Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.4
USERS' SCORE
Good
Based on 11 Reviews
8.3
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Cholesterol
5 mg
2%
Total Omega 3 Polyunsaturates† providing: EPA (eicosapentaenoic acid) DHA (docosahexaenoic acid)
950 mg 504 mg378 mg
*** *** ***
Top Medical Research Studies
8
We analyzed various trials to see how omega-3 fish oil affects rheumatoid arthritis (RA). Our research included 18 randomized controlled studies with 1,018 RA patients. The results showed omega-3 supplementation significantly increased beneficial omega-3 fatty acids, like EPA and DHA, and reduced triglycerides and tender joint count.
However, it didn't lead to significant changes in some inflammation markers and overall disease activity. While there are positive outcomes regarding certain symptoms, we found no remarkable evidence for its effectiveness in reducing inflammation levels.
However, it didn't lead to significant changes in some inflammation markers and overall disease activity. While there are positive outcomes regarding certain symptoms, we found no remarkable evidence for its effectiveness in reducing inflammation levels.
Read More
9
We investigated how docosahexaenoic acid (DHA) impacts osteoarthritis (OA), which is a common joint disease in older adults. Using both human and rat models, we found that DHA can enhance chondrocyte (cartilage cells) growth while reducing cell death.
Moreover, DHA treatment thickened cartilage and lowered degeneration compared to untreated OA models. Additionally, it improved the overall health of chondrocytes by promoting autophagy, which helps recycle damaged cellular components. Our findings suggest that DHA could be a promising therapy for OA treatment.
Moreover, DHA treatment thickened cartilage and lowered degeneration compared to untreated OA models. Additionally, it improved the overall health of chondrocytes by promoting autophagy, which helps recycle damaged cellular components. Our findings suggest that DHA could be a promising therapy for OA treatment.
Read More
8
We conducted a study to understand how various dietary factors, including oily fish, affect rheumatoid arthritis (RA). Through advanced genetic analysis, we found that higher consumption of certain foods, particularly oily fish, appears to lower the risk of developing RA. This suggests that incorporating more oily fish and cereal into our diets could be beneficial for those at risk or living with RA. However, other dietary factors did not show significant links to RA risk.
Read More
Most Useful Reviews
9
Joint pain relief
119 people found this helpful
I buy this Omega-3 for my mother, who suffers from arthritis. Since she began taking it in winter, her joint and muscle pain has significantly improved.
Read More
9
Supports joint health
89 people found this helpful
Omega-3s aid in supporting joint health and alleviating arthritis symptoms, which is crucial for me. They relieve inflammation and help preventosteoporosis.
Read More
9
Arthritis management
9 people found this helpful
I take this Omega-3 for my mother, who has arthritis. Since she started using it this winter, her joint pain has subsided.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.4
- All Researches
9
We investigated how docosahexaenoic acid (DHA) impacts osteoarthritis (OA), which is a common joint disease in older adults. Using both human and rat models, we found that DHA can enhance chondrocyte (cartilage cells) growth while reducing cell death.
Moreover, DHA treatment thickened cartilage and lowered degeneration compared to untreated OA models. Additionally, it improved the overall health of chondrocytes by promoting autophagy, which helps recycle damaged cellular components. Our findings suggest that DHA could be a promising therapy for OA treatment.
Moreover, DHA treatment thickened cartilage and lowered degeneration compared to untreated OA models. Additionally, it improved the overall health of chondrocytes by promoting autophagy, which helps recycle damaged cellular components. Our findings suggest that DHA could be a promising therapy for OA treatment.
Read More
8
We explored whether omega-3 fatty acids could help slow down osteoarthritis (OA) by changing how chondrocytes, the cells in our cartilage, respond to mechanical forces.
Our findings indicated that omega-3s significantly reduced chondrocyte sensitivity to compression and certain chemical signals linked to OA progression.
Interestingly, we also discovered that another type of fatty acid, omega-6, may actually make chondrocyte membranes more prone to damage.
This research showcases the importance of specific fatty acids in managing joint health and offers new ideas for nutritional strategies to combat OA.
Our findings indicated that omega-3s significantly reduced chondrocyte sensitivity to compression and certain chemical signals linked to OA progression.
Interestingly, we also discovered that another type of fatty acid, omega-6, may actually make chondrocyte membranes more prone to damage.
This research showcases the importance of specific fatty acids in managing joint health and offers new ideas for nutritional strategies to combat OA.
