We explored the impact of magnesium on secretory diarrhea, particularly in the context of cholera, a significant global health issue. The focus was on understanding how magnesium, often overlooked, could serve as an effective treatment option. In our study, we found that increasing levels of magnesium can significantly inhibit chloride secretion in intestinal cells, which is crucial during episodes of diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
Read More
8
Magnesium improves diarrhea symptoms
Hepatocyte nuclear factor 1B deletion, but not intragenic mutation, might be more susceptible to hypomagnesemia.
We investigated the relationship between magnesium treatment and diarrhea in patients with HNF1B syndrome, where we found that hypomagnesemia is quite common.
A notable case involved a patient with a de novo heterozygous deletion of the HNF1B gene, who suffered from severe diarrhea due to low magnesium levels. After receiving magnesium supplementation, the patient's diarrhea symptoms improved significantly.
Our findings indicate that those with HNF1B deletion are more likely to experience low magnesium levels compared to individuals with intragenic mutations. In fact, among a large group of patients with HNF1B syndrome, over half experienced hypomagnesemia.
This suggests a strong connection between magnesium deficiency and the gastrointestinal issues seen in this condition. It highlights the importance of monitoring magnesium levels in patients, as addressing this deficiency can lead to meaningful relief from diarrhea symptoms.
Read More
9
Magnesium improves diarrhea-related symptoms
Intestinal hypomagnesemia in an Iranian patient with a novel TRPM6 variant: a case report and review of the literature.
We observed a fascinating case involving a 70-day-old baby girl from Iran who was suffering from severe hypomagnesemia and secondary hypocalcemia. She exhibited signs like seizures and persistent watery diarrhea shortly after birth, leading to significant health challenges, including failure to thrive.
In her treatment, both magnesium and calcium supplementation were used. Despite an initial struggle with response to the magnesium, we noted that over time, her condition improved, and the diarrhea subsided. This suggests that magnesium might play a crucial role in managing diarrhea, especially in cases related to deficiencies.
Additionally, a genetic analysis revealed a novel alteration in her TRPM6 gene, which is notable because such variants are linked to magnesium transport issues. This connection highlights the importance of magnesium not only in treating diarrhea but also in the overall well-being of individuals with genetic predispositions affecting magnesium levels.
Our follow-up with the patient over two years showed no relapses, indicating a positive response to the treatment plan incorporating magnesium. While our findings centered on this specific instance, they contribute to a broader understanding of magnesium's therapeutic effects on diarrhea and related health problems.
Read More
Most Useful Reviews
0
Do not use
11 people found this helpful
Diarrhea appeared during use. I advise against taking this form of magnesium; it is not absorbed well at all! I experienced diarrhoea during its use.
Read More
9
No side effects
8 people found this helpful
No gastrointestinal side effects. With this Magnesium Oxide supplement by Solgar, I benefit from magnesium without the malabsorption issues suffered with other brands. Other supplements caused bloating, gas, stomach pain, and diarrhea, but I have had none of those with Solgar. It's helped reduce my muscle and nerve pain, and I enjoy much more restful sleep. Having taken Magnesium Oxide for over 7 years for my sciatica pain, it keeps the pain at bay, which was previously unbearable. The dosage of three pills allows me to take one every eight hours, and I feel great!
Read More
10
Effective solution
Simply excellent! I switched to this product after every magnesium I took caused diarrhoea. Since starting this one, my issues have stopped completely. Kudos to Solgar!
We explored the impact of magnesium on secretory diarrhea, particularly in the context of cholera, a significant global health issue. The focus was on understanding how magnesium, often overlooked, could serve as an effective treatment option. In our study, we found that increasing levels of magnesium can significantly inhibit chloride secretion in intestinal cells, which is crucial during episodes of diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
Read More
9
Magnesium improves diarrhea-related symptoms
Intestinal hypomagnesemia in an Iranian patient with a novel TRPM6 variant: a case report and review of the literature.
We observed a fascinating case involving a 70-day-old baby girl from Iran who was suffering from severe hypomagnesemia and secondary hypocalcemia. She exhibited signs like seizures and persistent watery diarrhea shortly after birth, leading to significant health challenges, including failure to thrive.
In her treatment, both magnesium and calcium supplementation were used. Despite an initial struggle with response to the magnesium, we noted that over time, her condition improved, and the diarrhea subsided. This suggests that magnesium might play a crucial role in managing diarrhea, especially in cases related to deficiencies.
