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Our analysis included the medical records of 96 patients with a history of these reactions. Among them, 47 had reactions to oral iron, while 49 reacted to IV iron. We conducted skin-prick tests with various iron salts, but found that these tests weren't very helpful for diagnosing IHRs. In fact, only a small percentage showed a positive reaction.
Interestingly, we noted that patients who were sensitive to IV iron experienced more severe reactions, including cases of anaphylaxis. Despite the challenges in diagnosing these allergies, we successfully conducted desensitization treatments for 15 patients needing iron, specifically using ferric carboxymaltose. This approach proved to be safe and effective, marking an important option for patients requiring iron therapy despite their hypersensitivity.
Our findings showed a significant reduction in allergenicity—up to 60% when combining iron with ascorbic acid. Although there was a clear improvement, the results suggest that these treatments may not eliminate allergenic responses entirely.
In essence, iron fortification could be a promising strategy for creating hypoallergenic dairy products.
The presence of iron enhanced the recruitment of specific immune cells and production of certain cytokines, which can worsen allergic reactions. In further laboratory tests, it was clear that iron oxide promoted harmful responses in immune cells.
Overall, while iron particles from subways may not be entirely responsible for all allergic reactions, they can certainly aggravate existing ones.
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In our analysis, we administered different protocols to patients based on their risk profiles. For low-risk patients, a 4-step drug provocation test (DPT) was performed, while those at higher risk underwent an 11-step rapid drug desensitization (RDD) protocol.
The results were promising, showing that the majority of patients could successfully complete FCM treatments without severe allergic reactions. Out of 21 patients undergoing RDD, 95.2% completed the treatment successfully. While some experienced mild reactions, such as urticaria, serious complications were infrequent.
Additionally, 10 low-risk patients who underwent DPT also completed their iron therapy effectively, though a couple of them experienced mild symptoms afterward. Overall, we found that RDD is a reliable method for safely administering FCM and that DPT is beneficial for low-risk individuals.
Our findings showed a significant reduction in allergenicity—up to 60% when combining iron with ascorbic acid. Although there was a clear improvement, the results suggest that these treatments may not eliminate allergenic responses entirely.
In essence, iron fortification could be a promising strategy for creating hypoallergenic dairy products.
We found that higher levels of iron were present in the combined exposure group, and when we used an iron-binding agent, it effectively reduced ferroptosis—a process damaging cells—in this context.
Our results suggest a potential new treatment avenue for asthma related to occupational COE exposure.
Our analysis included the medical records of 96 patients with a history of these reactions. Among them, 47 had reactions to oral iron, while 49 reacted to IV iron. We conducted skin-prick tests with various iron salts, but found that these tests weren't very helpful for diagnosing IHRs. In fact, only a small percentage showed a positive reaction.
Interestingly, we noted that patients who were sensitive to IV iron experienced more severe reactions, including cases of anaphylaxis. Despite the challenges in diagnosing these allergies, we successfully conducted desensitization treatments for 15 patients needing iron, specifically using ferric carboxymaltose. This approach proved to be safe and effective, marking an important option for patients requiring iron therapy despite their hypersensitivity.
The presence of iron enhanced the recruitment of specific immune cells and production of certain cytokines, which can worsen allergic reactions. In further laboratory tests, it was clear that iron oxide promoted harmful responses in immune cells.
Overall, while iron particles from subways may not be entirely responsible for all allergic reactions, they can certainly aggravate existing ones.
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Frequently Asked Questions
Allergies are the body's immune system responses to substances known as allergens, which can be harmless in most individuals. When a person with allergies encounters these allergens, their immune system mistakenly identifies them as a threat and launches a response. This can lead to symptoms ranging from mild, such as sneezing, itching, and rashes, to severe reactions known as anaphylaxis, which can be life-threatening. Common allergens include pollen, pet dander, certain foods like nuts and shellfish, insect stings, and medications.
Managing allergies often involves avoiding known allergens and using medications such as antihistamines or corticosteroids to alleviate symptoms. In some cases, doctors might recommend allergy shots or immunotherapy to help patients build tolerance over time. If you suspect you have allergies, consulting with a healthcare professional for proper diagnosis and treatment options is crucial. Understanding your triggers and how to live with allergies can significantly improve your quality of life.
Iron is a chemical element with the symbol Fe, derived from the Latin word "ferrum." It is a metal that is known for its strength and versatility, making it one of the most widely used materials in construction, manufacturing, and various industrial applications. Iron is the fourth most abundant element in the universe by mass and is primarily obtained through the mining of iron ores, such as hematite and magnetite. Once mined, it undergoes processes like smelting and refining to produce usable forms like cast iron, wrought iron, and steel.
In addition to its industrial uses, iron is also crucial for human health, as it plays a significant role in the production of hemoglobin, the protein in red blood cells responsible for transporting oxygen throughout the body. A deficiency in iron can lead to anemia, characterized by fatigue and weakened immunity. Overall, iron is a fundamental element that supports modern infrastructure and is vital for maintaining good health.
Based on user reviews, the timeline for seeing results from this iron supplement varies significantly among individuals. Several reviews indicate that users noticed positive effects within a couple of weeks to one and a half months of consistent use. For instance, one user mentioned experiencing improvements in health after just a few weeks ((Read Review)), while another reported noticing results after about one and a half months ((Read Review)).
