Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
USERS' SCORE
Moderately Good
Based on 16 Reviews
7.6
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%
Magnesium (as magnesium oxide)
400 mg
95%
Top Medical Research Studies
9
We aimed to find out how magnesium chloride influences liver health and oxidative stress in rats on a high-fat diet.
In our study, groups of rats were fed either a normal diet, a high-fat diet, or a high-fat diet supplemented with magnesium chloride.
We found that those receiving magnesium showed lower levels of liver enzymes and oxidative stress markers compared to the high-fat diet group alone.
This suggests that magnesium chloride could help protect against the harmful effects of a high-fat diet, although its efficacy in humans needs further investigation.
In our study, groups of rats were fed either a normal diet, a high-fat diet, or a high-fat diet supplemented with magnesium chloride.
We found that those receiving magnesium showed lower levels of liver enzymes and oxidative stress markers compared to the high-fat diet group alone.
This suggests that magnesium chloride could help protect against the harmful effects of a high-fat diet, although its efficacy in humans needs further investigation.
Read More
9
We examined how deep sea water (DSW), rich in magnesium, influences high cholesterol and blood pressure. In our study, we tested three different dosages of DSW on spontaneous hypertensive rats over eight weeks.
The results were promising; both systolic and diastolic pressures decreased. Specifically, higher doses of DSW significantly lowered serum cholesterol levels and reduced fat accumulation in liver tissues, showing potential protective effects against heart disease.
Overall, our findings suggest that DSW could be a beneficial alternative for managing cholesterol and blood pressure.
The results were promising; both systolic and diastolic pressures decreased. Specifically, higher doses of DSW significantly lowered serum cholesterol levels and reduced fat accumulation in liver tissues, showing potential protective effects against heart disease.
Overall, our findings suggest that DSW could be a beneficial alternative for managing cholesterol and blood pressure.
Read More
9
We explored how drinking deep seawater (DSW), rich in magnesium, impacts cholesterol levels in people with high cholesterol. In a study involving 42 volunteers, participants consumed 1050 mL of DSW, magnesium-fortified water, or reverse osmosis water daily for six weeks. The results were promising: those who drank DSW experienced a notable decrease in total cholesterol and low-density lipoprotein (LDL) cholesterol over time. Additionally, blood samples revealed that DSW also reduced markers of oxidative stress. This suggests that DSW may offer a valuable option for managing high cholesterol.
Read More
Most Useful Reviews
9
Restored health
2 people found this helpful
I am a big fan of this brand! I have noticed a marked improvement in my well-being after taking their vitamins. They have played a significant role in alleviating fatigue and anxiety, especially after having COVID. I appreciate the natural ingredients and the dark bottle in which they are stored, which adds to their quality. I highly recommend this product for the entire family, as it has helped restore sleep and overall health.
Read More
9
Enhanced well-being
2 people found this helpful
After taking Solgar Magnesium with Vitamin B6 for several months, I feel much more energetic and calm compared to before. I used to experience fatigue and muscle cramps, but those issues have dissipated since I began this supplement. I trust Solgar due to its high-quality natural ingredients and can confidently recommend it for anyone looking to boost magnesium levels for better health.
Read More
9
Migraine relief
1 people found this helpful
I highly recommend magnesium for migraine sufferers. Since I started taking it at night, I can't recall the last time I had a headache. This product has proven to be an excellent solution for my weather-related migraine issues. The relief it provides is remarkable.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
- All Researches
9
We aimed to find out how magnesium chloride influences liver health and oxidative stress in rats on a high-fat diet.
In our study, groups of rats were fed either a normal diet, a high-fat diet, or a high-fat diet supplemented with magnesium chloride.
We found that those receiving magnesium showed lower levels of liver enzymes and oxidative stress markers compared to the high-fat diet group alone.
This suggests that magnesium chloride could help protect against the harmful effects of a high-fat diet, although its efficacy in humans needs further investigation.
In our study, groups of rats were fed either a normal diet, a high-fat diet, or a high-fat diet supplemented with magnesium chloride.
We found that those receiving magnesium showed lower levels of liver enzymes and oxidative stress markers compared to the high-fat diet group alone.
This suggests that magnesium chloride could help protect against the harmful effects of a high-fat diet, although its efficacy in humans needs further investigation.
