Last update
5/30/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.5
USERS' SCORE
Good
Based on 7 Reviews
8.2
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate (800 mcg L-methylfolate) (as L-methylfolate as Metafolin®)
1,333 mcg DFE
333%
Top Medical Research Studies
8
We have explored how folate, a vital B-vitamin, may play a crucial role in lowering homocysteine levels, which is linked to heightened risks of cardiovascular diseases. The study highlights how high levels of homocysteine can contribute to atherosclerosis, a silent but dangerous condition leading to heart disease and stroke.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
Read More
7
Folate may slow atherosclerosis progression
We explored the relationship between folate and vitamin B12 levels and their impact on cardiovascular health by studying participants from São Paulo, Brazil. Specifically, we aimed to understand how these vitamins relate to changes in carotid intima-media thickness (cIMT), a key marker for early atherosclerosis.
Over a median follow-up of eight years, we observed that the majority of participants had adequate levels of these vitamins, thanks in part to mandatory folic acid fortification in food. Our findings indicated that individuals with the highest serum folate levels experienced a slower increase in cIMT compared to those with the lowest levels. In particular, the fourth quartile of serum folate showed a significant association with reduced cIMT progression.
Interestingly, we found no such effect with vitamin B12. Additionally, dietary folate intake was not linked to changes in cIMT. This suggests that while folate might play a beneficial role in cardiovascular health, vitamin B12 does not appear to have the same effect in this population.
Overall, our study highlights the potential importance of maintaining adequate folate levels for cardiovascular health, especially in regions with fortified food. However, it's essential to note that there were no significant deficiencies in these vitamins in our cohort, which underscores the effectiveness of food fortification programs.
Over a median follow-up of eight years, we observed that the majority of participants had adequate levels of these vitamins, thanks in part to mandatory folic acid fortification in food. Our findings indicated that individuals with the highest serum folate levels experienced a slower increase in cIMT compared to those with the lowest levels. In particular, the fourth quartile of serum folate showed a significant association with reduced cIMT progression.
Interestingly, we found no such effect with vitamin B12. Additionally, dietary folate intake was not linked to changes in cIMT. This suggests that while folate might play a beneficial role in cardiovascular health, vitamin B12 does not appear to have the same effect in this population.
Overall, our study highlights the potential importance of maintaining adequate folate levels for cardiovascular health, especially in regions with fortified food. However, it's essential to note that there were no significant deficiencies in these vitamins in our cohort, which underscores the effectiveness of food fortification programs.
Read More
8
We explored the connection between serum folate levels and stroke risk by examining a diverse group of 4,903 individuals from a Chinese community. Over a follow-up period of about 9.3 years, we recorded a total of 407 strokes, with the majority being ischemic strokes.
Our analysis revealed that individuals with higher folate levels (specifically those in the highest quartile, at 8.2 ng/mL or more) had a significantly lower risk of stroke. The data showed a hazard ratio of 0.68, indicating that these individuals were less likely to experience a stroke compared to those with lower folate levels.
An intriguing find was that homocysteine (Hcy) acted as a mediator in this relationship, accounting for about 14.5% of the connection between folate and stroke risk. Furthermore, we discovered that genetic factors, specifically the MTHFR gene polymorphism, could influence this relationship. We found that having the C677T genotype correlated with a positive impact of folate on stroke risk, while no such correlation was apparent for individuals with the other genotype.
Overall, the study suggests that adequate folate levels may be vital for reducing long-term stroke risk, with certain genetic variations playing a role in how folate affects cardiovascular health.
Our analysis revealed that individuals with higher folate levels (specifically those in the highest quartile, at 8.2 ng/mL or more) had a significantly lower risk of stroke. The data showed a hazard ratio of 0.68, indicating that these individuals were less likely to experience a stroke compared to those with lower folate levels.
An intriguing find was that homocysteine (Hcy) acted as a mediator in this relationship, accounting for about 14.5% of the connection between folate and stroke risk. Furthermore, we discovered that genetic factors, specifically the MTHFR gene polymorphism, could influence this relationship. We found that having the C677T genotype correlated with a positive impact of folate on stroke risk, while no such correlation was apparent for individuals with the other genotype.
