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SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.6
USERS' SCORE
Moderately Good
Based on 45 Reviews
7.8
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%
Magnesium (as magnesium oxide)
400 mg
95%
Top Medical Research Studies
9
We explored the impact of magnesium on migraine headaches, focusing on its potential benefits based on various studies. Magnesium deficiency is quite common and can arise from different factors, such as not consuming enough through diet or losing more through bodily systems.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
Read More
8
Vitamin B6 may aid migraines
Pyridoxine, folate and cobalamin for migraine: A systematic review.
Assesses B6 effectiveness in headaches
We explored how vitamin B6, along with other B vitamins like folate and B12, might help in preventing migraines. Through a thorough review of existing research, we discovered that while vitamin B6 showed some promise in reducing migraines with aura in adults, the results aren’t as clear-cut for individuals suffering from other forms of headaches. In fact, in the context of treating acute migraine attacks, the benefits of these vitamins have not been supported by strong evidence from studies.
We found several trials that looked specifically at vitamin B6 for migraine prevention. The results were generally positive, especially for those experiencing migraines with aura, where vitamin B6 exhibited significant benefits against placebo in multiple studies. However, when it comes to folate, using it alone didn’t show improved outcomes compared to placebo. Limited data on children and those suffering from migraines without aura prevented us from making definitive conclusions about vitamin B6’s effectiveness across different demographics.
Overall, there’s a potential positive effect of vitamin B6 in managing migraines, particularly in adults with aura. While the safety profile appears favorable, we advocate for more high-quality research to clarify its role in treating various types of migraines.
We found several trials that looked specifically at vitamin B6 for migraine prevention. The results were generally positive, especially for those experiencing migraines with aura, where vitamin B6 exhibited significant benefits against placebo in multiple studies. However, when it comes to folate, using it alone didn’t show improved outcomes compared to placebo. Limited data on children and those suffering from migraines without aura prevented us from making definitive conclusions about vitamin B6’s effectiveness across different demographics.
Overall, there’s a potential positive effect of vitamin B6 in managing migraines, particularly in adults with aura. While the safety profile appears favorable, we advocate for more high-quality research to clarify its role in treating various types of migraines.
Read More
7
We explored the role of vitamin B6 in treating headaches associated with histamine intolerance. The research indicated that headaches in these patients might be linked to low levels of diamine oxidase, the enzyme responsible for breaking down histamine in the body. Given that vitamin B6 plays a vital role in the activity of this enzyme, its supplementation was considered as a potential supportive treatment.
While the study highlighted that a histamine-free diet is the primary solution for managing these headaches, vitamin B6 supplementation appeared to be beneficial as well. It is thought that by increasing the activity of diamine oxidase, vitamin B6 could help reduce headache frequency and intensity in individuals suffering from histamine intolerance. However, it's important to underscore that the study did not focus exclusively on vitamin B6 effects; thus, we remain cautious in drawing strong conclusions about its isolated efficacy.
Overall, the findings suggest that while vitamin B6 might be a useful addition to a treatment plan for chronic headaches linked to histamine intolerance, it should be complemented with dietary adjustments and consideration of other factors.
While the study highlighted that a histamine-free diet is the primary solution for managing these headaches, vitamin B6 supplementation appeared to be beneficial as well. It is thought that by increasing the activity of diamine oxidase, vitamin B6 could help reduce headache frequency and intensity in individuals suffering from histamine intolerance. However, it's important to underscore that the study did not focus exclusively on vitamin B6 effects; thus, we remain cautious in drawing strong conclusions about its isolated efficacy.
Overall, the findings suggest that while vitamin B6 might be a useful addition to a treatment plan for chronic headaches linked to histamine intolerance, it should be complemented with dietary adjustments and consideration of other factors.
Read More
Most Useful Reviews
9.5
Reduced headache symptoms
I purchased this to alleviate PMS symptoms, and it has genuinely helped. I no longer experience headaches related to PMS, and my symptoms have diminished. I would recommend it if PMS affects you.
Read More
9.5
No more headaches
I bought this for my daughter, as per our paediatrician's advice. After five days of taking two tablets daily, she reported no headaches. Her mood has improved, and she sleeps soundly. We’ll continue with this.
Read More
10
No headaches now
I now take magnesium twice daily. I previously had migraines every week due to work stress, but I haven’t experienced one since starting this, which I’m very grateful for.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.6
9
Genetic metabolic disorder insights
Hypervalinemia and hyperleucine-isoleucinemia caused by mutations in the branched-chain-amino-acid aminotransferase gene.
