Last update
5/11/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.1
USERS' SCORE
Good
Based on 2 Reviews
8
Supplement Facts
Serving Size: 1 Nugget
Amount Per Serving
%DV
Vitamin B12 (as methylcobalamin)
1000 mcg
41,667%
Top Medical Research Studies
9
We observed how vitamin B12 deficiency can masquerade as serious conditions like hematologic malignancies, causing symptoms such as dizziness, nausea, and leukopenia. In our evaluation of a 39-year-old male, we found that treating severe B12 deficiency led to significant improvement in his blood counts.
After intensive vitamin B12 injections, his symptoms, including nausea, diminished, demonstrating the importance of assessing nutritional deficiencies before pursuing more invasive diagnoses. This case highlights how addressing vitamin B12 deficiency can effectively resolve challenging medical scenarios.
After intensive vitamin B12 injections, his symptoms, including nausea, diminished, demonstrating the importance of assessing nutritional deficiencies before pursuing more invasive diagnoses. This case highlights how addressing vitamin B12 deficiency can effectively resolve challenging medical scenarios.
Read More
9.5
We explored the possible link between vitamin B12 deficiency and nausea in a 62-year-old patient with Type 2 Diabetes Mellitus who had been on metformin for four years. After presenting with nausea, vomiting, and other symptoms, a diagnosis of megaloblastic anemia due to vitamin B12 deficiency was made. Remarkably, the patient's symptoms alleviated following vitamin B12 injections. This case suggests the importance of monitoring B12 levels to combat related nausea in those on metformin and mitigate anemia risks.
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8
We created a novel GLP-1 receptor agonist combined with a vitamin B12 precursor to enhance blood sugar control while minimizing nausea and vomiting. The study involved testing our Cbi-Ex4 compound in musk shrews, which are known to experience these side effects.
The results showed that Cbi-Ex4 not only provided better glycemic responses but also significantly reduced emetic events compared to traditional treatments. This encourages the potential clinical use of Cbi-Ex4, offering hope for patients who currently struggle with nausea from existing diabetes medications.
The results showed that Cbi-Ex4 not only provided better glycemic responses but also significantly reduced emetic events compared to traditional treatments. This encourages the potential clinical use of Cbi-Ex4, offering hope for patients who currently struggle with nausea from existing diabetes medications.
Read More
Most Useful Reviews
9
No nausea
I was prescribed this during my pregnancy and it worked well. My deficiency was addressed quickly, and thankfully, I experienced no nausea. I would recommend consulting your doctor before use.
Read More
2
Causes nausea
The product is delightful, but it's essential to consume it on a full stomach; otherwise, it may induce nausea.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.1
- All Researches
9.5
We explored the possible link between vitamin B12 deficiency and nausea in a 62-year-old patient with Type 2 Diabetes Mellitus who had been on metformin for four years. After presenting with nausea, vomiting, and other symptoms, a diagnosis of megaloblastic anemia due to vitamin B12 deficiency was made. Remarkably, the patient's symptoms alleviated following vitamin B12 injections. This case suggests the importance of monitoring B12 levels to combat related nausea in those on metformin and mitigate anemia risks.
Read More
9
We observed how vitamin B12 deficiency can masquerade as serious conditions like hematologic malignancies, causing symptoms such as dizziness, nausea, and leukopenia. In our evaluation of a 39-year-old male, we found that treating severe B12 deficiency led to significant improvement in his blood counts.
After intensive vitamin B12 injections, his symptoms, including nausea, diminished, demonstrating the importance of assessing nutritional deficiencies before pursuing more invasive diagnoses. This case highlights how addressing vitamin B12 deficiency can effectively resolve challenging medical scenarios.
After intensive vitamin B12 injections, his symptoms, including nausea, diminished, demonstrating the importance of assessing nutritional deficiencies before pursuing more invasive diagnoses. This case highlights how addressing vitamin B12 deficiency can effectively resolve challenging medical scenarios.
Read More
8
We created a novel GLP-1 receptor agonist combined with a vitamin B12 precursor to enhance blood sugar control while minimizing nausea and vomiting. The study involved testing our Cbi-Ex4 compound in musk shrews, which are known to experience these side effects.