It's worth noting that factors such as the dosage taken, individual body chemistry, and the presence of cofactors like Vitamin C can influence the speed of results. For example, one review stated a noticeable ferritin increase within five weeks when the supplement was taken with additional cofactors ((Read Review)). So, while some users have seen improvement relatively quickly, others may require several weeks or months to experience similar benefits. Overall, many users report effective results with continued use, making it essential to remain patient and consistent.
Based on user reviews, many individuals report remarkable improvements in their iron levels and overall health after using this iron supplement. Users have shared significant increases in ferritin and hemoglobin levels within a relatively short time frame. For example, one reviewer saw their ferritin rise from 11 to 70 after three months of use ((Read Review)), while another noted an increase from 3.2 to 19.7 in just five weeks ((Read Review)). Moreover, a user reported improvements in hemoglobin from 115 to 142 following consistent use, alongside minimal side effects such as stool discoloration ((Read Review)).
Several users also highlighted the supplement's gentle formulation, with many experiencing no allergic reactions or gastrointestinal discomfort, which can be a common issue with iron supplements. For instance, one user noted that it raised their ferritin from 7.5 to 31 without any side effects, particularly when combined with Vitamin C for better absorption ((Read Review)). Overall, while individual results can vary, the consensus among users suggests that this iron supplement is effective and well-tolerated, offering a much-needed boost for those struggling with iron deficiency.
Based on user reviews, many individuals reported positive experiences when combining this iron supplement with other supplements, particularly cofactors for enhanced absorption like Vitamin C. One user indicated that combining the iron supplement with Vitamin C notably improved their ferritin levels, suggesting that such combinations could be beneficial ((Read Review)). Additionally, numerous reviews emphasize the gentle nature of the supplement, with many users reporting no allergic reactions or gastrointestinal discomfort when taken alongside other supplements or medications. For instance, one reviewer stated that they experienced no allergies while successfully increasing their iron levels during pregnancy ((Read Review)).
On the other hand, while most reviews are overwhelmingly positive regarding tolerance and the lack of allergic reactions, one user did report an allergic rash after the first dose. They recommended starting with a small quantity to mitigate any unexpected reactions ((Read Review)). Overall, the consensus among users is that when considering combinations with other supplements, this iron supplement is generally well-tolerated and effective in improving iron levels without triggering allergies.
Users have reported a range of experiences regarding the right dosage of iron for treating allergies, with many finding effective doses that did not trigger any allergic reactions. For instance, one user noted taking three large doses of two tablets daily for three months without experiencing any issues with allergies or side effects, resulting in a significant increase in ferritin levels from 11 to 70 (Read Review). Another user mentioned raising their ferritin levels from 7.5 to 31 while combining the supplement with Vitamin C, indicating that a tailored approach could enhance efficacy without adverse effects (Read Review).
While most users reported positive outcomes without allergies, a few cautioned about individual sensitivities. One reviewer experienced a rash after taking the first pill, suggesting the importance of starting with a lower dose or consulting a healthcare provider to find the optimal amount (Read Review). The consensus implies that gentle formulations, particularly in chelated forms, facilitate absorption and minimize gastrointestinal distress, making them suitable for individuals with delicate stomachs or a history of allergies (Read Review). Ultimately, users recommend being mindful of dosage and individual reactions while using iron supplements.
References
- Aslan AF, Demir S, Toprak ID, Korkmaz P, Karabacak DE, et al. From diagnosis to desensitization in immediate hypersensitivity reactions to both oral and parenteral iron salts. Allergy Asthma Proc. 2025;46:152. doi:10.2500/aap.2025.46.240114
- Dindar Çelik F, Aksu K, Akkale Ö, Çelik Tuğlu H, Yağdıran M, et al. The experiences of ferric carboxymaltose desensitization and provocation. World Allergy Organ J. 2025;18:101025. doi:10.1016/j.waojou.2024.101025
- Lukose SJ, Divya MP, Beena AK, Rajakumar SN, Babu PS. Reduced allergenicity of hydrolysed whey protein concentrate complexed with iron: the effect of different enzymes, degree of hydrolysis and ascorbic acid. J Food Sci Technol. 2025;62:940. doi:10.1007/s13197-024-06085-y
- Afolabi BB, Babah OA, Adeyemo TA, Balogun M, Banke-Thomas A, et al. Intravenous versus oral iron for anaemia among pregnant women in Nigeria (IVON): an open-label, randomised controlled trial. Lancet Glob Health. 2024;12:e1649. doi:10.1016/S2214-109X(24)00239-0
- Chen X, Chen H, Zhang P, Ju Q, Wu Z, et al. Coke oven emissions exacerbate allergic asthma by promoting ferroptosis in airway epithelial cells. J Hazard Mater. 2024;478:135542. doi:10.1016/j.jhazmat.2024.135542
- Watanabe H, Honda A, Ichinose T, Ishikawa R, Miyasaka N, et al. Ferruginous components of particulate matters in subway environments, α-FeO or FeO, exacerbates allergies. Environ Pollut. 2024;355:124195. doi:10.1016/j.envpol.2024.124195
