' 
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.8
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Iron (as iron bisglycinate chelate†)
25 mg
139%
Top Medical Research Studies
9
HP alleviates iron-induced back pain
Inhibits Iron Overload-Induced Oxidative Stress through Activation of Signaling in a Rat Model of Lumbar Spinal Stenosis.
Relevant effects of HP treatment
We investigated how a substance called HP influences iron-related oxidative stress and its connection to back pain in a common condition known as lumbar spinal stenosis (LSS). LSS causes significant discomfort and disability, particularly for older adults, primarily due to hypertrophy of the ligamentum flavum, which can be exacerbated by oxidative stress stemming from imbalanced iron levels.
Our study involved exposing spinal cord neuron cultures to iron before treatment with HP at varying concentrations. We assessed the cells' health using tests to measure viability and cell damage. Additionally, in a rat model of LSS, we provided different doses of HP and monitored the effects over several weeks. The results were compelling: HP not only protected neurons from iron-induced damage but also promoted cellular health by boosting antioxidant defenses through a pathway known as NRF2.
Over the course of our observations, we noted significant reductions in both inflammation and oxidative stress markers in the rats treated with HP. This regulation of excess iron appeared to alleviate mechanical allodynia—a condition causing painful responses to light touch—and improved the overall functionality of the affected rats.
Our findings suggest that HP therapy may offer a promising approach to manage iron-related oxidative stress in LSS and the associated back pain, indicating a new avenue for treatment that could enhance quality of life.
Our study involved exposing spinal cord neuron cultures to iron before treatment with HP at varying concentrations. We assessed the cells' health using tests to measure viability and cell damage. Additionally, in a rat model of LSS, we provided different doses of HP and monitored the effects over several weeks. The results were compelling: HP not only protected neurons from iron-induced damage but also promoted cellular health by boosting antioxidant defenses through a pathway known as NRF2.
Over the course of our observations, we noted significant reductions in both inflammation and oxidative stress markers in the rats treated with HP. This regulation of excess iron appeared to alleviate mechanical allodynia—a condition causing painful responses to light touch—and improved the overall functionality of the affected rats.
Our findings suggest that HP therapy may offer a promising approach to manage iron-related oxidative stress in LSS and the associated back pain, indicating a new avenue for treatment that could enhance quality of life.
Read More
9
Iron's indirect role in back pain
Melittin regulates iron homeostasis and mediates macrophage polarization in rats with lumbar spinal stenosis.
Focus on melittin, not iron
We set out to explore how iron treatment impacts back pain, particularly in the context of lumbar spinal stenosis (LSS). This condition, marked by the narrowing of the spinal canal, often leads to nerve compression and chronic inflammation—both linked to heightened iron levels in the body.
In our study, we examined the effects of melittin, a component derived from bee venom, on iron metabolism and macrophage activity in rats suffering from LSS. By treating macrophages with melittin, we found that it promoted a shift toward M2 polarization, which is associated with healing and repair, especially in the presence of excessive iron.
Notably, we observed that melittin not only improved the locomotor recovery of the rats but also facilitated axonal growth. However, it’s crucial to mention that while melittin showed benefits in managing inflammation and promoting repair processes, the study did not isolate the direct impact of iron treatment on pain relief itself. This means we cannot conclusively state that iron treatment alone would yield significant results for back pain without the influence of melittin.
Overall, melittin appears to hold promise for supporting spinal health by regulating iron levels and modifying macrophage behavior, thereby enhancing recovery outcomes in models of LSS.
In our study, we examined the effects of melittin, a component derived from bee venom, on iron metabolism and macrophage activity in rats suffering from LSS. By treating macrophages with melittin, we found that it promoted a shift toward M2 polarization, which is associated with healing and repair, especially in the presence of excessive iron.
Notably, we observed that melittin not only improved the locomotor recovery of the rats but also facilitated axonal growth. However, it’s crucial to mention that while melittin showed benefits in managing inflammation and promoting repair processes, the study did not isolate the direct impact of iron treatment on pain relief itself. This means we cannot conclusively state that iron treatment alone would yield significant results for back pain without the influence of melittin.
Overall, melittin appears to hold promise for supporting spinal health by regulating iron levels and modifying macrophage behavior, thereby enhancing recovery outcomes in models of LSS.