Read More
9
We examined how deep sea water (DSW), rich in magnesium, influences high cholesterol and blood pressure. In our study, we tested three different dosages of DSW on spontaneous hypertensive rats over eight weeks.
The results were promising; both systolic and diastolic pressures decreased. Specifically, higher doses of DSW significantly lowered serum cholesterol levels and reduced fat accumulation in liver tissues, showing potential protective effects against heart disease.
Overall, our findings suggest that DSW could be a beneficial alternative for managing cholesterol and blood pressure.
The results were promising; both systolic and diastolic pressures decreased. Specifically, higher doses of DSW significantly lowered serum cholesterol levels and reduced fat accumulation in liver tissues, showing potential protective effects against heart disease.
Overall, our findings suggest that DSW could be a beneficial alternative for managing cholesterol and blood pressure.
Read More
9
We explored how drinking deep seawater (DSW), rich in magnesium, impacts cholesterol levels in people with high cholesterol. In a study involving 42 volunteers, participants consumed 1050 mL of DSW, magnesium-fortified water, or reverse osmosis water daily for six weeks. The results were promising: those who drank DSW experienced a notable decrease in total cholesterol and low-density lipoprotein (LDL) cholesterol over time. Additionally, blood samples revealed that DSW also reduced markers of oxidative stress. This suggests that DSW may offer a valuable option for managing high cholesterol.
Read More
9
We explored the connection between Pyridoxal 5'-Phosphate (PLP), a form of Vitamin B6, and cholesterol levels by analyzing data from over 6,400 adults. Our primary focus was to understand how PLP affects low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C).
The results revealed some intriguing patterns. We found that as PLP levels increased, LDL-C levels tended to decrease significantly—by about 17.7% for every one-unit increase in PLP. In contrast, higher PLP levels were also associated with an increase in HDL-C, demonstrating a 1.95 times greater likelihood of achieving high HDL-C levels with rising PLP concentrations.
Notably, these effects were more pronounced in particular groups, such as diabetic patients and those who don't consume alcohol. However, while the study suggests potential benefits of PLP supplementation, it's important to remember that it didn't isolate PLP's effects from other influencing factors, so we can't claim that these outcomes are exclusively due to Vitamin B6.
Overall, our findings may highlight a new avenue for nutritional approaches to managing cholesterol and preventing cardiovascular issues, but additional research is needed to fully understand the implications.
The results revealed some intriguing patterns. We found that as PLP levels increased, LDL-C levels tended to decrease significantly—by about 17.7% for every one-unit increase in PLP. In contrast, higher PLP levels were also associated with an increase in HDL-C, demonstrating a 1.95 times greater likelihood of achieving high HDL-C levels with rising PLP concentrations.
Notably, these effects were more pronounced in particular groups, such as diabetic patients and those who don't consume alcohol. However, while the study suggests potential benefits of PLP supplementation, it's important to remember that it didn't isolate PLP's effects from other influencing factors, so we can't claim that these outcomes are exclusively due to Vitamin B6.
Overall, our findings may highlight a new avenue for nutritional approaches to managing cholesterol and preventing cardiovascular issues, but additional research is needed to fully understand the implications.
Read More
9
Vitamin B6 reduces cholesterol levels
We aimed to understand how Vitamin B6 influences high cholesterol levels, particularly through its effects on lipid metabolism in rats induced by a high-fat diet. To set the stage for our exploration, we used male Sprague-Dawley rats and placed them on this fat-rich diet for two weeks to establish a hyperlipidemia model.
We then supplied two groups of rats with varying doses of Vitamin B6—2.00 mg/kg and 3.00 mg/kg daily over the next eight weeks. Our findings shed light on Vitamin B6's potential to lower harmful Low-Density Lipoprotein Cholesterol (LDL-C) and overall blood cholesterol levels.
What's more, we observed significant reductions in triglycerides, atherogenic indexes, and various lipid ratios, while beneficial High-Density Lipoprotein Cholesterol (HDL-C) levels were elevated. The supplementation helped reduce fat accumulation in the liver and restored more normal heart and body weight ratios, highlighting its possible protective role against fat-related conditions.
