Last update
5/27/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.3
USERS' SCORE
Good
Based on 4 Reviews
8.4
Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Iron (as iron bisglycinate chelate†)
25 mg
139%
Top Medical Research Studies
9
We explored a case involving a 66-year-old woman who developed a gastric ulcer after using oral iron supplements for an extended period. Iron therapy is commonly prescribed for treating iron deficiency anemia, but it often comes with gastrointestinal side effects.
In this instance, the patient had a history of GI bleeding and other medical conditions, which might have contributed to her increased risk. While gastrointestinal issues with iron supplements are not unusual, having a gastric ulcer as a direct result is rare, and only a handful of similar cases have been reported in medical literature.
Upon conducting endoscopic and histopathological evaluations, we identified iron deposits in the ulcer bed, confirming that the iron therapy was indeed linked to her gastric ulcer. After stopping the oral iron supplements, her symptoms resolved, highlighting the need for careful patient monitoring during iron therapy to prevent serious complications like ulcers.
Our findings emphasize the importance of recognizing and managing the potential adverse effects of oral iron to maintain a safe and effective treatment regimen for iron deficiency anemia.
In this instance, the patient had a history of GI bleeding and other medical conditions, which might have contributed to her increased risk. While gastrointestinal issues with iron supplements are not unusual, having a gastric ulcer as a direct result is rare, and only a handful of similar cases have been reported in medical literature.
Upon conducting endoscopic and histopathological evaluations, we identified iron deposits in the ulcer bed, confirming that the iron therapy was indeed linked to her gastric ulcer. After stopping the oral iron supplements, her symptoms resolved, highlighting the need for careful patient monitoring during iron therapy to prevent serious complications like ulcers.
Our findings emphasize the importance of recognizing and managing the potential adverse effects of oral iron to maintain a safe and effective treatment regimen for iron deficiency anemia.
Read More
9
We examined whether enhancing a certain factor, known as HIF-1α, could aid in healing diabetic pressure ulcers. To do this, we used a special delivery system to administer deferoxamine (DFO), an FDA-approved iron chelator. Our study on diabetic mice showed that using DFO not only sped up wound healing but also prevented the formation of ulcers in the first place. We observed improved collagen density and better blood flow to the wounds, which helped reduce cell death. This suggests a promising new way to tackle diabetic ulcers effectively.
Read More
9.5
Innovative approach for diabetic ulcer healing
We explored a novel approach to treating diabetic ulcers (DU) which often struggle with healing due to challenging conditions like high blood sugar and infections. Our method involves using iron oxide nanoparticles combined with glucose oxidase to create a pH-sensitive catalyst.
This treatment selectively targets harmful biofilms and promotes healing by adjusting the wound environment based on pH levels. By utilizing these nanoparticles, we observed significant improvements in healing time, leading to complete closure of wounds in diabetic mice within just 15 days. This approach holds promise for enhancing diabetic ulcer management clinically.
This treatment selectively targets harmful biofilms and promotes healing by adjusting the wound environment based on pH levels. By utilizing these nanoparticles, we observed significant improvements in healing time, leading to complete closure of wounds in diabetic mice within just 15 days. This approach holds promise for enhancing diabetic ulcer management clinically.
Read More
Most Useful Reviews
8
Iron deficiency improvement
30 people found this helpful
About three years ago, I experienced symptoms akin to depression due to low iron levels, specifically ferritin. After taking leave, my teacher recommended a check-up, as I had barely any iron in my annual health screenings. I underwent a temporary iron test and repeated it the following year. Additionally, this inadequacy aggravated my mouth ulcers. Meeting the healthcare professionals was a relief, as this situation was indeed distressing!
Read More
8
Relief from pain
Superb for individuals with stomach issues! It has significantly aided me without causing any stomach discomfort, despite iron typically inducing severe pain in me. I previously faced a peptic ulcer (at an early stage) and needed to be cautious. This particular remedy works excellently for me.
Read More
8
Noticeable improvements
The results became evident from the initial days. Though doctors maintained that everything was fine, I felt a pressing need to boost my iron levels as my haemoglobin consistently hovered at the lower limit. Since I hardly consume red meat or iron-rich foods, I opted for this medication, supplementing it with vitamin C and folic acid. Within a few days, I felt considerably better, and each day improved further; I no longer feel fatigued. My chronic gastritis and duodenal ulcer have shown remarkable improvement. I highly recommend it, but always consult a physician and complete necessary tests before use.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.3
- All Researches
9.5
Innovative approach for diabetic ulcer healing
We explored a novel approach to treating diabetic ulcers (DU) which often struggle with healing due to challenging conditions like high blood sugar and infections. Our method involves using iron oxide nanoparticles combined with glucose oxidase to create a pH-sensitive catalyst.
This treatment selectively targets harmful biofilms and promotes healing by adjusting the wound environment based on pH levels. By utilizing these nanoparticles, we observed significant improvements in healing time, leading to complete closure of wounds in diabetic mice within just 15 days. This approach holds promise for enhancing diabetic ulcer management clinically.
