We evaluated how switching to ferric citrate hydrate (FCH) impacts nausea in women with iron deficiency anemia (IDA) who struggled with oral iron. In a multicenter study of 30 patients, those on FCH experienced significant improvements. Nausea scores dropped from 5.7 to 1.7, and the overall incidence of nausea decreased notably. Also, 80% reported better experiences compared to previous treatments.
Overall, our findings suggest that FCH not only enhances medication adherence but also effectively reduces nausea and improves quality of life in these patients.
Read More
9
Iron treatment eases nausea in pregnancy
Efficacy and Safety of Microsomal Ferric Pyrophosphate Supplement for Iron Deficiency Anemia in Pregnancy.
We conducted a study to examine the effectiveness of a specific iron supplement, emulsified microsomal ferric pyrophosphate (EMFP), in treating iron deficiency anemia among pregnant women. Our focus was not only on improving hemoglobin levels but also on alleviating related symptoms, including nausea.
Within 30 days of starting treatment with EMFP, we observed significant increases in hemoglobin levels, alongside marked improvements in serum ferritin and iron levels. As nausea is a common complaint among pregnant women, we noted a decrease in various symptoms, including nausea, breathlessness, and dizziness, which contributed to a better quality of life for the participants.
Notably, treatment compliance was remarkably high at 99.5%, indicating that the participants were committed to managing their anemia effectively. Importantly, we did not encounter any severe side effects related to the treatment, suggesting a favorable safety profile.
Overall, our findings support the idea that iron treatment can help alleviate nausea and other discomforts related to iron deficiency anemia in pregnancy, positively impacting both mother and baby.
Read More
7
Daily vs. TIW iron supplementation
Daily versus three times weekly dosing for treatment of iron deficiency nonanemia in NCAA Division 1 female athletes.
We explored the effects of daily versus three times weekly (TIW) oral iron supplementation on nausea in NCAA Division 1 female athletes. The study involved 33 athletes who were either in track and field or soccer. Participants were given either daily doses or TIW doses of ferrous bisglycinate over eight weeks.
Both groups showed an increase in serum ferritin levels, which is a marker of iron stores. However, the TIW regimen resulted in a smaller increase of about 5.17 μg/L, compared to an increase of 12.88 μg/L with the daily regimen. Notably, those taking daily supplements experienced significantly more nausea and constipation than those on the TIW schedule.
While the daily regimen may boost iron levels more effectively, it can come at the cost of increased gastrointestinal discomfort. Meanwhile, the TIW regimen offers a gentler option with fewer side effects, positioning it as a viable alternative for athletes concerned about nausea.
Read More
Most Useful Reviews
9
No nausea experienced
9 people found this helpful
I have dealt with iron deficiency anaemia my entire adult life. I usually maintain my iron levels through diet but turned to Solgar's Gentle Iron when my haemoglobin fell to critical levels. It has low toxicity and is well-absorbed, unlike other supplements that upset my stomach. After taking it, my dizziness and darkening vision when standing quickly improved. I experienced no nausea or pain for five months. I recommend taking iron at night, avoiding food before and after, and combining it with vitamin C.
Read More
0
Severe nausea
9 people found this helpful
This product caused excruciating stomach cramps, diarrhoea, and severe nausea.
Read More
9
Nausea absent
8 people found this helpful
I took this iron for seven days post-menstruation, and I no longer felt dizzy. I suggest testing for ferritin levels. I did not experience nausea or any side effects. I am satisfied, as I used to get cold easily, which is a sign of low iron.
We conducted a study to examine the effectiveness of a specific iron supplement, emulsified microsomal ferric pyrophosphate (EMFP), in treating iron deficiency anemia among pregnant women. Our focus was not only on improving hemoglobin levels but also on alleviating related symptoms, including nausea.
