Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.3
USERS' SCORE
Good
Based on 14 Reviews
8.3
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%
Magnesium (as magnesium oxide)
400 mg
95%

Top Medical Research Studies

9
Magnesium reduces kidney stone risk
We conducted a randomized, double-blind, placebo-controlled clinical trial to explore how magnesium treatments influence kidney stones, specifically for those with high levels of oxalate in their urine. Our study involved 90 participants with a history of calcium kidney stones, all of whom were experiencing idiopathic hyperoxaluria. They were divided into three groups receiving either magnesium oxide (MgO), magnesium citrate (MgCit), or a placebo for eight weeks, while their diets were monitored to keep nutritional intake consistent.

After the treatment period, we observed promising results. Both MgO and MgCit effectively reduced the excretion of oxalate in urine, which is a key factor in kidney stone formation. The Group taking magnesium citrate showed even more significant reductions in both oxalate levels and the calcium oxalate supersaturation index, which measures the concentration of stone-forming minerals in urine. This was notably true for participants with normal magnesium levels.

Overall, we found that magnesium supplements might play a beneficial role in decreasing critical risk factors for kidney stones, especially for those using magnesium citrate. It's encouraging to see that this may offer a practical option for those struggling with recurrent stones due to high oxalate excretion.
Read More
8
Dietary magnesium may reduce stones
We wanted to understand the relationship between dietary magnesium intake and the prevalence of kidney stones. By examining data from the National Health and Nutrition Examination Survey spanning 2011 to 2018, we were able to analyze the self-reported history of kidney stones among participants.

Our findings indicated that those who consumed higher amounts of magnesium appeared to have a lower likelihood of experiencing kidney stones. Specifically, the average daily magnesium intake was lower in individuals with kidney stones, suggesting that magnesium might play a role in kidney stone formation.

In our analysis, we discovered that when grouped into different levels of magnesium intake, those in the highest intake category had significantly reduced odds of developing kidney stones compared to those in the lowest intake category. This trend suggests a protective effect of dietary magnesium against kidney stone disease.

While our results are promising, we recognize that further research is needed to determine if there is a direct causal relationship between magnesium intake and kidney stones. The evidence points towards a beneficial link, but more prospective studies will help clarify this important topic for better health outcomes.
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8
Vitamin B6 may lower kidney stones
We examined the relationship between vitamin B6 intake and kidney stone formation in women. This research involved over 85,000 women with no prior history of kidney stones, monitored over 14 years. The study utilized food-frequency questionnaires to track participants' dietary vitamin consumption from both food and supplements.

Our findings revealed that higher vitamin B6 intake appeared to lower the risk of developing kidney stones. Specifically, women consuming 40 mg or more of vitamin B6 per day had a risk reduction, with a relative risk of 0.66 compared to those taking less than 3 mg per day. This suggests that large doses of vitamin B6 might help in preventing the formation of these painful stones.

On the other hand, vitamin C intake did not show a significant link to kidney stone risk. Women who consumed high amounts of vitamin C didn't experience an increased or decreased risk of kidney stones relative to those with lower intake levels. Therefore, we conclude that while vitamin B6 may provide protective benefits against kidney stones, restricting vitamin C isn't necessary for prevention.
Read More

Most Useful Reviews

10
Doctor's recommendation
19 people found this helpful
Excellent for kidney stone prevention! My urologist recommended these tablets, citing studies that show B6 and Magnesium can prevent kidney stones in women. I’ve been taking them for 2-3 years, and they are absolutely fantastic! Although the recommended dosage is three tablets daily, I take only two, one in the morning and one in the evening with meals, and I haven’t had any issues with new stones.
Read More
9
Long-term relief
7 people found this helpful
Something that WORKS! This product has kept my kidney stones at bay for decades. If you’ve got them, get this!
Read More
9
Muscle spasms
4 people found this helpful
These tablets are excellent for muscle spasms. They are well-coated and easy to swallow, with no side effects. The absorption is quick, making them effective. I've found that the combination of B6 and magnesium is beneficial for kidney stones. I take up to three tablets daily with meals.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.3
  • All Researches
9
Magnesium reduces kidney stone risk
We conducted a randomized, double-blind, placebo-controlled clinical trial to explore how magnesium treatments influence kidney stones, specifically for those with high levels of oxalate in their urine. Our study involved 90 participants with a history of calcium kidney stones, all of whom were experiencing idiopathic hyperoxaluria. They were divided into three groups receiving either magnesium oxide (MgO), magnesium citrate (MgCit), or a placebo for eight weeks, while their diets were monitored to keep nutritional intake consistent.

