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SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.8
Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Iron (as iron bisglycinate chelate†)
25 mg
139%
Top Medical Research Studies
9
Rubiadin reduces liver iron overload
Rubiadin Mediates the Upregulation of Hepatic Hepcidin and Alleviates Iron Overload via BMP6/SMAD1/5/9-Signaling Pathway.
Study highly relevant to liver disease
We explored the effects of rubiadin, a beneficial compound derived from a Chinese herb, on iron metabolism and its implications for liver disease. Recognizing the challenges posed by iron overload diseases, we aimed to discover a safe approach to manage excessive iron accumulation in the body. Through experiments involving various analyses, we observed that rubiadin significantly downregulated proteins that are typically elevated in conditions of high iron, such as transferrin receptor 1 and ferroportin 1.
Furthermore, when we administered rubiadin to mice with iron overload, it resulted in decreased serum and duodenal iron levels and an increase in hepcidin mRNA expression in the liver. This suggests that rubiadin may not only help the body regulate iron better but might also protect against the harmful effects of excess iron.
Our research also delved into the mechanisms behind these effects. We found that rubiadin-induced hepcidin expression was mediated through a specific signaling pathway involving bone morphogenetic protein 6 (BMP6) and SMAD proteins. The ability of rubiadin to enhance hepcidin levels points toward a promising natural strategy for tackling iron overload in liver diseases and could have broader implications for treating related conditions.
Furthermore, when we administered rubiadin to mice with iron overload, it resulted in decreased serum and duodenal iron levels and an increase in hepcidin mRNA expression in the liver. This suggests that rubiadin may not only help the body regulate iron better but might also protect against the harmful effects of excess iron.
Our research also delved into the mechanisms behind these effects. We found that rubiadin-induced hepcidin expression was mediated through a specific signaling pathway involving bone morphogenetic protein 6 (BMP6) and SMAD proteins. The ability of rubiadin to enhance hepcidin levels points toward a promising natural strategy for tackling iron overload in liver diseases and could have broader implications for treating related conditions.
Read More
7
Iron's impact on liver disease
Long-term iron supplementation in four patients with X-linked erythropoietic protoporphyria: associations with serum proteins and erythrocyte protoporphyrin levels-a single-centre retrospective study.
Focus on liver treatment effects
We explored the long-term effects of iron supplementation in four patients suffering from X-linked erythropoietic protoporphyria (XLEPP), a rare genetic disorder that can lead to serious liver problems due to the buildup of a substance called protoporphyrin IX (PPIX) in the blood. This condition often causes severe photosensitivity and can result in liver damage, which, in some cases, may necessitate a liver transplant.
By providing iron, which is essential for producing heme, a component of hemoglobin, our aim was to see if we could lower blood levels of PPIX and improve liver function. The study observed these patients over periods extending up to eight years. Though case reports suggested potential benefits of iron supplementation—like reducing PPIX levels and alleviating liver damage—our findings pointed out that monitoring the dosage and long-term effects is essential for safety.
We also noted that there seems to be a need for standardized treatment protocols and guidelines to optimize care for XLEPP patients. As the research progresses, it remains crucial to reevaluate and understand the broader impact of iron treatment on liver health in this unique group of patients.
By providing iron, which is essential for producing heme, a component of hemoglobin, our aim was to see if we could lower blood levels of PPIX and improve liver function. The study observed these patients over periods extending up to eight years. Though case reports suggested potential benefits of iron supplementation—like reducing PPIX levels and alleviating liver damage—our findings pointed out that monitoring the dosage and long-term effects is essential for safety.
We also noted that there seems to be a need for standardized treatment protocols and guidelines to optimize care for XLEPP patients. As the research progresses, it remains crucial to reevaluate and understand the broader impact of iron treatment on liver health in this unique group of patients.
Read More
Most Useful Reviews
9.5
Effective iron supplement
Due to my persistently low haemoglobin levels linked to liver disease, I require ongoing iron supplements. After trying various preparations, I find Solgar chelated iron to be one of the few that genuinely alleviates my iron deficiency. An advantage of Solgar's encapsulated form is that it does not cause gastrointestinal discomfort, thus I recommend opting for chelated iron capsules over tablets, as they are gentler on the system even though slightly pricier.
Read More
3.8
Ineffective iron treatment
I initially took iron tablets to address my liver disease, which resulted in some minor improvement. However, I experienced weakness, dizziness, and dermatitis, signalling a decline in my condition. After a break from the pills, my blood tests revealed decreased iron levels, leading me to suspect poor absorption. Consequently, I moved on to seek a different oral iron treatment while managing my ongoing symptoms.