Within 30 days of starting treatment with EMFP, we observed significant increases in hemoglobin levels, alongside marked improvements in serum ferritin and iron levels. As nausea is a common complaint among pregnant women, we noted a decrease in various symptoms, including nausea, breathlessness, and dizziness, which contributed to a better quality of life for the participants.
Notably, treatment compliance was remarkably high at 99.5%, indicating that the participants were committed to managing their anemia effectively. Importantly, we did not encounter any severe side effects related to the treatment, suggesting a favorable safety profile.
Overall, our findings support the idea that iron treatment can help alleviate nausea and other discomforts related to iron deficiency anemia in pregnancy, positively impacting both mother and baby.
Read More
9
FCH reduces nausea in IDA treatment
A Multicenter Single-Arm Study of Switching to Ferric Citrate Hydrate for Iron Deficiency Anemia in Patients Intolerant to Oral Iron: RIO-SWITCH.
We evaluated how switching to ferric citrate hydrate (FCH) impacts nausea in women with iron deficiency anemia (IDA) who struggled with oral iron. In a multicenter study of 30 patients, those on FCH experienced significant improvements. Nausea scores dropped from 5.7 to 1.7, and the overall incidence of nausea decreased notably. Also, 80% reported better experiences compared to previous treatments.
Overall, our findings suggest that FCH not only enhances medication adherence but also effectively reduces nausea and improves quality of life in these patients.
Read More
7
Daily vs. TIW iron supplementation
Daily versus three times weekly dosing for treatment of iron deficiency nonanemia in NCAA Division 1 female athletes.
We explored the effects of daily versus three times weekly (TIW) oral iron supplementation on nausea in NCAA Division 1 female athletes. The study involved 33 athletes who were either in track and field or soccer. Participants were given either daily doses or TIW doses of ferrous bisglycinate over eight weeks.
Both groups showed an increase in serum ferritin levels, which is a marker of iron stores. However, the TIW regimen resulted in a smaller increase of about 5.17 μg/L, compared to an increase of 12.88 μg/L with the daily regimen. Notably, those taking daily supplements experienced significantly more nausea and constipation than those on the TIW schedule.
While the daily regimen may boost iron levels more effectively, it can come at the cost of increased gastrointestinal discomfort. Meanwhile, the TIW regimen offers a gentler option with fewer side effects, positioning it as a viable alternative for athletes concerned about nausea.
Read More
7
Ferric carboxymaltose reduces nausea
Low-dose ferric carboxymaltose vs. oral iron for improving hemoglobin levels in postpartum East Asian women: A randomized controlled trial.
This randomized controlled trial explored how low-dose ferric carboxymaltose (FCM) affects hemoglobin levels and nausea in postpartum East Asian women. Participants received either an intravenous FCM infusion or oral iron for four weeks.
We found that while FCM significantly increased hemoglobin levels after two weeks, both treatments showed no significant difference in final hemoglobin results after four weeks.
Notably, the FCM group experienced fewer gastrointestinal side effects, including nausea, suggesting it may be a more comfortable option for new mothers.
Read More
User Reviews
USERS' SCORE
Good
Based on 107 Reviews
8
All Reviews
Positive Reviews
Negative Reviews
9
No nausea experienced
9 people found this helpful
I have dealt with iron deficiency anaemia my entire adult life. I usually maintain my iron levels through diet but turned to Solgar's Gentle Iron when my haemoglobin fell to critical levels. It has low toxicity and is well-absorbed, unlike other supplements that upset my stomach. After taking it, my dizziness and darkening vision when standing quickly improved. I experienced no nausea or pain for five months. I recommend taking iron at night, avoiding food before and after, and combining it with vitamin C.
Read More
0
Severe nausea
9 people found this helpful
This product caused excruciating stomach cramps, diarrhoea, and severe nausea.
Read More
9
Nausea absent
8 people found this helpful
I took this iron for seven days post-menstruation, and I no longer felt dizzy. I suggest testing for ferritin levels. I did not experience nausea or any side effects. I am satisfied, as I used to get cold easily, which is a sign of low iron.
