' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 9 Researches
8.4
USERS' SCORE
Excellent
Based on 1 Reviews
10
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
5
Vitamin A (100% as natural beta-carotene from D. salina algae)
7,500 mcg
833%
Carotenoid Blend (from D. salina)(providing natural carotenoids: alpha-carotene, cryptoxanthin, zeaxanthin, lutein)
816 mcg
**
Top Medical Research Studies
9.5
Alitretinoin improves eczema treatment
The Endogenous Dual Retinoid Receptor Agonist Alitretinoin Exhibits Immunoregulatory Functions on Antigen-Presenting Cells.
Effectively addresses chronic eczema
We explored the effects of alitretinoin, a form of vitamin A, on chronic hand eczema (CHE). This powerful drug is known to target specific receptors in the skin, offering insights into its method of action. Through our detailed study, we examined skin samples from patients who responded well to alitretinoin treatment.
Our analysis revealed a total of 231 genes that were markedly regulated. We found that alitretinoin primarily impacts keratinocytes, the skin's primary cells, by addressing inflammation and enhancing skin barrier function. This treatment improved the expression of certain protective proteins while fostering the production of hyaluronic acid, a substance that helps hydrate and soothe the skin.
Furthermore, we observed that alitretinoin also affects immune cells, particularly dendritic cells, which play a vital role in our immune response. These cells, when treated with alitretinoin, displayed unique alterations in their appearance and function. They had lower levels of specific markers that typically spur an immune response and stimulated the production of IL-10, a cytokine that promotes immune tolerance. Most impressively, these treated cells were less effective at activating T cells, which are crucial for initiating inflammation.
Our findings indicate that alitretinoin not only treats the visible symptoms of eczema but also helps regulate the immune response, providing a dual approach in the management of chronic hand eczema. Ultimately, these insights show that vitamin A treatment holds significant promise for improving outcomes in eczema patients.
Our analysis revealed a total of 231 genes that were markedly regulated. We found that alitretinoin primarily impacts keratinocytes, the skin's primary cells, by addressing inflammation and enhancing skin barrier function. This treatment improved the expression of certain protective proteins while fostering the production of hyaluronic acid, a substance that helps hydrate and soothe the skin.
Furthermore, we observed that alitretinoin also affects immune cells, particularly dendritic cells, which play a vital role in our immune response. These cells, when treated with alitretinoin, displayed unique alterations in their appearance and function. They had lower levels of specific markers that typically spur an immune response and stimulated the production of IL-10, a cytokine that promotes immune tolerance. Most impressively, these treated cells were less effective at activating T cells, which are crucial for initiating inflammation.
Our findings indicate that alitretinoin not only treats the visible symptoms of eczema but also helps regulate the immune response, providing a dual approach in the management of chronic hand eczema. Ultimately, these insights show that vitamin A treatment holds significant promise for improving outcomes in eczema patients.
Read More
9
Alitretinoin treatment effectiveness assessed
Alitretinoin: A Review in Severe Chronic Hand Eczema.
Direct focus on alitretinoin usage
We examined the effectiveness of alitretinoin, a vitamin A derivative, for treating severe chronic hand eczema—especially for those who haven't found relief with strong topical steroids. In clinical trials, participants took alitretinoin daily for up to 24 weeks, and results showed a notable improvement in eczema severity and extent.
Many patients reported their hands becoming 'clear' or 'almost clear,' significantly more than those using a placebo. This exciting finding was consistent in real-world studies as well. Alitretinoin generally proved to be well tolerated, with most side effects being mild, manageable, and reversible.
Overall, we see that alitretinoin stands out as a valuable option for patients struggling with chronic hand eczema that doesn't respond to traditional treatments. It gives hope to individuals who have endured pain and discomfort due to this challenging condition.
Many patients reported their hands becoming 'clear' or 'almost clear,' significantly more than those using a placebo. This exciting finding was consistent in real-world studies as well. Alitretinoin generally proved to be well tolerated, with most side effects being mild, manageable, and reversible.
