Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.8
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.5
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%
Magnesium (as magnesium oxide)
400 mg
95%
Top Medical Research Studies
8
Magnesium scaffold shows promising results
We investigated the clinical safety and performance of a new magnesium scaffold known as DREAMS 3G. This innovative treatment aims to match the effectiveness of drug-eluting stents in coronary interventions.
Over one year, a total of 116 patients were monitored, showing promising results with minimal lumen loss and no adverse events like cardiac death or major thrombosis. Despite a few revascularization interventions, the scaffold appears to be a viable alternative.
Overall, our findings support its potential use in heart treatments.
Over one year, a total of 116 patients were monitored, showing promising results with minimal lumen loss and no adverse events like cardiac death or major thrombosis. Despite a few revascularization interventions, the scaffold appears to be a viable alternative.
Overall, our findings support its potential use in heart treatments.
Read More
9
We investigated the effects of magnesium oxide nanoparticles, created using fruit extract, on blood clotting and oxidative stress. Our experiments showed that these nanoparticles significantly extended clotting time, indicating an anticoagulant effect. They also effectively reduced damage to red blood cells and various tissues in laboratory tests, helping to restore their function. Importantly, we found these nanoparticles non-toxic, suggesting they could be a promising treatment option for oxidative stress-related conditions without adverse side effects. However, further research is needed to fully understand their potential in clinical applications.
Read More
8
We aimed to examine how bioresorbable magnesium scaffolds influence blood clotting. Using a cutting-edge stent flow chamber system, we compared the thrombogenicity of various stents, including the Magmaris magnesium scaffold and a prototype called DREAMS 3G.
Our findings indicated that the Magmaris scaffold exhibited significantly lower thrombogenicity than traditional stainless steel stents. Impressively, the DREAMS 3G prototype demonstrated even further reductions in clotting risks, suggesting it could enhance patient safety.
This study highlights the potential of magnesium-based scaffolds in improving cardiovascular treatments.
Our findings indicated that the Magmaris scaffold exhibited significantly lower thrombogenicity than traditional stainless steel stents. Impressively, the DREAMS 3G prototype demonstrated even further reductions in clotting risks, suggesting it could enhance patient safety.
This study highlights the potential of magnesium-based scaffolds in improving cardiovascular treatments.
Read More
Most Useful Reviews
9
Blood pressure relief
4 people found this helpful
Since I started taking magnesium B6 and taurine, I've forgotten about high blood pressure! I and my family have consumed seven packs and found it effective. This magnesium is not only cost-effective but also works better than other brands. I've stopped using pressure pills entirely after a month. I highly recommend it!
Read More
9
Overall improvement
1 people found this helpful
After taking magnesium for a month, my blood pressure normalised, headaches disappeared, and I felt more energised and alert in the morning. I highly recommend it for anyone seeking a similar outcome!
Read More
9
Doctor's recommendation
SOLGAR magnesium works well for reducing nervousness and anxiety. My blood pressure has significantly decreased, even though it was already low, so I take a smaller dose. I highly recommend it, but consult your doctor first.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.8
- All Researches
9.5
We explored the effects of high serum homocysteine levels on blood clot risks within a group of 1,014 patients who experienced thrombotic events. This group underwent a thorough evaluation for various thrombophilic conditions. Notably, we found that 12% of these patients had treatable high homocysteine levels.
Among those with high homocysteine, we examined a treatment regimen that included vitamin B6, alongside L-methyl folate and vitamin B12. After approximately 18 months of this combined treatment, we observed significant reductions in homocysteine levels, with many patients reaching normal levels.
Importantly, when high homocysteine was the only identified thrombophilia, those who achieved normalization of their homocysteine levels reported a remarkable decrease in new thrombotic events. Thus, while vitamin B6 plays a role in lowering homocysteine, its specific isolated impact on blood clotting remains unclear as part of the combined therapy.