Read More
3.5
Insufficient dosage
Unfortunately, the dosage is inadequate for my severe iron deficiency related to liver disease, necessitating long-term use. As is well known, iron supplements can be quite damaging to the liver and hard on the intestines.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
9
Rubiadin reduces liver iron overload
Rubiadin Mediates the Upregulation of Hepatic Hepcidin and Alleviates Iron Overload via BMP6/SMAD1/5/9-Signaling Pathway.
Study highly relevant to liver disease
We explored the effects of rubiadin, a beneficial compound derived from a Chinese herb, on iron metabolism and its implications for liver disease. Recognizing the challenges posed by iron overload diseases, we aimed to discover a safe approach to manage excessive iron accumulation in the body. Through experiments involving various analyses, we observed that rubiadin significantly downregulated proteins that are typically elevated in conditions of high iron, such as transferrin receptor 1 and ferroportin 1.
Furthermore, when we administered rubiadin to mice with iron overload, it resulted in decreased serum and duodenal iron levels and an increase in hepcidin mRNA expression in the liver. This suggests that rubiadin may not only help the body regulate iron better but might also protect against the harmful effects of excess iron.
Our research also delved into the mechanisms behind these effects. We found that rubiadin-induced hepcidin expression was mediated through a specific signaling pathway involving bone morphogenetic protein 6 (BMP6) and SMAD proteins. The ability of rubiadin to enhance hepcidin levels points toward a promising natural strategy for tackling iron overload in liver diseases and could have broader implications for treating related conditions.
Furthermore, when we administered rubiadin to mice with iron overload, it resulted in decreased serum and duodenal iron levels and an increase in hepcidin mRNA expression in the liver. This suggests that rubiadin may not only help the body regulate iron better but might also protect against the harmful effects of excess iron.
Our research also delved into the mechanisms behind these effects. We found that rubiadin-induced hepcidin expression was mediated through a specific signaling pathway involving bone morphogenetic protein 6 (BMP6) and SMAD proteins. The ability of rubiadin to enhance hepcidin levels points toward a promising natural strategy for tackling iron overload in liver diseases and could have broader implications for treating related conditions.
Read More
7
Iron's impact on liver disease
Long-term iron supplementation in four patients with X-linked erythropoietic protoporphyria: associations with serum proteins and erythrocyte protoporphyrin levels-a single-centre retrospective study.
Focus on liver treatment effects
We explored the long-term effects of iron supplementation in four patients suffering from X-linked erythropoietic protoporphyria (XLEPP), a rare genetic disorder that can lead to serious liver problems due to the buildup of a substance called protoporphyrin IX (PPIX) in the blood. This condition often causes severe photosensitivity and can result in liver damage, which, in some cases, may necessitate a liver transplant.
By providing iron, which is essential for producing heme, a component of hemoglobin, our aim was to see if we could lower blood levels of PPIX and improve liver function. The study observed these patients over periods extending up to eight years. Though case reports suggested potential benefits of iron supplementation—like reducing PPIX levels and alleviating liver damage—our findings pointed out that monitoring the dosage and long-term effects is essential for safety.
We also noted that there seems to be a need for standardized treatment protocols and guidelines to optimize care for XLEPP patients. As the research progresses, it remains crucial to reevaluate and understand the broader impact of iron treatment on liver health in this unique group of patients.
By providing iron, which is essential for producing heme, a component of hemoglobin, our aim was to see if we could lower blood levels of PPIX and improve liver function. The study observed these patients over periods extending up to eight years. Though case reports suggested potential benefits of iron supplementation—like reducing PPIX levels and alleviating liver damage—our findings pointed out that monitoring the dosage and long-term effects is essential for safety.
We also noted that there seems to be a need for standardized treatment protocols and guidelines to optimize care for XLEPP patients. As the research progresses, it remains crucial to reevaluate and understand the broader impact of iron treatment on liver health in this unique group of patients.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.8
9.5
Effective iron supplement
Due to my persistently low haemoglobin levels linked to liver disease, I require ongoing iron supplements. After trying various preparations, I find Solgar chelated iron to be one of the few that genuinely alleviates my iron deficiency. An advantage of Solgar's encapsulated form is that it does not cause gastrointestinal discomfort, thus I recommend opting for chelated iron capsules over tablets, as they are gentler on the system even though slightly pricier.
Read More
3.8
Ineffective iron treatment
I initially took iron tablets to address my liver disease, which resulted in some minor improvement. However, I experienced weakness, dizziness, and dermatitis, signalling a decline in my condition. After a break from the pills, my blood tests revealed decreased iron levels, leading me to suspect poor absorption. Consequently, I moved on to seek a different oral iron treatment while managing my ongoing symptoms.
Read More
3.5
Insufficient dosage
Unfortunately, the dosage is inadequate for my severe iron deficiency related to liver disease, necessitating long-term use. As is well known, iron supplements can be quite damaging to the liver and hard on the intestines.