Overall, we see that alitretinoin stands out as a valuable option for patients struggling with chronic hand eczema that doesn't respond to traditional treatments. It gives hope to individuals who have endured pain and discomfort due to this challenging condition.
Read More
9
Alitretinoin improves chronic hand eczema
Alitretinoin for the treatment of severe chronic eczema of the hands.
Effective vitamin A treatment insight
We explored the therapeutic potential of alitretinoin, a form of vitamin A, for treating severe chronic hand eczema (CHE). This condition is quite prevalent, impacting up to 10% of people, and it can significantly affect their quality of life.
Alitretinoin is the first systemic treatment approved in the European Union for cases of CHE that haven't responded to conventional topical therapies. Our review highlighted various aspects, including how the drug works in the body, its effectiveness, and safety profile.
Patients who participated in clinical trials reported both objective and subjective improvements in their symptoms, along with a notable enhancement in their quality of life. However, we must exercise caution with patients who have pre-existing health issues or women who could become pregnant.
Overall, the findings suggest that alitretinoin could be a valid treatment option for those struggling with severe CHE.
Alitretinoin is the first systemic treatment approved in the European Union for cases of CHE that haven't responded to conventional topical therapies. Our review highlighted various aspects, including how the drug works in the body, its effectiveness, and safety profile.
Patients who participated in clinical trials reported both objective and subjective improvements in their symptoms, along with a notable enhancement in their quality of life. However, we must exercise caution with patients who have pre-existing health issues or women who could become pregnant.
Overall, the findings suggest that alitretinoin could be a valid treatment option for those struggling with severe CHE.
Read More
Most Useful Reviews
10
Eczema improvement
I have eczema and seborrheic dermatitis, and I read that vitamin A might help. After just a few days of taking it, my eczema is 90% cleared up, and it’s no longer itchy. My scalp feels less irritated, and my eyes are much more comfortable. My rosacea on my cheeks has calmed down significantly, and the keratosis bumps I've had since childhood are gone! My skin feels much better and less dry. It has made a tremendous difference in under a week, and the pill is tiny and easy to swallow.
Read More
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9.5
Alitretinoin improves eczema treatment
The Endogenous Dual Retinoid Receptor Agonist Alitretinoin Exhibits Immunoregulatory Functions on Antigen-Presenting Cells.
Effectively addresses chronic eczema
We explored the effects of alitretinoin, a form of vitamin A, on chronic hand eczema (CHE). This powerful drug is known to target specific receptors in the skin, offering insights into its method of action. Through our detailed study, we examined skin samples from patients who responded well to alitretinoin treatment.
Our analysis revealed a total of 231 genes that were markedly regulated. We found that alitretinoin primarily impacts keratinocytes, the skin's primary cells, by addressing inflammation and enhancing skin barrier function. This treatment improved the expression of certain protective proteins while fostering the production of hyaluronic acid, a substance that helps hydrate and soothe the skin.
Furthermore, we observed that alitretinoin also affects immune cells, particularly dendritic cells, which play a vital role in our immune response. These cells, when treated with alitretinoin, displayed unique alterations in their appearance and function. They had lower levels of specific markers that typically spur an immune response and stimulated the production of IL-10, a cytokine that promotes immune tolerance. Most impressively, these treated cells were less effective at activating T cells, which are crucial for initiating inflammation.
Our findings indicate that alitretinoin not only treats the visible symptoms of eczema but also helps regulate the immune response, providing a dual approach in the management of chronic hand eczema. Ultimately, these insights show that vitamin A treatment holds significant promise for improving outcomes in eczema patients.
Our analysis revealed a total of 231 genes that were markedly regulated. We found that alitretinoin primarily impacts keratinocytes, the skin's primary cells, by addressing inflammation and enhancing skin barrier function. This treatment improved the expression of certain protective proteins while fostering the production of hyaluronic acid, a substance that helps hydrate and soothe the skin.