Read More
9
No nausea noted
5 people found this helpful
This is a wonderful iron supplement with high quality and easily digestible components that do not cause irritation or nausea. I felt better while using this product, and in consultation with my nutritionist, I took it alongside vitamin C to improve absorption. I highly recommend it.
Read More
9
No gastrointestinal issues
5 people found this helpful
Solgar’s Gentle Iron is by far the most effective iron supplement I have used. It doesn't cause nausea or stomach discomfort—unlike many others I’ve tried. If you find this review helpful, please give it a thumbs up!
Nausea is a sensation that often precedes vomiting and is characterized by an uneasy feeling in the stomach. It can be caused by a variety of factors, including motion sickness, certain medications, food poisoning, or underlying health conditions. The experience of nausea can range from mildly uncomfortable to intensely distressing and is often accompanied by other symptoms such as sweating, increased salivation, or a feeling of lightheadedness.
Many people experience nausea at some point in their lives, making it a common issue. Fortunately, there are several remedies and treatments available that can help alleviate this unpleasant sensation. Over-the-counter medications, home remedies like ginger tea, and lifestyle changes, such as eating smaller meals or avoiding certain triggers, can be effective in reducing nausea. However, if nausea is persistent or accompanied by severe symptoms like severe abdominal pain or fever, it’s essential to consult with a healthcare professional for an accurate diagnosis and appropriate treatment.
Iron is a chemical element with the symbol Fe, derived from the Latin word "ferrum." It is a metal that is known for its strength and versatility, making it one of the most widely used materials in construction, manufacturing, and various industrial applications. Iron is the fourth most abundant element in the universe by mass and is primarily obtained through the mining of iron ores, such as hematite and magnetite. Once mined, it undergoes processes like smelting and refining to produce usable forms like cast iron, wrought iron, and steel.
In addition to its industrial uses, iron is also crucial for human health, as it plays a significant role in the production of hemoglobin, the protein in red blood cells responsible for transporting oxygen throughout the body. A deficiency in iron can lead to anemia, characterized by fatigue and weakened immunity. Overall, iron is a fundamental element that supports modern infrastructure and is vital for maintaining good health.
Based on user reviews, the timeframe to start seeing results from this iron supplement varies but many report experiencing significant improvements relatively quickly. Users have mentioned feeling better within a week to two weeks of consistent use. For example, a reviewer experienced no side effects and felt promising results after over a week (Read Review), while others noted improvements to their iron levels within two weeks during pregnancy (Read Review).
Moreover, certain users shared that they noticed positive changes in their symptoms, such as reduced dizziness and improved energy levels after about a week (Read Review), and one user reported raising their haemoglobin from 90 to 136 over two months without nausea (Read Review). Overall, while individual experiences may vary, many consumers have had positive results within a few days to a couple of weeks of starting the supplement.
This supplement appears to have scientific support for alleviating nausea, particularly in contexts where iron deficiency is a concern. A study on emulsified microsomal ferric pyrophosphate (EMFP) demonstrated that treatment not only improved hemoglobin levels in pregnant women but also significantly decreased symptoms associated with iron deficiency, including nausea [1]. The findings suggest that addressing iron deficiency may positively affect overall quality of life by alleviating nausea symptoms, which are commonly reported among this demographic.
Further evidence comes from research involving ferric citrate hydrate (FCH), where participants reported a significant reduction in nausea scores after switching to this treatment, suggesting it offers both improved adherence and greater comfort compared to other iron supplements [4]. Therefore, if you're seeking a supplement aimed at managing nausea associated with iron deficiency, these studies indicate that certain forms of iron supplementation could be both effective and gentle on the gastrointestinal system.