Overall, our study suggests that Vitamin B6 could play an essential role in combating dyslipidemia and promoting better liver health through various mechanisms. These findings provide promising insights into a nutritional approach to managing high cholesterol and emphasize the importance of diet in health management.
We then supplied two groups of rats with varying doses of Vitamin B6—2.00 mg/kg and 3.00 mg/kg daily over the next eight weeks. Our findings shed light on Vitamin B6's potential to lower harmful Low-Density Lipoprotein Cholesterol (LDL-C) and overall blood cholesterol levels.
What's more, we observed significant reductions in triglycerides, atherogenic indexes, and various lipid ratios, while beneficial High-Density Lipoprotein Cholesterol (HDL-C) levels were elevated. The supplementation helped reduce fat accumulation in the liver and restored more normal heart and body weight ratios, highlighting its possible protective role against fat-related conditions.
Overall, our study suggests that Vitamin B6 could play an essential role in combating dyslipidemia and promoting better liver health through various mechanisms. These findings provide promising insights into a nutritional approach to managing high cholesterol and emphasize the importance of diet in health management.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 16 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Restored health
2 people found this helpful
I am a big fan of this brand! I have noticed a marked improvement in my well-being after taking their vitamins. They have played a significant role in alleviating fatigue and anxiety, especially after having COVID. I appreciate the natural ingredients and the dark bottle in which they are stored, which adds to their quality. I highly recommend this product for the entire family, as it has helped restore sleep and overall health.
Read More
9
Enhanced well-being
2 people found this helpful
After taking Solgar Magnesium with Vitamin B6 for several months, I feel much more energetic and calm compared to before. I used to experience fatigue and muscle cramps, but those issues have dissipated since I began this supplement. I trust Solgar due to its high-quality natural ingredients and can confidently recommend it for anyone looking to boost magnesium levels for better health.
Read More
9
Migraine relief
1 people found this helpful
I highly recommend magnesium for migraine sufferers. Since I started taking it at night, I can't recall the last time I had a headache. This product has proven to be an excellent solution for my weather-related migraine issues. The relief it provides is remarkable.
Read More
9
Effectively normalised pressure
1 people found this helpful
The results were instantly visible. Several doses of magnesium lowered my husband’s pressure. Previously, he took magnesium + B6 from various brands costing around 400 UAH per month, but there was no improvement. At high pressure, taking between one to three tablets daily normalises it. I strongly endorse this magnesium; it truly works and pairs well with potassium.
Read More
7.5
Normalised blood pressure
276 people found this helpful
Magnesium B6 has helped my mother manage hypertension significantly. She follows a regimen prescribed by a neurologist involving one tablet of Magnesium B6 after meals and a vitamin B complex during the day for two months each spring and autumn. This has transformed her mood to a calmer, more youthful state while her blood pressure is more stable. Magnesium B6 not only aids in normalising blood pressure in early stages of the disease, but it also alleviates anxiety and insomnia, promoting overall well-being. Cardiologists suggest a daily intake of 400-600 mg for effective results.
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Frequently Asked Questions
7
Calmed irritability levels
2 people found this helpful
Previously, I used a Ukrainian-made magnesium B6 with no results, but these vitamins are excellent. After two weeks of taking them, I noticed a calming effect and felt less irritable. The ingredients are of high quality, the dosage is one tablet three times a day, and the economical packaging lasts a long time. The quality of the magnesium is top-notch.
7.5
Normalised blood pressure
276 people found this helpful
Magnesium B6 has helped my mother manage hypertension significantly. She follows a regimen prescribed by a neurologist involving one tablet of Magnesium B6 after meals and a vitamin B complex during the day for two months each spring and autumn. This has transformed her mood to a calmer, more youthful state while her blood pressure is more stable. Magnesium B6 not only aids in normalising blood pressure in early stages of the disease, but it also alleviates anxiety and insomnia, promoting overall well-being. Cardiologists suggest a daily intake of 400-600 mg for effective results.
0
Ineffective supplement
8 people found this helpful
I was very disappointed with this Magnesium B6 from Solgar. Despite expecting better absorption due to the combination with vitamin B6, I found it to be in the inferior oxide form. This resulted in little benefit for my high blood pressure, and the synthetic form of B6 felt inadequate. I regret the money spent on this product, and now I’m left with 250 tablets I can't use.