Overall, the study suggests that adequate folate levels may be vital for reducing long-term stroke risk, with certain genetic variations playing a role in how folate affects cardiovascular health.
Read More
Most Useful Reviews
9
Active folate form
I took this supplement three months before and during pregnancy due to my body's inability to absorb ordinary folic acid. The active form - matafolin - is ideal for me and supports the cardiovascular system. The pack contains 100 tablets, and I took one daily. I highly recommend it.
Read More
9
Reduces homocysteine levels
This is the best form of folic acid in methylfolate, an active variant that's better absorbed and necessary for supporting the cardiovascular and nervous systems. My husband and I regularly take it, and we have experienced no side effects. The tablets are small and come in a dark glass jar.
Read More
7.5
Homocysteine regulation
3 people found this helpful
This product is a good-quality L-methylfolate supplement, also known as metafolin, which penetrates tissues across the blood-brain barrier. It aids in regulating homocysteine, which is associated with various illnesses, including cardiovascular disease and certain cancers. After trying this Solgar product, I’m pleased to report that I’ve experienced no adverse side effects.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.5
- All Researches
8
We explored the connection between serum folate levels and stroke risk by examining a diverse group of 4,903 individuals from a Chinese community. Over a follow-up period of about 9.3 years, we recorded a total of 407 strokes, with the majority being ischemic strokes.
Our analysis revealed that individuals with higher folate levels (specifically those in the highest quartile, at 8.2 ng/mL or more) had a significantly lower risk of stroke. The data showed a hazard ratio of 0.68, indicating that these individuals were less likely to experience a stroke compared to those with lower folate levels.
An intriguing find was that homocysteine (Hcy) acted as a mediator in this relationship, accounting for about 14.5% of the connection between folate and stroke risk. Furthermore, we discovered that genetic factors, specifically the MTHFR gene polymorphism, could influence this relationship. We found that having the C677T genotype correlated with a positive impact of folate on stroke risk, while no such correlation was apparent for individuals with the other genotype.
Overall, the study suggests that adequate folate levels may be vital for reducing long-term stroke risk, with certain genetic variations playing a role in how folate affects cardiovascular health.
Our analysis revealed that individuals with higher folate levels (specifically those in the highest quartile, at 8.2 ng/mL or more) had a significantly lower risk of stroke. The data showed a hazard ratio of 0.68, indicating that these individuals were less likely to experience a stroke compared to those with lower folate levels.
An intriguing find was that homocysteine (Hcy) acted as a mediator in this relationship, accounting for about 14.5% of the connection between folate and stroke risk. Furthermore, we discovered that genetic factors, specifically the MTHFR gene polymorphism, could influence this relationship. We found that having the C677T genotype correlated with a positive impact of folate on stroke risk, while no such correlation was apparent for individuals with the other genotype.
Overall, the study suggests that adequate folate levels may be vital for reducing long-term stroke risk, with certain genetic variations playing a role in how folate affects cardiovascular health.
Read More
8
We have explored how folate, a vital B-vitamin, may play a crucial role in lowering homocysteine levels, which is linked to heightened risks of cardiovascular diseases. The study highlights how high levels of homocysteine can contribute to atherosclerosis, a silent but dangerous condition leading to heart disease and stroke.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
Read More
7
Folate may slow atherosclerosis progression
We explored the relationship between folate and vitamin B12 levels and their impact on cardiovascular health by studying participants from São Paulo, Brazil. Specifically, we aimed to understand how these vitamins relate to changes in carotid intima-media thickness (cIMT), a key marker for early atherosclerosis.
Over a median follow-up of eight years, we observed that the majority of participants had adequate levels of these vitamins, thanks in part to mandatory folic acid fortification in food. Our findings indicated that individuals with the highest serum folate levels experienced a slower increase in cIMT compared to those with the lowest levels. In particular, the fourth quartile of serum folate showed a significant association with reduced cIMT progression.
