Effects of altering dietary essential fatty acids on requirements for non-steroidal anti-inflammatory drugs in patients with rheumatoid arthritis: a double blind placebo controlled study.
This study explored whether evening primrose oil (EPO) could replace non-steroidal anti-inflammatory drugs (NSAIDs) for people with rheumatoid arthritis (RA).
Over 12 months, we noticed that patients taking EPO showed notable subjective improvements and were able to reduce their NSAID intake.
However, a follow-up after three months of placebo indicated that while they felt better initially, their symptoms returned.
Importantly, EPO didn't change underlying disease progression, meaning it may not be a cure but can support symptom relief.
Read More
8
EPO shows promise for arthritis
Evening primrose oil and celecoxib inhibited pathological angiogenesis, inflammation, and oxidative stress in adjuvant-induced arthritis: novel role of angiopoietin-1.
We explored the effects of evening primrose oil (EPO) on rheumatoid arthritis, a condition marked by inflammation and dangerous new blood vessel formation. In our study, we used male albino rats with induced arthritis to see how EPO, alone or combined with common medications like aspirin and celecoxib, could help.
The results were promising, showing that EPO could normalize body weight and reduce harmful levels of specific inflammatory markers. Moreover, it helped decrease inflammation and improve overall joint health. Although combining EPO with other treatments enhanced its effects, we observed that EPO alone provides significant benefits in managing arthritis symptoms.
We evaluated the potential benefits of evening primrose oil in treating rheumatoid arthritis (RA) through a systematic review that included 22 studies. Results suggest that oils high in gamma linolenic acid (like evening primrose oil) may help reduce pain and improve disability in RA patients.
However, while some data supports these benefits, side effects were noted, and the effectiveness wasn’t consistent across all studies. Overall, there’s moderate evidence supporting evening primrose oil’s role in managing RA symptoms, but more rigorous research is needed to strengthen these findings.
Read More
Most Useful Reviews
9
Anti-inflammatory benefits
1 people found this helpful
This oil effectively reduces PMS and menopause pain and is useful for chronic skin ailments like eczema and acne. Evening Primrose Oil serves as an anti-inflammatory agent, proving advantageous for arthritis. I wholeheartedly recommend this brand.
Read More
9
Reduces arthritis pain
Evening primrose oil significantly alleviates pain from PMS and menopause while combating chronic skin diseases such as eczema, acne, and psoriasis. It also effectively tackles arthritis and other health issues. I highly recommend it.
Read More
8
Reduced arthritis symptoms
411 people found this helpful
I regularly take Evening Primrose Oil, alternating with a DIM-plus regulator for estrogen metabolism. This oil, rich in gamma-linolenic acid (omega-6), is not produced by the body but has numerous benefits, such as alleviating arthritis symptoms. Continuous intake is necessary to feel the full effects on the body. I noticed improvements in my menstrual cycle and skin condition. It's crucial to consult a doctor for dosage, especially during pregnancy.
We examined the impact of evening primrose oil combined with fish oil on patients with rheumatoid arthritis through a 12-week study involving 60 participants. The results showed that both fish oil and the combination with evening primrose oil led to significant improvements in symptoms, like reduced disease activity scores and fewer tender joints.
However, while evening primrose oil contributed positively, the study emphasized the notable benefits of omega-3 fatty acids alone as well. Overall, this suggests a potential pathway for improving arthritis symptoms through these supplements.
Read More
8
EPO shows promise for arthritis
Evening primrose oil and celecoxib inhibited pathological angiogenesis, inflammation, and oxidative stress in adjuvant-induced arthritis: novel role of angiopoietin-1.
We explored the effects of evening primrose oil (EPO) on rheumatoid arthritis, a condition marked by inflammation and dangerous new blood vessel formation. In our study, we used male albino rats with induced arthritis to see how EPO, alone or combined with common medications like aspirin and celecoxib, could help.
The results were promising, showing that EPO could normalize body weight and reduce harmful levels of specific inflammatory markers. Moreover, it helped decrease inflammation and improve overall joint health. Although combining EPO with other treatments enhanced its effects, we observed that EPO alone provides significant benefits in managing arthritis symptoms.