The results showed that Cbi-Ex4 not only provided better glycemic responses but also significantly reduced emetic events compared to traditional treatments. This encourages the potential clinical use of Cbi-Ex4, offering hope for patients who currently struggle with nausea from existing diabetes medications.
The results showed that Cbi-Ex4 not only provided better glycemic responses but also significantly reduced emetic events compared to traditional treatments. This encourages the potential clinical use of Cbi-Ex4, offering hope for patients who currently struggle with nausea from existing diabetes medications.
Read More
8
We observed how the B12-Ex4 conjugate may be a game-changer in managing type 2 diabetes. It effectively improved glucose tolerance in male rats without causing the nausea and malaise commonly associated with its unconjugated counterpart, Ex4.
In our study, we tested both the conjugate and Ex4 on food intake, weight, and nausea, noting that B12-Ex4 did not penetrate the brain as much, which could explain the reduced side effects.
Overall, our findings suggest that B12-Ex4 could be a promising therapeutic option, minimizing unwanted nausea while enhancing glucose management.
In our study, we tested both the conjugate and Ex4 on food intake, weight, and nausea, noting that B12-Ex4 did not penetrate the brain as much, which could explain the reduced side effects.
Overall, our findings suggest that B12-Ex4 could be a promising therapeutic option, minimizing unwanted nausea while enhancing glucose management.
Read More
8
We examined a case of a 28-year-old man who experienced persistent headaches, nausea, and vomiting, ultimately diagnosed with cerebral venous thrombosis (CVT). This condition was linked to a mutation in the MTHFR gene and resulted in elevated homocysteine levels.
After treatment with heparin, warfarin, and vitamin B12, the patient showed significant improvement in symptoms.
This underscores the importance of screening for MTHFR mutations in patients with CVT.
After treatment with heparin, warfarin, and vitamin B12, the patient showed significant improvement in symptoms.
This underscores the importance of screening for MTHFR mutations in patients with CVT.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
No nausea
I was prescribed this during my pregnancy and it worked well. My deficiency was addressed quickly, and thankfully, I experienced no nausea. I would recommend consulting your doctor before use.
Read More
2
Causes nausea
The product is delightful, but it's essential to consume it on a full stomach; otherwise, it may induce nausea.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Salimiaghdam N, Jumaah O, Acob T, Hakobyan K, Chen E. Vitamin B12 Deficiency in Pernicious Anemia: A Hemolytic Anemia Mimic. Cureus. 2025;17:e79176. 10.7759/cureus.79176
- Choi E, Galicia Garcia G, Kishore Anna K, Albuja Altamirano MF, Yip L, et al. Vitamin B12 Deficiency Manifesting As Pancytopenia, Lymphadenopathy, and Fever: A Clinical Mimic of Hematologic Malignancies. Cureus. 2024;16:e64676. 10.7759/cureus.64676
- Meyers TM, Reeves PT, Lombardo JL, Anisowicz SK, Larson NS, et al. Autoimmune gastritis as an unexpected cause of diarrhea in a young adult with type I diabetes: a case report. J Med Case Rep. 2023;17:342. 10.1186/s13256-023-04039-0
- Albai O, Timar B, Paun DL, Sima A, Roman D, et al. Metformin Treatment: A Potential Cause of Megaloblastic Anemia in Patients with Type 2 Diabetes Mellitus. Diabetes Metab Syndr Obes. 2020;13:3873. 10.2147/DMSO.S270393
- Borner T, Workinger JL, Tinsley IC, Fortin SM, Stein LM, et al. Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis. Cell Rep. 2020;31:107768. 10.1016/j.celrep.2020.107768
- Mietlicki-Baase EG, Liberini CG, Workinger JL, Bonaccorso RL, Borner T, et al. A vitamin B12 conjugate of exendin-4 improves glucose tolerance without associated nausea or hypophagia in rodents. Diabetes Obes Metab. 2018;20:1223. 10.1111/dom.13222
- Dikici S, Saritas A, Besir FH, Celbek G, Arslan G. May headache be the first sign of mutation in the MTHFR gene?. World J Emerg Med. 2013;4:69. PubMed