Interestingly, we found no such effect with vitamin B12. Additionally, dietary folate intake was not linked to changes in cIMT. This suggests that while folate might play a beneficial role in cardiovascular health, vitamin B12 does not appear to have the same effect in this population.
Overall, our study highlights the potential importance of maintaining adequate folate levels for cardiovascular health, especially in regions with fortified food. However, it's essential to note that there were no significant deficiencies in these vitamins in our cohort, which underscores the effectiveness of food fortification programs.
Over a median follow-up of eight years, we observed that the majority of participants had adequate levels of these vitamins, thanks in part to mandatory folic acid fortification in food. Our findings indicated that individuals with the highest serum folate levels experienced a slower increase in cIMT compared to those with the lowest levels. In particular, the fourth quartile of serum folate showed a significant association with reduced cIMT progression.
Interestingly, we found no such effect with vitamin B12. Additionally, dietary folate intake was not linked to changes in cIMT. This suggests that while folate might play a beneficial role in cardiovascular health, vitamin B12 does not appear to have the same effect in this population.
Overall, our study highlights the potential importance of maintaining adequate folate levels for cardiovascular health, especially in regions with fortified food. However, it's essential to note that there were no significant deficiencies in these vitamins in our cohort, which underscores the effectiveness of food fortification programs.
Read More
7
We explored the relationship between hypertension and global DNA methylation levels in a group of 2,300 individuals aged 30 to 75 from rural Punjab, India. Our research particularly aimed to see how folate, along with other vitamins and biochemical markers, affects blood pressure and cardiovascular health.
After screening, we identified 900 individuals—450 with hypertension and 450 without. The results revealed that those suffering from hypertension had significantly lower levels of global DNA methylation compared to those who were normotensive. Intriguingly, individuals with the lowest levels of DNA methylation were at a notably increased risk for hypertension.
Another key finding was that hypertensive individuals who were on medication and had controlled blood pressure showed higher levels of DNA methylation than those with uncontrolled hypertension. This suggests that managing blood pressure effectively, combined with adequate folate levels, might help improve methylation, a crucial process linked to health.
Overall, this study highlights the complex interconnections between folate, global DNA methylation, and hypertension, suggesting that folate could play an important role in managing cardiovascular health in our rural population.
After screening, we identified 900 individuals—450 with hypertension and 450 without. The results revealed that those suffering from hypertension had significantly lower levels of global DNA methylation compared to those who were normotensive. Intriguingly, individuals with the lowest levels of DNA methylation were at a notably increased risk for hypertension.
Another key finding was that hypertensive individuals who were on medication and had controlled blood pressure showed higher levels of DNA methylation than those with uncontrolled hypertension. This suggests that managing blood pressure effectively, combined with adequate folate levels, might help improve methylation, a crucial process linked to health.
Overall, this study highlights the complex interconnections between folate, global DNA methylation, and hypertension, suggesting that folate could play an important role in managing cardiovascular health in our rural population.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Active folate form
I took this supplement three months before and during pregnancy due to my body's inability to absorb ordinary folic acid. The active form - matafolin - is ideal for me and supports the cardiovascular system. The pack contains 100 tablets, and I took one daily. I highly recommend it.
Read More
9
Reduces homocysteine levels
This is the best form of folic acid in methylfolate, an active variant that's better absorbed and necessary for supporting the cardiovascular and nervous systems. My husband and I regularly take it, and we have experienced no side effects. The tablets are small and come in a dark glass jar.
Read More
7.5
Homocysteine regulation
3 people found this helpful
This product is a good-quality L-methylfolate supplement, also known as metafolin, which penetrates tissues across the blood-brain barrier. It aids in regulating homocysteine, which is associated with various illnesses, including cardiovascular disease and certain cancers. After trying this Solgar product, I’m pleased to report that I’ve experienced no adverse side effects.
Read More
7.5
Essential during pregnancy
This active form of folic acid meets daily needs and supports cardiovascular and nervous system health. It’s vital during pregnancy and lactation. I value its quality and absorption, making it an essential part of my health regimen.