We evaluated the potential benefits of evening primrose oil in treating rheumatoid arthritis (RA) through a systematic review that included 22 studies. Results suggest that oils high in gamma linolenic acid (like evening primrose oil) may help reduce pain and improve disability in RA patients.
However, while some data supports these benefits, side effects were noted, and the effectiveness wasn’t consistent across all studies. Overall, there’s moderate evidence supporting evening primrose oil’s role in managing RA symptoms, but more rigorous research is needed to strengthen these findings.
Read More
7
EPO shows symptom relief potential
Effects of altering dietary essential fatty acids on requirements for non-steroidal anti-inflammatory drugs in patients with rheumatoid arthritis: a double blind placebo controlled study.
This study explored whether evening primrose oil (EPO) could replace non-steroidal anti-inflammatory drugs (NSAIDs) for people with rheumatoid arthritis (RA).
Over 12 months, we noticed that patients taking EPO showed notable subjective improvements and were able to reduce their NSAID intake.
However, a follow-up after three months of placebo indicated that while they felt better initially, their symptoms returned.
Importantly, EPO didn't change underlying disease progression, meaning it may not be a cure but can support symptom relief.
Read More
4
Mild benefits of evening primrose oil
Evening primrose oil in patients with rheumatoid arthritis and side-effects of non-steroidal anti-inflammatory drugs.
We conducted a six-month double-blind study exploring the effects of evening primrose oil on rheumatoid arthritis.
In total, 40 patients participated, with half receiving evening primrose oil and the other half a placebo.
While we noted a slight improvement in morning stiffness at three months with evening primrose oil, olive oil showed more significant reductions in pain and overall joint issues at the six-month mark.
This suggests that evening primrose oil provides only mild benefits, while olive oil may have important, previously overlooked advantages.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.3
All Reviews
Positive Reviews
Negative Reviews
9
Anti-inflammatory benefits
1 people found this helpful
This oil effectively reduces PMS and menopause pain and is useful for chronic skin ailments like eczema and acne. Evening Primrose Oil serves as an anti-inflammatory agent, proving advantageous for arthritis. I wholeheartedly recommend this brand.
Read More
9
Reduces arthritis pain
Evening primrose oil significantly alleviates pain from PMS and menopause while combating chronic skin diseases such as eczema, acne, and psoriasis. It also effectively tackles arthritis and other health issues. I highly recommend it.
Read More
8
Reduced arthritis symptoms
411 people found this helpful
I regularly take Evening Primrose Oil, alternating with a DIM-plus regulator for estrogen metabolism. This oil, rich in gamma-linolenic acid (omega-6), is not produced by the body but has numerous benefits, such as alleviating arthritis symptoms. Continuous intake is necessary to feel the full effects on the body. I noticed improvements in my menstrual cycle and skin condition. It's crucial to consult a doctor for dosage, especially during pregnancy.
Read More
7.5
Helps during menopause
2 people found this helpful
Evening Primrose Oil contains essential fatty acids necessary for health. It's known to reduce PMS pain and improve chronic skin issues like eczema and acne. It’s beneficial during menopause and for arthritis, offering an anti-inflammatory effect. I used it for my mother during her menopause, and the results were quite positive; her condition improved significantly.
Read More
9
Alleviates joint pain
Thanks to this oil, my monthly cycle is less burdensome, and I feel far more relaxed. It also eases my joint pain resulting from rheumatoid arthritis, which I've endured for several years.
Arthritis is a general term that refers to inflammation of the joints, which can lead to pain, stiffness, and swelling. It encompasses over 100 different types, with osteoarthritis and rheumatoid arthritis being the most common. Osteoarthritis, often associated with aging, occurs when the cartilage that cushions the joints wears down over time. In contrast, rheumatoid arthritis is an autoimmune disorder where the body's immune system mistakenly attacks the joints, leading to chronic inflammation and potential disability if left untreated.
