Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.3
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%
Magnesium (as magnesium oxide)
400 mg
95%
Top Medical Research Studies
9
Magnesium citrate outperforms sodium phosphate
We explored the effectiveness of magnesium citrate versus sodium phosphate for bowel preparation before colonoscopy. In our study, which involved over 600 patients, we found that magnesium led to superior bowel cleansing when taken a day prior. Additionally, sodium phosphate, especially when split into doses, showed better cleansing results compared to when taken all at once.
Importantly, we noted that sodium phosphate was associated with a higher occurrence of rectosigmoid ulcers compared to magnesium. Overall, magnesium citrate appears to be a better option for those preparing for colonoscopy.
Importantly, we noted that sodium phosphate was associated with a higher occurrence of rectosigmoid ulcers compared to magnesium. Overall, magnesium citrate appears to be a better option for those preparing for colonoscopy.
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9
We delved into the effects of pyridoxine, a stable form of vitamin B6, on endothelial cells under high glucose conditions, which can impair cell function and contribute to complications like diabetic ulcers. The study examined how pyridoxine might help these cells migrate and respond properly to shear stress, something they struggle with in high-sugar environments.
During the research, human aortic endothelial cells were cultured in various glucose concentrations, both with and without pyridoxine. We found that at a concentration of 100 mg/L, pyridoxine not only enhanced the migratory ability of the cells but also significantly improved their alignment and elongation ability when exposed to shear stress. Importantly, these benefits were observed in high-glucose conditions that typically hinder normal cell function.
The implications are promising: since vitamin B6 is considered safe in doses below 250 mg per day, it could be a viable treatment option for issues related to diabetes, such as ulcers or atherosclerosis, due to its role in promoting better endothelial cell function. Our findings suggest that incorporating pyridoxine into treatment regimens may help address some of the challenges faced by individuals with diabetes and contribute to better wound healing.
During the research, human aortic endothelial cells were cultured in various glucose concentrations, both with and without pyridoxine. We found that at a concentration of 100 mg/L, pyridoxine not only enhanced the migratory ability of the cells but also significantly improved their alignment and elongation ability when exposed to shear stress. Importantly, these benefits were observed in high-glucose conditions that typically hinder normal cell function.
The implications are promising: since vitamin B6 is considered safe in doses below 250 mg per day, it could be a viable treatment option for issues related to diabetes, such as ulcers or atherosclerosis, due to its role in promoting better endothelial cell function. Our findings suggest that incorporating pyridoxine into treatment regimens may help address some of the challenges faced by individuals with diabetes and contribute to better wound healing.
Read More
7
We examined how well magnesium-containing antacids work as a stress ulcer treatment in patients on mechanical ventilation. In a randomized controlled trial with 244 patients, we compared three treatment options: magnesium-based antacids, ranitidine, and sucralfate.
While we found that sucralfate significantly reduced the risk of late-onset pneumonia compared to the magnesium antacid and ranitidine, there was no significant difference in gastric bleeding or early-onset pneumonia. Overall, the magnesium treatment did not appear to offer added benefits in this context.
While we found that sucralfate significantly reduced the risk of late-onset pneumonia compared to the magnesium antacid and ranitidine, there was no significant difference in gastric bleeding or early-onset pneumonia. Overall, the magnesium treatment did not appear to offer added benefits in this context.
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Most Useful Reviews
9
Recommended for ulcers
Excellent company and product. Some may feel embarrassed about the presence of magnesium oxide, but it truly depends on the reason for use. For gastritis or an ulcer, this is precisely what you need. A quick search online will provide further information. I highly recommend it!
Read More
7.5
Improved ulcer conditions
1 people found this helpful
Daily magnesium supplementation can enhance calcium absorption. I used to be frustrated while drinking milk due to mouth ulcers, but now I can enjoy it without issues. The glass bottle is sturdy and charming, and one bottle lasts a considerable time.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.3
- All Researches
9
Magnesium citrate outperforms sodium phosphate
We explored the effectiveness of magnesium citrate versus sodium phosphate for bowel preparation before colonoscopy. In our study, which involved over 600 patients, we found that magnesium led to superior bowel cleansing when taken a day prior. Additionally, sodium phosphate, especially when split into doses, showed better cleansing results compared to when taken all at once.
