' 
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 11 Reviews
8.4
Supplement Facts
Serving Size: 2 Vegetable Capsules
Amount Per Serving
%DV
Choline (as choline bitartrate)
500 mg
91%
Inositol
500 mg
**
Top Medical Research Studies
8
Inositol treatment for brain tumors
Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation.
Evaluates inositol's therapeutic potential
We explored the effects of inositol treatment on medulloblastoma, which is a leading cause of brain tumors in children. Specifically, we found that some medulloblastoma cells showed a unique sensitivity to changes in inositol metabolism due to the presence of the BMI1 gene.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Read More
Most Useful Reviews
8.8
Lowered stress levels
Solgar Choline/Inositol is a great supplement that supports healthy brain, nervous system, and metabolic function. After using it, I’ve experienced improvements in my memory, concentration, and reduced stress. The capsules are easy to swallow and well tolerated.
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8.8
Supports nervous system
I am thrilled with the results! This supplement enhances both brain function and the state of my nervous system. I take it twice daily with meals.
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8.8
Brain activation
It certainly helps to activate the brain.
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Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
- All Researches
8
Inositol treatment for brain tumors
Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation.
Evaluates inositol's therapeutic potential
We explored the effects of inositol treatment on medulloblastoma, which is a leading cause of brain tumors in children. Specifically, we found that some medulloblastoma cells showed a unique sensitivity to changes in inositol metabolism due to the presence of the BMI1 gene.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Lowered stress levels
Solgar Choline/Inositol is a great supplement that supports healthy brain, nervous system, and metabolic function. After using it, I’ve experienced improvements in my memory, concentration, and reduced stress. The capsules are easy to swallow and well tolerated.
8.8
Supports nervous system
I am thrilled with the results! This supplement enhances both brain function and the state of my nervous system. I take it twice daily with meals.
8.8
Brain activation
It certainly helps to activate the brain.
8.8
Remarkable improvement
I found this supplement to be a great alternative for prednisone. My mother has an autoimmune disease, and since starting this, her improvement has been notable. The product is affordable from iHerb, and I've already ordered it four times.
8
Positive brain effects
Combining choline and inositol can significantly enhance brain function and mood. Choline boosts memory and cognitive skills, while Inositol may alleviate anxiety. We began with one capsule daily and gradually increased the dose to two to four, which has been effective for us. Solgar's reputation for quality reassures me of its effectiveness.
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