9
Restored health
2 people found this helpful
I am a big fan of this brand! I have noticed a marked improvement in my well-being after taking their vitamins. They have played a significant role in alleviating fatigue and anxiety, especially after having COVID. I appreciate the natural ingredients and the dark bottle in which they are stored, which adds to their quality. I highly recommend this product for the entire family, as it has helped restore sleep and overall health.
9
Enhanced well-being
2 people found this helpful
After taking Solgar Magnesium with Vitamin B6 for several months, I feel much more energetic and calm compared to before. I used to experience fatigue and muscle cramps, but those issues have dissipated since I began this supplement. I trust Solgar due to its high-quality natural ingredients and can confidently recommend it for anyone looking to boost magnesium levels for better health.
9
Migraine relief
1 people found this helpful
I highly recommend magnesium for migraine sufferers. Since I started taking it at night, I can't recall the last time I had a headache. This product has proven to be an excellent solution for my weather-related migraine issues. The relief it provides is remarkable.
2
Ineffective absorption noted
Magnesium in oxide form is poorly absorbed by the body. This supplement contains oxide magnesium, which is almost ineffective! I don't understand why a reputable manufacturer would produce such a formulation. For a daily dose of magnesium, you need to take three capsules, which is not very economical and also not effective.
9
Effectively normalised pressure
1 people found this helpful
The results were instantly visible. Several doses of magnesium lowered my husband’s pressure. Previously, he took magnesium + B6 from various brands costing around 400 UAH per month, but there was no improvement. At high pressure, taking between one to three tablets daily normalises it. I strongly endorse this magnesium; it truly works and pairs well with potassium.
4
Unsatisfactory magnesium form
16 people found this helpful
Solgar should produce magnesium citrate instead of the less effective oxide form. Its only advantage is being better than no magnesium at all. The cost is not justified, as there are cheaper alternatives available in better forms such as citrate or malate. Additionally, the B6 here is not the most usable form, which detracts from its potential benefits against high cholesterol. Overall, I find this product not value for money.
9
We explored how drinking deep seawater (DSW), rich in magnesium, impacts cholesterol levels in people with high cholesterol. In a study involving 42 volunteers, participants consumed 1050 mL of DSW, magnesium-fortified water, or reverse osmosis water daily for six weeks. The results were promising: those who drank DSW experienced a notable decrease in total cholesterol and low-density lipoprotein (LDL) cholesterol over time. Additionally, blood samples revealed that DSW also reduced markers of oxidative stress. This suggests that DSW may offer a valuable option for managing high cholesterol.
8
We examined how magnesium levels in urine relate to cardiovascular disease risk factors, focusing on cholesterol and other health measures. In a large, diverse group of 4,211 participants from 50 countries, we found that higher urinary magnesium was linked to lower body mass index, blood pressure, and total cholesterol.
Notably, people with the highest magnesium levels experienced significantly lower risks for obesity and hypertension compared to those with the lowest levels. These findings suggest that increasing magnesium intake may have meaningful benefits for heart health.
Notably, people with the highest magnesium levels experienced significantly lower risks for obesity and hypertension compared to those with the lowest levels. These findings suggest that increasing magnesium intake may have meaningful benefits for heart health.
7
We investigated how a new nutraceutical combination, RenaTris, could affect cholesterol levels in uremic rats. In our study, uremic rats experienced a rise in cholesterol levels due to their high-phosphate diet.
Interestingly, the addition of RenaTris—including magnesium and other ingredients—resulted in a notable reduction of cholesterol by 18.9%.
While the treatment didn’t improve other health markers related to kidney function, it suggests a beneficial effect on cholesterol management, especially for patients with chronic kidney disease.
Interestingly, the addition of RenaTris—including magnesium and other ingredients—resulted in a notable reduction of cholesterol by 18.9%.
While the treatment didn’t improve other health markers related to kidney function, it suggests a beneficial effect on cholesterol management, especially for patients with chronic kidney disease.
References
- Mohammed KA, Goji ADT, Tanko Y, Muhammed A, Salisu IA. Protective Effects of Magnesium Chloride on Liver Enzymes and Biomarkers of Oxidative Stress in high fat diet fed Rats. Niger J Physiol Sci. 2019;34:149.