Symptoms of arthritis can vary widely depending on the type but typically include joint pain, swelling, reduced range of motion, and sometimes fatigue. Diagnosis usually involves a combination of physical exams, imaging tests, and blood tests. While there is currently no cure for arthritis, various treatments ranging from lifestyle modifications, physical therapy, and medications can help manage symptoms and improve quality of life. For those affected, seeking early diagnosis and intervention is crucial for slowing disease progression and preserving joint function.
Evening Primrose Oil is derived from the seeds of the evening primrose plant (Oenothera biennis), a native North American flowering plant known for its bright yellow blooms that open in the evening. This oil is rich in gamma-linolenic acid (GLA), an omega-6 fatty acid that plays a crucial role in various bodily functions, including maintaining skin health and regulating inflammation. Due to its high GLA content, evening primrose oil is often used as a dietary supplement to assist with a variety of health concerns, such as symptoms associated with premenstrual syndrome (PMS), menopause, and conditions that involve inflammation like eczema.
In addition to its potential health benefits when taken in supplement form, many users also apply evening primrose oil topically to help improve skin health, reduce dryness, and soothe irritations. While some research supports its benefits, results can vary, and it’s always recommended to consult with a healthcare professional before adding any new supplement to your routine. Overall, evening primrose oil is celebrated for its versatility as both a dietary and topical addition, making it a popular choice among those seeking natural wellness options.
Evening Primrose Oil (EPO) has been studied for its potential benefits in managing arthritis symptoms, primarily due to its high content of gamma-linolenic acid (GLA), an omega-6 fatty acid. Some research suggests that GLA may help reduce inflammation and pain associated with arthritis, particularly rheumatoid arthritis. A few small studies have indicated that EPO can improve overall joint function and reduce stiffness, making it a tempting option for those seeking natural remedies. However, results can vary significantly among individuals, and more extensive, well-designed trials are needed to fully establish its effectiveness.
It's important to note that while some individuals may find relief with EPO, it should not replace conventional medical treatment for arthritis. Always consult with a healthcare professional before starting any new supplement, especially if you are currently on medication or have underlying health issues. They can provide guidance tailored to your specific health needs and help you understand how EPO might fit into your broader treatment plan.
Based on user reviews, individuals taking Evening Primrose Oil for arthritis have reported varying timelines for experiencing results. While some users note immediate relief in joint pain, others indicate that continuous intake is essential to feel the full effects, emphasizing the importance of perseverance in treatment for chronic conditions like arthritis. For example, one user mentioned that they felt significant improvement after consistent use, suggesting it takes time for the body to respond to the supplement's anti-inflammatory properties Read Review.
Many reviewers recommend the supplement due to its reported benefits for arthritis, hinting at a cumulative effect rather than a quick fix. Another user shared their positive experience with easing joint pain over time as part of their long-term health regimen Read Review. Therefore, while some might notice improvements sooner, a period of continued use appears necessary for optimal effects on joint health.
Evening primrose oil (EPO) has shown potential in supporting the treatment of rheumatoid arthritis (RA) based on several studies. For instance, a 12-week trial involving 60 participants found that combining EPO with fish oil resulted in significant improvements in disease activity and symptom management, suggesting that these supplements can play a role in alleviating arthritis symptoms [1]. Additionally, EPO's application in a study using male albino rats demonstrated its ability to reduce inflammation and improve joint health, which further supports its therapeutic benefits for arthritis sufferers [2].
However, the evidence is not entirely conclusive. A systematic review of 22 studies found moderate support for EPO's role in reducing pain and disability in RA patients, though side effects and inconsistent effectiveness were also noted [3]. Additionally, a six-month double-blind study indicated that while EPO offered mild relief from symptoms like morning stiffness, it fell short compared to other alternatives, such as olive oil, which provided more significant benefits [4]. Overall, while there is some scientific backing for evening primrose oil in managing arthritis symptoms, further rigorous research is necessary to fully establish its efficacy and clarify its role alongside other treatment options.
