Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.4
USERS' SCORE
Moderately Good
Based on 45 Reviews
7.1
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%
Magnesium (as magnesium oxide)
400 mg
95%
Top Medical Research Studies
9
Magnesium aids migraine management
We explored the impact of magnesium on migraine headaches, focusing on its potential benefits based on various studies. Magnesium deficiency is quite common and can arise from different factors, such as not consuming enough through diet or losing more through bodily systems.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
Read More
8
We examined how various tocolytic drugs delay preterm birth, analyzing data from 122 trials involving nearly 13,700 women.
Our findings suggest that all classes of tocolytics, including magnesium sulfate, are likely effective for delaying birth up to 7 days compared to no treatment.
While these treatments showed promise, they also carried risks of side effects, such as nausea and headaches, particularly with betamimetics and calcium channel blockers. We found no definitive conclusions on their impact on neonatal outcomes, leaving room for further research.
Our findings suggest that all classes of tocolytics, including magnesium sulfate, are likely effective for delaying birth up to 7 days compared to no treatment.
While these treatments showed promise, they also carried risks of side effects, such as nausea and headaches, particularly with betamimetics and calcium channel blockers. We found no definitive conclusions on their impact on neonatal outcomes, leaving room for further research.
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8
We explored how vitamin B6, along with other B vitamins like folate and B12, might help in preventing migraines. Through a thorough review of existing research, we discovered that while vitamin B6 showed some promise in reducing migraines with aura in adults, the results aren’t as clear-cut for individuals suffering from other forms of headaches. In fact, in the context of treating acute migraine attacks, the benefits of these vitamins have not been supported by strong evidence from studies.
We found several trials that looked specifically at vitamin B6 for migraine prevention. The results were generally positive, especially for those experiencing migraines with aura, where vitamin B6 exhibited significant benefits against placebo in multiple studies. However, when it comes to folate, using it alone didn’t show improved outcomes compared to placebo. Limited data on children and those suffering from migraines without aura prevented us from making definitive conclusions about vitamin B6’s effectiveness across different demographics.
Overall, there’s a potential positive effect of vitamin B6 in managing migraines, particularly in adults with aura. While the safety profile appears favorable, we advocate for more high-quality research to clarify its role in treating various types of migraines.
We found several trials that looked specifically at vitamin B6 for migraine prevention. The results were generally positive, especially for those experiencing migraines with aura, where vitamin B6 exhibited significant benefits against placebo in multiple studies. However, when it comes to folate, using it alone didn’t show improved outcomes compared to placebo. Limited data on children and those suffering from migraines without aura prevented us from making definitive conclusions about vitamin B6’s effectiveness across different demographics.
Overall, there’s a potential positive effect of vitamin B6 in managing migraines, particularly in adults with aura. While the safety profile appears favorable, we advocate for more high-quality research to clarify its role in treating various types of migraines.
Read More
Most Useful Reviews
9
Reduced headache symptoms
15 people found this helpful
I purchased this to alleviate PMS symptoms, and it has genuinely helped. I no longer experience headaches related to PMS, and my symptoms have diminished. I would recommend it if PMS affects you.
Read More
9
No more headaches
7 people found this helpful
I bought this for my daughter, as per our paediatrician's advice. After five days of taking two tablets daily, she reported no headaches. Her mood has improved, and she sleeps soundly. We’ll continue with this.
Read More
10
No headaches now
4 people found this helpful
I now take magnesium twice daily. I previously had migraines every week due to work stress, but I haven’t experienced one since starting this, which I’m very grateful for.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.4
- All Researches
9
Magnesium aids migraine management
We explored the impact of magnesium on migraine headaches, focusing on its potential benefits based on various studies. Magnesium deficiency is quite common and can arise from different factors, such as not consuming enough through diet or losing more through bodily systems.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
Read More
9
We examined the effects of magnesium treatment on individuals suffering from episodic migraine and tension-type headache, aiming to understand its potential benefits alongside other therapeutic approaches. The study involved 104 participants, who were assessed for anxiety, depression, insomnia, and fatigue before and after receiving various treatments, including magnesium.