Read More
7.5
Enhances energy levels
This is bioavailable folic acid that I take as the standard form isn't absorbed by my body. It plays a role in several bodily functions, including the nervous and cardiovascular systems. I noticed an increase in energy after a month, and I find the tablets are small and easy to take.
Read More
Frequently Asked Questions
7.5
Enhances energy levels
This is bioavailable folic acid that I take as the standard form isn't absorbed by my body. It plays a role in several bodily functions, including the nervous and cardiovascular systems. I noticed an increase in energy after a month, and I find the tablets are small and easy to take.
9
Active folate form
I took this supplement three months before and during pregnancy due to my body's inability to absorb ordinary folic acid. The active form - matafolin - is ideal for me and supports the cardiovascular system. The pack contains 100 tablets, and I took one daily. I highly recommend it.
9
Reduces homocysteine levels
This is the best form of folic acid in methylfolate, an active variant that's better absorbed and necessary for supporting the cardiovascular and nervous systems. My husband and I regularly take it, and we have experienced no side effects. The tablets are small and come in a dark glass jar.
7.5
No digestive issues
I love Solgar! Folate supports the nervous and cardiovascular systems. The tablets are easy to take, with no stomach discomfort or intestinal issues like with traditional folic acid. The dosage is excellent with consistent results, and I am very satisfied.
8
We explored the connection between serum folate levels and stroke risk by examining a diverse group of 4,903 individuals from a Chinese community. Over a follow-up period of about 9.3 years, we recorded a total of 407 strokes, with the majority being ischemic strokes.
Our analysis revealed that individuals with higher folate levels (specifically those in the highest quartile, at 8.2 ng/mL or more) had a significantly lower risk of stroke. The data showed a hazard ratio of 0.68, indicating that these individuals were less likely to experience a stroke compared to those with lower folate levels.
An intriguing find was that homocysteine (Hcy) acted as a mediator in this relationship, accounting for about 14.5% of the connection between folate and stroke risk. Furthermore, we discovered that genetic factors, specifically the MTHFR gene polymorphism, could influence this relationship. We found that having the C677T genotype correlated with a positive impact of folate on stroke risk, while no such correlation was apparent for individuals with the other genotype.
Overall, the study suggests that adequate folate levels may be vital for reducing long-term stroke risk, with certain genetic variations playing a role in how folate affects cardiovascular health.
Our analysis revealed that individuals with higher folate levels (specifically those in the highest quartile, at 8.2 ng/mL or more) had a significantly lower risk of stroke. The data showed a hazard ratio of 0.68, indicating that these individuals were less likely to experience a stroke compared to those with lower folate levels.
An intriguing find was that homocysteine (Hcy) acted as a mediator in this relationship, accounting for about 14.5% of the connection between folate and stroke risk. Furthermore, we discovered that genetic factors, specifically the MTHFR gene polymorphism, could influence this relationship. We found that having the C677T genotype correlated with a positive impact of folate on stroke risk, while no such correlation was apparent for individuals with the other genotype.
Overall, the study suggests that adequate folate levels may be vital for reducing long-term stroke risk, with certain genetic variations playing a role in how folate affects cardiovascular health.
8
We have explored how folate, a vital B-vitamin, may play a crucial role in lowering homocysteine levels, which is linked to heightened risks of cardiovascular diseases. The study highlights how high levels of homocysteine can contribute to atherosclerosis, a silent but dangerous condition leading to heart disease and stroke.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
7
Folate may slow atherosclerosis progression
We explored the relationship between folate and vitamin B12 levels and their impact on cardiovascular health by studying participants from São Paulo, Brazil. Specifically, we aimed to understand how these vitamins relate to changes in carotid intima-media thickness (cIMT), a key marker for early atherosclerosis.
Over a median follow-up of eight years, we observed that the majority of participants had adequate levels of these vitamins, thanks in part to mandatory folic acid fortification in food. Our findings indicated that individuals with the highest serum folate levels experienced a slower increase in cIMT compared to those with the lowest levels. In particular, the fourth quartile of serum folate showed a significant association with reduced cIMT progression.