Read More
8
We conducted a study to understand how various dietary factors, including oily fish, affect rheumatoid arthritis (RA). Through advanced genetic analysis, we found that higher consumption of certain foods, particularly oily fish, appears to lower the risk of developing RA. This suggests that incorporating more oily fish and cereal into our diets could be beneficial for those at risk or living with RA. However, other dietary factors did not show significant links to RA risk.
Read More
8
We analyzed various trials to see how omega-3 fish oil affects rheumatoid arthritis (RA). Our research included 18 randomized controlled studies with 1,018 RA patients. The results showed omega-3 supplementation significantly increased beneficial omega-3 fatty acids, like EPA and DHA, and reduced triglycerides and tender joint count.
However, it didn't lead to significant changes in some inflammation markers and overall disease activity. While there are positive outcomes regarding certain symptoms, we found no remarkable evidence for its effectiveness in reducing inflammation levels.
However, it didn't lead to significant changes in some inflammation markers and overall disease activity. While there are positive outcomes regarding certain symptoms, we found no remarkable evidence for its effectiveness in reducing inflammation levels.
Read More
8
We investigated the effectiveness of a smart cage system for measuring locomotor activity in mice with inflammatory arthritis. The study induced arthritis and tracked changes over time, focusing on mice fed diets with or without fish oil.
Our findings revealed that despite traditional measurements like clinical index and ankle thickness not showing significant differences based on diet, mice given fish oil demonstrated notably increased locomotor activity. This suggests that omega-3 fish oil may enhance mobility during arthritis, highlighting the potential of smart cages for assessing disease impacts more comprehensively.
Our findings revealed that despite traditional measurements like clinical index and ankle thickness not showing significant differences based on diet, mice given fish oil demonstrated notably increased locomotor activity. This suggests that omega-3 fish oil may enhance mobility during arthritis, highlighting the potential of smart cages for assessing disease impacts more comprehensively.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Joint pain relief
119 people found this helpful
I buy this Omega-3 for my mother, who suffers from arthritis. Since she began taking it in winter, her joint and muscle pain has significantly improved.
Read More
9
Supports joint health
89 people found this helpful
Omega-3s aid in supporting joint health and alleviating arthritis symptoms, which is crucial for me. They relieve inflammation and help preventosteoporosis.
Read More
9
Arthritis management
9 people found this helpful
I take this Omega-3 for my mother, who has arthritis. Since she started using it this winter, her joint pain has subsided.
Read More
9
Improved joint function
8 people found this helpful
This Omega-3 is essential for heart health and joint support. I've noticed significant improvements in my arthritis symptoms, and after a month of use, my joints feel much better.
Read More
9
Prescription success
1 people found this helpful
My rheumatologist first prescribed this Omega-3 for my rheumatoid arthritis. After consistent use, my vitamin D levels improved significantly, and it positively impacted my arthritis. I recommend this brand.
Read More
Frequently Asked Questions
9
Improved joint function
8 people found this helpful
This Omega-3 is essential for heart health and joint support. I've noticed significant improvements in my arthritis symptoms, and after a month of use, my joints feel much better.
9
Joint pain relief
119 people found this helpful
I buy this Omega-3 for my mother, who suffers from arthritis. Since she began taking it in winter, her joint and muscle pain has significantly improved.
9
Arthritis management
9 people found this helpful
I take this Omega-3 for my mother, who has arthritis. Since she started using it this winter, her joint pain has subsided.
9
Prescription success
1 people found this helpful
My rheumatologist first prescribed this Omega-3 for my rheumatoid arthritis. After consistent use, my vitamin D levels improved significantly, and it positively impacted my arthritis. I recommend this brand.
9
Supports joint health
89 people found this helpful
Omega-3s aid in supporting joint health and alleviating arthritis symptoms, which is crucial for me. They relieve inflammation and help preventosteoporosis.
9
Joint pain relief
Omega-3s are excellent for managing arthritis and reducing joint pain. They help prevent osteoporosis and alleviate inflammation effectively.
8
Effective for arthritis
2 people found this helpful
Fish oil is crucial for preventing cardiovascular diseases and has greatly improved my arthritis symptoms. The 950 mg dosage is convenient, and I find the quality of Solgar's product superb.
7
Reduced joint pain
174 people found this helpful
I regularly take this Omega-3, which has proven to be an excellent supplement. I've noticed my skin feels less dry, and the discomfort in my neck and headaches tied to vessel issues have decreased. The dosage and ratio of EPA and DHA are perfect, making it easy to manage my arthritis symptoms. I wholeheartedly recommend it!