Our findings indicated that a significant portion of patients reported anxiety and depression, affecting their headache severity. After treatment, we noticed a marked decrease in headache intensity, along with improvements in anxiety and depressive symptoms. However, the specific impact of magnesium alone couldn’t be isolated in this study, as we looked at it alongside other medications like anxiolytics and antidepressants.
Overall, while magnesium was part of the treatment plan and showed potential benefits, we must acknowledge that its individual effectiveness cannot be clearly determined from our research. It appears to contribute to an overall improvement in managing headaches when combined with other treatments.
Our findings indicated that a significant portion of patients reported anxiety and depression, affecting their headache severity. After treatment, we noticed a marked decrease in headache intensity, along with improvements in anxiety and depressive symptoms. However, the specific impact of magnesium alone couldn’t be isolated in this study, as we looked at it alongside other medications like anxiolytics and antidepressants.
Overall, while magnesium was part of the treatment plan and showed potential benefits, we must acknowledge that its individual effectiveness cannot be clearly determined from our research. It appears to contribute to an overall improvement in managing headaches when combined with other treatments.
Read More
9
We explored a case involving a 36-year-old woman with endometriosis suffering from frequent headaches and debilitating pain. While traditional medications didn't work for her, she started a new treatment plan that included acupuncture and supplements like magnesium and turmeric.
After this multimodal approach, her headache frequency decreased significantly, along with improvements in her lumbopelvic pain, sleep quality, and overall focus. This case indicates that integrating various alternative therapies can provide significant relief for those with challenging symptoms.
After this multimodal approach, her headache frequency decreased significantly, along with improvements in her lumbopelvic pain, sleep quality, and overall focus. This case indicates that integrating various alternative therapies can provide significant relief for those with challenging symptoms.
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9
We explored the effects of vitamin B6 treatment in a unique case involving a 25-year-old man who experienced headaches and memory issues due to a specific genetic condition. This condition caused a build-up of branched-chain amino acids (BCAAs) like valine and leucine in the bloodstream, leading to neurological symptoms.
The patient had notable brain MRI findings, and metabolic tests revealed significantly high plasma levels of BCAAs. Interestingly, standard tests for a related disorder, maple syrup urine disease, came back normal, helping guide the investigation. Upon discovering mutations in the BCAT2 gene, which heavily influences BCAA metabolism, we were curious about the role of vitamin B6 in this scenario.
After the patient began taking vitamin B6, we observed impressive reductions in his BCAA levels, especially valine, and improvements in the brain MRI lesions. Although the initial focus was on his headaches, it's important to note that the study didn’t isolate the specific effects of vitamin B6 on headaches alone. Instead, the broader context of metabolic improvement is significant.
Ultimately, our findings highlight a new and rare amino acid metabolism disorder linked to genetic mutations. They also suggest that vitamin B6 supplementation may lead to beneficial outcomes in managing BCAA-related conditions, even if direct links to headache relief weren’t the sole focus of this particular case.
The patient had notable brain MRI findings, and metabolic tests revealed significantly high plasma levels of BCAAs. Interestingly, standard tests for a related disorder, maple syrup urine disease, came back normal, helping guide the investigation. Upon discovering mutations in the BCAT2 gene, which heavily influences BCAA metabolism, we were curious about the role of vitamin B6 in this scenario.
After the patient began taking vitamin B6, we observed impressive reductions in his BCAA levels, especially valine, and improvements in the brain MRI lesions. Although the initial focus was on his headaches, it's important to note that the study didn’t isolate the specific effects of vitamin B6 on headaches alone. Instead, the broader context of metabolic improvement is significant.
Ultimately, our findings highlight a new and rare amino acid metabolism disorder linked to genetic mutations. They also suggest that vitamin B6 supplementation may lead to beneficial outcomes in managing BCAA-related conditions, even if direct links to headache relief weren’t the sole focus of this particular case.
Read More
8
We conducted a study assessing how nonprescription therapies, particularly a combination product containing magnesium, affect symptoms of vestibular migraine (VM). Our research involved collecting data from patients diagnosed with VM who were given guidance on lifestyle changes, like hydration and nutrition, alongside the supplement.
