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Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Melatonin (N-Acetyl-5-Methoxytryptamine)
10 mg
**
The product is found useful for the following medical conditions
Reflux details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
USERS' SCORE
Good
Based on 1 Review
8.5
9
Melatonin reduces reflux esophagitis damage
Melatonin protects against experimental reflux esophagitis.
Most Relevant Research
We explored how melatonin can protect the esophagus from reflux esophagitis (RE), a condition where stomach contents flow back into the esophagus, often causing painful inflammation. In our research with rats, we found that melatonin pretreatment resulted in significantly fewer bleeding lesions and lower levels of harmful lipid peroxidation typically caused by RE.
Additionally, melatonin helped replenish important antioxidants in the esophagus, suggesting its potential to neutralize free radicals that contribute to tissue damage. As we delved into the immune response, we observed that melatonin decreased the levels of certain pro-inflammatory cytokines, like TNF-alpha and IL-6, while keeping the levels of the anti-inflammatory cytokine IL-10 steady.
Interestingly, when we tested a melatonin receptor blocker, luzindole, we discovered that this approach did not hinder melatonin's protective effects. This indicates that melatonin works its magic in a receptor-independent way as well, not just through its antioxidant properties but also by modulating inflammation. Overall, we found that melatonin could be a beneficial ally for those suffering from reflux esophagitis, providing insights for future treatment strategies.
Additionally, melatonin helped replenish important antioxidants in the esophagus, suggesting its potential to neutralize free radicals that contribute to tissue damage. As we delved into the immune response, we observed that melatonin decreased the levels of certain pro-inflammatory cytokines, like TNF-alpha and IL-6, while keeping the levels of the anti-inflammatory cytokine IL-10 steady.
Interestingly, when we tested a melatonin receptor blocker, luzindole, we discovered that this approach did not hinder melatonin's protective effects. This indicates that melatonin works its magic in a receptor-independent way as well, not just through its antioxidant properties but also by modulating inflammation. Overall, we found that melatonin could be a beneficial ally for those suffering from reflux esophagitis, providing insights for future treatment strategies.
8
Easier to swallow
Most Useful Review
My husband has severe reflux. Unlike other brands we've tried, this small pill is far easier for him to swallow.
Insomnia details
SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8.2
USERS' SCORE
Good
Based on 3 Reviews
8.4
9
Melatonin delivery enhances sleep
Silk fibroin microneedles loaded with melatonin for circadian rhythm regulation.
Most Relevant Research
We developed a new way to deliver melatonin for those struggling with insomnia by creating microneedles made from silk fibroin. These tiny needles are designed to improve how the body absorbs melatonin, making it easier for people to get to sleep and stay asleep.
Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.
Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.
We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.
Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.
Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.
We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.
9.5
Effective melatonin
Most Useful Review
It really works. I am a chronic insomniac, and my doctor recommended melatonin for nightly use. This brand works well for me; I fall asleep quickly and wake feeling rested.
Nausea details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Moderately Good
Based on 1 Review
7.7
7
Melatonin linked to nausea management
Melatonin Immunoreactivity in Malignant Small Intestinal Neuroendocrine Tumours.
Most Relevant Research
We explored how melatonin could affect nausea in patients with small intestinal neuroendocrine tumors (SI-NETs). Our research involved studying tumor tissue from 26 patients, examining their primary tumors alongside metastases for the presence of melatonin and its receptors.
Interestingly, we found that higher melatonin levels in the body were linked to reported experiences of nausea. Specifically, patients with higher plasma melatonin levels at both time points indicated more frequent nausea occurrences. This underscores the potential role of melatonin in influencing nausea symptoms.
However, it's notable that in those cases where the disease was stable or improving, plasma levels of melatonin dropped after treatment, suggesting a complicated relationship between melatonin levels and treatment responses. These findings provide some valuable insights into the endocrine roles of melatonin in SI-NETs and signal a need for future studies to further dissect these relationships.
Interestingly, we found that higher melatonin levels in the body were linked to reported experiences of nausea. Specifically, patients with higher plasma melatonin levels at both time points indicated more frequent nausea occurrences. This underscores the potential role of melatonin in influencing nausea symptoms.
However, it's notable that in those cases where the disease was stable or improving, plasma levels of melatonin dropped after treatment, suggesting a complicated relationship between melatonin levels and treatment responses. These findings provide some valuable insights into the endocrine roles of melatonin in SI-NETs and signal a need for future studies to further dissect these relationships.
0
Adverse reaction
Most Useful Review
This Melatonin did the exact opposite of what I expected. I experienced a poor reaction, was nauseated, and struggled to sleep through the night.