Additionally, a genetic analysis revealed a novel alteration in her TRPM6 gene, which is notable because such variants are linked to magnesium transport issues. This connection highlights the importance of magnesium not only in treating diarrhea but also in the overall well-being of individuals with genetic predispositions affecting magnesium levels.
Our follow-up with the patient over two years showed no relapses, indicating a positive response to the treatment plan incorporating magnesium. While our findings centered on this specific instance, they contribute to a broader understanding of magnesium's therapeutic effects on diarrhea and related health problems.
Read More
9
Magnesium reduces diarrhea incidence
Dietary supplementation with potassium-magnesium sulfate modulates the antioxidant capacity, immunity, and gut microbiota in weaned piglets.
In our exploration of how potassium-magnesium sulfate (PMS) impacts diarrhea in weaned piglets, we set out to understand its effects on growth performance, immunity, and gut health. A total of 216 piglets were divided into six groups, with varying levels of PMS in their diets.
Our findings revealed some compelling results: the addition of PMS significantly reduced the diarrhea rate among the piglets. Notably, when we included 0.3% PMS in their diet, we observed improved antioxidant capacity, which plays a crucial role in maintaining overall gut health.
We also discovered that PMS supplementation positively influenced intestinal immunity by lowering certain inflammatory markers, further suggesting its beneficial role in digestive health. Additionally, the changes in gut bacteria composition indicated that magnesium may help foster a healthier gut environment.
Overall, our study sheds light on magnesium's potential role as a treatment option for reducing diarrhea in weaned piglets, emphasizing its effectiveness in fostering both immunity and gut health.
Read More
9
Impact of magnesium on diarrhea
Bioactivities of (Wall.) and Study against Cyclooxygenase Enzymes.
We conducted a study to assess the effectiveness of magnesium in treating diarrhea, particularly focusing on its role in extracts from (Wall.) leaves. To evaluate this, we utilized several tests that mimic diarrhea conditions. Our findings showed that while magnesium was mentioned in connection with the extracts, it was administered alongside other treatments. This means we're not entirely sure how much of the anti-diarrheal effect was due to magnesium itself.
In our tests, the methanol extract of (Wall.) leaves was particularly noteworthy, showing significant inhibition of diarrhea at a dose of 400 mg/kg. However, the role of magnesium in this context remains ambiguous since it wasn't given alone. In essence, while the extract worked well against diarrhea, the individual contribution of magnesium to this benefit is unclear.
Overall, we support the traditional use of (Wall.) plants in managing diarrhea and pain, but we need more focused research to isolate the effects of magnesium.
Read More
8
Magnesium improves diarrhea symptoms
Hepatocyte nuclear factor 1B deletion, but not intragenic mutation, might be more susceptible to hypomagnesemia.
We investigated the relationship between magnesium treatment and diarrhea in patients with HNF1B syndrome, where we found that hypomagnesemia is quite common.
A notable case involved a patient with a de novo heterozygous deletion of the HNF1B gene, who suffered from severe diarrhea due to low magnesium levels. After receiving magnesium supplementation, the patient's diarrhea symptoms improved significantly.
Our findings indicate that those with HNF1B deletion are more likely to experience low magnesium levels compared to individuals with intragenic mutations. In fact, among a large group of patients with HNF1B syndrome, over half experienced hypomagnesemia.
This suggests a strong connection between magnesium deficiency and the gastrointestinal issues seen in this condition. It highlights the importance of monitoring magnesium levels in patients, as addressing this deficiency can lead to meaningful relief from diarrhea symptoms.
Diarrhea appeared during use. I advise against taking this form of magnesium; it is not absorbed well at all! I experienced diarrhoea during its use.
Read More
9
No side effects
8 people found this helpful
No gastrointestinal side effects. With this Magnesium Oxide supplement by Solgar, I benefit from magnesium without the malabsorption issues suffered with other brands. Other supplements caused bloating, gas, stomach pain, and diarrhea, but I have had none of those with Solgar. It's helped reduce my muscle and nerve pain, and I enjoy much more restful sleep. Having taken Magnesium Oxide for over 7 years for my sciatica pain, it keeps the pain at bay, which was previously unbearable. The dosage of three pills allows me to take one every eight hours, and I feel great!
Read More
10
Effective solution
Simply excellent! I switched to this product after every magnesium I took caused diarrhoea. Since starting this one, my issues have stopped completely. Kudos to Solgar!