After three months of treatment, we observed promising results. The severity and frequency of headache-related symptoms showed significant improvement based on assessments using established scales. For instance, participants reported a reduction in dizziness and headache intensity, with many noting a better quality of life.
Notably, half of the patients observed an enhancement in their symptoms, while most tolerated the supplement without any issues. These findings suggest that magnesium, when combined with other nutrients, could contribute positively to managing VM headaches.
Overall, our study offers preliminary support for magnesium's potential role in treating VM, particularly through a holistic approach that includes lifestyle modifications.
After three months of treatment, we observed promising results. The severity and frequency of headache-related symptoms showed significant improvement based on assessments using established scales. For instance, participants reported a reduction in dizziness and headache intensity, with many noting a better quality of life.
Notably, half of the patients observed an enhancement in their symptoms, while most tolerated the supplement without any issues. These findings suggest that magnesium, when combined with other nutrients, could contribute positively to managing VM headaches.
Overall, our study offers preliminary support for magnesium's potential role in treating VM, particularly through a holistic approach that includes lifestyle modifications.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 45 Reviews
7.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced headache symptoms
15 people found this helpful
I purchased this to alleviate PMS symptoms, and it has genuinely helped. I no longer experience headaches related to PMS, and my symptoms have diminished. I would recommend it if PMS affects you.
Read More
9
No more headaches
7 people found this helpful
I bought this for my daughter, as per our paediatrician's advice. After five days of taking two tablets daily, she reported no headaches. Her mood has improved, and she sleeps soundly. We’ll continue with this.
Read More
10
No headaches now
4 people found this helpful
I now take magnesium twice daily. I previously had migraines every week due to work stress, but I haven’t experienced one since starting this, which I’m very grateful for.
Read More
9
Migraines are gone
4 people found this helpful
After a week of taking this, I noticed a positive change. My work is stressful, causing frequent headaches, but this product has improved my sleep and reduced headaches significantly.
Read More
9
Migraine relief achieved
3 people found this helpful
I experienced severe migraine headaches, especially pre-menstruation, but after taking this magnesium, those headaches have nearly disappeared.
Read More
Frequently Asked Questions
9
No more headaches
7 people found this helpful
I bought this for my daughter, as per our paediatrician's advice. After five days of taking two tablets daily, she reported no headaches. Her mood has improved, and she sleeps soundly. We’ll continue with this.
7.5
Improved sleep quality
2 people found this helpful
I felt the effect after the first dose! I take three tablets at night. I woke up relaxed, and my headaches decreased. The quantity—250 tablets at a favourable price—pleased me. I plan to take a course for one month, then have a break. I ordered Biotin (B7) to strengthen my nails and prevent hair loss, but I haven't seen results yet.
7.5
Reduced headache pain
3 people found this helpful
I suffered from chronic muscle pain and migraines, but after a month of using this product, my headaches have improved greatly, and the mysterious pain is almost gone.
9
Reduced headache symptoms
15 people found this helpful
I purchased this to alleviate PMS symptoms, and it has genuinely helped. I no longer experience headaches related to PMS, and my symptoms have diminished. I would recommend it if PMS affects you.
10
No headaches now
4 people found this helpful
I now take magnesium twice daily. I previously had migraines every week due to work stress, but I haven’t experienced one since starting this, which I’m very grateful for.
9
Headache elimination
1 people found this helpful
After taking magnesium for a month, my blood pressure normalised, my headaches disappeared, and I found it easier to wake up. My overall productivity increased. Recommend!
0
Caused headaches
2 people found this helpful
This magnesium didn't agree with me and triggered headaches instead. I had high hopes, but I believe a different, more absorbable form would be better. It feels like money wasted.
7.5
Helps with pain
2 people found this helpful
Magnesium combined with B6 helps with menstrual pain, and I noticed relief from headaches, but I advise careful dosage to avoid side effects.
