Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Good
Based on 2 Reviews
8.3
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%
Magnesium (as magnesium oxide)
400 mg
95%
Top Medical Research Studies
8
We explored the effects of vitamin B6, specifically its active form called pyridoxal phosphate (PLP), on allergic responses. Our research focused on how this vitamin might influence interleukin-33 (IL-33), a key cytokine involved in type 2 inflammation, typically seen in asthma and other allergic conditions.
We found that healthy individuals had higher levels of PLP in their blood compared to asthma patients. Notably, lower PLP levels correlated with worse lung function and increased inflammation in those with asthma. In tests using mouse models of lung inflammation, we observed that PLP significantly reduced the type 2 immune response, suggesting a protective role against allergic reactions.
Delving deeper, we identified that the conversion of pyridoxal to PLP was critical for regulating IL-33 stability. Moreover, we found that a protein called MDM2 contributed to IL-33's stability by facilitating its degradation. Using PLP helped to decrease IL-33 levels in the lungs and enhance the regulation of this protein, providing a potential new avenue for allergy treatment.
Additionally, inhalation of PLP showed promise in mitigating asthma-related symptoms in mouse models. Overall, our findings indicate that vitamin B6 could serve as a beneficial strategy in managing type 2 inflammation and offer new hope for developing effective treatments for allergy-related diseases.
We found that healthy individuals had higher levels of PLP in their blood compared to asthma patients. Notably, lower PLP levels correlated with worse lung function and increased inflammation in those with asthma. In tests using mouse models of lung inflammation, we observed that PLP significantly reduced the type 2 immune response, suggesting a protective role against allergic reactions.
Delving deeper, we identified that the conversion of pyridoxal to PLP was critical for regulating IL-33 stability. Moreover, we found that a protein called MDM2 contributed to IL-33's stability by facilitating its degradation. Using PLP helped to decrease IL-33 levels in the lungs and enhance the regulation of this protein, providing a potential new avenue for allergy treatment.
Additionally, inhalation of PLP showed promise in mitigating asthma-related symptoms in mouse models. Overall, our findings indicate that vitamin B6 could serve as a beneficial strategy in managing type 2 inflammation and offer new hope for developing effective treatments for allergy-related diseases.
Read More
7
We dove deep into the question of whether vitamin B6 has any impact on allergic reactions associated with Dengzhan Xixin, a medication given through injections. Our analysis was based on a nested case-control study, leveraging data from 20 hospitals across China. The participants included patients who received dexamethasone due to suspected allergic reactions after being administered Dengzhan Xixin, allowing us to compare them with those who did not experience such reactions.
Surprisingly, our findings linked the use of vitamin B6 to heightened risks of allergic reactions when combined with Dengzhan Xixin. Specifically, when patients received vitamin B6 or ambroxol alongside the medication, the likelihood of experiencing an allergic reaction increased significantly. The data suggested that the condition upon admission was also an important factor associated with these reactions.
While this study sheds light on potential risk factors for allergic reactions, the relationship between vitamin B6 and these allergies doesn’t position it as a clear solution for managing allergy symptoms. Further exploration and research are needed to confirm these findings and understand them in greater depth. Ultimately, our work pushes forward the conversation about safety in clinical practices surrounding Dengzhan Xixin and its use in treatments.
Surprisingly, our findings linked the use of vitamin B6 to heightened risks of allergic reactions when combined with Dengzhan Xixin. Specifically, when patients received vitamin B6 or ambroxol alongside the medication, the likelihood of experiencing an allergic reaction increased significantly. The data suggested that the condition upon admission was also an important factor associated with these reactions.
While this study sheds light on potential risk factors for allergic reactions, the relationship between vitamin B6 and these allergies doesn’t position it as a clear solution for managing allergy symptoms. Further exploration and research are needed to confirm these findings and understand them in greater depth. Ultimately, our work pushes forward the conversation about safety in clinical practices surrounding Dengzhan Xixin and its use in treatments.