Interestingly, we found no such effect with vitamin B12. Additionally, dietary folate intake was not linked to changes in cIMT. This suggests that while folate might play a beneficial role in cardiovascular health, vitamin B12 does not appear to have the same effect in this population.
Overall, our study highlights the potential importance of maintaining adequate folate levels for cardiovascular health, especially in regions with fortified food. However, it's essential to note that there were no significant deficiencies in these vitamins in our cohort, which underscores the effectiveness of food fortification programs.
Over a median follow-up of eight years, we observed that the majority of participants had adequate levels of these vitamins, thanks in part to mandatory folic acid fortification in food. Our findings indicated that individuals with the highest serum folate levels experienced a slower increase in cIMT compared to those with the lowest levels. In particular, the fourth quartile of serum folate showed a significant association with reduced cIMT progression.
Interestingly, we found no such effect with vitamin B12. Additionally, dietary folate intake was not linked to changes in cIMT. This suggests that while folate might play a beneficial role in cardiovascular health, vitamin B12 does not appear to have the same effect in this population.
Overall, our study highlights the potential importance of maintaining adequate folate levels for cardiovascular health, especially in regions with fortified food. However, it's essential to note that there were no significant deficiencies in these vitamins in our cohort, which underscores the effectiveness of food fortification programs.
7
We explored the relationship between hypertension and global DNA methylation levels in a group of 2,300 individuals aged 30 to 75 from rural Punjab, India. Our research particularly aimed to see how folate, along with other vitamins and biochemical markers, affects blood pressure and cardiovascular health.
After screening, we identified 900 individuals—450 with hypertension and 450 without. The results revealed that those suffering from hypertension had significantly lower levels of global DNA methylation compared to those who were normotensive. Intriguingly, individuals with the lowest levels of DNA methylation were at a notably increased risk for hypertension.
Another key finding was that hypertensive individuals who were on medication and had controlled blood pressure showed higher levels of DNA methylation than those with uncontrolled hypertension. This suggests that managing blood pressure effectively, combined with adequate folate levels, might help improve methylation, a crucial process linked to health.
Overall, this study highlights the complex interconnections between folate, global DNA methylation, and hypertension, suggesting that folate could play an important role in managing cardiovascular health in our rural population.
After screening, we identified 900 individuals—450 with hypertension and 450 without. The results revealed that those suffering from hypertension had significantly lower levels of global DNA methylation compared to those who were normotensive. Intriguingly, individuals with the lowest levels of DNA methylation were at a notably increased risk for hypertension.
Another key finding was that hypertensive individuals who were on medication and had controlled blood pressure showed higher levels of DNA methylation than those with uncontrolled hypertension. This suggests that managing blood pressure effectively, combined with adequate folate levels, might help improve methylation, a crucial process linked to health.
Overall, this study highlights the complex interconnections between folate, global DNA methylation, and hypertension, suggesting that folate could play an important role in managing cardiovascular health in our rural population.
References
- Liang Z, Fan F, Liu B, Li K, Chen H, et al. Association Between Serum Folate Concentrations and 10-Year Stroke Risk in a Prospective Community Cohort: Mediation and Interaction Analyses. Nutrients. 2024;17. 10.3390/nu17010159
- Palchetti CZ, Gonçalves NG, Suemoto CK, Santos IS, Lotufo PA, et al. Serum folate levels, but not vitamin B12, are associated with slower progression in carotid intima-media thickness in a population exposed to mandatory folic acid fortification. Clin Nutr ESPEN. 2025;65:144. 10.1016/j.clnesp.2024.11.034
- Prasad K. Atherogenic Effect of Homocysteine, a Biomarker of Inflammation and Its Treatment. Int J Angiol. 2024;33:262. 10.1055/s-0044-1788280
- Kaushik A, Bhattacharjee D, Chaudhary V, Dahal S, Devi NK, et al. Hypertension and global DNA methylation: a population-based study in rural, Punjab, India. Sci Rep. 2024;14:25826. 10.1038/s41598-024-77437-z