After the treatment period, we observed promising results. Both MgO and MgCit effectively reduced the excretion of oxalate in urine, which is a key factor in kidney stone formation. The Group taking magnesium citrate showed even more significant reductions in both oxalate levels and the calcium oxalate supersaturation index, which measures the concentration of stone-forming minerals in urine. This was notably true for participants with normal magnesium levels.

Overall, we found that magnesium supplements might play a beneficial role in decreasing critical risk factors for kidney stones, especially for those using magnesium citrate. It's encouraging to see that this may offer a practical option for those struggling with recurrent stones due to high oxalate excretion.
Read More
9
Vitamin B6 may reduce stones
The study examined the potential of pyridoxamine, a derivative of vitamin B6, in reducing kidney stones and oxalate excretion in conditions known as hyperoxaluria. The researchers aimed to find an effective treatment that would lower urine oxalate levels, which contribute significantly to kidney stone formation.

They tested this using an experimental model with rats, comparing those treated with pyridoxamine to a control group. We observed marked reductions in both urine glycolate and oxalate excretion in the rats given pyridoxamine. These reductions were notable, approximately 50%, when compared to the untreated hyperoxaluric animals.

Additionally, the treatment led to a significant drop in the formation of calcium oxalate crystals, which are a primary component of kidney stones. This finding, combined with the safety profile of pyridoxamine in humans, suggests that it could be a promising option for managing primary hyperoxaluria and related kidney stone issues.

Overall, the potential of pyridoxamine as a therapeutic treatment appears significant and worthy of further exploration for those suffering from kidney stone diseases.
Read More
9
Vitamin B6 aids in kidney stone prevention
We conducted a study to investigate the potential of vitamin B6 and banana stem extract in preventing kidney stones, specifically focusing on their effects on calcium oxalate crystallization. Our research involved thirty-six male China-1 mice, which were placed into four groups: a normal group, a crystallization group, and two treatment groups receiving vitamin B6 and banana stem extract, respectively. The mice in the latter three groups were induced with calcium oxalate crystallization through specific solutions for a duration of three weeks.

After the experimental period, we carefully observed the results. We found that both vitamin B6 and banana stem extract significantly reduced the areas of crystallization compared to the crystallization-only group. Interestingly, the banana stem extract group showed even more promising results, indicating the lowest crystallization density. Additionally, the levels of oxalate in the renal tissue were notably decreased in both treatment groups. However, it's worth mentioning that neither treatment appeared to impact the calcium content in the kidney tissues.

Our findings suggest that vitamin B6 may offer beneficial effects alongside banana stem extract in managing conditions related to kidney stones, particularly in cases of hypercalciuric urolithiasis. This opens up avenues for further exploration in dietary interventions for individuals prone to kidney stone formation.
Read More
8
Magnesium's complex role in kidney stones
We analyzed how magnesium levels in urine might influence the occurrence of kidney stones. The study involved a mix of 468 patients who had been diagnosed with various types of urinary stones and underwent a detailed 24-hour urine analysis.

Our investigation found that 24-hour urinary magnesium was positively associated with both kidney stones and stones in multiple locations. Specifically, higher levels of magnesium corresponded with increased risk for these conditions. This relationship was particularly interesting because magnesium was highly correlated with another mineral, urinary phosphorus.

On the flip side, we also identified that 24-hour urinary creatinine acted as a protective factor against kidney and ureter stones, suggesting that maintaining adequate creatinine levels could potentially help prevent these types of stones. Additionally, eGFR (estimated Glomerular Filtration Rate) was noted as a risk factor especially for ureter stones and those that appear in multiple locations.