Overall, our findings highlight the relevance of managing high homocysteine through vitamin treatment to potentially lower the risk of blood clots, especially in individuals with no other identified thrombophilia.
Among those with high homocysteine, we examined a treatment regimen that included vitamin B6, alongside L-methyl folate and vitamin B12. After approximately 18 months of this combined treatment, we observed significant reductions in homocysteine levels, with many patients reaching normal levels.
Importantly, when high homocysteine was the only identified thrombophilia, those who achieved normalization of their homocysteine levels reported a remarkable decrease in new thrombotic events. Thus, while vitamin B6 plays a role in lowering homocysteine, its specific isolated impact on blood clotting remains unclear as part of the combined therapy.
Overall, our findings highlight the relevance of managing high homocysteine through vitamin treatment to potentially lower the risk of blood clots, especially in individuals with no other identified thrombophilia.
Read More
9
We investigated the effects of magnesium oxide nanoparticles, created using fruit extract, on blood clotting and oxidative stress. Our experiments showed that these nanoparticles significantly extended clotting time, indicating an anticoagulant effect. They also effectively reduced damage to red blood cells and various tissues in laboratory tests, helping to restore their function. Importantly, we found these nanoparticles non-toxic, suggesting they could be a promising treatment option for oxidative stress-related conditions without adverse side effects. However, further research is needed to fully understand their potential in clinical applications.
Read More
9
We explored the connection between vitamin levels and cerebral venous sinus thrombosis (CVST), particularly focusing on vitamin B6. Our case series documented three instances of CVST where patients presented with headaches, and two experienced additional symptoms like visual disturbances.
In our findings, we noted that two of these patients had notably low levels of vitamin B12, alongside the presence of hyperhomocysteinemia (hHcy). Treatment included low-molecular-weight heparin and supplements of vitamins B6, B9, and B12.
While vitamin B6 was used as part of the supplementation strategy, the specific impact of vitamin B6 alone on blood clotting wasn't thoroughly isolated in this study. All patients showed positive responses to the treatment, with follow-up imaging indicating resolution of the thrombosis in two cases.
This suggests that addressing vitamin deficiencies, particularly in those on vegetarian diets, is vital. Nevertheless, further dedicated research is necessary to determine the isolated effect of vitamin B6 on blood clots.
In our findings, we noted that two of these patients had notably low levels of vitamin B12, alongside the presence of hyperhomocysteinemia (hHcy). Treatment included low-molecular-weight heparin and supplements of vitamins B6, B9, and B12.
While vitamin B6 was used as part of the supplementation strategy, the specific impact of vitamin B6 alone on blood clotting wasn't thoroughly isolated in this study. All patients showed positive responses to the treatment, with follow-up imaging indicating resolution of the thrombosis in two cases.
This suggests that addressing vitamin deficiencies, particularly in those on vegetarian diets, is vital. Nevertheless, further dedicated research is necessary to determine the isolated effect of vitamin B6 on blood clots.
Read More
9
We explored the intriguing case of a 30-year-old woman who experienced severe headaches and neurological symptoms, later linked to blood clotting issues. Initially diagnosed with suspected viral encephalopathy, she faced multiple health challenges including a pulmonary embolism and persistent migraines.
After undergoing various investigations, her doctors discovered she had a dangerously high homocysteine level of over 350 μmol/L, indicating a metabolic disorder known as homocystinuria due to cystathionine β-synthase deficiency. This condition is typically identified in childhood, making her case particularly unusual.
To tackle her elevated homocysteine, a treatment plan involving vitamin B6 (pyridoxine) and betaine was implemented. Remarkably, this approach successfully normalized her homocysteine levels, and she has since avoided any further thrombotic events. Though vitamin B6 is a key player in her treatment, it was administered alongside betaine, which complicates isolating the effects of B6 on blood clot prevention alone.