Users of Solgar's Gentle Iron supplement have shared a range of positive experiences primarily focused on symptom reduction and improved iron levels. Many report significant improvements in energy and overall vitality, with some experiences noting the alleviation of symptoms such as dizziness and cold sensitivity. For instance, a long-time sufferer of iron deficiency anemia mentioned an improvement in dizziness and vision stability after using the supplement for a brief period (Read Review). Another reviewer observed an elevation in hemoglobin from 90 to 136 over two months without experiencing any nausea, showcasing the supplement's effectiveness for various users (Read Review).
Additionally, several users have emphasized the lack of gastrointestinal discomfort typically associated with iron supplements, such as nausea and constipation. One reviewer noted a complete avoidance of these side effects, with noticeable benefits on their energy and hair health after consistent use (Read Review). It appears that many consumers have found success in safely raising their iron levels without the adverse effects commonly experienced with other supplements
Users report a highly favorable experience when combining Solgar's Gentle Iron supplement with other supplements, particularly vitamin C. Many customers highlight that taking vitamin C alongside their iron significantly enhances absorption and improves the overall effectiveness of the supplement. For instance, one reviewer noted using vitamin C in consultation with a nutritionist to boost absorption while experiencing no gastrointestinal discomfort or nausea (Read Review). Another user similarly mentioned that pairing the iron with folic acid and vitamin C further optimized their results, enabling them to manage their supplementation effectively without adverse effects (Read Review).
Despite the generally positive feedback regarding pairing iron with vitamin C, some users caution against combining it with other substances like zinc and fiber, as these may hinder absorption (Read Review) . Overall, the combination of Solgar's Gentle Iron with vitamin C appears to be a well-recommended strategy for those looking to tackle iron deficiencies effectively while minimizing side effects such as nausea and stomach discomfort.
Based on user reviews, the right dose of iron for treating nausea often hinges on choosing the right supplement and method of intake. Users have found that taking Solgar’s Gentle Iron, particularly at night and away from food, tends to minimize any gastrointestinal discomfort, including nausea. For instance, one user reported, "I recommend taking iron at night, avoiding food before and after" which helped them avoid nausea altogether Read Review. Moreover, several reviews highlighted that this specific iron supplement does not induce nausea or stomach pain, making it a favored choice among those with sensitive stomachs. One user mentioned, "I’ve taken this iron for two years... it eliminated the nausea I experienced with other supplements" Read Review.
9
Gentle on stomach
2 people found this helpful
I have consistently low haemoglobin and ferritin, and previous medications caused nausea. Solgar is gentle and easy to take, with no side effects. I've felt promising results after over a week, and will report back on my next blood test.
9
Soft iron noted
2 people found this helpful
I took this iron during my pregnancy, and in two weeks, it raised my haemoglobin levels without side effects or nausea. I feel no need to try other iron preparations now.
9
Nausea absent
8 people found this helpful
I took this iron for seven days post-menstruation, and I no longer felt dizzy. I suggest testing for ferritin levels. I did not experience nausea or any side effects. I am satisfied, as I used to get cold easily, which is a sign of low iron.
9
Quick results
3 people found this helpful
Over two months, I raised my haemoglobin from 90 to 136 with no nausea or constipation. I found it convenient and easy to take, taking two capsules daily, and I definitely recommend it.
9
No nausea experienced
9 people found this helpful
I have dealt with iron deficiency anaemia my entire adult life. I usually maintain my iron levels through diet but turned to Solgar's Gentle Iron when my haemoglobin fell to critical levels. It has low toxicity and is well-absorbed, unlike other supplements that upset my stomach. After taking it, my dizziness and darkening vision when standing quickly improved. I experienced no nausea or pain for five months. I recommend taking iron at night, avoiding food before and after, and combining it with vitamin C.
9
Energy boost noted
4 people found this helpful
The quality of Solgar’s iron is fantastic! My energy levels surged, and there’s no nausea or constipation. As a woman needing to replenish iron, this supplement has effectively improved my hair and overall vitality.