Ultimately, our study underscores that while magnesium is linked to stone formation, there are other contributing factors at play as well. This knowledge could guide improvements in dietary or medicinal strategies aimed at preventing kidney stones, especially emphasizing the need for a balanced intake of minerals in our diets.
Read More
8
Magnesium's role in kidney stones
We analyzed a study focused on the effects of a combination of probiotics, potassium, and magnesium on kidney stone formation, specifically looking at crystalluria, which is the presence of crystals in urine that can signal the recurrence of kidney stones. The study involved 23 patients with calcium oxalate kidney stones who had crystalluria but normal metabolic profiles.

Over the course of 20 days, the patients received daily supplementation with beneficial bacteria, including Lactobacillus paracasei, Lactobacillus plantarum, and Bifidobacterium breve, along with potassium citrate and magnesium. After treatment, we observed a decrease in the presence of crystalluria at multiple follow-up points—1, 3, 6, and 12 months later.

Interestingly, while we noted that the probiotics and other agents helped reduce crystalluria, the study did not isolate the specific effects of magnesium alone. Therefore, we must be cautious in drawing firm conclusions about magnesium’s standalone effectiveness in this context.

Overall, the findings suggest that combining these supplements can be beneficial for patients with kidney stones, but the role of magnesium specifically requires further investigation.
Read More

User Reviews

USERS' SCORE
Good
Based on 14 Reviews
8.3
  • All Reviews
  • Positive Reviews
  • Negative Reviews
10
Doctor's recommendation
19 people found this helpful
Excellent for kidney stone prevention! My urologist recommended these tablets, citing studies that show B6 and Magnesium can prevent kidney stones in women. I’ve been taking them for 2-3 years, and they are absolutely fantastic! Although the recommended dosage is three tablets daily, I take only two, one in the morning and one in the evening with meals, and I haven’t had any issues with new stones.
Read More
9
Long-term relief
7 people found this helpful
Something that WORKS! This product has kept my kidney stones at bay for decades. If you’ve got them, get this!
Read More
9
Muscle spasms
4 people found this helpful
These tablets are excellent for muscle spasms. They are well-coated and easy to swallow, with no side effects. The absorption is quick, making them effective. I've found that the combination of B6 and magnesium is beneficial for kidney stones. I take up to three tablets daily with meals.
Read More
7.5
Effective combination
4 people found this helpful
While magnesium alone is less absorbed, this combination with B6 is highly effective for kidney stones. I found it beneficial and would appreciate your support in acknowledging this!
Read More
9
Convenient combination
I've been using these vitamins for years to combat kidney stones. It's great to have them combined in one pill, thus reducing my daily intake. They continue to work effectively for me.
Read More

Frequently Asked Questions

9
Convenient combination
I've been using these vitamins for years to combat kidney stones. It's great to have them combined in one pill, thus reducing my daily intake. They continue to work effectively for me.
9
Muscle spasms
4 people found this helpful
These tablets are excellent for muscle spasms. They are well-coated and easy to swallow, with no side effects. The absorption is quick, making them effective. I've found that the combination of B6 and magnesium is beneficial for kidney stones. I take up to three tablets daily with meals.
7.5
Stress relief
6 people found this helpful
Magnesium B6 is a brilliant product. I initially bought it for my child with kidney stones, but I use it myself for stress relief. It has been incredibly helpful during tough times, and I don't experience drowsiness. Other similar products are costlier and require taking large quantities, whereas this one only needs a couple of tablets a day.
7.5
Kidney stone prevention
This product prevents kidney stones and helps manage cholesterol levels and insulin production. It also aids in carbohydrate metabolism and liver detoxification by controlling glutathione synthesis.
7.5
Supports bone health
Mg B6 is fantastic! My whole family takes it. It supports bone health, improves metabolism, helps maintain normal blood sugar levels, and prevents kidney stones and gallbladder stones.
7.5
Effective combination
4 people found this helpful
While magnesium alone is less absorbed, this combination with B6 is highly effective for kidney stones. I found it beneficial and would appreciate your support in acknowledging this!
7
Magnesium reduces kidney stone risk
We examined the relationship between magnesium intake and the risk of kidney stones in adults aged 50 and older. By analyzing data collected from the National Health and Nutrition Examination Survey spanning over a decade, we aimed to understand whether increasing magnesium levels could help reduce the chances of developing kidney stones.