After undergoing various investigations, her doctors discovered she had a dangerously high homocysteine level of over 350 μmol/L, indicating a metabolic disorder known as homocystinuria due to cystathionine β-synthase deficiency. This condition is typically identified in childhood, making her case particularly unusual.
To tackle her elevated homocysteine, a treatment plan involving vitamin B6 (pyridoxine) and betaine was implemented. Remarkably, this approach successfully normalized her homocysteine levels, and she has since avoided any further thrombotic events. Though vitamin B6 is a key player in her treatment, it was administered alongside betaine, which complicates isolating the effects of B6 on blood clot prevention alone.
Read More
8
We explored whether magnesium intake could influence the risk of retinal vein occlusion (RVO), a leading cause of vision loss. Our analysis involved over 16,000 participants from a national health survey.
We discovered that sufficient magnesium intake was linked to a significant 64% reduced risk of RVO.
This finding was especially relevant for adults under 60, those with hypertension, and individuals without glaucoma. Further studies are needed to confirm magnesium's preventive benefits for RVO.
We discovered that sufficient magnesium intake was linked to a significant 64% reduced risk of RVO.
This finding was especially relevant for adults under 60, those with hypertension, and individuals without glaucoma. Further studies are needed to confirm magnesium's preventive benefits for RVO.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Blood pressure relief
4 people found this helpful
Since I started taking magnesium B6 and taurine, I've forgotten about high blood pressure! I and my family have consumed seven packs and found it effective. This magnesium is not only cost-effective but also works better than other brands. I've stopped using pressure pills entirely after a month. I highly recommend it!
Read More
9
Overall improvement
1 people found this helpful
After taking magnesium for a month, my blood pressure normalised, headaches disappeared, and I felt more energised and alert in the morning. I highly recommend it for anyone seeking a similar outcome!
Read More
9
Doctor's recommendation
SOLGAR magnesium works well for reducing nervousness and anxiety. My blood pressure has significantly decreased, even though it was already low, so I take a smaller dose. I highly recommend it, but consult your doctor first.
Read More
7.5
No more cramps
I no longer experience cramps, which were due to a magnesium deficiency. Additionally, it assists with my blood pressure alongside my medication.
Read More
2
Low effectiveness observed
5 people found this helpful
I bought it for my parents, hoping it would alleviate their high blood pressure and nervousness, but the effect was minimal. Previously, Ultra-Mag without B6 had yielded better results. I would recommend trying a different magnesium brand instead.
Read More
Frequently Asked Questions
9
Overall improvement
1 people found this helpful
After taking magnesium for a month, my blood pressure normalised, headaches disappeared, and I felt more energised and alert in the morning. I highly recommend it for anyone seeking a similar outcome!
9
Blood pressure relief
4 people found this helpful
Since I started taking magnesium B6 and taurine, I've forgotten about high blood pressure! I and my family have consumed seven packs and found it effective. This magnesium is not only cost-effective but also works better than other brands. I've stopped using pressure pills entirely after a month. I highly recommend it!
6
Gradual improvement
6 people found this helpful
I continued using this for three months and noticed a relative improvement in high blood pressure. However, it’s not miraculous; maintaining a healthy diet and regular walking is still necessary for better results with blood pressure readings.
2
Low effectiveness observed
5 people found this helpful
I bought it for my parents, hoping it would alleviate their high blood pressure and nervousness, but the effect was minimal. Previously, Ultra-Mag without B6 had yielded better results. I would recommend trying a different magnesium brand instead.
7.5
No more cramps
I no longer experience cramps, which were due to a magnesium deficiency. Additionally, it assists with my blood pressure alongside my medication.
9
Doctor's recommendation
SOLGAR magnesium works well for reducing nervousness and anxiety. My blood pressure has significantly decreased, even though it was already low, so I take a smaller dose. I highly recommend it, but consult your doctor first.