Furthermore, we observed that alitretinoin also affects immune cells, particularly dendritic cells, which play a vital role in our immune response. These cells, when treated with alitretinoin, displayed unique alterations in their appearance and function. They had lower levels of specific markers that typically spur an immune response and stimulated the production of IL-10, a cytokine that promotes immune tolerance. Most impressively, these treated cells were less effective at activating T cells, which are crucial for initiating inflammation.
Our findings indicate that alitretinoin not only treats the visible symptoms of eczema but also helps regulate the immune response, providing a dual approach in the management of chronic hand eczema. Ultimately, these insights show that vitamin A treatment holds significant promise for improving outcomes in eczema patients.
Read More
9
Alitretinoin improves chronic hand eczema
Alitretinoin for the treatment of severe chronic eczema of the hands.
Effective vitamin A treatment insight
We explored the therapeutic potential of alitretinoin, a form of vitamin A, for treating severe chronic hand eczema (CHE). This condition is quite prevalent, impacting up to 10% of people, and it can significantly affect their quality of life.
Alitretinoin is the first systemic treatment approved in the European Union for cases of CHE that haven't responded to conventional topical therapies. Our review highlighted various aspects, including how the drug works in the body, its effectiveness, and safety profile.
Patients who participated in clinical trials reported both objective and subjective improvements in their symptoms, along with a notable enhancement in their quality of life. However, we must exercise caution with patients who have pre-existing health issues or women who could become pregnant.
Overall, the findings suggest that alitretinoin could be a valid treatment option for those struggling with severe CHE.
Alitretinoin is the first systemic treatment approved in the European Union for cases of CHE that haven't responded to conventional topical therapies. Our review highlighted various aspects, including how the drug works in the body, its effectiveness, and safety profile.
Patients who participated in clinical trials reported both objective and subjective improvements in their symptoms, along with a notable enhancement in their quality of life. However, we must exercise caution with patients who have pre-existing health issues or women who could become pregnant.
Overall, the findings suggest that alitretinoin could be a valid treatment option for those struggling with severe CHE.
Read More
9
Alitretinoin improves hand eczema
Effectiveness of alitretinoin in severe chronic hand eczema: PASSION, a real-world observational study.
Effective treatment for eczema
We explored the effectiveness of oral alitretinoin, a vitamin A derivative, for treating severe chronic hand eczema (CHE). With 631 patients participating in this observational study, we administered treatment for up to 24 weeks while monitoring outcomes in real-world conditions.
Our findings were encouraging; by the end of the study, nearly 30% of participants reported significant improvements in their conditions. Utilizing assessments such as the Physician Global Assessment and the EQ-5D quality of life questionnaire, we noted a clear enhancement in patients' overall well-being and work productivity. Notably, quality of life scores increased dramatically from baseline levels, indicating relief for many who suffer from this difficult skin condition.
Moreover, workplace impairment substantially reduced over the course of the study, suggesting that alitretinoin helps not only with the physical symptoms but also allows individuals to return to their daily activities more effectively. Although some patients reported adverse effects, these were generally manageable, and no new safety concerns arose throughout the study.
In summary, we observed that alitretinoin offers significant improvements for those grappling with severe CHE, enhancing both quality of life and ability to work.
Our findings were encouraging; by the end of the study, nearly 30% of participants reported significant improvements in their conditions. Utilizing assessments such as the Physician Global Assessment and the EQ-5D quality of life questionnaire, we noted a clear enhancement in patients' overall well-being and work productivity. Notably, quality of life scores increased dramatically from baseline levels, indicating relief for many who suffer from this difficult skin condition.
Moreover, workplace impairment substantially reduced over the course of the study, suggesting that alitretinoin helps not only with the physical symptoms but also allows individuals to return to their daily activities more effectively. Although some patients reported adverse effects, these were generally manageable, and no new safety concerns arose throughout the study.
In summary, we observed that alitretinoin offers significant improvements for those grappling with severe CHE, enhancing both quality of life and ability to work.
Read More
9
Alitretinoin treatment effectiveness assessed
Alitretinoin: A Review in Severe Chronic Hand Eczema.