7.5
Less fatigue experienced
2 people found this helpful
I've been taking Solgar Magnesium with Vitamin B6 for months, and it has improved my health. I used to suffer from headaches and fatigue, but I feel calmer and more energetic since starting this supplement. It's a quality product, and I recommend it for anyone wanting to boost magnesium levels.
0
No noticeable effect
3 people found this helpful
I ordered this for my son due to the small dosage and pill size, taking it alongside Magnesium + B6 as advised by our neurologist. I saw no change in behaviour. I even tried it myself but experienced no benefits. My earlier experience with chelated magnesium showed me what real effects should feel like, like improved sleep and headache relief.
0
Preferred alternatives
I have tried various forms of magnesium, but this is my least favourite. Unlike magnesium glycinate, which alleviated my headache quickly, this version from Solgar did not provide the same relief, despite some calming effects. Other brands work better for me.
0
Severe headache
After three days of use, I experienced a severe and persistent headache, so I stopped using it. The magnesium quantity is good, and the packaging protects from light, but ultimately, I had to discontinue it. There is no taste.
0
Headache after use
This magnesium didn’t suit me; it caused headaches. Perhaps I chose the wrong form.
9
Magnesium aids migraine management
We explored the impact of magnesium on migraine headaches, focusing on its potential benefits based on various studies. Magnesium deficiency is quite common and can arise from different factors, such as not consuming enough through diet or losing more through bodily systems.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
7
We explored the impact of magnesium treatment on headaches, focusing specifically on its role in preventing migraines. The evidence suggests that magnesium may be beneficial for some individuals in managing headache frequency and intensity. It is often recommended not only for migraine prevention but also for acute treatment when given intravenously.
Importantly, we noted that magnesium tends to have a good safety profile, with any adverse effects typically being mild and related to gastrointestinal tolerance. This makes it a potentially attractive option for those seeking relief from headaches. However, it's crucial to approach magnesium use with careful consideration, recognizing that responses can vary from person to person.
Overall, our examination highlights magnesium as a valuable tool in the headache management arsenal, although it should be part of a more comprehensive treatment strategy. Knowing its benefits allows us to better inform those struggling with headache disorders.
Importantly, we noted that magnesium tends to have a good safety profile, with any adverse effects typically being mild and related to gastrointestinal tolerance. This makes it a potentially attractive option for those seeking relief from headaches. However, it's crucial to approach magnesium use with careful consideration, recognizing that responses can vary from person to person.
Overall, our examination highlights magnesium as a valuable tool in the headache management arsenal, although it should be part of a more comprehensive treatment strategy. Knowing its benefits allows us to better inform those struggling with headache disorders.
8
We conducted a study assessing how nonprescription therapies, particularly a combination product containing magnesium, affect symptoms of vestibular migraine (VM). Our research involved collecting data from patients diagnosed with VM who were given guidance on lifestyle changes, like hydration and nutrition, alongside the supplement.
After three months of treatment, we observed promising results. The severity and frequency of headache-related symptoms showed significant improvement based on assessments using established scales. For instance, participants reported a reduction in dizziness and headache intensity, with many noting a better quality of life.
Notably, half of the patients observed an enhancement in their symptoms, while most tolerated the supplement without any issues. These findings suggest that magnesium, when combined with other nutrients, could contribute positively to managing VM headaches.
Overall, our study offers preliminary support for magnesium's potential role in treating VM, particularly through a holistic approach that includes lifestyle modifications.
After three months of treatment, we observed promising results. The severity and frequency of headache-related symptoms showed significant improvement based on assessments using established scales. For instance, participants reported a reduction in dizziness and headache intensity, with many noting a better quality of life.
Notably, half of the patients observed an enhancement in their symptoms, while most tolerated the supplement without any issues. These findings suggest that magnesium, when combined with other nutrients, could contribute positively to managing VM headaches.
Overall, our study offers preliminary support for magnesium's potential role in treating VM, particularly through a holistic approach that includes lifestyle modifications.
9
We examined the effects of magnesium treatment on individuals suffering from episodic migraine and tension-type headache, aiming to understand its potential benefits alongside other therapeutic approaches. The study involved 104 participants, who were assessed for anxiety, depression, insomnia, and fatigue before and after receiving various treatments, including magnesium.