4
Minimal effect noted
9 people found this helpful
I will try magnesium citrate instead of magnesium oxide due to its low digestibility. I initially bought it for my husband to help control his blood pressure, but we did not notice a strong effect. We plan to switch to magnesium citrate, enticed by its price and quantity ratio compared to other options in pharmacies.
8
MAGT1 deficiency increases thrombosis risk
We studied how a lack of magnesium transporter 1 (MAGT1) impacts blood clot formation and the risk of stroke. Using various laboratory and animal models, we observed that MAGT1 deficiency leads to enhanced platelet activity and quicker clotting. This deficiency resulted in faster artery blockage and severe brain damage during strokes. Interestingly, restoring magnesium levels or blocking certain channels helped normalize platelet behavior. Overall, we found that MAGT1's function is crucial for vascular health, indicating its deficiency could elevate risks for thrombosis and ischemic stroke.
8
We aimed to examine how bioresorbable magnesium scaffolds influence blood clotting. Using a cutting-edge stent flow chamber system, we compared the thrombogenicity of various stents, including the Magmaris magnesium scaffold and a prototype called DREAMS 3G.
Our findings indicated that the Magmaris scaffold exhibited significantly lower thrombogenicity than traditional stainless steel stents. Impressively, the DREAMS 3G prototype demonstrated even further reductions in clotting risks, suggesting it could enhance patient safety.
This study highlights the potential of magnesium-based scaffolds in improving cardiovascular treatments.
Our findings indicated that the Magmaris scaffold exhibited significantly lower thrombogenicity than traditional stainless steel stents. Impressively, the DREAMS 3G prototype demonstrated even further reductions in clotting risks, suggesting it could enhance patient safety.
This study highlights the potential of magnesium-based scaffolds in improving cardiovascular treatments.
8
We looked into the effects of Vitamin B6, along with B12 and folic acid, on the risk of blood clots among Indian soldiers stationed at high altitudes. This study aimed to find out if these vitamins could lower homocysteine levels—an amino acid linked to an increased risk of thrombosis.
In a well-structured randomized field trial, 12,000 soldiers taking these vitamins were compared to another group receiving no intervention. After one year, we saw promising results: the soldiers who took the Vitamin B complex maintained healthier levels of homocysteine, plasminogen activator inhibitor (PAI 1), and fibrinogen, while their nitric oxide levels increased.
Most importantly, over two years, only five thrombotic episodes occurred in the intervention group compared to 17 in the control group. This indicates a clear protective effect of the vitamin regimen against thrombosis. Although the study did assess Vitamin B6 alongside B12 and folic acid, it points to its potential relevance in reducing blood clot risks in high-altitude conditions.
In a well-structured randomized field trial, 12,000 soldiers taking these vitamins were compared to another group receiving no intervention. After one year, we saw promising results: the soldiers who took the Vitamin B complex maintained healthier levels of homocysteine, plasminogen activator inhibitor (PAI 1), and fibrinogen, while their nitric oxide levels increased.
Most importantly, over two years, only five thrombotic episodes occurred in the intervention group compared to 17 in the control group. This indicates a clear protective effect of the vitamin regimen against thrombosis. Although the study did assess Vitamin B6 alongside B12 and folic acid, it points to its potential relevance in reducing blood clot risks in high-altitude conditions.
We explored a fascinating case involving a young woman who faced severe, recurring thrombotic events linked to exceptionally high levels of homocysteine in her blood—an amino acid known to be harmful to blood vessels. In her treatment, doctors combined anticoagulation therapy with warfarin and vitamin supplementation, including vitamin B6, vitamin B12, and folate.
While vitamin B6 is part of this treatment routine, the study doesn't clearly distinguish its individual effectiveness on preventing blood clots. After twelve years of treatment, the patient’s homocysteine levels did improve and stabilize within a moderate range, and notably, she did not experience any more thromboembolic incidents during this time.
This brings us to a crucial point: while vitamin B6 was included in her regimen, we cannot definitively say it made a significant difference on its own in managing blood clot risks. It appears to be one part of a larger picture that includes multiple treatments aimed at improving her condition.