Based on user reviews, many individuals report significant improvements in various symptoms due to their use of Evening Primrose Oil. Specifically, users have noted a reduction in pain associated with premenstrual syndrome (PMS) and menopause, alongside improvements in chronic skin conditions like eczema and acne Read Review. Additionally, several reviewers highlighted its anti-inflammatory effects, especially for arthritis, with one user mentioning that the oil helped ease joint pain stemming from rheumatoid arthritis after years of suffering Read Review.
Moreover, consistent usage seems to play a crucial role in experiencing these benefits. One user specified that regular intake of Evening Primrose Oil led to noticeable improvements in both menstrual cycles and skin conditions Read Review. This reflects a common sentiment among reviewers who emphasize the importance of sustained use for optimal results. While individual results may vary, the collective experiences suggest that many users find Evening Primrose Oil to be an effective supplement for alleviating various symptoms related to women's health and chronic conditions.
Based on user reviews, many individuals have reported positive experiences when combining Evening Primrose Oil with other supplements for managing arthritis. For instance, one user mentioned taking Evening Primrose Oil alongside a DIM-plus regulator for estrogen metabolism, highlighting the oil's rich content of gamma-linolenic acid (omega-6) and its anti-inflammatory benefits for arthritis symptoms Read Review. This suggests that users appreciate the synergistic effects of these supplements in enhancing their overall therapeutic regimen.
Additionally, multiple reviewers emphasized the necessity of consistent use for optimal results, indicating that incorporating Evening Primrose Oil with other supplements results in greater relief from joint pain and associated symptoms Read Review. While specific combinations apart from estrogen regulators are not frequently mentioned, feedback indicates that many users find Evening Primrose Oil to be a valuable addition to their pain management protocols, especially alongside other health-supporting supplements.
Based on user reviews, Evening Primrose Oil has been recognized for its potential in alleviating arthritis symptoms. Users report that this oil offers anti-inflammatory benefits, highlighting its effectiveness for various joint issues, including rheumatoid arthritis. One user specifically noted that it eases joint pain associated with rheumatoid arthritis, stating that their experience improved significantly after using the oil for several years Read Review. Several other reviews mention its advantages for conditions like menopause and chronic skin ailments, indicating its broad spectrum of benefits Read Review, Read Review.
While the precise dosage for Evening Primrose Oil isn’t detailed in user reviews, it's noted that continuous intake is necessary to feel the full effects Read Review. Users emphasize consulting a doctor for proper dosage, especially in unique circumstances such as pregnancy Read Review. Therefore, it's advisable to follow professional guidance when determining the right dosage for treating arthritis with Evening Primrose Oil.
8
Reduced arthritis symptoms
411 people found this helpful
I regularly take Evening Primrose Oil, alternating with a DIM-plus regulator for estrogen metabolism. This oil, rich in gamma-linolenic acid (omega-6), is not produced by the body but has numerous benefits, such as alleviating arthritis symptoms. Continuous intake is necessary to feel the full effects on the body. I noticed improvements in my menstrual cycle and skin condition. It's crucial to consult a doctor for dosage, especially during pregnancy.
9
Alleviates joint pain
Thanks to this oil, my monthly cycle is less burdensome, and I feel far more relaxed. It also eases my joint pain resulting from rheumatoid arthritis, which I've endured for several years.
9
Anti-inflammatory benefits
1 people found this helpful
This oil effectively reduces PMS and menopause pain and is useful for chronic skin ailments like eczema and acne. Evening Primrose Oil serves as an anti-inflammatory agent, proving advantageous for arthritis. I wholeheartedly recommend this brand.
6
Helps with arthritis
Evening primrose oil supplements omega-3s and is crucial for a healthy balance of essential fatty acids. It supports the absorption of food, as fats slow down hunger and carry important fat-soluble vitamins like A, D, E, and K. It possesses many medicinal properties, including alleviating pain from PMS and improving chronic skin conditions like eczema, acne, and psoriasis. Additionally, it acts as an anti-inflammatory, offering benefits for women during menopause and arthritis.