Our findings indicated that a significant portion of patients reported anxiety and depression, affecting their headache severity. After treatment, we noticed a marked decrease in headache intensity, along with improvements in anxiety and depressive symptoms. However, the specific impact of magnesium alone couldn’t be isolated in this study, as we looked at it alongside other medications like anxiolytics and antidepressants.
Overall, while magnesium was part of the treatment plan and showed potential benefits, we must acknowledge that its individual effectiveness cannot be clearly determined from our research. It appears to contribute to an overall improvement in managing headaches when combined with other treatments.
Our findings indicated that a significant portion of patients reported anxiety and depression, affecting their headache severity. After treatment, we noticed a marked decrease in headache intensity, along with improvements in anxiety and depressive symptoms. However, the specific impact of magnesium alone couldn’t be isolated in this study, as we looked at it alongside other medications like anxiolytics and antidepressants.
Overall, while magnesium was part of the treatment plan and showed potential benefits, we must acknowledge that its individual effectiveness cannot be clearly determined from our research. It appears to contribute to an overall improvement in managing headaches when combined with other treatments.
7
The effectiveness of magnesium in treating headaches has garnered attention, particularly when we consider its potential role as a dietary supplement for both children and adults. In examining its impact, studies have indeed explored how magnesium may help alleviate headache symptoms.
Our review highlighted research findings that suggest magnesium may not only reduce headache frequency but also the intensity of pain experienced during episodes. Interestingly, some studies specifically noted that certain dietary supplements, including magnesium, could yield positive outcomes for individuals suffering from headaches.
It’s important to note, however, that while there are promising indications, the evaluation of magnesium's effectiveness often comes paired with other treatments. This raises questions about its isolated impact. Therefore, while there’s evidence pointing to magnesium's benefits, its exact role, particularly when not combined with other therapies, remains to be clarified.
Our review highlighted research findings that suggest magnesium may not only reduce headache frequency but also the intensity of pain experienced during episodes. Interestingly, some studies specifically noted that certain dietary supplements, including magnesium, could yield positive outcomes for individuals suffering from headaches.
It’s important to note, however, that while there are promising indications, the evaluation of magnesium's effectiveness often comes paired with other treatments. This raises questions about its isolated impact. Therefore, while there’s evidence pointing to magnesium's benefits, its exact role, particularly when not combined with other therapies, remains to be clarified.
References
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- Tepper SJ, Tepper K. Nutraceuticals and Headache 2024: Riboflavin, Coenzyme Q10, Feverfew, Magnesium, Melatonin, and Butterbur. Curr Pain Headache Rep. 2025;29:33. 10.1007/s11916-025-01358-3
- Hannigan IP, Rosengren SM, Di Tanna GL, Watson SRD, Welgampola MS. Effects of nonprescription therapies on vestibular migraine: a questionnaire-based observational study. Intern Med J. 2024;54:916. 10.1111/imj.16314
- Mirzaeva LM, Lobzina AS, Akhmedova KN, Shvartsman GI, Kula II, et al. [Therapeutic approaches to comorbid pathology in episodic migraine and tension-type headache]. Zh Nevrol Psikhiatr Im S S Korsakova. 2023;123:52. 10.17116/jnevro202312309152
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- Frank M, Abouzari M, Djalilian HR. Meniere's disease is a manifestation of migraine. Curr Opin Otolaryngol Head Neck Surg. 2023;31:313. 10.1097/MOO.0000000000000908
- Verhaak A, Bakaysa S, Johnson A, Veronesi M, Williamson A, et al. Migraine treatment in pregnancy: A survey of comfort and treatment practices of women's healthcare providers. Headache. 2023;63:211. 10.1111/head.14436
- Mahajan R, Anand KS, Mahajan RK, Garg J, Juneja A. Serum Magnesium Levels During the Ictal and Interictal Phase in Patients of Migraine: A Prospective Observational Study. Neurol India. 2022;70:1852. 10.4103/0028-3886.359247
- Wilson A, Hodgetts-Morton VA, Marson EJ, Markland AD, Larkai E, et al. Tocolytics for delaying preterm birth: a network meta-analysis (0924). Cochrane Database Syst Rev. 2022;8:CD014978. 10.1002/14651858.CD014978.pub2
- Bhurat R, Premkumar S, Manokaran RK. Serum Magnesium Levels in Children With and Without Migraine: A Cross-Sectional Study. Indian Pediatr. 2022;59:623.