Read More
9
Highly absorbable
The most bioavailable magnesium is chelated. Glycinate, suitable for sensitive stomachs, does not cause diarrhoea like cheaper forms. I take magnesium regularly, as it helps relax and calm me down.
Read More
6
Mild discomfort
It may have a slightly stronger effect; I have a slight stomachache and mild diarrhoea, but it seems to work.
Diarrhea is a condition characterized by the frequent passage of loose or watery stools, which can occur due to various factors, including infections, dietary choices, and underlying health conditions. It often results from the body's response to an irritation of the gastrointestinal tract, which can be caused by viruses, bacteria, parasites, or certain medications. While most cases tend to be short-lived and resolve on their own, diarrhea can lead to dehydration, especially in vulnerable populations such as young children and the elderly.
Managing diarrhea typically involves staying hydrated by drinking clear fluids and, when necessary, replenishing lost electrolytes. In some cases, over-the-counter medications may provide relief, although it’s essential to consult a healthcare professional for persistent or severe symptoms. A focus on bland, easy-to-digest foods can also help during recovery. Remember, if diarrhea persists for more than a couple of days or is accompanied by other concerning symptoms—like high fever, severe abdominal pain, or blood in stools—seeking medical attention is crucial.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Magnesium can have an effect on digestive health, but its role in managing diarrhea is complex. Magnesium is known to have a laxative effect, especially in higher doses or in certain forms, such as magnesium citrate or magnesium sulfate. This means that while magnesium can be beneficial for individuals suffering from constipation, it may exacerbate diarrhea for those who are already experiencing loose stools.
In some cases, magnesium may be helpful in alleviating diarrhea due to its overall importance in digestive function and maintaining electrolyte balance. However, if diarrhea is persistent or severe, it's crucial to consult a healthcare professional for proper evaluation and treatment. Overall, magnesium should not be seen as a primary treatment for diarrhea, and those experiencing digestive discomfort should consider other remedies and strategies alongside any magnesium supplementation.
Based on user reviews, the timeframe to experience results from taking magnesium supplements for diarrhea varies significantly among individuals. In some cases, users have reported immediate relief, stating that they found this particular magnesium effective and experienced a significant reduction in their diarrhea symptoms shortly after switching to it. For instance, one user who had struggled with diarrhea caused by other magnesium forms mentioned that their issues stopped completely after starting this new product Read Review.
However, not all experiences have been positive. A few users noted that they experienced diarrhea while taking the supplement, which indicates that results can differ widely depending on individual tolerance to the specific form of magnesium. One user cautioned against using this supplement, stating it was poorly absorbed and that it exacerbated their diarrhea Read Review. Overall, while some users may see benefits quickly, others may experience adverse effects, so it is essential to monitor your own response when trying a new supplement.
Recent studies provide compelling evidence that magnesium supplementation may be beneficial in managing various forms of diarrhea, including secretory diarrhea related to cholera. One investigation demonstrated that magnesium significantly inhibits chloride secretion in intestinal cells, reducing fluid loss associated with cholera by up to 40% [1]. Furthermore, research involving patients with hypomagnesemia and diarrhea showed substantial improvement in symptoms following magnesium supplementation, indicating a strong link between magnesium deficiency and gastrointestinal issues [2].
However, while magnesium appears to offer therapeutic benefits, caution is advised when considering its combined use with other treatments. In a study exploring naldemedine, a medication used for opioid-induced constipation, researchers found that adding magnesium could enhance bowel movement frequency but also raised the incidence of diarrhea [6]. Therefore, while scientific evidence supports the potential of magnesium as a treatment for diarrhea, healthcare providers should monitor patients closely for adverse effects, particularly when magnesium is used in conjunction with other medications or therapies.
Based on user reviews, experiences with magnesium supplements for diarrhea and related symptoms can vary considerably. Some users report significant improvements, particularly when switching from less effective forms of magnesium. For example, one user shared that after transitioning to this magnesium product, their long-standing diarrhea issues ceased completely, expressing high satisfaction Read Review. Additionally, another user highlighted the bioavailability of chelated magnesium, specifically glycinate, noting that it didn’t cause diarrhea and helped them feel more relaxed and calm Read Review.
Conversely, there are reports of adverse effects such as diarrhea, stomach cramps, and discomfort among some users. For instance, one user warned against taking this magnesium as it led to diarrhea and was poorly absorbed Read Review, while another experienced severe side effects including cramps and nausea Read Review. Overall, user experiences indicate that while many find relief and improved symptoms with certain magnesium formulations, others may endure unpleasant side effects. Thus, individual results can vary significantly, underscoring the importance of finding the right type for one’s specific needs.