Our findings revealed that there is indeed a noteworthy link between magnesium consumption and kidney stones. Specifically, we observed that individuals who consumed higher amounts of magnesium had lower odds of experiencing kidney stones. This trend was especially significant for women, who showed a clearer inverse relationship with magnesium intake.

Interestingly, our results indicated that the protective benefits of magnesium plateau around a daily intake of 350 mg. This means that while increasing magnesium consumption can lower the risk of kidney stones, beyond this threshold, additional magnesium may not yield further benefits.

Overall, our study sheds light on the potential role of magnesium in preventing kidney stones and emphasizes the importance of maintaining a balanced diet rich in this essential mineral for individuals over 50.
8
Magnesium's complex role in kidney stones
We analyzed how magnesium levels in urine might influence the occurrence of kidney stones. The study involved a mix of 468 patients who had been diagnosed with various types of urinary stones and underwent a detailed 24-hour urine analysis.

Our investigation found that 24-hour urinary magnesium was positively associated with both kidney stones and stones in multiple locations. Specifically, higher levels of magnesium corresponded with increased risk for these conditions. This relationship was particularly interesting because magnesium was highly correlated with another mineral, urinary phosphorus.

On the flip side, we also identified that 24-hour urinary creatinine acted as a protective factor against kidney and ureter stones, suggesting that maintaining adequate creatinine levels could potentially help prevent these types of stones. Additionally, eGFR (estimated Glomerular Filtration Rate) was noted as a risk factor especially for ureter stones and those that appear in multiple locations.

Ultimately, our study underscores that while magnesium is linked to stone formation, there are other contributing factors at play as well. This knowledge could guide improvements in dietary or medicinal strategies aimed at preventing kidney stones, especially emphasizing the need for a balanced intake of minerals in our diets.

