Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 15 Researches
8.3
USERS' SCORE
Moderately Good
Based on 54 Reviews
7.6
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%
Magnesium (as magnesium oxide)
400 mg
95%
Top Medical Research Studies
9
We analyzed how magnesium supplementation affects the biology of rheumatoid arthritis (RA) in mice. By feeding one group a diet rich in magnesium and another a standard diet over 15 days, we examined changes in their tissue responses.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Read More
9
We investigated how magnesium (Mg) affects the severity of autoimmune lupus in mice. By feeding MRL/lpr female mice a standard or high magnesium diet for nine weeks, we measured impacts on skin lesions and pathogenic autoantibodies.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
Read More
8
Magnesium shows promise for NMOSD
Our investigation focused on how magnesium L-threonate might help those with neuromyelitis optica spectrum disorder (NMOSD).
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
Read More
Most Useful Reviews
9
Visible results achieved
8 people found this helpful
I bought this product for my seven-year-old son, hoping for better results than other medications we've tried, as directed by a neurologist. Unlike other brands, this drug has shown immediate improvement in his condition. I administer it morning and evening with meals. I’ve even started giving it to my eldest daughter as she prepares for exams, and we all notice the excellent results. I'll definitely order more. Stay healthy!
Read More
9
Headaches resolved
7 people found this helpful
I ordered this magnesium for my daughter, who struggled with headaches and mood swings. After just five days of taking two tablets daily, she reported no headaches. Her mood improved significantly, and we intend to keep her on it regularly for ongoing benefits.
Read More
7.5
Decreased irritability
7 people found this helpful
Excellent pills! I will order again. I liked the small tablet size. Initially, I felt a bit restless on the first day, but that quickly passed. Whenever I took a break and resumed, this occurred again, but eventually, everything normalised. I became calmer, with no drowsiness. My previous tendency to feel fatigued has lifted, and I am functioning better now. I highly recommend this product and plan to order more.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 15 Researches
8.3
- All Researches
9
We analyzed how magnesium supplementation affects the biology of rheumatoid arthritis (RA) in mice. By feeding one group a diet rich in magnesium and another a standard diet over 15 days, we examined changes in their tissue responses.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Read More
9
We investigated how magnesium (Mg) affects the severity of autoimmune lupus in mice. By feeding MRL/lpr female mice a standard or high magnesium diet for nine weeks, we measured impacts on skin lesions and pathogenic autoantibodies.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
Read More
9
We explored the potential of a new magnesium-aluminum layered double hydroxide combined with nano-ceria in treating rheumatoid arthritis (RA). This innovative therapy targets the unhealthy immune environment and the harmful buildup of hydrogen ions associated with RA. By neutralizing excess acidity, we observed improved immune responses, encouraging the body to heal damaged bones. This approach showed promising results in mice models, indicating it may be a viable future treatment for managing RA effectively.
Read More
9
Magnesium aids arthritis through immunity
We explored the effects of a high magnesium diet on rheumatoid arthritis using two mouse models. Our findings suggest that magnesium can significantly reduce arthritis severity and joint damage, while also promoting immune cell types that help combat inflammation.
Interestingly, these benefits seem to hinge on an immune mediator called IL-10 and changes in the gut microbiome, such as increased beneficial bacteria. While our results are promising, it is important to recognize that the protective effects depend on sufficient levels of IL-10, indicating that the relationship between magnesium and immune regulation is quite intricate.
Interestingly, these benefits seem to hinge on an immune mediator called IL-10 and changes in the gut microbiome, such as increased beneficial bacteria. While our results are promising, it is important to recognize that the protective effects depend on sufficient levels of IL-10, indicating that the relationship between magnesium and immune regulation is quite intricate.
Read More
9
Magnesium mitigates MS-related mood issues
We investigated the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression in multiple sclerosis (MS), a disease often accompanied by these mood disorders. Our findings indicated that MgH treatment significantly improved anxiety and depression-like behaviors in mice with experimental autoimmune encephalomyelitis (EAE).
