Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Good
Based on 125 Reviews
8.1
Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Iron (as iron bisglycinate chelate†)
25 mg
139%
Top Medical Research Studies
8
We examined how curcumin-mediated photodynamic therapy (CUR-PDT) induces a specific type of cell death called ferroptosis in fibroblast-like synoviocytes from rheumatoid arthritis patients.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Read More
7
We explored the impact of iron accumulation in multiple sclerosis (MS) lesions using advanced MRI techniques. Tracking 50 participants over an average of 3.3 years, we observed that iron deposits, identified as hyper-paramagnetic signals (HPS), closely linked with impaired remyelination and greater disability. Specifically, lesions with early signs of HPS showed a significant decline in myelin recovery compared to those without such deposits. These findings suggest that measuring iron levels could guide therapies aimed at enhancing myelin repair in MS patients.
Read More
8
Ferroportin regulates RA cell activity
We aimed to understand how iron affects autoimmune disorders, specifically focusing on rheumatoid arthritis (RA). Our study explored the function of ferroportin (FPN), a membrane iron transporter, in the proliferation and movement of fibroblast-like synoviocytes (FLS) linked to RA.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
Read More
Most Useful Reviews
9
Improved health
241 people found this helpful
I am alive! I have chronic anaemia and have tried various forms of iron. Oral iron often causes digestive issues, especially at high doses. Solgar is gentle and has had no side effects for me; I noticed a positive effect within three days. Remember: iron absorbs poorly with tea, coffee, and dairy. It’s best taken with vegetables, fruits, or protein. Health to you, Russians!
Read More
9
Increased haemoglobin
210 people found this helpful
I have suffered from low haemoglobin and ferritin for ages. After struggling with ineffective medications, I found this iron supplement and raised my haemoglobin from 100 to 125 and ferritin from 3 to 18 in 1.5 months. I will order more as the results are encouraging, and the price is reasonable.
Read More
9
Rediscovered vitality
100 people found this helpful
I always believed I was lazy and unmotivated until I realised I was iron deficient. After starting this supplement, my energy returned, my mood improved, and I felt like myself again. It’s essential to check your iron levels if you feel lost; this product has transformed my life.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
- All Researches
8
Ferroportin regulates RA cell activity
We aimed to understand how iron affects autoimmune disorders, specifically focusing on rheumatoid arthritis (RA). Our study explored the function of ferroportin (FPN), a membrane iron transporter, in the proliferation and movement of fibroblast-like synoviocytes (FLS) linked to RA.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
Read More
8
We examined how curcumin-mediated photodynamic therapy (CUR-PDT) induces a specific type of cell death called ferroptosis in fibroblast-like synoviocytes from rheumatoid arthritis patients.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Read More
7
We explored the impact of iron accumulation in multiple sclerosis (MS) lesions using advanced MRI techniques. Tracking 50 participants over an average of 3.3 years, we observed that iron deposits, identified as hyper-paramagnetic signals (HPS), closely linked with impaired remyelination and greater disability. Specifically, lesions with early signs of HPS showed a significant decline in myelin recovery compared to those without such deposits. These findings suggest that measuring iron levels could guide therapies aimed at enhancing myelin repair in MS patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 125 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved health
241 people found this helpful
I am alive! I have chronic anaemia and have tried various forms of iron. Oral iron often causes digestive issues, especially at high doses. Solgar is gentle and has had no side effects for me; I noticed a positive effect within three days. Remember: iron absorbs poorly with tea, coffee, and dairy. It’s best taken with vegetables, fruits, or protein. Health to you, Russians!
Read More
9
Increased haemoglobin
210 people found this helpful
I have suffered from low haemoglobin and ferritin for ages. After struggling with ineffective medications, I found this iron supplement and raised my haemoglobin from 100 to 125 and ferritin from 3 to 18 in 1.5 months. I will order more as the results are encouraging, and the price is reasonable.
Read More
9
Rediscovered vitality
100 people found this helpful
I always believed I was lazy and unmotivated until I realised I was iron deficient. After starting this supplement, my energy returned, my mood improved, and I felt like myself again. It’s essential to check your iron levels if you feel lost; this product has transformed my life.
Read More
7.5
Gradual improvement
99 people found this helpful
I trusted this well-known brand during pregnancy, and it increased my haemoglobin levels. There wasn’t a sudden spike, but it has been a steady rise, which takes time but is comforting.
Read More
7.5
Stable haemoglobin
97 people found this helpful
I saw improvements during pregnancy while using this supplement, which helped to increase my haemoglobin levels. Over time, it’s evident that it has contributed positively.