Importantly, we noted that sodium phosphate was associated with a higher occurrence of rectosigmoid ulcers compared to magnesium. Overall, magnesium citrate appears to be a better option for those preparing for colonoscopy.
Importantly, we noted that sodium phosphate was associated with a higher occurrence of rectosigmoid ulcers compared to magnesium. Overall, magnesium citrate appears to be a better option for those preparing for colonoscopy.
Read More
9
We investigated the potential benefits of vitamin B6 in treating ulcerations linked to MTHFR polymorphisms, which can lead to complications like thrombophilia and vasculopathy. In this exploration, we noted two patients who experienced painful ulcers on their lower extremities.
During their treatment journey, both individuals showed significant improvement after starting a regimen of oral vitamin supplements, including vitamin B6, alongside proper wound care. Interestingly, one of the patients faced a return of ulcerations when he stopped his therapy but enjoyed healing after resuming treatment.
This suggests that vitamin B6, as part of a broader vitamin combination, could play a crucial role in healing ulcers for some individuals with specific genetic factors. However, it’s important to remember that while the results are promising, further research is needed to fully understand the isolated impact of vitamin B6.
During their treatment journey, both individuals showed significant improvement after starting a regimen of oral vitamin supplements, including vitamin B6, alongside proper wound care. Interestingly, one of the patients faced a return of ulcerations when he stopped his therapy but enjoyed healing after resuming treatment.
This suggests that vitamin B6, as part of a broader vitamin combination, could play a crucial role in healing ulcers for some individuals with specific genetic factors. However, it’s important to remember that while the results are promising, further research is needed to fully understand the isolated impact of vitamin B6.
Read More
9
We delved into the effects of pyridoxine, a stable form of vitamin B6, on endothelial cells under high glucose conditions, which can impair cell function and contribute to complications like diabetic ulcers. The study examined how pyridoxine might help these cells migrate and respond properly to shear stress, something they struggle with in high-sugar environments.
During the research, human aortic endothelial cells were cultured in various glucose concentrations, both with and without pyridoxine. We found that at a concentration of 100 mg/L, pyridoxine not only enhanced the migratory ability of the cells but also significantly improved their alignment and elongation ability when exposed to shear stress. Importantly, these benefits were observed in high-glucose conditions that typically hinder normal cell function.
The implications are promising: since vitamin B6 is considered safe in doses below 250 mg per day, it could be a viable treatment option for issues related to diabetes, such as ulcers or atherosclerosis, due to its role in promoting better endothelial cell function. Our findings suggest that incorporating pyridoxine into treatment regimens may help address some of the challenges faced by individuals with diabetes and contribute to better wound healing.
During the research, human aortic endothelial cells were cultured in various glucose concentrations, both with and without pyridoxine. We found that at a concentration of 100 mg/L, pyridoxine not only enhanced the migratory ability of the cells but also significantly improved their alignment and elongation ability when exposed to shear stress. Importantly, these benefits were observed in high-glucose conditions that typically hinder normal cell function.
The implications are promising: since vitamin B6 is considered safe in doses below 250 mg per day, it could be a viable treatment option for issues related to diabetes, such as ulcers or atherosclerosis, due to its role in promoting better endothelial cell function. Our findings suggest that incorporating pyridoxine into treatment regimens may help address some of the challenges faced by individuals with diabetes and contribute to better wound healing.
Read More
We explored the effects of vitamin B6 within a treatment protocol aimed at patients suffering from Buerger's disease (BD) and related ulcers. In this pilot study, patients received l-arginine and a combination of vitamins, including vitamin B6, to improve their vascular health and promote healing.
Among the patients treated, 11 out of 15 experienced notable improvements in pain, ulcer healing, and even the recovery of peripheral pulses. We observed this positive response relatively quickly, within a timeframe of 8 weeks to 8 months.
While vitamin B6 was part of a multifaceted treatment plan, isolating its specific impact on ulcer healing is challenging due to the combination of therapies used. Nonetheless, incorporating B6, alongside l-arginine and other vitamins, may contribute positively to the overall treatment outcome for these patients struggling with severe symptoms of Buerger's disease.
Among the patients treated, 11 out of 15 experienced notable improvements in pain, ulcer healing, and even the recovery of peripheral pulses. We observed this positive response relatively quickly, within a timeframe of 8 weeks to 8 months.