This treatment selectively targets harmful biofilms and promotes healing by adjusting the wound environment based on pH levels. By utilizing these nanoparticles, we observed significant improvements in healing time, leading to complete closure of wounds in diabetic mice within just 15 days. This approach holds promise for enhancing diabetic ulcer management clinically.
Read More
9
We examined how a hoof care product containing iron, among other ingredients, impacts digital dermatitis (DD) in dairy cows. In our study, we compared two groups of 132 cows in Germany—one treated with a product made of iron complex salts, zinc salts, and aluminum, and the other serving as a control group that received no product aside from washing. We applied the treatment on one hind foot of each cow twice a week for a year while monitoring the prevalence and severity of DD lesions.
Throughout the study, we observed notable results. The treatment group displayed a significantly smaller overall disease severity compared to the control group. Specifically, the odds of having an active DD lesion were nearly six times higher in those without treatment. Interestingly, heifers that joined during the trial received the treatment beforehand and experienced a marked reduction in active lesions compared to their untreated counterparts. This suggests that the combination of iron and other ingredients effectively lessens the impact of this common hoof disease in dairy herds.
In conclusion, the findings highlight the potential of this hoof care product, not just in treating existing cases of DD but also in preventing new ones, especially in young animals entering herds. While we acknowledge that iron acts alongside other components, the overall effectiveness of the product is worth noting for those seeking alternatives to traditional chemicals in hoof care.
Throughout the study, we observed notable results. The treatment group displayed a significantly smaller overall disease severity compared to the control group. Specifically, the odds of having an active DD lesion were nearly six times higher in those without treatment. Interestingly, heifers that joined during the trial received the treatment beforehand and experienced a marked reduction in active lesions compared to their untreated counterparts. This suggests that the combination of iron and other ingredients effectively lessens the impact of this common hoof disease in dairy herds.
In conclusion, the findings highlight the potential of this hoof care product, not just in treating existing cases of DD but also in preventing new ones, especially in young animals entering herds. While we acknowledge that iron acts alongside other components, the overall effectiveness of the product is worth noting for those seeking alternatives to traditional chemicals in hoof care.
Read More
9
We explored a groundbreaking approach to treating oral ulcers, especially in diabetic patients, using a special hydrogel infused with ferric iron and shikonin nanoparticles. This hydrogel, known as FSH3, is designed to adhere well to mucosal lesions, creating an effective barrier when applied.
By combining silk fibroin and hyaluronic acid, the hydrogel becomes light-sensitive, solidifying upon UV exposure to provide a durable treatment option. With the unique properties of ferric iron included in the formulation, we observed enhanced healing effects, including improved elimination of harmful bacteria and better management of oxidative stress around the ulcer site.
In tests conducted on diabetic rats, FSH3 significantly accelerated the healing process compared to traditional treatments. It did so by balancing the inflammatory response and preserving the oral microbiota, which are essential for efficiently regenerating tissue. Overall, our findings suggest that iron, when incorporated into this innovative hydrogel, holds promise for advancing treatments for oral ulcers in diabetic patients.
By combining silk fibroin and hyaluronic acid, the hydrogel becomes light-sensitive, solidifying upon UV exposure to provide a durable treatment option. With the unique properties of ferric iron included in the formulation, we observed enhanced healing effects, including improved elimination of harmful bacteria and better management of oxidative stress around the ulcer site.
In tests conducted on diabetic rats, FSH3 significantly accelerated the healing process compared to traditional treatments. It did so by balancing the inflammatory response and preserving the oral microbiota, which are essential for efficiently regenerating tissue. Overall, our findings suggest that iron, when incorporated into this innovative hydrogel, holds promise for advancing treatments for oral ulcers in diabetic patients.
Read More
9
We explored a case involving a 66-year-old woman who developed a gastric ulcer after using oral iron supplements for an extended period. Iron therapy is commonly prescribed for treating iron deficiency anemia, but it often comes with gastrointestinal side effects.
In this instance, the patient had a history of GI bleeding and other medical conditions, which might have contributed to her increased risk. While gastrointestinal issues with iron supplements are not unusual, having a gastric ulcer as a direct result is rare, and only a handful of similar cases have been reported in medical literature.
Upon conducting endoscopic and histopathological evaluations, we identified iron deposits in the ulcer bed, confirming that the iron therapy was indeed linked to her gastric ulcer. After stopping the oral iron supplements, her symptoms resolved, highlighting the need for careful patient monitoring during iron therapy to prevent serious complications like ulcers.
Our findings emphasize the importance of recognizing and managing the potential adverse effects of oral iron to maintain a safe and effective treatment regimen for iron deficiency anemia.
In this instance, the patient had a history of GI bleeding and other medical conditions, which might have contributed to her increased risk. While gastrointestinal issues with iron supplements are not unusual, having a gastric ulcer as a direct result is rare, and only a handful of similar cases have been reported in medical literature.