References

  1. Zhang J, Luo H, Wu H, Qian Y, Tang Z, et al. The association between domestic water hardness and kidney stone disease: a prospective cohort study from the UK Biobank. Int J Surg. 2025;111:1957. 10.1097/JS9.0000000000002198
  2. Ma L, Qiao Y, Wang R, Chen H, Liu G, et al. Machine Learning Models Decoding the Association Between Urinary Stone Diseases and Metabolic Urinary Profiles. Metabolites. 2024;14. 10.3390/metabo14120674
  3. Zhao H, Wang Y, Guan L, Sun Y. Association Between Magnesium Intake and Chronic Kidney Diseases and Kidney Stones in Adults Aged 50 years and Older: Dose-Response Analysis of a Nationally Representative Population-Based Study. J Ren Nutr. 2024. 10.1053/j.jrn.2024.11.004
  4. Vittori M, Bove P, Signoretti M, Cipriani C, Gasparoli C, et al. Oral supplementation with probiotics, potassium citrate, and magnesium in reducing crystalluria in stone formers: A phase II study. Urologia. 2024;91:681. 10.1177/03915603241272146
  5. Taheri M, Jalali S, Borumandnia N, Tavasoli S, Basiri A, et al. Effect of magnesium oxide or citrate supplements on metabolic risk factors in kidney stone formers with idiopathic hyperoxaluria: a randomized clinical trial. Magnes Res. 2024;37:12. 10.1684/mrh.2024.0524
  6. Penniston KL, Coughlin MM, Jhagroo RA. Magnesium Supplementation Increases Urine Magnesium and Citrate in Stone Formers With Hypomagnesuria. J Ren Nutr. 2024. 10.1053/j.jrn.2024.06.002
  7. Li Q, Krieger NS, Yang L, Asplin J, Bushinsky DA. Magnesium Decreases Urine Supersaturation but Not Calcium Oxalate Stone Formation in Genetic Hypercalciuric Stone-Forming Rats. Nephron. 2024;148:480. 10.1159/000534495
  8. Shringi S, Raker CA, Tang J. Dietary Magnesium Intake and Kidney Stone: The National Health and Nutrition Examination Survey 2011-2018. R I Med J (2013). 2023;106:20.
  9. Rodriguez-Hesles CA, Alkhatatbeh H, Alonso Bartolomé MB, Valladares Ferreiro CA, Ayllón Blanco HR, et al. Urine alkalinization for dissolution of uric acid stones and treatment of other urological diseases with a treatment combining potassium magnesium citrate and theobromine. Arch Ital Urol Androl. 2025;97:13824. 10.4081/aiua.2025.13824
  10. Zeng H, Liu Z, He Y, Chen H, He J, et al. Multivitamins co-intake can reduce the prevalence of kidney stones: a large-scale cross-sectional study. Int Urol Nephrol. 2024;56:2991. 10.1007/s11255-024-04021-9
  11. Gupta M, Gallante B, Bamberger JN, Khusid JA, Parkhomenko E, et al. Prospective Randomized Evaluation of Idiopathic Hyperoxaluria Treatments. J Endourol. 2021;35:1844. 10.1089/end.2021.0122
  12. Cealan A, Coman RT, Simon V, Andras I, Telecan T, et al. Evaluation of the efficacy of standardized extract combined with magnesium and vitamin B6 for the treatment of patients with uncomplicated nephrolithiasis. Med Pharm Rep. 2019;92:153. 10.15386/mpr-1246
  13. Yang H, Male M, Li Y, Wang N, Zhao C, et al. Efficacy of Hydroxy-L-proline (HYP) analogs in the treatment of primary hyperoxaluria in Drosophila Melanogaster. BMC Nephrol. 2018;19:167. 10.1186/s12882-018-0980-8
  14. Fargue S, Knight J, Holmes RP, Rumsby G, Danpure CJ. Effects of alanine:glyoxylate aminotransferase variants and pyridoxine sensitivity on oxalate metabolism in a cell-based cytotoxicity assay. Biochim Biophys Acta. 2016;1862:1055. 10.1016/j.bbadis.2016.02.004
  15. Spasov AA, Iezhitsa IN, Kharitonova MV, Kravchenko MS, Snigur GL, et al. [Experimental evidence of magnesium salts for treatment of calcium oxalate nephrolithiasis in an animal model based on sodium oxalate and a cyclooxygenase 2 selective inhibitor]. Patol Fiziol Eksp Ter. 2013.
  16. Scheinman JI, Voziyan PA, Belmont JM, Chetyrkin SV, Kim D, et al. Pyridoxamine lowers oxalate excretion and kidney crystals in experimental hyperoxaluria: a potential therapy for primary hyperoxaluria. Urol Res. 2005;33:368.
  17. Monico CG, Rossetti S, Olson JB, Milliner DS. Pyridoxine effect in type I primary hyperoxaluria is associated with the most common mutant allele. Kidney Int. 2005;67:1704.
  18. Nakatani T, Ishii K, Yoneda Y, Kamikawa S, Kanazawa T, et al. The preventive effect of sodium pentosan polysulfate against renal stone formation in hyperoxaluric rats. Urol Res. 2002;30:329.
  19. Di Tommaso L, Tolomelli B, Mezzini R, Marchetti M, Cenacchi G, et al. Renal calcium phosphate and oxalate deposition in prolonged vitamin B6 deficiency: studies on a rat model of urolithiasis. BJU Int. 2002;89:571.
  20. Li S, Wu C, Nong H, Deng Y. [Morphometrical study on inhibitory effect of vitamin B6 and banana-stem extract on calcium crystallization]. Zhonghua Wai Ke Za Zhi. 1998;36:763.
  21. Curhan GC. Epidemiologic evidence for the role of oxalate in idiopathic nephrolithiasis. J Endourol. 1999;13:629.
  22. Curhan GC, Willett WC, Speizer FE, Stampfer MJ. Intake of vitamins B6 and C and the risk of kidney stones in women. J Am Soc Nephrol. 1999;10:840.
  23. Selvam R, Ravichandran V. Restoration of tissue antioxidants and prevention of renal stone deposition in vitamin B6 deficient rats fed with vitamin E or methionine. Indian J Exp Biol. 1993;31:882.
  24. Grimm U, Steinhauser I, Wulff K, Knapp A, Zschiesche M. [Studies on tryptophan metabolism in calcium oxalate urolithiasis]. Z Urol Nephrol. 1988;81:299.
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