Indicates limited headache connection
We explored the effects of vitamin B6 treatment in a unique case involving a 25-year-old man who experienced headaches and memory issues due to a specific genetic condition. This condition caused a build-up of branched-chain amino acids (BCAAs) like valine and leucine in the bloodstream, leading to neurological symptoms.
The patient had notable brain MRI findings, and metabolic tests revealed significantly high plasma levels of BCAAs. Interestingly, standard tests for a related disorder, maple syrup urine disease, came back normal, helping guide the investigation. Upon discovering mutations in the BCAT2 gene, which heavily influences BCAA metabolism, we were curious about the role of vitamin B6 in this scenario.
After the patient began taking vitamin B6, we observed impressive reductions in his BCAA levels, especially valine, and improvements in the brain MRI lesions. Although the initial focus was on his headaches, it's important to note that the study didn’t isolate the specific effects of vitamin B6 on headaches alone. Instead, the broader context of metabolic improvement is significant.
Ultimately, our findings highlight a new and rare amino acid metabolism disorder linked to genetic mutations. They also suggest that vitamin B6 supplementation may lead to beneficial outcomes in managing BCAA-related conditions, even if direct links to headache relief weren’t the sole focus of this particular case.
The patient had notable brain MRI findings, and metabolic tests revealed significantly high plasma levels of BCAAs. Interestingly, standard tests for a related disorder, maple syrup urine disease, came back normal, helping guide the investigation. Upon discovering mutations in the BCAT2 gene, which heavily influences BCAA metabolism, we were curious about the role of vitamin B6 in this scenario.
After the patient began taking vitamin B6, we observed impressive reductions in his BCAA levels, especially valine, and improvements in the brain MRI lesions. Although the initial focus was on his headaches, it's important to note that the study didn’t isolate the specific effects of vitamin B6 on headaches alone. Instead, the broader context of metabolic improvement is significant.
Ultimately, our findings highlight a new and rare amino acid metabolism disorder linked to genetic mutations. They also suggest that vitamin B6 supplementation may lead to beneficial outcomes in managing BCAA-related conditions, even if direct links to headache relief weren’t the sole focus of this particular case.
Read More
9
We explored the impact of magnesium on migraine headaches, focusing on its potential benefits based on various studies. Magnesium deficiency is quite common and can arise from different factors, such as not consuming enough through diet or losing more through bodily systems.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
A wealth of research, including case reports and controlled trials, suggests that magnesium supplementation can effectively alleviate migraines, both in the short term and long term. The proposed reasons for this effectiveness range from magnesium's role in preventing spreading cortical depression to its ability to manage oxidative stress and inflammation.
This evidence leads us to consider magnesium not just as a dietary supplement but as an important player in migraine management. Understanding these links helps us contemplate magnesium’s role in prevention and treatment, promising a potential path for those who suffer from this debilitating condition.
Read More
9
Magnesium's role in headache treatment
[Therapeutic approaches to comorbid pathology in episodic migraine and tension-type headache].
Combined treatment limits magnesium's isolation
We examined the effects of magnesium treatment on individuals suffering from episodic migraine and tension-type headache, aiming to understand its potential benefits alongside other therapeutic approaches. The study involved 104 participants, who were assessed for anxiety, depression, insomnia, and fatigue before and after receiving various treatments, including magnesium.
Our findings indicated that a significant portion of patients reported anxiety and depression, affecting their headache severity. After treatment, we noticed a marked decrease in headache intensity, along with improvements in anxiety and depressive symptoms. However, the specific impact of magnesium alone couldn’t be isolated in this study, as we looked at it alongside other medications like anxiolytics and antidepressants.
Overall, while magnesium was part of the treatment plan and showed potential benefits, we must acknowledge that its individual effectiveness cannot be clearly determined from our research. It appears to contribute to an overall improvement in managing headaches when combined with other treatments.
Our findings indicated that a significant portion of patients reported anxiety and depression, affecting their headache severity. After treatment, we noticed a marked decrease in headache intensity, along with improvements in anxiety and depressive symptoms. However, the specific impact of magnesium alone couldn’t be isolated in this study, as we looked at it alongside other medications like anxiolytics and antidepressants.
Overall, while magnesium was part of the treatment plan and showed potential benefits, we must acknowledge that its individual effectiveness cannot be clearly determined from our research. It appears to contribute to an overall improvement in managing headaches when combined with other treatments.
