Magnesium reduces kidney stone riskEffect of magnesium oxide or citrate supplements on metabolic risk factors in kidney stone formers with idiopathic hyperoxaluria: a randomized clinical trial.
We conducted a randomized, double-blind, placebo-controlled clinical trial to explore how magnesium treatments influence kidney stones, specifically for those with high levels of oxalate in their urine. Our study involved 90 participants with a history of calcium kidney stones, all of whom were experiencing idiopathic hyperoxaluria. They were divided into three groups receiving either magnesium oxide (MgO), magnesium citrate (MgCit), or a placebo for eight weeks, while their diets were monitored to keep nutritional intake consistent.
After the treatment period, we observed promising results. Both MgO and MgCit effectively reduced the excretion of oxalate in urine, which is a key factor in kidney stone formation. The Group taking magnesium citrate showed even more significant reductions in both oxalate levels and the calcium oxalate supersaturation index, which measures the concentration of stone-forming minerals in urine. This was notably true for participants with normal magnesium levels.
Overall, we found that magnesium supplements might play a beneficial role in decreasing critical risk factors for kidney stones, especially for those using magnesium citrate. It's encouraging to see that this may offer a practical option for those struggling with recurrent stones due to high oxalate excretion.
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Vitamin B6 may reduce stonesPyridoxamine lowers oxalate excretion and kidney crystals in experimental hyperoxaluria: a potential therapy for primary hyperoxaluria.
The study examined the potential of pyridoxamine, a derivative of vitamin B6, in reducing kidney stones and oxalate excretion in conditions known as hyperoxaluria. The researchers aimed to find an effective treatment that would lower urine oxalate levels, which contribute significantly to kidney stone formation.
They tested this using an experimental model with rats, comparing those treated with pyridoxamine to a control group. We observed marked reductions in both urine glycolate and oxalate excretion in the rats given pyridoxamine. These reductions were notable, approximately 50%, when compared to the untreated hyperoxaluric animals.
Additionally, the treatment led to a significant drop in the formation of calcium oxalate crystals, which are a primary component of kidney stones. This finding, combined with the safety profile of pyridoxamine in humans, suggests that it could be a promising option for managing primary hyperoxaluria and related kidney stone issues.
Overall, the potential of pyridoxamine as a therapeutic treatment appears significant and worthy of further exploration for those suffering from kidney stone diseases.
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Vitamin B6 aids in kidney stone prevention[Morphometrical study on inhibitory effect of vitamin B6 and banana-stem extract on calcium crystallization].
We conducted a study to investigate the potential of vitamin B6 and banana stem extract in preventing kidney stones, specifically focusing on their effects on calcium oxalate crystallization. Our research involved thirty-six male China-1 mice, which were placed into four groups: a normal group, a crystallization group, and two treatment groups receiving vitamin B6 and banana stem extract, respectively. The mice in the latter three groups were induced with calcium oxalate crystallization through specific solutions for a duration of three weeks.
After the experimental period, we carefully observed the results. We found that both vitamin B6 and banana stem extract significantly reduced the areas of crystallization compared to the crystallization-only group. Interestingly, the banana stem extract group showed even more promising results, indicating the lowest crystallization density. Additionally, the levels of oxalate in the renal tissue were notably decreased in both treatment groups. However, it's worth mentioning that neither treatment appeared to impact the calcium content in the kidney tissues.
Our findings suggest that vitamin B6 may offer beneficial effects alongside banana stem extract in managing conditions related to kidney stones, particularly in cases of hypercalciuric urolithiasis. This opens up avenues for further exploration in dietary interventions for individuals prone to kidney stone formation.
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Magnesium's complex role in kidney stonesMachine Learning Models Decoding the Association Between Urinary Stone Diseases and Metabolic Urinary Profiles.
We analyzed how magnesium levels in urine might influence the occurrence of kidney stones. The study involved a mix of 468 patients who had been diagnosed with various types of urinary stones and underwent a detailed 24-hour urine analysis.
Our investigation found that 24-hour urinary magnesium was positively associated with both kidney stones and stones in multiple locations. Specifically, higher levels of magnesium corresponded with increased risk for these conditions. This relationship was particularly interesting because magnesium was highly correlated with another mineral, urinary phosphorus.
On the flip side, we also identified that 24-hour urinary creatinine acted as a protective factor against kidney and ureter stones, suggesting that maintaining adequate creatinine levels could potentially help prevent these types of stones. Additionally, eGFR (estimated Glomerular Filtration Rate) was noted as a risk factor especially for ureter stones and those that appear in multiple locations.
Ultimately, our study underscores that while magnesium is linked to stone formation, there are other contributing factors at play as well. This knowledge could guide improvements in dietary or medicinal strategies aimed at preventing kidney stones, especially emphasizing the need for a balanced intake of minerals in our diets.
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Magnesium's role in kidney stonesOral supplementation with probiotics, potassium citrate, and magnesium in reducing crystalluria in stone formers: A phase II study.
We analyzed a study focused on the effects of a combination of probiotics, potassium, and magnesium on kidney stone formation, specifically looking at crystalluria, which is the presence of crystals in urine that can signal the recurrence of kidney stones. The study involved 23 patients with calcium oxalate kidney stones who had crystalluria but normal metabolic profiles.
Over the course of 20 days, the patients received daily supplementation with beneficial bacteria, including Lactobacillus paracasei, Lactobacillus plantarum, and Bifidobacterium breve, along with potassium citrate and magnesium. After treatment, we observed a decrease in the presence of crystalluria at multiple follow-up points—1, 3, 6, and 12 months later.
Interestingly, while we noted that the probiotics and other agents helped reduce crystalluria, the study did not isolate the specific effects of magnesium alone. Therefore, we must be cautious in drawing firm conclusions about magnesium’s standalone effectiveness in this context.
Overall, the findings suggest that combining these supplements can be beneficial for patients with kidney stones, but the role of magnesium specifically requires further investigation.
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