Read More
8
Magnesium enhances postoperative recovery
We conducted a study to see how magnesium sulfate could influence recovery after total knee arthroplasty in older patients. Using a double-blind, randomized control design, 148 patients were split into two groups: one received magnesium sulfate while the other got saline.
We found that magnesium sulfate not only reduced early postoperative pain but also enhanced the quality of recovery. This suggests that incorporating magnesium into pain management could be beneficial for older adults undergoing knee surgery, improving their overall recovery experience.
We found that magnesium sulfate not only reduced early postoperative pain but also enhanced the quality of recovery. This suggests that incorporating magnesium into pain management could be beneficial for older adults undergoing knee surgery, improving their overall recovery experience.
Read More
Most Useful Reviews
7.5
Noticeable improvements
53 people found this helpful
Helps with cracked toes. My daughter, aged 10, has been taking magnesium regularly. She also suffers from allergies, which for the past six years has caused her fingers to be coarse and peeling. While creams provide temporary relief, they do not address the underlying cause. I discovered from nutritionists that a deficiency in vitamin B6 could lead to such symptoms. I quickly purchased it, and to my delight, the improvements were immediately noticeable. I'm now considering giving it to my husband, as he also has a similar hereditary issue. If anyone else faces this problem, I recommend giving it a go.
Read More
2
Individual response
I had been waiting a long time for this medication to be available, but my hopes were not realised. Unfortunately, it did not improve my sleep, and I seemingly developed a mild allergy to vitamin B6, leading me to stop taking it. However, it suited my husband exceedingly well, making him much calmer and more stable. It appears that the effects can vary from person to person.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
- All Researches
8
Magnesium enhances postoperative recovery
We conducted a study to see how magnesium sulfate could influence recovery after total knee arthroplasty in older patients. Using a double-blind, randomized control design, 148 patients were split into two groups: one received magnesium sulfate while the other got saline.
We found that magnesium sulfate not only reduced early postoperative pain but also enhanced the quality of recovery. This suggests that incorporating magnesium into pain management could be beneficial for older adults undergoing knee surgery, improving their overall recovery experience.
We found that magnesium sulfate not only reduced early postoperative pain but also enhanced the quality of recovery. This suggests that incorporating magnesium into pain management could be beneficial for older adults undergoing knee surgery, improving their overall recovery experience.
Read More
8
We explored the effects of vitamin B6, specifically its active form called pyridoxal phosphate (PLP), on allergic responses. Our research focused on how this vitamin might influence interleukin-33 (IL-33), a key cytokine involved in type 2 inflammation, typically seen in asthma and other allergic conditions.
We found that healthy individuals had higher levels of PLP in their blood compared to asthma patients. Notably, lower PLP levels correlated with worse lung function and increased inflammation in those with asthma. In tests using mouse models of lung inflammation, we observed that PLP significantly reduced the type 2 immune response, suggesting a protective role against allergic reactions.
Delving deeper, we identified that the conversion of pyridoxal to PLP was critical for regulating IL-33 stability. Moreover, we found that a protein called MDM2 contributed to IL-33's stability by facilitating its degradation. Using PLP helped to decrease IL-33 levels in the lungs and enhance the regulation of this protein, providing a potential new avenue for allergy treatment.
Additionally, inhalation of PLP showed promise in mitigating asthma-related symptoms in mouse models. Overall, our findings indicate that vitamin B6 could serve as a beneficial strategy in managing type 2 inflammation and offer new hope for developing effective treatments for allergy-related diseases.
We found that healthy individuals had higher levels of PLP in their blood compared to asthma patients. Notably, lower PLP levels correlated with worse lung function and increased inflammation in those with asthma. In tests using mouse models of lung inflammation, we observed that PLP significantly reduced the type 2 immune response, suggesting a protective role against allergic reactions.