While vitamin B6 is part of this treatment routine, the study doesn't clearly distinguish its individual effectiveness on preventing blood clots. After twelve years of treatment, the patient’s homocysteine levels did improve and stabilize within a moderate range, and notably, she did not experience any more thromboembolic incidents during this time.
This brings us to a crucial point: while vitamin B6 was included in her regimen, we cannot definitively say it made a significant difference on its own in managing blood clot risks. It appears to be one part of a larger picture that includes multiple treatments aimed at improving her condition.
References
- Kim J, Kim M, Lee CS, Choi EY. Sufficient Magnesium Intake Reduces Retinal Vein Occlusion Risk: National Health and Nutrition Examination Survey Analysis. Nutrients. 2025;17. 10.3390/nu17071285
- Guo X, Zeng X, He Y, Zhang X, Shi W, et al. An Antibacterial, Antioxidant Adherent Sponge Constructed for Control of Arterial Bleeding Via Gallic Acid-Mediated Robust Assembly of Fibrous Clay in Collagen. ACS Appl Mater Interfaces. 2025;17:16489. 10.1021/acsami.4c19209
- Müller M, Ludwig L, Englert H, Riedl KA, Müller MC, et al. A novel stent flow chamber system demonstrates reduced thrombogenicity of bioresorbable magnesium scaffolds. Sci Rep. 2024;14:26691. 10.1038/s41598-024-77266-0
- Zhang J, Chen Z, Rao L, He Y. Coronary bioresorbable metallic stents: Advancements and future perspectives. J Cardiol. 2025;85:69. 10.1016/j.jjcc.2024.08.003
- Włodarczak A, Rola P, Włodarczak S, Szudrowicz M, Giniewicz K, et al. Two-Year Outcomes for Patients with Non-ST-Elevation Acute Coronary Syndrome Treated with Magmaris and Absorb Bioresorbable Scaffolds in Large-Vessel Lesions. J Pers Med. 2024;14. 10.3390/jpm14050540
- Galli S, Troiano S, Palloshi A, Rapetto C, Pisano F, et al. Comparison of acute versus stable coronary syndrome in patients treated with the Magmaris scaffold: Two-year results from the Magmaris Multicenter Italian Registry. Cardiovasc Revasc Med. 2023;57:53. 10.1016/j.carrev.2023.06.022
- Włodarczak A, Rola P, Barycki M, Furtan Ł, Łanocha M, et al. Mid-term safety and efficacy of magnesium bioresorbable vascular scaffolds - magmaris in diabetic population. 2-Years outcome in acute coronary syndrome cohort. Diab Vasc Dis Res. 2023;20:14791641231188705. 10.1177/14791641231188705
- Gotru SK, Mammadova-Bach E, Sogkas G, Schuhmann MK, Schmitt K, et al. MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice. Arterioscler Thromb Vasc Biol. 2023;43:1494. 10.1161/ATVBAHA.122.318115
- Haude M, Wlodarczak A, van der Schaaf RJ, Torzewski J, Ferdinande B, et al. A new resorbable magnesium scaffold for de novo coronary lesions (DREAMS 3): one-year results of the BIOMAG-I first-in-human study. EuroIntervention. 2023;19:e414. 10.4244/EIJ-D-23-00326
- Wlodarczak A, Montorsi P, Torzewski J, Bennett J, Starmer G, et al. One- and two-year clinical outcomes of treatment with resorbable magnesium scaffolds for coronary artery disease: the prospective, international, multicentre BIOSOLVE-IV registry. EuroIntervention. 2023;19:232. 10.4244/EIJ-D-22-01069