Additionally, MgH reduced disease severity and inflammatory damage. The proposed mechanism behind these effects involves modulation of microglial polarization and reduced oxidative stress. Thus, MgH shows promise as a potential treatment for psychiatric issues associated with MS.
Additionally, MgH reduced disease severity and inflammatory damage. The proposed mechanism behind these effects involves modulation of microglial polarization and reduced oxidative stress. Thus, MgH shows promise as a potential treatment for psychiatric issues associated with MS.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 54 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Visible results achieved
8 people found this helpful
I bought this product for my seven-year-old son, hoping for better results than other medications we've tried, as directed by a neurologist. Unlike other brands, this drug has shown immediate improvement in his condition. I administer it morning and evening with meals. I’ve even started giving it to my eldest daughter as she prepares for exams, and we all notice the excellent results. I'll definitely order more. Stay healthy!
Read More
9
Headaches resolved
7 people found this helpful
I ordered this magnesium for my daughter, who struggled with headaches and mood swings. After just five days of taking two tablets daily, she reported no headaches. Her mood improved significantly, and we intend to keep her on it regularly for ongoing benefits.
Read More
7.5
Decreased irritability
7 people found this helpful
Excellent pills! I will order again. I liked the small tablet size. Initially, I felt a bit restless on the first day, but that quickly passed. Whenever I took a break and resumed, this occurred again, but eventually, everything normalised. I became calmer, with no drowsiness. My previous tendency to feel fatigued has lifted, and I am functioning better now. I highly recommend this product and plan to order more.
Read More
10
Achieved peaceful state
4 people found this helpful
I started taking Magnesium B6 from Solgar, taking three tablets daily. Within days, I noticed an overwhelming sense of calm, a complete shift in my state of mind. After several months, my overall peace of mind returned, truly reflecting a "Zen" feeling.
Read More
9
Better stress management
4 people found this helpful
Good Magnesium + B6! I ordered it for myself and, after just a week, began to sleep better than I have in ages. I also wake up feeling refreshed. I hope it continues to help with stress management. I’m considering ordering for my husband as well! The price is very attractive for such a quantity of tablets. Solgar is a trusted brand. Thank you, iHerb!
Read More
Frequently Asked Questions
9
Headaches resolved
7 people found this helpful
I ordered this magnesium for my daughter, who struggled with headaches and mood swings. After just five days of taking two tablets daily, she reported no headaches. Her mood improved significantly, and we intend to keep her on it regularly for ongoing benefits.
9
Sleep and mood improvement
1 people found this helpful
This excellent product has been part of my daily routine for three months, taking one tablet two to three times a day. I felt improvements in sleep and mood just four days after starting. Solgar is a trustworthy line of supplements, so I have no doubts when it comes to ordering these pills again. Highly recommended!
9
Reduced eye twitching
3 people found this helpful
My eye twitched continuously for months, despite recommendations to take Magnesium B6. I initially tried pure magnesium but it didn’t help and even made me feel unwell. Finally, after ordering Magnesium B6, the twitching noticeably lessened within two weeks. I highly recommend it for calmness.
9
Less fatigue
1 people found this helpful
As a mother of three, juggling work and household chores is exhausting. My husband helps, but we often feel very fatigued. I ordered Magnesium B6 after reading about its benefits for chronic fatigue. After over two weeks, we both noticed significantly less physical and mental fatigue. This drug is incredibly supportive!
10
Achieved peaceful state
4 people found this helpful
I started taking Magnesium B6 from Solgar, taking three tablets daily. Within days, I noticed an overwhelming sense of calm, a complete shift in my state of mind. After several months, my overall peace of mind returned, truly reflecting a "Zen" feeling.
9
Better stress management
4 people found this helpful
Good Magnesium + B6! I ordered it for myself and, after just a week, began to sleep better than I have in ages. I also wake up feeling refreshed. I hope it continues to help with stress management. I’m considering ordering for my husband as well! The price is very attractive for such a quantity of tablets. Solgar is a trusted brand. Thank you, iHerb!