9
No nausea noted
5 people found this helpful
This is a wonderful iron supplement with high quality and easily digestible components that do not cause irritation or nausea. I felt better while using this product, and in consultation with my nutritionist, I took it alongside vitamin C to improve absorption. I highly recommend it.
9
Doctor recommended
2 people found this helpful
I was advised to take this iron, and thankfully, it does not cause nausea, even on an empty stomach. My hair loss has stopped as I also take folic acid and vitamin C for better iron absorption.
9
No stomach pain
2 people found this helpful
I've often suffered from stomach pain after taking iron supplements, but Solgar's formula is easy to digest with no side effects for me. It's crucial to take it with vitamin C and avoid combining it with zinc or fibre to maintain absorption.
9
Nausea resolved
2 people found this helpful
I’ve been taking this iron for two years, gradually raising my haemoglobin from 115 to 143. It eliminated the nausea I experienced with other supplements, and using vitamin C improved absorption.
9
Iron treatment eases nausea in pregnancy
Efficacy and Safety of Microsomal Ferric Pyrophosphate Supplement for Iron Deficiency Anemia in Pregnancy.
We conducted a study to examine the effectiveness of a specific iron supplement, emulsified microsomal ferric pyrophosphate (EMFP), in treating iron deficiency anemia among pregnant women. Our focus was not only on improving hemoglobin levels but also on alleviating related symptoms, including nausea.
Within 30 days of starting treatment with EMFP, we observed significant increases in hemoglobin levels, alongside marked improvements in serum ferritin and iron levels. As nausea is a common complaint among pregnant women, we noted a decrease in various symptoms, including nausea, breathlessness, and dizziness, which contributed to a better quality of life for the participants.
Notably, treatment compliance was remarkably high at 99.5%, indicating that the participants were committed to managing their anemia effectively. Importantly, we did not encounter any severe side effects related to the treatment, suggesting a favorable safety profile.
Overall, our findings support the idea that iron treatment can help alleviate nausea and other discomforts related to iron deficiency anemia in pregnancy, positively impacting both mother and baby.
9
FCH reduces nausea in IDA treatment
A Multicenter Single-Arm Study of Switching to Ferric Citrate Hydrate for Iron Deficiency Anemia in Patients Intolerant to Oral Iron: RIO-SWITCH.
We evaluated how switching to ferric citrate hydrate (FCH) impacts nausea in women with iron deficiency anemia (IDA) who struggled with oral iron. In a multicenter study of 30 patients, those on FCH experienced significant improvements. Nausea scores dropped from 5.7 to 1.7, and the overall incidence of nausea decreased notably. Also, 80% reported better experiences compared to previous treatments.
Overall, our findings suggest that FCH not only enhances medication adherence but also effectively reduces nausea and improves quality of life in these patients.
References
Srivastav A, Kshirsagar S, Adhav T, Ganu G, Shah A. Efficacy and Safety of Microsomal Ferric Pyrophosphate Supplement for Iron Deficiency Anemia in Pregnancy. Cureus. 2024;16:e57108. doi:10.7759/cureus.57108
Schulte J, Peterson K, Thomsen T, Lentz S, Hall M, et al. Daily versus three times weekly dosing for treatment of iron deficiency nonanemia in NCAA Division 1 female athletes. PM R. 2024;16:316. doi:10.1002/pmrj.13172
Nagao T, Takahashi K, Takahashi S, Yokomizo R, Samura O, et al. Low-dose ferric carboxymaltose vs. oral iron for improving hemoglobin levels in postpartum East Asian women: A randomized controlled trial. PLoS One. 2025;20:e0319795. doi:10.1371/journal.pone.0319795
Wada-Hiraike O, Maruyama A, Mitobe Y, Iriyama T, Mori-Uchino M, et al. A Multicenter Single-Arm Study of Switching to Ferric Citrate Hydrate for Iron Deficiency Anemia in Patients Intolerant to Oral Iron: RIO-SWITCH. Adv Ther. 2025. doi:10.1007/s12325-025-03123-9