SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.4
USERS' SCORE
Good
Based on 14 Reviews
8.5
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%
Magnesium (as magnesium oxide)
400 mg
95%

Top Medical Research Studies

8
Magnesium potentially benefits CFS patients
Red blood cell magnesium and chronic fatigue syndrome.
High relevance for CFS treatment
We investigated the relationship between magnesium levels in red blood cells and chronic fatigue syndrome (CFS). A case-control study revealed that CFS patients had lower magnesium levels than healthy individuals.

In a randomized, double-blind trial, 32 CFS patients received either magnesium sulphate or a placebo for six weeks. Those treated with magnesium reported significant improvements in energy, emotional wellbeing, and pain relief, with twelve out of fifteen feeling better.

In contrast, only three out of seventeen patients on placebo reported any improvement. Overall, these findings suggest that magnesium treatment may positively impact the wellbeing of those suffering from CFS.
Read More
7
Magnesium sulfate shows potential benefits
[A case of chronic fatigue syndrome who showed a beneficial effect by intravenous administration of magnesium sulphate].
Relevant study on treatment efficacy
We aimed to understand the effects of magnesium sulfate treatment on a patient with chronic fatigue syndrome. The case involved a 29-year-old woman experiencing severe fatigue alongside various symptoms, including swelling lymph nodes and muscle pain.

After other treatments failed to provide relief, we administered magnesium sulfate intravenously once a week. Remarkably, after six weeks, the patient reported a significant reduction in fatigue and improved daily functioning, eventually leading to her discharge from the hospital.
Read More
7
Magnesium shows limited benefit for fatigue
Magnesium status and parameters of the oxidant-antioxidant balance in patients with chronic fatigue: effects of supplementation with magnesium.
Moderate relevance due to mixed results
We investigated how magnesium levels relate to chronic fatigue by studying 93 patients with unexplained fatigue.

Around 47% of participants showed magnesium deficiency, linked to reduced plasma antioxidant capacity.

Although magnesium supplementation didn't increase blood glutathione levels, we observed improved magnesium stores and vitamin E levels.

However, this did not equate to a significant boost in antioxidant activity or a decrease in lipid vulnerability. Therefore, while magnesium may help improve some parameters, it is not a panacea for chronic fatigue syndrome.
Read More

Most Useful Reviews

9.5
Fatigue disappeared
In one word, Solgar! After being prescribed magnesium with vitamin B6 by three doctors due to chronic stress and smoking, I felt a surge of energy almost immediately. My fatigue vanished, and I no longer woke up at night. I'm pleased to have found this quality product.
Read More
9.5
Family-wide benefits
My family and I greatly benefit from this magnesium. My husband sleeps better, and after two weeks of use, apathy and fatigue disappeared. The tablets are small and easy to swallow, and the quality is outstanding.
Read More
7
Good recovery
I purchased it as I was too lazy to eat properly. I sleep well, recover from fatigue, and find the effect to be beneficial.
Read More

Medical Researches

SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.4
  • All Researches
8
Magnesium potentially benefits CFS patients
Red blood cell magnesium and chronic fatigue syndrome.
High relevance for CFS treatment
We investigated the relationship between magnesium levels in red blood cells and chronic fatigue syndrome (CFS). A case-control study revealed that CFS patients had lower magnesium levels than healthy individuals.

In a randomized, double-blind trial, 32 CFS patients received either magnesium sulphate or a placebo for six weeks. Those treated with magnesium reported significant improvements in energy, emotional wellbeing, and pain relief, with twelve out of fifteen feeling better.

In contrast, only three out of seventeen patients on placebo reported any improvement. Overall, these findings suggest that magnesium treatment may positively impact the wellbeing of those suffering from CFS.
Read More
8
Beta-glucan shows cognitive benefits
Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
Limited isolated effect of B6
We conducted a study exploring the effects of beta-glucan combined with vitamins, including vitamin B6, on individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). This research involved a 36-week trial where 65 participants were split into two groups: one received a daily supplement containing beta-glucan and vitamins, while the other received a placebo.

While the beta-glucan supplementation showed promising results in reducing cognitive fatigue, the specific impact of vitamin B6 on chronic fatigue syndrome was not clearly determined. This is because vitamin B6 was part of a combination treatment, making it difficult to assess its isolated benefits.

Ultimately, we observed that yeast-derived beta-glucan might hold potential in alleviating cognitive challenges associated with ME/CFS, which opens up avenues for further research. However, it’s important to remember that additional studies are needed to fully understand how vitamin B6 and other components contribute to this condition.
Read More
7
Magnesium shows limited benefit for fatigue
Magnesium status and parameters of the oxidant-antioxidant balance in patients with chronic fatigue: effects of supplementation with magnesium.
Moderate relevance due to mixed results
We investigated how magnesium levels relate to chronic fatigue by studying 93 patients with unexplained fatigue.

Around 47% of participants showed magnesium deficiency, linked to reduced plasma antioxidant capacity.

Although magnesium supplementation didn't increase blood glutathione levels, we observed improved magnesium stores and vitamin E levels.

However, this did not equate to a significant boost in antioxidant activity or a decrease in lipid vulnerability. Therefore, while magnesium may help improve some parameters, it is not a panacea for chronic fatigue syndrome.
Read More
7
Magnesium sulfate shows potential benefits
[A case of chronic fatigue syndrome who showed a beneficial effect by intravenous administration of magnesium sulphate].
Relevant study on treatment efficacy
We aimed to understand the effects of magnesium sulfate treatment on a patient with chronic fatigue syndrome. The case involved a 29-year-old woman experiencing severe fatigue alongside various symptoms, including swelling lymph nodes and muscle pain.

After other treatments failed to provide relief, we administered magnesium sulfate intravenously once a week. Remarkably, after six weeks, the patient reported a significant reduction in fatigue and improved daily functioning, eventually leading to her discharge from the hospital.
Read More
7
Magnesium shows promise for CFS
[Therapy of chronic fatigue syndrome].
Effective treatment still uncertain
We explored the effects of magnesium on chronic fatigue syndrome (CFS), a condition marked by extended periods of debilitating fatigue. While there’s no definitive therapy established for CFS, our review of clinical trials reveals that magnesium treatment has shown promise, enhancing the well-being of some patients.

Other treatments like acyclovir have proven ineffective, and although intravenous immunoglobulin therapy shows potential, its results remain debated. We recognize that restoring immune function may be a piece of the puzzle, but overall, the effectiveness of magnesium for treating CFS symptoms is yet to be firmly established.
Read More

User Reviews

USERS' SCORE
Good
Based on 14 Reviews
8.5
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9.5
Fatigue disappeared
In one word, Solgar! After being prescribed magnesium with vitamin B6 by three doctors due to chronic stress and smoking, I felt a surge of energy almost immediately. My fatigue vanished, and I no longer woke up at night. I'm pleased to have found this quality product.
9.5
Family-wide benefits
My family and I greatly benefit from this magnesium. My husband sleeps better, and after two weeks of use, apathy and fatigue disappeared. The tablets are small and easy to swallow, and the quality is outstanding.
7
Good recovery
I purchased it as I was too lazy to eat properly. I sleep well, recover from fatigue, and find the effect to be beneficial.
9.5
PMS symptoms gone
This magnesium helps me manage PMS. I start taking it a week before my period, and it prevents symptoms almost completely. I find it particularly calming, relieving my stomach and back pain.
8.8
Increased energy levels
This product dramatically increased my energy levels. I’ve suffered from chronic fatigue and lethargy for years, and I never thought magnesium deficiency was to blame. I took 1-2 pills at night, not the full dose, but I noticed positive results.

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