Delving deeper, we identified that the conversion of pyridoxal to PLP was critical for regulating IL-33 stability. Moreover, we found that a protein called MDM2 contributed to IL-33's stability by facilitating its degradation. Using PLP helped to decrease IL-33 levels in the lungs and enhance the regulation of this protein, providing a potential new avenue for allergy treatment.
Additionally, inhalation of PLP showed promise in mitigating asthma-related symptoms in mouse models. Overall, our findings indicate that vitamin B6 could serve as a beneficial strategy in managing type 2 inflammation and offer new hope for developing effective treatments for allergy-related diseases.
Read More
7
We dove deep into the question of whether vitamin B6 has any impact on allergic reactions associated with Dengzhan Xixin, a medication given through injections. Our analysis was based on a nested case-control study, leveraging data from 20 hospitals across China. The participants included patients who received dexamethasone due to suspected allergic reactions after being administered Dengzhan Xixin, allowing us to compare them with those who did not experience such reactions.
Surprisingly, our findings linked the use of vitamin B6 to heightened risks of allergic reactions when combined with Dengzhan Xixin. Specifically, when patients received vitamin B6 or ambroxol alongside the medication, the likelihood of experiencing an allergic reaction increased significantly. The data suggested that the condition upon admission was also an important factor associated with these reactions.
While this study sheds light on potential risk factors for allergic reactions, the relationship between vitamin B6 and these allergies doesn’t position it as a clear solution for managing allergy symptoms. Further exploration and research are needed to confirm these findings and understand them in greater depth. Ultimately, our work pushes forward the conversation about safety in clinical practices surrounding Dengzhan Xixin and its use in treatments.
Surprisingly, our findings linked the use of vitamin B6 to heightened risks of allergic reactions when combined with Dengzhan Xixin. Specifically, when patients received vitamin B6 or ambroxol alongside the medication, the likelihood of experiencing an allergic reaction increased significantly. The data suggested that the condition upon admission was also an important factor associated with these reactions.
While this study sheds light on potential risk factors for allergic reactions, the relationship between vitamin B6 and these allergies doesn’t position it as a clear solution for managing allergy symptoms. Further exploration and research are needed to confirm these findings and understand them in greater depth. Ultimately, our work pushes forward the conversation about safety in clinical practices surrounding Dengzhan Xixin and its use in treatments.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Noticeable improvements
53 people found this helpful
Helps with cracked toes. My daughter, aged 10, has been taking magnesium regularly. She also suffers from allergies, which for the past six years has caused her fingers to be coarse and peeling. While creams provide temporary relief, they do not address the underlying cause. I discovered from nutritionists that a deficiency in vitamin B6 could lead to such symptoms. I quickly purchased it, and to my delight, the improvements were immediately noticeable. I'm now considering giving it to my husband, as he also has a similar hereditary issue. If anyone else faces this problem, I recommend giving it a go.
Read More
2
Individual response
I had been waiting a long time for this medication to be available, but my hopes were not realised. Unfortunately, it did not improve my sleep, and I seemingly developed a mild allergy to vitamin B6, leading me to stop taking it. However, it suited my husband exceedingly well, making him much calmer and more stable. It appears that the effects can vary from person to person.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Xu H, Hao C, Wang X, Du J, Zhang T, et al. Effect of Magnesium Sulfate Infusion on Postoperative Quality of Recovery in Patients Undergoing Total Knee Arthroplasty: A Prospective, Double-Blind, Randomized Controlled Trial. Drug Des Devel Ther. 2024;18:919. 10.2147/DDDT.S444896
- Zhu S, Zhong S, Cheng K, Zhang LS, Bai JW, et al. Vitamin B6 regulates IL-33 homeostasis to alleviate type 2 inflammation. Cell Mol Immunol. 2023;20:794. 10.1038/s41423-023-01029-6
- Yang W, Cheng H, Xie YM, Yang H, Zhuang Y. [Nested case control study to analyze suspected cases and their related factors of allargic reactions to parenterally administered dengzhan xixin]. Zhongguo Zhong Yao Za Zhi. 2013;38:3024.