8
We explored whether omega-3 fatty acids could help slow down osteoarthritis (OA) by changing how chondrocytes, the cells in our cartilage, respond to mechanical forces.
Our findings indicated that omega-3s significantly reduced chondrocyte sensitivity to compression and certain chemical signals linked to OA progression.
Interestingly, we also discovered that another type of fatty acid, omega-6, may actually make chondrocyte membranes more prone to damage.
This research showcases the importance of specific fatty acids in managing joint health and offers new ideas for nutritional strategies to combat OA.
Our findings indicated that omega-3s significantly reduced chondrocyte sensitivity to compression and certain chemical signals linked to OA progression.
Interestingly, we also discovered that another type of fatty acid, omega-6, may actually make chondrocyte membranes more prone to damage.
This research showcases the importance of specific fatty acids in managing joint health and offers new ideas for nutritional strategies to combat OA.
7
We investigated how a 12-week nutritional intervention affects cholesterol levels and lipoprotein subfractions in patients with psoriatic arthritis.
Participants were divided into three groups: one received a placebo, another had personalized dietary guidance with omega-3 supplementation, and the last followed an individualized diet with a placebo.
Results indicated that those on the omega-3 diet saw favorable changes in HDL subfractions and improvements in LDL patterns, which could help identify cardiovascular risks. However, the overall LDL levels did not significantly change for all participants.
Participants were divided into three groups: one received a placebo, another had personalized dietary guidance with omega-3 supplementation, and the last followed an individualized diet with a placebo.
Results indicated that those on the omega-3 diet saw favorable changes in HDL subfractions and improvements in LDL patterns, which could help identify cardiovascular risks. However, the overall LDL levels did not significantly change for all participants.
7
We investigated the link between omega-3 fatty acids and osteoarthritis using data from over 22,800 participants in the NHANES study between 2003 and 2016. The findings revealed that omega-3 intake was linked to lower rates of osteoarthritis in adults aged 40 to 59.
However, despite this association, our Mendelian randomization analysis did not establish a causal connection between omega-3 intake and osteoarthritis risk. This suggests that while omega-3s might correlate with better outcomes, they may not directly prevent or treat osteoarthritis.
However, despite this association, our Mendelian randomization analysis did not establish a causal connection between omega-3 intake and osteoarthritis risk. This suggests that while omega-3s might correlate with better outcomes, they may not directly prevent or treat osteoarthritis.
8
Omega-3s alleviate osteoarthritis progression
We explored how omega-3 polyunsaturated fatty acids (PUFAs) could ease the pain of obesity-related osteoarthritis (OA). In our study, we found that a diet rich in omega-3s helped reduce damage to cartilage in experimental mice.
It appears that these fatty acids decrease inflammation by impacting a specific signaling pathway involving HMGB1. This means that omega-3s might offer a new dietary approach for managing OA by protecting joint health.
It appears that these fatty acids decrease inflammation by impacting a specific signaling pathway involving HMGB1. This means that omega-3s might offer a new dietary approach for managing OA by protecting joint health.
We explored how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, could help in treating osteoarthritis (OA). Our research showed that DHA has strong anti-inflammatory and cartilage-protecting effects on OA cells and improves joint health in mice.
However, we found that a molecule called Malat1 dampens these beneficial effects. Despite this, DHA still showed promise as a potential treatment for OA patients with increased Malat1 levels, particularly in supporting cartilage regeneration.
However, we found that a molecule called Malat1 dampens these beneficial effects. Despite this, DHA still showed promise as a potential treatment for OA patients with increased Malat1 levels, particularly in supporting cartilage regeneration.
8
We conducted a study to understand how various dietary factors, including oily fish, affect rheumatoid arthritis (RA). Through advanced genetic analysis, we found that higher consumption of certain foods, particularly oily fish, appears to lower the risk of developing RA. This suggests that incorporating more oily fish and cereal into our diets could be beneficial for those at risk or living with RA. However, other dietary factors did not show significant links to RA risk.
7
We examined the relationship between omega-3 and omega-6 fatty acid intake and rheumatoid arthritis (RA) risk using a large dataset from the National Health and Nutrition Examination Survey.
Over 50,000 participants shared their dietary habits through 24-hour recall interviews, which helped us assess potential links to RA.
The findings revealed a noteworthy negative correlation, suggesting that higher intakes of both omega-3 and omega-6 fatty acids may reduce the risk of developing RA in adults in the US.
Over 50,000 participants shared their dietary habits through 24-hour recall interviews, which helped us assess potential links to RA.