Read More
8
Vitamin B6's effect on headaches
Efficacy and Tolerability Evaluation of a Nutraceutical Composition Containing Vitex agnus-castus Extract (EVX40™), Pyridoxine, and Magnesium in Premenstrual Syndrome: A Real-World, Interventional, Comparative Study.
Some relevance, unclear outcomes
We evaluated the effectiveness of vitamin B6 in alleviating headaches associated with premenstrual syndrome (PMS). In a real-world study, participants were assigned to different treatment groups, with one group receiving a combination of Ezedayz tablets containing vitamin B6, along with other ingredients, while others received traditional therapies.
Throughout the three-month study, participants rated their headache severity, among other PMS symptoms. Though all groups reported some improvements, the data indicated that those taking Ezedayz tablets, either alone or with standard treatments, enjoyed a more significant reduction in headaches and other PMS symptoms.
Notably, while the combined therapy appeared promising in enhancing overall quality of life, the specific impact of vitamin B6 on headaches couldn't be isolated due to the formulation's combination with other active ingredients. Overall, while we observed benefits, the direct effect of vitamin B6 alone remains unclear, emphasizing the need for further focused research.
Throughout the three-month study, participants rated their headache severity, among other PMS symptoms. Though all groups reported some improvements, the data indicated that those taking Ezedayz tablets, either alone or with standard treatments, enjoyed a more significant reduction in headaches and other PMS symptoms.
Notably, while the combined therapy appeared promising in enhancing overall quality of life, the specific impact of vitamin B6 on headaches couldn't be isolated due to the formulation's combination with other active ingredients. Overall, while we observed benefits, the direct effect of vitamin B6 alone remains unclear, emphasizing the need for further focused research.
Read More
8
Vitamin B6 may aid migraines
Pyridoxine, folate and cobalamin for migraine: A systematic review.
Assesses B6 effectiveness in headaches
We explored how vitamin B6, along with other B vitamins like folate and B12, might help in preventing migraines. Through a thorough review of existing research, we discovered that while vitamin B6 showed some promise in reducing migraines with aura in adults, the results aren’t as clear-cut for individuals suffering from other forms of headaches. In fact, in the context of treating acute migraine attacks, the benefits of these vitamins have not been supported by strong evidence from studies.
We found several trials that looked specifically at vitamin B6 for migraine prevention. The results were generally positive, especially for those experiencing migraines with aura, where vitamin B6 exhibited significant benefits against placebo in multiple studies. However, when it comes to folate, using it alone didn’t show improved outcomes compared to placebo. Limited data on children and those suffering from migraines without aura prevented us from making definitive conclusions about vitamin B6’s effectiveness across different demographics.
Overall, there’s a potential positive effect of vitamin B6 in managing migraines, particularly in adults with aura. While the safety profile appears favorable, we advocate for more high-quality research to clarify its role in treating various types of migraines.
We found several trials that looked specifically at vitamin B6 for migraine prevention. The results were generally positive, especially for those experiencing migraines with aura, where vitamin B6 exhibited significant benefits against placebo in multiple studies. However, when it comes to folate, using it alone didn’t show improved outcomes compared to placebo. Limited data on children and those suffering from migraines without aura prevented us from making definitive conclusions about vitamin B6’s effectiveness across different demographics.
Overall, there’s a potential positive effect of vitamin B6 in managing migraines, particularly in adults with aura. While the safety profile appears favorable, we advocate for more high-quality research to clarify its role in treating various types of migraines.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 45 Reviews
7.8
10
No headaches now
I now take magnesium twice daily. I previously had migraines every week due to work stress, but I haven’t experienced one since starting this, which I’m very grateful for.
9.5
Reduced headache symptoms
I purchased this to alleviate PMS symptoms, and it has genuinely helped. I no longer experience headaches related to PMS, and my symptoms have diminished. I would recommend it if PMS affects you.
9.5
No more headaches
I bought this for my daughter, as per our paediatrician's advice. After five days of taking two tablets daily, she reported no headaches. Her mood has improved, and she sleeps soundly. We’ll continue with this.
9.5
Migraines are gone
After a week of taking this, I noticed a positive change. My work is stressful, causing frequent headaches, but this product has improved my sleep and reduced headaches significantly.
9.5
Migraine relief achieved
I experienced severe migraine headaches, especially pre-menstruation, but after taking this magnesium, those headaches have nearly disappeared.