9
Stabilised emotional state
3 people found this helpful
I feel much better! Due to prolonged stress, I developed an eyelid twitch that was noticeable to others. No sedatives worked over two months. However, after ordering magnesium, a miracle occurred! Within two weeks, the twitch stopped. My emotional state stabilised, nervousness reduced, and my sleep improved. I take one tablet three times daily with food.
7.5
Reduced irritability reported
12 people found this helpful
Solgar magnesium is the best I’ve tried; other brands didn’t match its quality. Prescribed by my neurologist, it alleviated my eye twitching and reduced irritability after long-term use. I highly recommend it for its effectiveness and great absorption, though discounts from Solgar would be appreciated.
9
Mood improvement observed
3 people found this helpful
This product is wonderful! My husband has been quite stressed and irritable, so I began giving him Magnesium from Solgar alongside other vitamins. After a week, he became much calmer and more like his usual self, full of jokes instead of grumbles. I will reorder this.
7.5
Muscle contraction relief
1 people found this helpful
Excellent! This is my second order. My sister and husband have used it for a while, finding it soothing and helpful for muscle contractions. The packaging is commendable, and the quality is very good!
9
We analyzed how magnesium supplementation affects the biology of rheumatoid arthritis (RA) in mice. By feeding one group a diet rich in magnesium and another a standard diet over 15 days, we examined changes in their tissue responses.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
Our findings revealed that increased magnesium intake may alter gene expression linked to oxidative stress and cellular aging, processes that are significant in RA development. This suggests that magnesium could be beneficial for managing RA and potentially other autoimmune disorders by reducing disease severity and joint damage.
9
Magnesium aids arthritis through immunity
We explored the effects of a high magnesium diet on rheumatoid arthritis using two mouse models. Our findings suggest that magnesium can significantly reduce arthritis severity and joint damage, while also promoting immune cell types that help combat inflammation.
Interestingly, these benefits seem to hinge on an immune mediator called IL-10 and changes in the gut microbiome, such as increased beneficial bacteria. While our results are promising, it is important to recognize that the protective effects depend on sufficient levels of IL-10, indicating that the relationship between magnesium and immune regulation is quite intricate.
Interestingly, these benefits seem to hinge on an immune mediator called IL-10 and changes in the gut microbiome, such as increased beneficial bacteria. While our results are promising, it is important to recognize that the protective effects depend on sufficient levels of IL-10, indicating that the relationship between magnesium and immune regulation is quite intricate.
8
Magnesium shows promise for NMOSD
Our investigation focused on how magnesium L-threonate might help those with neuromyelitis optica spectrum disorder (NMOSD).
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
We examined both mice and cultured human cells to see if long-term magnesium treatment could reduce neuroinflammation, demyelination, and strengthen the blood-brain barrier.
The results were promising; magnesium supplementation appeared to alleviate damage linked to NMOSD by improving blood-brain barrier integrity and dampening inflammation.
This suggests magnesium could be a novel approach to treating NMOSD.
9
We investigated how magnesium (Mg) affects the severity of autoimmune lupus in mice. By feeding MRL/lpr female mice a standard or high magnesium diet for nine weeks, we measured impacts on skin lesions and pathogenic autoantibodies.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
The results were encouraging: mice on the high magnesium diet showed significant reductions in skin issues and harmful anti-dsDNA antibodies. Plus, their immune systems displayed more regulatory T cells. However, there were no notable differences in other measured health indicators.
Overall, magnesium supplementation may be a cost-effective and safe complementary treatment for lupus.
