Solgar Vitamin K2

We designed a multicenter, double-blind, placebo-controlled trial to explore if vitamin K2 can effectively manage nocturnal leg cramps (NLCs).

Conducted in China with older adults experiencing regular cramps, participants were randomly assigned to receive either vitamin K2 or a placebo for 8 weeks. Remarkably, our findings demonstrated that vitamin K2 significantly reduced the frequency, duration, and intensity of NLCs, making it a promising option for those suffering from this discomfort.

Notably, the treatment showed good safety profiles, reinforcing its potential utility in managing leg cramps.

Leg pain relief

Most Useful Review

Very helpful! For about a year, I suffered from heaviness in my legs, making it painful to walk for long periods. After taking vitamin K2 from this company, everything disappeared. I can now move freely like a swallow! I purchased more, as this product has become my number one!

Osteoporosis details

SCIENTIFIC SCORE

Possibly Effective

Based on 32 Researches

Vitamin K2 supports BMD in osteoporosis

Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.

Most Relevant Research

To explore vitamin K2's effect on osteoporosis, we conducted a thorough analysis of nine studies involving 6,853 participants.

The findings suggest that vitamin K2 significantly improves bone mineral density (BMD) and reduces certain bone markers.

While there were increased adverse reactions, they were not serious. Overall, this suggests that vitamin K2 can be a beneficial and safe option for postmenopausal women managing osteoporosis.

9.5

Preventing osteoporosis

Most Useful Review

MK-7 is a highly bioavailable form of vitamin K2 involved in blood clotting and cellular regulation. It slows down the effects of natural aging and is vital for activating calcium-binding proteins. Vitamin K2 prevents osteoporosis and improves bone health. It is often taken alongside vitamin D, which aids calcium absorption, ensuring both vitamins work effectively. If my review is helpful, please click "Yes".

The therapeutic effect of GAS6 in remyelination is dependent upon Tyro3.

Most Relevant Research

We investigated the role of GAS6 in promoting remyelination, particularly in relation to vitamin K's effect on a type of receptor.

Our findings highlight that GAS6 needs to be modified through vitamin K for proper function.

When introduced to wild-type mice, this treatment significantly increased the number of myelinated axons compared to a control group.

However, in mice lacking the specific Tyro3 receptor, no significant improvement was noted. This indicates that Tyro3 is crucial for the effectiveness of GAS6 in aiding recovery for conditions like multiple sclerosis.

9.5

Essential for calcium absorption

Most Useful Review

The best vitamin K2, necessary for absorbing calcium and D3, especially after fractures. Without K2, calcium may not be utilized properly and can calcify the nerves, including the optic nerves, which is dangerous. It’s vital to protect the body and direct calcium and D3 appropriately.

Bone Pain details

Directs calcium effectively

Most Useful Review

If consuming over 4000 IU of vitamin D3, it’s crucial to take it alongside K2. While vitamin D helps absorb calcium, K2 directs this calcium to where it’s needed in the skeleton, preventing deposits in organs and arteries. Most arterial plaque comprises calcium, and K2 activates osteocalcin for calcium binding in bone. This vitamin is essential for effective calcium management.

Kidney Stones details

Vitamin K1 may reduce kidney stones

Vitamin K1 Inhibition of Renal Crystal Formation through Matrix Gla Protein in the Kidney.

Most Relevant Research

We explored the effect of vitamin K1 (VK1) on kidney stone formation by treating rats for eight weeks. Our observations showed that VK1 significantly reduced crystal formation in the kidneys.

It boosted levels of matrix Gla protein, which plays a crucial role in preventing crystal deposition. We noticed that VK1 even countered the negative effects of warfarin on cell viability. Overall, our findings suggest that VK1 could be a promising treatment to help prevent kidney stones.

9.5

Avoiding stone formation

Most Useful Review

I consistently take this alongside D3 at high doses to prevent the formation of kidney stones and gallbladder stones.

Sleep Apnea details

Normal sleep restored

Most Useful Review

Best manufacturer. Excellent vitamins; my sleep has returned to normal, and I now have a reserve of energy. In Russia, we lack vitamin D, so it can be beneficial even in summer. I was pleased with the results, especially after trying another company that offered no improvement. A nice bonus is that the packaging is in dark glass. There is no unpleasant smell, and they are easy to consume. I recommend buying them. The only drawback is the price, which may not suit everyone; however, considering the costs at our pharmacies, they are worth it! This is the best manufacturer.

Cancer details

SCIENTIFIC SCORE

Possibly Effective

Based on 11 Researches

Vitamin K2 inhibits cancer cell growth

Vitamin K2 Inhibits Hepatocellular Carcinoma Cell Proliferation by Binding to 17β-Hydroxysteroid Dehydrogenase 4.

Most Relevant Research

We investigated how vitamin K2 (VK2) influences the growth of cancer cells, particularly focusing on hepatocellular carcinoma (HCC). Our study centered on the interaction between VK2 and a protein known as HSD17B4, which is known to promote cancer cell proliferation. Previous research had shown that VK2 can bind to this protein, but we aimed to uncover the specific mechanisms behind its potential anti-cancer effects.