Read More
8
Chitogel with Deferiprone aids recovery
Prevention of peridural adhesions in spinal surgery: Assessing safety and efficacy of Chitogel with Deferiprone in a sheep model.
Highly relevant to surgical recovery
We explored the potential of a Chitogel and Deferiprone mixture in preventing harmful scarring after spinal surgery. In this study, fifteen sheep underwent laminectomy, a common spinal procedure, and were treated with various gels, including a control group without treatment.
After three months, we evaluated the outcomes using MRI and tissue examination. The results showed that the combination of Chitogel with Deferiprone at 20 mM was not only safe but also effectively reduced inflammation and the formation of adhesions. This suggests a promising approach to improving post-surgery recovery in patients.
After three months, we evaluated the outcomes using MRI and tissue examination. The results showed that the combination of Chitogel with Deferiprone at 20 mM was not only safe but also effectively reduced inflammation and the formation of adhesions. This suggests a promising approach to improving post-surgery recovery in patients.
Read More
Most Useful Reviews
8.8
Improved energy levels
After childbirth, my severe anaemia led me to take medication prescribed by the maternity hospital, especially as I struggled with back pain. I noticed my eyelids were often pale, and I experienced frequent dizziness. Thankfully, I now wake up feeling refreshed each morning. I regularly purchased the popular supplement, but I’ve since cancelled it. I take one capsule daily but plan to shift to one every two days.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.8
- All Researches
9
Iron's indirect role in back pain
Melittin regulates iron homeostasis and mediates macrophage polarization in rats with lumbar spinal stenosis.
Focus on melittin, not iron
We set out to explore how iron treatment impacts back pain, particularly in the context of lumbar spinal stenosis (LSS). This condition, marked by the narrowing of the spinal canal, often leads to nerve compression and chronic inflammation—both linked to heightened iron levels in the body.
In our study, we examined the effects of melittin, a component derived from bee venom, on iron metabolism and macrophage activity in rats suffering from LSS. By treating macrophages with melittin, we found that it promoted a shift toward M2 polarization, which is associated with healing and repair, especially in the presence of excessive iron.
Notably, we observed that melittin not only improved the locomotor recovery of the rats but also facilitated axonal growth. However, it’s crucial to mention that while melittin showed benefits in managing inflammation and promoting repair processes, the study did not isolate the direct impact of iron treatment on pain relief itself. This means we cannot conclusively state that iron treatment alone would yield significant results for back pain without the influence of melittin.
Overall, melittin appears to hold promise for supporting spinal health by regulating iron levels and modifying macrophage behavior, thereby enhancing recovery outcomes in models of LSS.
In our study, we examined the effects of melittin, a component derived from bee venom, on iron metabolism and macrophage activity in rats suffering from LSS. By treating macrophages with melittin, we found that it promoted a shift toward M2 polarization, which is associated with healing and repair, especially in the presence of excessive iron.
Notably, we observed that melittin not only improved the locomotor recovery of the rats but also facilitated axonal growth. However, it’s crucial to mention that while melittin showed benefits in managing inflammation and promoting repair processes, the study did not isolate the direct impact of iron treatment on pain relief itself. This means we cannot conclusively state that iron treatment alone would yield significant results for back pain without the influence of melittin.
Overall, melittin appears to hold promise for supporting spinal health by regulating iron levels and modifying macrophage behavior, thereby enhancing recovery outcomes in models of LSS.
Read More
9
HP alleviates iron-induced back pain
Inhibits Iron Overload-Induced Oxidative Stress through Activation of Signaling in a Rat Model of Lumbar Spinal Stenosis.
Relevant effects of HP treatment
We investigated how a substance called HP influences iron-related oxidative stress and its connection to back pain in a common condition known as lumbar spinal stenosis (LSS). LSS causes significant discomfort and disability, particularly for older adults, primarily due to hypertrophy of the ligamentum flavum, which can be exacerbated by oxidative stress stemming from imbalanced iron levels.
Our study involved exposing spinal cord neuron cultures to iron before treatment with HP at varying concentrations. We assessed the cells' health using tests to measure viability and cell damage. Additionally, in a rat model of LSS, we provided different doses of HP and monitored the effects over several weeks. The results were compelling: HP not only protected neurons from iron-induced damage but also promoted cellular health by boosting antioxidant defenses through a pathway known as NRF2.
