We explored how vitamin A affects our body’s response to cold, specifically looking at its role in transforming white fat into brown fat, a process known as browning. This transformation is significant, as it can help reduce obesity and improve metabolic health.
In our investigation, we conducted cold exposure studies involving both mice and humans. We observed that exposure to cold led to an increase in circulating vitamin A, also known as retinol, and its transporter protein, Rbp. However, in mice lacking this protein, we found that their ability to adapt to the cold and promote thermogenesis—essentially, generating heat through fat—was severely compromised.
Interestingly, we also noted that stimulating human fat cells with retinol heightened the expression of genes associated with thermogenesis and boosted mitochondrial activity, which is vital for burning fat. In humans, the rise in vitamin A during cold exposure hinted at improved fat utilization.
Overall, our findings revealed that not only are vitamin A levels responsive to cold, but effective transportation of this vitamin is crucial for cold-induced fat browning and the body's ability to generate heat.
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Most Useful Reviews
9
Essential during colds
Excellent Vitamin A is vital for our bodies, particularly during the cold season. At the first sign of illness, I consume it and even give it to my children, making recovery much easier and quicker!
Read More
7
Supports skin health
Very useful for skin health! I took this beta-carotene alongside other supplements to support immunity and skin health, noticing improved skin and energy. It’s easily absorbed and has no side effects, especially beneficial during the cold season.
We explored how vitamin A affects our body’s response to cold, specifically looking at its role in transforming white fat into brown fat, a process known as browning. This transformation is significant, as it can help reduce obesity and improve metabolic health.
In our investigation, we conducted cold exposure studies involving both mice and humans. We observed that exposure to cold led to an increase in circulating vitamin A, also known as retinol, and its transporter protein, Rbp. However, in mice lacking this protein, we found that their ability to adapt to the cold and promote thermogenesis—essentially, generating heat through fat—was severely compromised.
Interestingly, we also noted that stimulating human fat cells with retinol heightened the expression of genes associated with thermogenesis and boosted mitochondrial activity, which is vital for burning fat. In humans, the rise in vitamin A during cold exposure hinted at improved fat utilization.
Overall, our findings revealed that not only are vitamin A levels responsive to cold, but effective transportation of this vitamin is crucial for cold-induced fat browning and the body's ability to generate heat.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.4
All Reviews
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Negative Reviews
9
Essential during colds
Excellent Vitamin A is vital for our bodies, particularly during the cold season. At the first sign of illness, I consume it and even give it to my children, making recovery much easier and quicker!
Read More
7
Supports skin health
Very useful for skin health! I took this beta-carotene alongside other supplements to support immunity and skin health, noticing improved skin and energy. It’s easily absorbed and has no side effects, especially beneficial during the cold season.
Read More
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References
Fenzl A, Kulterer OC, Spirk K, Mitulović G, Marculescu R, et al. Intact vitamin A transport is critical for cold-mediated adipose tissue browning and thermogenesis. Mol Metab. 2020;42:101088. 10.1016/j.molmet.2020.101088