- Bharadwaj VN, Meyerowitz J, Zou B, Klukinov M, Yan N, et al. Impact of Magnesium on Oxytocin Receptor Function. Pharmaceutics. 2022;14. 10.3390/pharmaceutics14051105
- Martin BR. Multimodal Care for Headaches, Lumbopelvic Pain, and Dysmenorrhea in a Woman With Endometriosis: A Case Report. J Chiropr Med. 2021;20:148. 10.1016/j.jcm.2021.10.002
- Sureja VP, Kheni DB, Dubey VP, Kansagra J, Soni ZK, et al. Efficacy and Tolerability Evaluation of a Nutraceutical Composition Containing Vitex agnus-castus Extract (EVX40™), Pyridoxine, and Magnesium in Premenstrual Syndrome: A Real-World, Interventional, Comparative Study. Cureus. 2023;15:e42832. 10.7759/cureus.42832
- Liampas IN, Siokas V, Aloizou AM, Tsouris Z, Dastamani M, et al. Pyridoxine, folate and cobalamin for migraine: A systematic review. Acta Neurol Scand. 2020;142:108. 10.1111/ane.13251
- Bravaccio C, Terrone G, Rizzo R, Gulisano M, Tosi M, et al. Use of nutritional supplements based on melatonin, tryptophan and vitamin B6 (Melamil Tripto®) in children with primary chronic headache, with or without sleep disorders: a pilot study. Minerva Pediatr. 2020;72:30. 10.23736/S0026-4946.19.05533-6
- Askari G, Nasiri M, Mozaffari-Khosravi H, Rezaie M, Bagheri-Bidakhavidi M, et al. The effects of folic acid and pyridoxine supplementation on characteristics of migraine attacks in migraine patients with aura: A double-blind, randomized placebo-controlled, clinical trial. Nutrition. 2017;38:74. 10.1016/j.nut.2017.01.007
- Woods E, Dawson C, Senthil L, Geberhiwot T. Cerebral venous thrombosis as the first presentation of classical homocystinuria in an adult patient. BMJ Case Rep. 2017;2017. 10.1136/bcr-2016-217477
- Menon S, Nasir B, Avgan N, Ghassabian S, Oliver C, et al. The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients. J Headache Pain. 2016;17:60. 10.1186/s10194-016-0652-7
- Wang XL, Li CJ, Xing Y, Yang YH, Jia JP. Hypervalinemia and hyperleucine-isoleucinemia caused by mutations in the branched-chain-amino-acid aminotransferase gene. J Inherit Metab Dis. 2015;38:855. 10.1007/s10545-015-9814-z
- Menon S, Lea RA, Roy B, Hanna M, Wee S, et al. Genotypes of the MTHFR C677T and MTRR A66G genes act independently to reduce migraine disability in response to vitamin supplementation. Pharmacogenet Genomics. 2012;22:741. 10.1097/FPC.0b013e3283576b6b
- Lea R, Colson N, Quinlan S, Macmillan J, Griffiths L. The effects of vitamin supplementation and MTHFR (C677T) genotype on homocysteine-lowering and migraine disability. Pharmacogenet Genomics. 2009;19:422. 10.1097/FPC.0b013e32832af5a3
- Villegas-Salas E, Ponce de León R, Juárez-Perez MA, Grubb GS. Effect of vitamin B6 on the side effects of a low-dose combined oral contraceptive. Contraception. 1997;55:245.
- Jarisch R, Wantke F. Wine and headache. Int Arch Allergy Immunol. 1996;110:7.
- Bernstein AL. Vitamin B6 in clinical neurology. Ann N Y Acad Sci. 1990;585:250.