Through our experiments, we observed that VK2 can inhibit the growth of HCC cells by binding directly to HSD17B4. Interestingly, VK2 did not alter the expression levels of HSD17B4, which suggests that its impact on cell growth is due to other mechanisms. Specifically, we found that VK2 impedes the activation of important signaling pathways, including AKT and MEK/ERK, which play a critical role in cancer cell proliferation. As a result, this inhibition leads to decreased activity of another protein, STAT3, associated with cancer growth.

Moreover, VK2 demonstrated the ability to suppress the growth of transplanted tumors that were influenced by HSD17B4. These findings not only shed light on VK2's mechanism of action, but they also offer promising insights into its potential role in preventing or treating HCC in future applications.

8.8

Night sweats relief

Most Useful Review

A great solution for toothache and night sweats. I used Solgar K2 for a few weeks, and it stopped my night sweats and alleviated toothache. I feared I required a root canal, but the K2 eliminated the swelling and pain. Now I sleep comfortably without night sweats, and I no longer wake up agonised by pain. This has truly changed my life.

High Cholesterol details

SCIENTIFIC SCORE

Questionable

Based on 3 Researches

Vitamin K2 reduces cholesterol, atherosclerosis

Effects of vitamin K2 (menatetrenone) on atherosclerosis and blood coagulation in hypercholesterolemic rabbits.

Most Relevant Research

We explored whether vitamin K2, a form of vitamin K, could help in managing high cholesterol and atherosclerosis in rabbits with elevated cholesterol levels.

Over a span of ten weeks, we administered different doses of vitamin K2 to rabbits fed a cholesterol-rich diet.

The findings were encouraging; the vitamin K2-treated rabbits had significantly lower cholesterol levels compared to a control group.

Additionally, it seems that vitamin K2 at moderate doses helped slow down the development of atherosclerosis without any adverse effects on blood coagulation.

9.5

Effective calcium redistribution

Most Useful Review

I would classify this vitamin as "Smart". It is secretive yet long-lasting. It handles the task of redistributing calcium in the body, as I learned from my therapist. K2 removes calcium from areas where it shouldn't be, like in blood vessel walls, and directs it to where it's needed—teeth and bones. Taking pure calcium without K2 increases the risk of calcification of blood vessels. I am delighted that there is such a vitamin, and Solgar provides it in the concentration I require.

Blood Clot details

SCIENTIFIC SCORE

Possibly Effective

Based on 16 Researches

VKAs may aid blood clot resolution

Long-term left ventricular thrombosis resolution in patients receiving vitamin k antagonists: a multicenter observational study.

Most Relevant Research

We evaluated the effectiveness of vitamin K antagonists (VKAs) in treating left ventricular thrombosis (LVT). Over a year, a cohort of 90 patients was observed for LVT resolution and complications.

By the end of the study, approximately 70% of participants saw their blood clots resolve, with lower success rates linked to factors like reduced heart function. While VKAs showed promise, the treatment's safety profile was also notable, with few severe complications reported.

9.5

Reduces heavy bleeding

Most Useful Review

Fine! This is my favourite jar. I take it along with a large dosage of Vit. D (over 5000 units). A pleasant bonus - it thickens the blood and stops heavy periods, so caution is advised for those with thick blood.

Chronic Fatigue Syndrome details

I discovered that vitamin D is well absorbed alongside vitamin K2. Perhaps just a coincidence, but my hair loss ceased and my fatigue has diminished.

Heart Disease details

SCIENTIFIC SCORE

Questionable

Based on 6 Researches

Vitamin K1 reduces coronary calcifications

Effect of vitamin K1 supplementation on coronary calcifications in hemodialysis patients: a randomized controlled trial.

Most Relevant Research

We aimed to determine how vitamin K1 affects coronary artery calcifications in patients undergoing hemodialysis. In our study with 60 participants, we compared the effects of intravenous vitamin K1 against a placebo over 12 months.

The results showed that vitamin K1 significantly slowed the progression of coronary artery calcifications by 55%, compared to the placebo group. This finding suggests vitamin K1 may offer an important benefit in managing heart health for those with chronic kidney disease.

8.8

Protects against health risks

Most Useful Review

Vitamin K2 plays a crucial role in regulating calcium in the body, directing it to bones and teeth while preventing accumulation in arteries and soft tissues, thus protecting the heart. It is also essential for blood clotting and may help fight rheumatoid arthritis, supporting overall health, which I find particularly significant.

Cardiovascular Disease details

SCIENTIFIC SCORE

Possibly Effective

Based on 5 Researches

Vitamin K assists in thrombosis resolution

Long-term left ventricular thrombosis resolution in patients receiving vitamin k antagonists: a multicenter observational study.

Most Relevant Research

We examined the effectiveness and safety of vitamin K antagonists (VKAs) in resolving left ventricular thrombosis in a group of 90 patients over 12 months.

While we found that 70% experienced resolution of the thrombosis by the end of the study, the presence of low left ventricular ejection fraction and aneurysms negatively impacted outcomes.

Overall, the rate of complications, including strokes and major bleeding, remained low during the treatment period, indicating that VKAs can be a viable option, though some patients may face challenges in resolution.

8.3

Trustworthy for treatment

Most Useful Review

Solgar is my favourite and trusted producer, whom I rely on entirely. Their products actively help with cardiovascular disease, ensuring I maintain my health effectively.