References
- Toaima DN, Abdel-Maksoud KS, Atef HM, Salah NY. Magnesium, fibrinolysis and clotting interplay among children and adolescents with type 1 diabetes mellitus; potential mediators of diabetic microangiopathy. Nutr Diabetes. 2025;15:13. 10.1038/s41387-025-00368-9
- Laragione T, Harris C, Gulko PS. Magnesium Supplementation Modifies Arthritis Synovial and Splenic Transcriptomic Signatures Including Ferroptosis and Cell Senescence Biological Pathways. Nutrients. 2024;16. 10.3390/nu16234247
- Fu C, Huang L, Lian C, Yue J, Lin P, et al. Effects of long-term magnesium L-threonate supplementation on neuroinflammation, demyelination and blood-brain barrier integrity in mice with neuromyelitis optica spectrum disorder. Brain Res. 2025;1846:149234. 10.1016/j.brainres.2024.149234
- Yan Y, Yao C, Zhang B, Yang Z, Xie J, et al. Olanzapine vs. magnesium valproate vs. lamotrigine in anti-N-methyl-D-aspartic acid receptor encephalitis: a retrospective study. BMC Neurol. 2024;24:331. 10.1186/s12883-024-03811-z
- Verlato A, Laragione T, Bin S, Kim RH, Salem F, et al. Revised version with tracked changes oral Magnesium reduces levels of pathogenic autoantibodies and skin disease in murine lupus. BMC Immunol. 2024;25:58. 10.1186/s12865-024-00650-y
- Liu H, Zhang K, Xiong L. Dietary magnesium intake and rheumatoid arthritis patients' all-cause mortality: evidence from the NHANES database. J Health Popul Nutr. 2024;43:112. 10.1186/s41043-024-00597-1
- Fu H, Guo Y, Fang W, Wang J, Hu P, et al. Anti-Acidification and Immune Regulation by Nano-Ceria-Loaded Mg-Al Layered Double Hydroxide for Rheumatoid Arthritis Therapy. Adv Sci (Weinh). 2024;11:e2307094. 10.1002/advs.202307094
- Fang J, Cao T, Liu C, Wang D, Zhang H, et al. Association between magnesium, copper, and potassium intakes with risk of rheumatoid arthritis: a cross-sectional study from National Health and Nutrition Examination Survey (NHANES). BMC Public Health. 2023;23:2085. 10.1186/s12889-023-16906-y
- Laragione T, Harris C, Azizgolshani N, Beeton C, Bongers G, et al. Magnesium increases numbers of Foxp3+ Treg cells and reduces arthritis severity and joint damage in an IL-10-dependent manner mediated by the intestinal microbiome. EBioMedicine. 2023;92:104603. 10.1016/j.ebiom.2023.104603
- Li Z, Chen K, Shao Q, Lu H, Zhang X, et al. Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress. J Neuroinflammation. 2023;20:16. 10.1186/s12974-023-02696-y
- Du X, Yang Y, Zhan X, Huang Y, Fu Y, et al. Vitamin B6 prevents excessive inflammation by reducing accumulation of sphingosine-1-phosphate in a sphingosine-1-phosphate lyase-dependent manner. J Cell Mol Med. 2020;24:13129. 10.1111/jcmm.15917
- Mallone F, Lucchino L, Franzone F, Marenco M, Carlesimo SC, et al. High-dose vitamin B supplementation for persistent visual deficit in multiple sclerosis: a pilot study. Drug Discov Ther. 2020;14:122. 10.5582/ddt.2020.03031
- Rezaeimanesh N, Saeedi R, Sahraian MA, Razeghi Jahromi S, Naser Moghadasi A. The possible beneficial effects of higher vitamin B6 intake from diet on cognitive function of patients with neuromyelitis optica spectrum disorder. Mult Scler Relat Disord. 2020;42:102132. 10.1016/j.msard.2020.102132
- Sande JS, Ulvik A, Midttun Ø, Ueland PM, Hammer HB, et al. Vitamin B-6 Status Correlates with Disease Activity in Rheumatoid Arthritis Patients During Treatment with TNFα Inhibitors. J Nutr. 2019;149:770. 10.1093/jn/nxz001
- Syngle A, Vohra K, Garg N, Kaur L, Chand P. Advanced glycation end-products inhibition improves endothelial dysfunction in rheumatoid arthritis. Int J Rheum Dis. 2012;15:45. 10.1111/j.1756-185X.2011.01679.x
