support gut health, countering chronic inflammation and restoring the balance of gut microbiota. This is significant because gut issues are increasingly recognized as a contributing factor to Alzheimer's. The compound not only helped repair intestinal barriers but also reduced inflammation markers associated with a leaky gut.
Overall, these findings suggest that D-Pinitol could serve as a multifaceted approach to modify the progression of Alzheimer's in its early stages, potentially shifting the landscape of how we treat this serious condition.
Read More
7
Inositol improves cognition in females
ApoE2 affects insulin signaling in the hippocampus and spatial cognition of aged mice in a sex-dependent manner.
Moderate relevance to Alzheimer's treatment
Our investigation focuses on the role of inositol supplementation in enhancing cognitive function in mice, particularly in the context of the ApoE2 genetic background, which is thought to provide some protective effects against Alzheimer's disease.
We discovered that aged female mice carrying the ApoE2 genotype exhibited a decline in spatial cognitive abilities compared to their ApoE3 counterparts. This decline was linked to impaired insulin signaling within the hippocampus, a brain region crucial for memory and learning.
Upon looking closer, we found that the ApoE2 females had lower levels of inositol, a compound that plays a role in insulin signaling. Encouragingly, when these mice received inositol supplementation, we observed improvements in insulin signaling, better glucose tolerance, and enhanced cognitive functions.
Interestingly, we did not find similar effects in male mice, highlighting that the benefits of inositol may be sex-specific, particularly for aged females. This research adds an intriguing chapter to our understanding of how certain genetic factors interact with metabolic processes to influence cognitive health, pointing to inositol as a potential avenue for therapeutic intervention.
We discovered that aged female mice carrying the ApoE2 genotype exhibited a decline in spatial cognitive abilities compared to their ApoE3 counterparts. This decline was linked to impaired insulin signaling within the hippocampus, a brain region crucial for memory and learning.
Upon looking closer, we found that the ApoE2 females had lower levels of inositol, a compound that plays a role in insulin signaling. Encouragingly, when these mice received inositol supplementation, we observed improvements in insulin signaling, better glucose tolerance, and enhanced cognitive functions.
Interestingly, we did not find similar effects in male mice, highlighting that the benefits of inositol may be sex-specific, particularly for aged females. This research adds an intriguing chapter to our understanding of how certain genetic factors interact with metabolic processes to influence cognitive health, pointing to inositol as a potential avenue for therapeutic intervention.
Read More
Most Useful Reviews
9
Memory improvement
This free-form choline supplement is excellent quality and effectively enhances memory and cognitive reasoning. I would highly recommend it for anyone looking to improve their memory or ease the effects of Alzheimer's disease.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
9
D-Pinitol shows promise in Alzheimer's
Therapeutic Efficacy of the Inositol D-Pinitol as a Multi-Faceted Disease Modifier in the 5×FAD Humanized Mouse Model of Alzheimer's Amyloidosis.
Addresses multifaceted Alzheimer treatment.
We explored the potential of D-Pinitol (DPIN), a compound derived from carob pods, as a game-changing treatment for Alzheimer's disease (AD). With AD being a leading cause of dementia and lacking effective long-term solutions, we sought to evaluate how DPIN could alter the course of this debilitating condition.
Our research focused on the 5×FAD mouse model, which closely mimics the Alzheimer-like symptoms in humans. Through chronic oral administration of DPIN at a dosage of 200 mg/kg/day, we observed various promising effects. Notably, DPIN improved cognitive performance in the mice, reduced harmful amyloid beta and tau protein levels, and even enhanced the expression of insulin-degrading enzymes that could help regulate insulin in the system.
Additionally, DPIN seemed to support gut health, countering chronic inflammation and restoring the balance of gut microbiota. This is significant because gut issues are increasingly recognized as a contributing factor to Alzheimer's. The compound not only helped repair intestinal barriers but also reduced inflammation markers associated with a leaky gut.
Overall, these findings suggest that D-Pinitol could serve as a multifaceted approach to modify the progression of Alzheimer's in its early stages, potentially shifting the landscape of how we treat this serious condition.
Our research focused on the 5×FAD mouse model, which closely mimics the Alzheimer-like symptoms in humans. Through chronic oral administration of DPIN at a dosage of 200 mg/kg/day, we observed various promising effects. Notably, DPIN improved cognitive performance in the mice, reduced harmful amyloid beta and tau protein levels, and even enhanced the expression of insulin-degrading enzymes that could help regulate insulin in the system.
Additionally, DPIN seemed to support gut health, countering chronic inflammation and restoring the balance of gut microbiota. This is significant because gut issues are increasingly recognized as a contributing factor to Alzheimer's. The compound not only helped repair intestinal barriers but also reduced inflammation markers associated with a leaky gut.
Overall, these findings suggest that D-Pinitol could serve as a multifaceted approach to modify the progression of Alzheimer's in its early stages, potentially shifting the landscape of how we treat this serious condition.
Read More
7
Inositol improves cognition in females
ApoE2 affects insulin signaling in the hippocampus and spatial cognition of aged mice in a sex-dependent manner.
Moderate relevance to Alzheimer's treatment
Our investigation focuses on the role of inositol supplementation in enhancing cognitive function in mice, particularly in the context of the ApoE2 genetic background, which is thought to provide some protective effects against Alzheimer's disease.
We discovered that aged female mice carrying the ApoE2 genotype exhibited a decline in spatial cognitive abilities compared to their ApoE3 counterparts. This decline was linked to impaired insulin signaling within the hippocampus, a brain region crucial for memory and learning.
Upon looking closer, we found that the ApoE2 females had lower levels of inositol, a compound that plays a role in insulin signaling. Encouragingly, when these mice received inositol supplementation, we observed improvements in insulin signaling, better glucose tolerance, and enhanced cognitive functions.
Interestingly, we did not find similar effects in male mice, highlighting that the benefits of inositol may be sex-specific, particularly for aged females. This research adds an intriguing chapter to our understanding of how certain genetic factors interact with metabolic processes to influence cognitive health, pointing to inositol as a potential avenue for therapeutic intervention.
We discovered that aged female mice carrying the ApoE2 genotype exhibited a decline in spatial cognitive abilities compared to their ApoE3 counterparts. This decline was linked to impaired insulin signaling within the hippocampus, a brain region crucial for memory and learning.
Upon looking closer, we found that the ApoE2 females had lower levels of inositol, a compound that plays a role in insulin signaling. Encouragingly, when these mice received inositol supplementation, we observed improvements in insulin signaling, better glucose tolerance, and enhanced cognitive functions.
Interestingly, we did not find similar effects in male mice, highlighting that the benefits of inositol may be sex-specific, particularly for aged females. This research adds an intriguing chapter to our understanding of how certain genetic factors interact with metabolic processes to influence cognitive health, pointing to inositol as a potential avenue for therapeutic intervention.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
9
Memory improvement
This free-form choline supplement is excellent quality and effectively enhances memory and cognitive reasoning. I would highly recommend it for anyone looking to improve their memory or ease the effects of Alzheimer's disease.