Direct focus on alitretinoin usage
We examined the effectiveness of alitretinoin, a vitamin A derivative, for treating severe chronic hand eczema—especially for those who haven't found relief with strong topical steroids. In clinical trials, participants took alitretinoin daily for up to 24 weeks, and results showed a notable improvement in eczema severity and extent.
Many patients reported their hands becoming 'clear' or 'almost clear,' significantly more than those using a placebo. This exciting finding was consistent in real-world studies as well. Alitretinoin generally proved to be well tolerated, with most side effects being mild, manageable, and reversible.
Overall, we see that alitretinoin stands out as a valuable option for patients struggling with chronic hand eczema that doesn't respond to traditional treatments. It gives hope to individuals who have endured pain and discomfort due to this challenging condition.
Many patients reported their hands becoming 'clear' or 'almost clear,' significantly more than those using a placebo. This exciting finding was consistent in real-world studies as well. Alitretinoin generally proved to be well tolerated, with most side effects being mild, manageable, and reversible.
Overall, we see that alitretinoin stands out as a valuable option for patients struggling with chronic hand eczema that doesn't respond to traditional treatments. It gives hope to individuals who have endured pain and discomfort due to this challenging condition.
Read More
8
Vitamin A levels, eczema correlation
Changes and clinical significance of serum vitamin A, 25-(OH)D3, TG2, IL-4 and IL-13 levels in children with eczema.
Low treatment effect isolated
We wanted to understand how vitamin A levels impact the severity of eczema in children. In our research, we analyzed clinical data from 159 children diagnosed with eczema, grouping them based on the severity of their condition—mild, moderate, and severe.
Throughout the study, we made some interesting observations. It became clear that as the severity of eczema increased, the levels of vitamin A declined significantly. We also noted a similar trend with vitamin D levels. Meanwhile, certain inflammatory markers such as TG2, IL-4, and IL-13 rose in correlation with worse symptoms.
This relationship was highlighted by our findings indicating a negative correlation between vitamin A and vitamin D levels and the severity of eczema, measured through SCORAD scores. This means as vitamin A levels dropped, the severity of eczema worsened, while increased inflammatory markers suggested intensifying symptoms.
After three months of treatment, all serum levels, including that of vitamin A, improved significantly across all groups. However, while vitamin A appears to be associated with the severity of eczema, we cannot conclude that vitamin A treatment alone effectively alleviates eczema symptoms, as no specific treatment effects were isolated during our analysis.
Overall, we believe that keeping an eye on vitamin A levels, along with these other markers, can give us valuable insights into eczema severity and treatment responses in children.
Throughout the study, we made some interesting observations. It became clear that as the severity of eczema increased, the levels of vitamin A declined significantly. We also noted a similar trend with vitamin D levels. Meanwhile, certain inflammatory markers such as TG2, IL-4, and IL-13 rose in correlation with worse symptoms.
This relationship was highlighted by our findings indicating a negative correlation between vitamin A and vitamin D levels and the severity of eczema, measured through SCORAD scores. This means as vitamin A levels dropped, the severity of eczema worsened, while increased inflammatory markers suggested intensifying symptoms.
After three months of treatment, all serum levels, including that of vitamin A, improved significantly across all groups. However, while vitamin A appears to be associated with the severity of eczema, we cannot conclude that vitamin A treatment alone effectively alleviates eczema symptoms, as no specific treatment effects were isolated during our analysis.
Overall, we believe that keeping an eye on vitamin A levels, along with these other markers, can give us valuable insights into eczema severity and treatment responses in children.
Read More
User Reviews
USERS' SCORE
Excellent
Based on 1 Reviews
10
10
Eczema improvement
I have eczema and seborrheic dermatitis, and I read that vitamin A might help. After just a few days of taking it, my eczema is 90% cleared up, and it’s no longer itchy. My scalp feels less irritated, and my eyes are much more comfortable. My rosacea on my cheeks has calmed down significantly, and the keratosis bumps I've had since childhood are gone! My skin feels much better and less dry. It has made a tremendous difference in under a week, and the pill is tiny and easy to swallow.
Read More