Read More
Frequently Asked Questions
9
Improved health
241 people found this helpful
I am alive! I have chronic anaemia and have tried various forms of iron. Oral iron often causes digestive issues, especially at high doses. Solgar is gentle and has had no side effects for me; I noticed a positive effect within three days. Remember: iron absorbs poorly with tea, coffee, and dairy. It’s best taken with vegetables, fruits, or protein. Health to you, Russians!
9
Increased haemoglobin
210 people found this helpful
I have suffered from low haemoglobin and ferritin for ages. After struggling with ineffective medications, I found this iron supplement and raised my haemoglobin from 100 to 125 and ferritin from 3 to 18 in 1.5 months. I will order more as the results are encouraging, and the price is reasonable.
10
Ferritin increase
81 people found this helpful
After three months of taking two tablets three times daily, my ferritin level rose from 11 to 70. I have experienced no side effects, such as constipation. I've ordered another jar.
9
Rediscovered vitality
100 people found this helpful
I always believed I was lazy and unmotivated until I realised I was iron deficient. After starting this supplement, my energy returned, my mood improved, and I felt like myself again. It’s essential to check your iron levels if you feel lost; this product has transformed my life.
7.5
Gradual improvement
99 people found this helpful
I trusted this well-known brand during pregnancy, and it increased my haemoglobin levels. There wasn’t a sudden spike, but it has been a steady rise, which takes time but is comforting.
9
Mood enhancement
7 people found this helpful
This excellent iron supplement doesn’t irritate my stomach, despite my gastritis. After a month, my ferritin rose from 25 to 69, giving me more strength and improving my mood significantly. I plan to continue until my levels are normal.
8
Increased ferritin levels
13 people found this helpful
This product really works! Previously, no iron supplements had helped, but Solgar has given me hope. Within a month, my ferritin increased by 14 units, and my iron level rose by 10. I was overjoyed with the results and will be ordering more soon. I take the pills with vitamin C for better absorption.
10
Remarkable improvement
8 people found this helpful
I bought this for my mother, who had low haemoglobin below 100. After three months of taking 1 tablet daily with folic acid and vitamin C, her haemoglobin reached 140! I couldn't believe the transformation; the drug genuinely works!
0
Caused hemorrhoid issues
8 people found this helpful
After following the product instructions for a week, my stools became very hard, leading to hemorrhoids for the first time in my life. I regret ordering this product, as it is definitely not as gentle as advertised.
9
Effective iron therapy
62 people found this helpful
This Solgar iron was recommended by my doctor and has proven effective, as my tests confirm. Iron is essential for anyone feeling fatigued or having memory issues. I recommend a course of 30-60 mg daily, ideally consumed every other day for optimum absorption, ideally with vitamin C.
0
Severe intestinal issues
15 people found this helpful
Unfortunately, after three days on this iron, I experienced severe intestinal distress and diarrhoea, forcing me to stop. My gastrointestinal function returned to normal once I discontinued it.
8
Ferroportin regulates RA cell activity
We aimed to understand how iron affects autoimmune disorders, specifically focusing on rheumatoid arthritis (RA). Our study explored the function of ferroportin (FPN), a membrane iron transporter, in the proliferation and movement of fibroblast-like synoviocytes (FLS) linked to RA.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
8
We examined how curcumin-mediated photodynamic therapy (CUR-PDT) induces a specific type of cell death called ferroptosis in fibroblast-like synoviocytes from rheumatoid arthritis patients.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
7
We explored the impact of iron accumulation in multiple sclerosis (MS) lesions using advanced MRI techniques. Tracking 50 participants over an average of 3.3 years, we observed that iron deposits, identified as hyper-paramagnetic signals (HPS), closely linked with impaired remyelination and greater disability. Specifically, lesions with early signs of HPS showed a significant decline in myelin recovery compared to those without such deposits. These findings suggest that measuring iron levels could guide therapies aimed at enhancing myelin repair in MS patients.
References
- Shao W, Liu F, Zhu L, Qian W, Meng Q, et al. Ferroportin inhibits the proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis via regulating ROS/PI3K/AKT signaling pathway. Eur J Pharmacol. 2025;987:177205. doi:10.1016/j.ejphar.2024.177205
- Sun L, Niu Y, Liao B, Liu L, Peng Y, et al. CUR-PDT induces ferroptosis of RA-FLS via the Nrf2/xCT/GPX4 pathway to inhibit proliferation in rheumatoid arthritis. Inflamm Res. 2025;74:53. doi:10.1007/s00011-025-02019-2
- Shin HG, Kim W, Lee JH, Lee HS, Nam Y, et al. Association of iron deposition in MS lesion with remyelination capacity using susceptibility source separation MRI. Neuroimage Clin. 2025;45:103748. doi:10.1016/j.nicl.2025.103748