Based on user reviews, experiences with combining this magnesium supplement with other supplements for managing diarrhea appear mixed. Several users reported severe side effects, including diarrhea, when using certain forms of magnesium. One user specifically advised against a poorly absorbed form of magnesium that exacerbated their diarrhea symptoms Read Review. Another review mentioned that while the supplement did not work for them, it had positive effects for a family member, highlighting the variability in individual responses Read Review.
Conversely, some users experienced considerable relief from their diarrhea symptoms when switching to a more bioavailable form of magnesium, specifically glycinate, which is well-tolerated by sensitive stomachs Read Review. Another user praised a particular magnesium product they transitioned to, stating that it completely alleviated their previous diarrhea issues Read Review. These reviews suggest that while certain magnesium supplements can effectively address diarrhea, others may induce adverse reactions, thus emphasizing the importance of choosing the right type for individual needs.
According to recent research, magnesium may play a beneficial role in managing diarrhea, particularly in cases of cholera and related gastrointestinal issues. Studies showed that magnesium supplementation could significantly inhibit chloride secretion in intestinal cells, which is particularly effective during episodes of secretory diarrhea. In a controlled environment mimicking cholera, magnesium reduced fluid loss by about 40%, providing a promising avenue for future treatments [1].
While there isn't a definitive "optimal" dose stated across all studies, it is noteworthy that even at increased supplementation levels—up to 1200 mg per day—participants did not report significant gastrointestinal issues such as diarrhea [3]. Moreover, in specific patient scenarios involving genetic predispositions, addressing magnesium deficiency has provided relief from diarrhea symptoms, suggesting that individual conditions might influence the required dosage [2]. As with any supplementation, it's crucial to consult a healthcare professional to tailor the dosage to individual needs and ensure safety.
10
Effective solution
Simply excellent! I switched to this product after every magnesium I took caused diarrhoea. Since starting this one, my issues have stopped completely. Kudos to Solgar!
0
Do not use
11 people found this helpful
Diarrhea appeared during use. I advise against taking this form of magnesium; it is not absorbed well at all! I experienced diarrhoea during its use.
9
Highly absorbable
The most bioavailable magnesium is chelated. Glycinate, suitable for sensitive stomachs, does not cause diarrhoea like cheaper forms. I take magnesium regularly, as it helps relax and calm me down.
2
Severe stomach issues
It's good, but it has side effects. It didn't work for me, but it did for my sister. I always take magnesium before bedtime, which helps relax my muscles and strengthens my joints. However, after trying this form of magnesium, I experienced severe stomach cramps, diarrhea, and a desire to vomit.
9.5
Magnesium shows potential for diarrhea
Mg2+ supplementation treats secretory diarrhea in mice by activating calcium-sensing receptor in intestinal epithelial cells.
We explored the impact of magnesium on secretory diarrhea, particularly in the context of cholera, a significant global health issue. The focus was on understanding how magnesium, often overlooked, could serve as an effective treatment option. In our study, we found that increasing levels of magnesium can significantly inhibit chloride secretion in intestinal cells, which is crucial during episodes of diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
8
Magnesium improves diarrhea symptoms
Hepatocyte nuclear factor 1B deletion, but not intragenic mutation, might be more susceptible to hypomagnesemia.
We investigated the relationship between magnesium treatment and diarrhea in patients with HNF1B syndrome, where we found that hypomagnesemia is quite common.
A notable case involved a patient with a de novo heterozygous deletion of the HNF1B gene, who suffered from severe diarrhea due to low magnesium levels. After receiving magnesium supplementation, the patient's diarrhea symptoms improved significantly.
Our findings indicate that those with HNF1B deletion are more likely to experience low magnesium levels compared to individuals with intragenic mutations. In fact, among a large group of patients with HNF1B syndrome, over half experienced hypomagnesemia.
This suggests a strong connection between magnesium deficiency and the gastrointestinal issues seen in this condition. It highlights the importance of monitoring magnesium levels in patients, as addressing this deficiency can lead to meaningful relief from diarrhea symptoms.
We investigated the effects of naldemedine, a medication often used to treat opioid-induced constipation, in combination with magnesium oxide (MgO) and other laxatives during hospital stays. Our study focused on how these treatments affected daily bowel movements and the occurrence of diarrhea.