- Haude M, Wlodarczak A, van der Schaaf RJ, Torzewski J, Ferdinande B, et al. Safety and performance of the third-generation drug-eluting resorbable coronary magnesium scaffold system in the treatment of subjects with de novo coronary artery lesions: 6-month results of the prospective, multicenter BIOMAG-I first-in-human study. EClinicalMedicine. 2023;59:101940. 10.1016/j.eclinm.2023.101940
- Pompei G, Campo G, Ruggiero R, Maffeo D, Sgura F, et al. Long-term outcomes of patients treated with sirolimus-eluting resorbable magnesium scaffolds: Insights from the SHERPA-MAGIC study. Int J Cardiol. 2023;383:1. 10.1016/j.ijcard.2023.04.029
- Fedele G, Castiglioni S, Maier JAM, Locatelli L. The Effects of Sirolimus and Magnesium on Primary Human Coronary Endothelial Cells: An In Vitro Study. Int J Mol Sci. 2023;24. 10.3390/ijms24032930
- Tonai K, Katayama S, Koyama K, Sata N, Tomioka Y, et al. Association between hypomagnesemia and coagulopathy in sepsis: a retrospective observational study. BMC Anesthesiol. 2022;22:359. 10.1186/s12871-022-01903-2
- Seguchi M, Aytekin A, Lenz T, Nicol P, Alvarez-Covarrubias HA, et al. Challenges of the newer generation of resorbable magnesium scaffolds: Lessons from failure mechanisms of the past generation. J Cardiol. 2023;81:179. 10.1016/j.jjcc.2022.09.003
- Venkatappa MM, Udagani C, Hanumegowda SM, Pramod SN, Venkataramaiah S, et al. Effect of Biofunctional Green Synthesized MgO-Nanoparticles on Oxidative-Stress-Induced Tissue Damage and Thrombosis. Molecules. 2022;27. 10.3390/molecules27165162
- Baby N, George M, Rajasekharan A, Ajith S, Zabeer M, et al. Cerebral Venous Sinus Thrombosis Secondary to Vitamin B12 Deficiency - A Case Series with Emphasis on Food Fortification. Ann Afr Med. 2024;23:496. 10.4103/aam.aam_138_23
- Woods E, Dawson C, Senthil L, Geberhiwot T. Cerebral venous thrombosis as the first presentation of classical homocystinuria in an adult patient. BMJ Case Rep. 2017;2017. 10.1136/bcr-2016-217477
- Kotwal J, Kotwal A, Bhalla S, Singh PK, Nair V. Effectiveness of homocysteine lowering vitamins in prevention of thrombotic tendency at high altitude area: A randomized field trial. Thromb Res. 2015;136:758. 10.1016/j.thromres.2015.08.001
- Glueck CJ, Smith D, Gandhi N, Hemachandra K, Shah P, et al. Treatable high homocysteine alone or in concert with five other thrombophilias in 1014 patients with thrombotic events. Blood Coagul Fibrinolysis. 2015;26:736. 10.1097/MBC.0000000000000276
- Awan Z, Aljenedil S, Rosenblatt DS, Cusson J, Gilfix BM, et al. Severe hyperhomocysteinemia due to cystathionine β-synthase deficiency, and Factor V Leiden mutation in a patient with recurrent venous thrombosis. Thromb J. 2014;12:30. 10.1186/s12959-014-0030-0
- Liu F, Zhu L, Chen P, Shi Z, Liu S. [Two cases of pulmonary thromboembolism associated with protein C and protein S deficiency and literature review]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013;38:971. 10.3969/j.issn.1672-7347.2013.09.018
- Mendiratta V, Prakash A, Jain A, Jain M. Isolated distal cutaneous thrombosis: an unusual presentation and an interesting etiology. Indian J Dermatol Venereol Leprol. 2011;77:494. 10.4103/0378-6323.82412
- Dworakowska D, Kazimierska E, Weyer-Hepka J, Dworakowski R, Jakóbiewicz-Banecka J, et al. [Hyperhomocysteinemia complicated by myocardial infarction and portal vein thrombosis--case report]. Pol Arch Med Wewn. 2006;115:234.