7.5
Helps during menopause
2 people found this helpful
Evening Primrose Oil contains essential fatty acids necessary for health. It's known to reduce PMS pain and improve chronic skin issues like eczema and acne. It’s beneficial during menopause and for arthritis, offering an anti-inflammatory effect. I used it for my mother during her menopause, and the results were quite positive; her condition improved significantly.
9
Evening primrose oil shows promise
Clinical Benefits of n-3 PUFA and ɤ-Linolenic Acid in Patients with Rheumatoid Arthritis.
We examined the impact of evening primrose oil combined with fish oil on patients with rheumatoid arthritis through a 12-week study involving 60 participants. The results showed that both fish oil and the combination with evening primrose oil led to significant improvements in symptoms, like reduced disease activity scores and fewer tender joints.
However, while evening primrose oil contributed positively, the study emphasized the notable benefits of omega-3 fatty acids alone as well. Overall, this suggests a potential pathway for improving arthritis symptoms through these supplements.
8
EPO shows promise for arthritis
Evening primrose oil and celecoxib inhibited pathological angiogenesis, inflammation, and oxidative stress in adjuvant-induced arthritis: novel role of angiopoietin-1.
We explored the effects of evening primrose oil (EPO) on rheumatoid arthritis, a condition marked by inflammation and dangerous new blood vessel formation. In our study, we used male albino rats with induced arthritis to see how EPO, alone or combined with common medications like aspirin and celecoxib, could help.
The results were promising, showing that EPO could normalize body weight and reduce harmful levels of specific inflammatory markers. Moreover, it helped decrease inflammation and improve overall joint health. Although combining EPO with other treatments enhanced its effects, we observed that EPO alone provides significant benefits in managing arthritis symptoms.
We evaluated the potential benefits of evening primrose oil in treating rheumatoid arthritis (RA) through a systematic review that included 22 studies. Results suggest that oils high in gamma linolenic acid (like evening primrose oil) may help reduce pain and improve disability in RA patients.
However, while some data supports these benefits, side effects were noted, and the effectiveness wasn’t consistent across all studies. Overall, there’s moderate evidence supporting evening primrose oil’s role in managing RA symptoms, but more rigorous research is needed to strengthen these findings.
4
Mild benefits of evening primrose oil
Evening primrose oil in patients with rheumatoid arthritis and side-effects of non-steroidal anti-inflammatory drugs.
We conducted a six-month double-blind study exploring the effects of evening primrose oil on rheumatoid arthritis.
In total, 40 patients participated, with half receiving evening primrose oil and the other half a placebo.
While we noted a slight improvement in morning stiffness at three months with evening primrose oil, olive oil showed more significant reductions in pain and overall joint issues at the six-month mark.
This suggests that evening primrose oil provides only mild benefits, while olive oil may have important, previously overlooked advantages.
References
Veselinovic M, Vasiljevic D, Vucic V, Arsic A, Petrovic S, et al. Clinical Benefits of n-3 PUFA and ɤ-Linolenic Acid in Patients with Rheumatoid Arthritis. Nutrients. 2017;9. 10.3390/nu9040325
El-Sayed RM, Moustafa YM, El-Azab MF. Evening primrose oil and celecoxib inhibited pathological angiogenesis, inflammation, and oxidative stress in adjuvant-induced arthritis: novel role of angiopoietin-1. Inflammopharmacology. 2014;22:305. 10.1007/s10787-014-0200-5
Cameron M, Gagnier JJ, Chrubasik S. Herbal therapy for treating rheumatoid arthritis. Cochrane Database Syst Rev. 2011. 10.1002/14651858.CD002948.pub2
Brzeski M, Madhok R, Capell HA. Evening primrose oil in patients with rheumatoid arthritis and side-effects of non-steroidal anti-inflammatory drugs. Br J Rheumatol. 1991;30:370.
Belch JJ, Ansell D, Madhok R, O'Dowd A, Sturrock RD. Effects of altering dietary essential fatty acids on requirements for non-steroidal anti-inflammatory drugs in patients with rheumatoid arthritis: a double blind placebo controlled study. Ann Rheum Dis. 1988;47:96.