Upon conducting endoscopic and histopathological evaluations, we identified iron deposits in the ulcer bed, confirming that the iron therapy was indeed linked to her gastric ulcer. After stopping the oral iron supplements, her symptoms resolved, highlighting the need for careful patient monitoring during iron therapy to prevent serious complications like ulcers.
Our findings emphasize the importance of recognizing and managing the potential adverse effects of oral iron to maintain a safe and effective treatment regimen for iron deficiency anemia.
Read More
9
We examined a complex case of a recurrent ulcer following colon surgery. After multiple treatments, a patient received iron infusions due to iron deficiency anemia but continued to experience bleeding from the ulcer.
Despite standard medical interventions failing to heal the ulcer, hyperbaric oxygen therapy was introduced. After 30 sessions of HBOT, follow-up colonoscopies showed significant healing of the ulcer.
Remarkably, the patient experienced no further bleeding, and his iron levels improved significantly over the next year.
Despite standard medical interventions failing to heal the ulcer, hyperbaric oxygen therapy was introduced. After 30 sessions of HBOT, follow-up colonoscopies showed significant healing of the ulcer.
Remarkably, the patient experienced no further bleeding, and his iron levels improved significantly over the next year.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
8
Iron deficiency improvement
30 people found this helpful
About three years ago, I experienced symptoms akin to depression due to low iron levels, specifically ferritin. After taking leave, my teacher recommended a check-up, as I had barely any iron in my annual health screenings. I underwent a temporary iron test and repeated it the following year. Additionally, this inadequacy aggravated my mouth ulcers. Meeting the healthcare professionals was a relief, as this situation was indeed distressing!
Read More
8
Relief from pain
Superb for individuals with stomach issues! It has significantly aided me without causing any stomach discomfort, despite iron typically inducing severe pain in me. I previously faced a peptic ulcer (at an early stage) and needed to be cautious. This particular remedy works excellently for me.
Read More
8
Noticeable improvements
The results became evident from the initial days. Though doctors maintained that everything was fine, I felt a pressing need to boost my iron levels as my haemoglobin consistently hovered at the lower limit. Since I hardly consume red meat or iron-rich foods, I opted for this medication, supplementing it with vitamin C and folic acid. Within a few days, I felt considerably better, and each day improved further; I no longer feel fatigued. My chronic gastritis and duodenal ulcer have shown remarkable improvement. I highly recommend it, but always consult a physician and complete necessary tests before use.
Read More
8
Gastrointestinal safety
This form of iron was recommended by doctors following an exacerbation of my duodenal ulcer. There was an urgent need to boost my haemoglobin without harming my gastrointestinal tract. The outcome was confirmed by analysis – all results were satisfactory.
Read More
Frequently Asked Questions
References
- Grimm K, Fiedler A, Kröger C. Investigation on the effectiveness of a new hoof care product to sustainably reduce and prevent digital dermatitis in dairy cow herds. J Dairy Sci. 2025;108:1869. 10.3168/jds.2024-25134
- Chen X, Li Z, Ge X, Qi X, Xiang Y, et al. Ferric Iron/Shikonin Nanoparticle-Embedded Hydrogels with Robust Adhesion and Healing Functions for Treating Oral Ulcers in Diabetes. Adv Sci (Weinh). 2024;11:e2405463. 10.1002/advs.202405463
- Parajuli SR, Vikash F, Amin S, Shrestha M, Paudel A, et al. Gastric Ulcer From Prolonged Oral Iron Therapy: A Case Report and Literature Review. Cureus. 2024;16:e67905. 10.7759/cureus.67905
- Harada A, Umeno J, Morisaki S, Saiki T, Taniguchi Y, et al. [A case of chronic enteropathy associated with SLCO2A1 gene diagnosed by capsule endoscopy and successfully treated by ferric carboxymaltose]. Nihon Shokakibyo Gakkai Zasshi. 2022;119:651. 10.11405/nisshoshi.119.651
- Du X, Jia B, Wang W, Zhang C, Liu X, et al. pH-switchable nanozyme cascade catalysis: a strategy for spatial-temporal modulation of pathological wound microenvironment to rescue stalled healing in diabetic ulcer. J Nanobiotechnology. 2022;20:12. 10.1186/s12951-021-01215-6
- Pateria P, Chong A. A recurrent, ischaemic ileocolonic anastomosis ulcer refractory to surgery treated with hyperbaric oxygen. Diving Hyperb Med. 2018;48:194. 10.28920/dhm48.3.194-196
- Duscher D, Neofytou E, Wong VW, Maan ZN, Rennert RC, et al. Transdermal deferoxamine prevents pressure-induced diabetic ulcers. Proc Natl Acad Sci U S A. 2015;112:94. 10.1073/pnas.1413445112
- Chari ST, Keate RF. Ileocolonic anastomotic ulcers: a case series and review of the literature. Am J Gastroenterol. 2000;95:1239. PubMed