Over the course of our observations, we noted significant reductions in both inflammation and oxidative stress markers in the rats treated with HP. This regulation of excess iron appeared to alleviate mechanical allodynia—a condition causing painful responses to light touch—and improved the overall functionality of the affected rats.
Our findings suggest that HP therapy may offer a promising approach to manage iron-related oxidative stress in LSS and the associated back pain, indicating a new avenue for treatment that could enhance quality of life.
Our study involved exposing spinal cord neuron cultures to iron before treatment with HP at varying concentrations. We assessed the cells' health using tests to measure viability and cell damage. Additionally, in a rat model of LSS, we provided different doses of HP and monitored the effects over several weeks. The results were compelling: HP not only protected neurons from iron-induced damage but also promoted cellular health by boosting antioxidant defenses through a pathway known as NRF2.
Over the course of our observations, we noted significant reductions in both inflammation and oxidative stress markers in the rats treated with HP. This regulation of excess iron appeared to alleviate mechanical allodynia—a condition causing painful responses to light touch—and improved the overall functionality of the affected rats.
Our findings suggest that HP therapy may offer a promising approach to manage iron-related oxidative stress in LSS and the associated back pain, indicating a new avenue for treatment that could enhance quality of life.
Read More
8
Chitogel with Deferiprone aids recovery
Prevention of peridural adhesions in spinal surgery: Assessing safety and efficacy of Chitogel with Deferiprone in a sheep model.
Highly relevant to surgical recovery
We explored the potential of a Chitogel and Deferiprone mixture in preventing harmful scarring after spinal surgery. In this study, fifteen sheep underwent laminectomy, a common spinal procedure, and were treated with various gels, including a control group without treatment.
After three months, we evaluated the outcomes using MRI and tissue examination. The results showed that the combination of Chitogel with Deferiprone at 20 mM was not only safe but also effectively reduced inflammation and the formation of adhesions. This suggests a promising approach to improving post-surgery recovery in patients.
After three months, we evaluated the outcomes using MRI and tissue examination. The results showed that the combination of Chitogel with Deferiprone at 20 mM was not only safe but also effectively reduced inflammation and the formation of adhesions. This suggests a promising approach to improving post-surgery recovery in patients.
Read More
8
Alkaline minerals reduce back pain
Supplementation with alkaline minerals reduces symptoms in patients with chronic low back pain.
High relevance for LBP management
We aimed to understand if alkaline mineral supplementation could alleviate low back pain. In our open study, 82 participants took a lactose-based alkaline multimineral supplement for four weeks alongside their regular medications. Remarkably, pain scores dropped by 49%, and 76 out of 82 patients experienced relief.
We noted significant increases in blood buffering capacity and pH, suggesting that an acid-base imbalance could play a role in back pain. However, minerals like iron did not show significant changes. Ultimately, this simple supplement appears to greatly help those suffering from chronic low back pain.
We noted significant increases in blood buffering capacity and pH, suggesting that an acid-base imbalance could play a role in back pain. However, minerals like iron did not show significant changes. Ultimately, this simple supplement appears to greatly help those suffering from chronic low back pain.
Read More
5
Magnetostimulation: Mixed effects noted
Changeability of tissue's magnetic remanence after galvanic-magnetostimulation in upper-back pain treatment.
Results show limited direct benefits
We examined how magnetostimulation impacts upper-back pain in a clinical trial involving 55 participants, including healthy individuals and those with cervico-brachial pain. Using the innovative GMT 2.0 device, the treatment involved 40-minute sessions over 10 days for those in the treatment group.
The results revealed that while there were some positive changes in movement and certain health markers, there was no direct indication that magnetostimulation specifically alleviated back pain. The treatment did, however, normalize certain tissue properties and improve overall well-being.
The results revealed that while there were some positive changes in movement and certain health markers, there was no direct indication that magnetostimulation specifically alleviated back pain. The treatment did, however, normalize certain tissue properties and improve overall well-being.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Improved energy levels
After childbirth, my severe anaemia led me to take medication prescribed by the maternity hospital, especially as I struggled with back pain. I noticed my eyelids were often pale, and I experienced frequent dizziness. Thankfully, I now wake up feeling refreshed each morning. I regularly purchased the popular supplement, but I’ve since cancelled it. I take one capsule daily but plan to shift to one every two days.
Read More