Analysis of 93 inpatients who received at least four doses of naldemedine revealed that the addition of magnesium or other laxatives significantly increased the average daily defecation counts when compared to naldemedine alone.
However, we also noted that the combination treatments were associated with higher rates of diarrhea. This suggests that while magnesium might enhance bowel movement frequency, it could also lead to more diarrhea, which is an important consideration for treatment.
Therefore, we concluded that introducing naldemedine either alone or with magnesium could be beneficial, but healthcare providers should carefully monitor for signs of diarrhea and adjust treatments as needed.
4
Magnesium and diarrhea analysis
Perspective: Call for Re-evaluation of the Tolerable Upper Intake Level for Magnesium Supplementation in Adults.
We explored how magnesium supplementation affects diarrhea, particularly in adults. In recent research, we carefully reviewed data from intervention studies conducted between 1997 and 2022, focusing mainly on single-ingredient magnesium products. Our goal was to determine whether higher doses of magnesium cause significant gastrointestinal issues, especially diarrhea, which had previously shaped the established upper intake limit.
The findings were enlightening. Out of ten studies we analyzed, including five meta-analyses and five randomized controlled trials, seven indicated no significant difference in diarrhea incidents between those receiving magnesium and those given a placebo. It was interesting to note that even at doses as high as 1200 mg per day, participants generally did not report diarrhea.
When reviewing adverse event data reported to the FDA, we found just 40 cases of gastrointestinal issues linked to magnesium supplementation. Quite tellingly, only one-third of these involved complaints about diarrhea. This suggests that the concern regarding magnesium causing significant gastrointestinal problems may be overstated.
Overall, our evaluation indicates that adults can often consume magnesium supplements above the current upper intake level without significant adverse effects related to diarrhea. This opens up opportunities for increasing magnesium intake, which could help address inadequacies in this essential nutrient for many individuals.
References
de Souza Goncalves L, Chu T, Master R, Chhetri PD, Gao Q, et al. Mg2+ supplementation treats secretory diarrhea in mice by activating calcium-sensing receptor in intestinal epithelial cells. J Clin Invest. 2024;134. 10.1172/JCI171249
Wang Y, Xiao X, Lin Q, Song R, Wang X, et al. Hepatocyte nuclear factor 1B deletion, but not intragenic mutation, might be more susceptible to hypomagnesemia. J Diabetes Investig. 2024;15:121. 10.1111/jdi.14084
Costello R, Rosanoff A, Nielsen F, West C. Perspective: Call for Re-evaluation of the Tolerable Upper Intake Level for Magnesium Supplementation in Adults. Adv Nutr. 2023;14:973. 10.1016/j.advnut.2023.06.008
Kamali F, Jamee M, Sayer JA, Sadeghi-Bojd S, Golchehre Z, et al. Intestinal hypomagnesemia in an Iranian patient with a novel TRPM6 variant: a case report and review of the literature. CEN Case Rep. 2023;12:413. 10.1007/s13730-023-00785-8
Cao S, Huang K, Wen X, Gao J, Cui B, et al. Dietary supplementation with potassium-magnesium sulfate modulates the antioxidant capacity, immunity, and gut microbiota in weaned piglets. Front Microbiol. 2022;13:961989. 10.3389/fmicb.2022.961989
Takemura M, Niki K, Miyaguchi S, Ueda M. Naldemedine-laxative combination: retrospective inpatient study. BMJ Support Palliat Care. 2024;13:e816. 10.1136/spcare-2022-003685
Sarkar KK, Mitra T, Rahman MA, Raja IM, Aktaruzzaman M, et al. Bioactivities of (Wall.) and Study against Cyclooxygenase Enzymes. Biomed Res Int. 2022;2022:1331758. 10.1155/2022/1331758
Li J, Yin L, Wang L, Li J, Huang P, et al. Effects of vitamin B6 on growth, diarrhea rate, intestinal morphology, function, and inflammatory factors expression in a high-protein diet fed to weaned piglets1. J Anim Sci. 2019;97:4865. 10.1093/jas/skz338
Miki T, Goto R, Fujimoto M, Okada N, Hardt WD. The Bactericidal Lectin RegIIIβ Prolongs Gut Colonization and Enteropathy in the Streptomycin Mouse Model for Salmonella Diarrhea. Cell Host Microbe. 2017;21:195. 10.1016/j.chom.2016.12.008