While vitamin B6 was part of a multifaceted treatment plan, isolating its specific impact on ulcer healing is challenging due to the combination of therapies used. Nonetheless, incorporating B6, alongside l-arginine and other vitamins, may contribute positively to the overall treatment outcome for these patients struggling with severe symptoms of Buerger's disease.
Read More
9
We explored how vitamin B6 contributes to the treatment of ulcers in patients suffering from livedoid vasculopathy. The study involved a 49-year-old woman whose condition was exacerbated by elevated homocysteine levels due to renal issues and deficiencies in vitamin B6 and B12.
To address her symptoms, we treated her with low-molecular heparin, pentoxifylline, and supplemented her diet with folic acid as well as the essential vitamins B6 and B12. Through this comprehensive treatment plan, we observed a notable reduction in her homocysteine levels.
Encouragingly, the therapy led to the healing of her ulcers without any recurrences over a span of 16 months. While the specific effects of vitamin B6 alone are challenging to isolate given the multifaceted treatment, it clearly played a role as part of a broader strategy to combat hyperhomocysteinemia and improve her condition.
To address her symptoms, we treated her with low-molecular heparin, pentoxifylline, and supplemented her diet with folic acid as well as the essential vitamins B6 and B12. Through this comprehensive treatment plan, we observed a notable reduction in her homocysteine levels.
Encouragingly, the therapy led to the healing of her ulcers without any recurrences over a span of 16 months. While the specific effects of vitamin B6 alone are challenging to isolate given the multifaceted treatment, it clearly played a role as part of a broader strategy to combat hyperhomocysteinemia and improve her condition.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Recommended for ulcers
Excellent company and product. Some may feel embarrassed about the presence of magnesium oxide, but it truly depends on the reason for use. For gastritis or an ulcer, this is precisely what you need. A quick search online will provide further information. I highly recommend it!
Read More
7.5
Improved ulcer conditions
1 people found this helpful
Daily magnesium supplementation can enhance calcium absorption. I used to be frustrated while drinking milk due to mouth ulcers, but now I can enjoy it without issues. The glass bottle is sturdy and charming, and one bottle lasts a considerable time.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Cao S, Muniyappan M, Kim S, Kim IH. Co-Administration of Vitamin U and Antacids in Diets Relieves Gastric Ulcers in Finishing Pigs. J Anim Physiol Anim Nutr (Berl). 2024. 10.1111/jpn.14073
- Berkelhammer C, Ekambaram A, Silva RG. Low-volume oral colonoscopy bowel preparation: sodium phosphate and magnesium citrate. Gastrointest Endosc. 2002;56:89.
- Prod'hom G, Leuenberger P, Koerfer J, Blum A, Chiolero R, et al. Nosocomial pneumonia in mechanically ventilated patients receiving antacid, ranitidine, or sucralfate as prophylaxis for stress ulcer. A randomized controlled trial. Ann Intern Med. 1994;120:653.
- Turkowski Y, Razvi S, Ahmed AR. Pyoderma gangrenosum-like lesion secondary to methylenetetrahydrofolate reductase mutation: an unusual presentation of a rare disease. BMJ Case Rep. 2019;12. 10.1136/bcr-2018-228403
- New D, Eaton P, Knable A, Callen JP. The use of B vitamins for cutaneous ulcerations mimicking pyoderma gangrenosum in patients with MTHFR polymorphism. Arch Dermatol. 2011;147:450. 10.1001/archdermatol.2011.77
- Kelso BG, Brower JB, Targovnik JH, Caplan MR. Pyridoxine restores endothelial cell function in high glucose. Metab Syndr Relat Disord. 2011;9:63. 10.1089/met.2010.0085
- Glueck CJ, Haque M, Winarska M, Dharashivkar S, Fontaine RN, et al. Stromelysin-1 5A/6A and eNOS T-786C polymorphisms, MTHFR C677T and A1298C mutations, and cigarette-cannabis smoking: a pilot, hypothesis-generating study of gene-environment pathophysiological associations with Buerger's disease. Clin Appl Thromb Hemost. 2006;12:427.
- Meiss F, Marsch WC, Fischer M. Livedoid vasculopathy. The role of hyperhomocysteinemia and its simple therapeutic consequences. Eur J Dermatol. 2006;16:159.