- Lupo MG, Biancorosso N, Brilli E, Tarantino G, Adorni MP, et al. Cholesterol-Lowering Action of a Novel Nutraceutical Combination in Uremic Rats: Insights into the Molecular Mechanism in a Hepatoma Cell Line. Nutrients. 2020;12. 10.3390/nu12020436
- Yamori Y, Sagara M, Mizushima S, Liu L, Ikeda K, et al. An inverse association between magnesium in 24-h urine and cardiovascular risk factors in middle-aged subjects in 50 CARDIAC Study populations. Hypertens Res. 2015;38:219. 10.1038/hr.2014.158
- Sheu MJ, Chou PY, Lin WH, Pan CH, Chien YC, et al. Deep sea water modulates blood pressure and exhibits hypolipidemic effects via the AMPK-ACC pathway: an in vivo study. Mar Drugs. 2013;11:2183. 10.3390/md11062183
- Fu ZY, Yang FL, Hsu HW, Lu YF. Drinking deep seawater decreases serum total and low-density lipoprotein-cholesterol in hypercholesterolemic subjects. J Med Food. 2012;15:535. 10.1089/jmf.2011.2007
- Song Y, Ridker PM, Manson JE, Cook NR, Buring JE, et al. Magnesium intake, C-reactive protein, and the prevalence of metabolic syndrome in middle-aged and older U.S. women. Diabetes Care. 2005;28:1438.
- Tapola NS, Lyyra ML, Karvonen HM, Uusitupa MI, Sarkkinen ES. The effect of meat products enriched with plant sterols and minerals on serum lipids and blood pressure. Int J Food Sci Nutr. 2004;55:389.
- Cohen H, Sherer Y, Shaish A, Shoenfeld Y, Levkovitz H, et al. Atherogenesis inhibition induced by magnesium-chloride fortification of drinking water. Biol Trace Elem Res. 2002;90:251.
- Evans DA, Tariq M, Sujata B, McCann G, Sobki S. The effects of magnesium sulphate and EDTA in the hypercholesterolaemic rabbit. Diabetes Obes Metab. 2001;3:417.
- Zhang RY, Chen Y, Yan XQ, Zhang Y, Zhou H, et al. Association of pyridoxal 5'-phosphate (PLP) with lipid profiles: a population-based cohort study. Front Nutr. 2025;12:1545301. 10.3389/fnut.2025.1545301
- Xie RP, Liang XF, Peng D, Zhang QW, Wu DL, et al. Dietary supplementation of pyridoxine can enhance the growth performance and improve the protein, lipid utilization efficiency of mandarin fish (Siniperca chuatsi). Fish Physiol Biochem. 2023;49:1063. 10.1007/s10695-023-01223-3
- Abbas Torki S, Bahadori E, Shekari S, Fathi S, Gholamalizadeh M, et al. Association between the index of nutritional quality and lipid profile in adult women. Endocrinol Diabetes Metab. 2022;5:e358. 10.1002/edm2.358
- Haidari F, Mohammadshahi M, Zarei M, Haghighizadeh MH, Mirzaee F. The Effect of Pyridoxine Hydrochloride Supplementation on Leptin, Adiponectin, Glycemic Indices, and Anthropometric Indices in Obese and Overweight Women. Clin Nutr Res. 2021;10:230. 10.7762/cnr.2021.10.3.230
- Zhang Q, Zhang DL, Zhou XL, Li Q, He N, et al. Antihyperlipidemic and Hepatoprotective Properties of Vitamin B6 Supplementation in Rats with High-Fat Diet-Induced Hyperlipidemia. Endocr Metab Immune Disord Drug Targets. 2021;21:2260. 10.2174/1871530321666210809152555
- Shabbir M, Afsar T, Razak S, Almajwal A, Khan MR. Phytochemical analysis and Evaluation of hepatoprotective effect of Maytenus royleanus leaves extract against anti-tuberculosis drug induced liver injury in mice. Lipids Health Dis. 2020;19:46. 10.1186/s12944-020-01231-9
- Li J, Yin L, Wang L, Li J, Huang P, et al. Effects of vitamin B6 on growth, diarrhea rate, intestinal morphology, function, and inflammatory factors expression in a high-protein diet fed to weaned piglets1. J Anim Sci. 2019;97:4865. 10.1093/jas/skz338