The findings revealed a noteworthy negative correlation, suggesting that higher intakes of both omega-3 and omega-6 fatty acids may reduce the risk of developing RA in adults in the US.
4
Omega-3 has limited arthritis impact
We investigated the effects of omega-3 fatty acid supplements on rheumatoid arthritis using data from 23 randomized placebo-controlled trials. Our analysis showed only a small effect in reducing pain, joint tenderness, and swelling.
We observed that while there was a slight reduction in NSAID use, the overall benefit seemed limited. The findings also indicated very low to low quality evidence, suggesting that previous claims of significant benefits could be overstated due to issues with study design.
We observed that while there was a slight reduction in NSAID use, the overall benefit seemed limited. The findings also indicated very low to low quality evidence, suggesting that previous claims of significant benefits could be overstated due to issues with study design.
7
We investigated how over-the-counter fish oil supplements affect patients with and without rheumatoid arthritis (RA). By studying 104 participants, we discovered that those taking fish oil had higher levels of beneficial omega-3 fatty acids and their related mediators, regardless of their RA status.
This suggests that fish oil can enhance levels of important anti-inflammatory substances in the body, potentially benefiting individuals with chronic inflammation like RA. However, the exact impact on RA symptoms remains unclear and more research is needed to fully understand these effects.
This suggests that fish oil can enhance levels of important anti-inflammatory substances in the body, potentially benefiting individuals with chronic inflammation like RA. However, the exact impact on RA symptoms remains unclear and more research is needed to fully understand these effects.
References
- Marushack GK, Savadipour A, Tang R, Garcia-Castorena JM, Rashidi N, et al. Polyunsaturated fatty acids suppress PIEZO ion channel mechanotransduction in articular chondrocytes. FASEB J. 2025;39:e70290. 10.1096/fj.202400544RR
- Wang Y, Hu S, Zhang W, Zhang B, Yang Z. Dietary factors and rheumatoid arthritis: new perspectives from a Mendelian randomisation analysis. Br J Nutr. 2025;133:107. 10.1017/S0007114524002721
- Wang W, Xu Y, Zhou J, Zang Y. Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials. Clin Rheumatol. 2024;43:2479. 10.1007/s10067-024-07040-0
- Scherer D, Leite BF, Morimoto MA, Oliveira TL, Klemz BNC, et al. Nutritional effect on lipoproteins and their subfractions in patients with Psoriatic Arthritis: a 12-week randomized trial-the DIETA trial. Adv Rheumatol. 2024;64:47. 10.1186/s42358-024-00389-5
- Liu Y, Song F, Liu M, Huang X, Xue S, et al. Association between omega-3 polyunsaturated fatty acids and osteoarthritis: results from the NHANES 2003-2016 and Mendelian randomization study. Lipids Health Dis. 2024;23:147. 10.1186/s12944-024-02139-4
- Kang T, Xi Y, Qian T, Lu S, Du M, et al. Exploring the link between dietary omega-3 and omega-6 fatty acid intake and rheumatoid arthritis risk: NHANES 1999-2020 study. Clin Exp Rheumatol. 2024;42:1720. 10.55563/clinexprheumatol/91tmfb
- Laevski AM, Doucet MR, Doucet MS, LeBlanc AA, Pineau PE, et al. Dietary omega-3 fatty acids modulate the production of platelet-derived microvesicles in an in vivo inflammatory arthritis model. Eur J Nutr. 2024;63:2221. 10.1007/s00394-024-03397-9
- Doucet MR, Laevski AM, Doiron JA, Boudreau LH, Surette ME. Locomotor activity as an effective measure of the severity of inflammatory arthritis in a mouse model. PLoS One. 2024;19:e0291399. 10.1371/journal.pone.0291399
- Xiong T, Huang S, Wang X, Shi Y, He J, et al. n-3 polyunsaturated fatty acids alleviate the progression of obesity-related osteoarthritis and protect cartilage through inhibiting the HMGB1-RAGE/TLR4 signaling pathway. Int Immunopharmacol. 2024;128:111498. 10.1016/j.intimp.2024.111498
- Yu H, Gong Z, Wang G, Cao R, Yin H, et al. DHA attenuates cartilage degeneration by mediating apoptosis and autophagy in human chondrocytes and rat models of osteoarthritis. In Vitro Cell Dev Biol Anim. 2023;59:455. 10.1007/s11626-023-00781-3
- Léger T, Brun A, Lanchais K, Rigaudière JP, Briat A, et al. Docosahexaenoic acid and etanercept could reduce functional and metabolic alterations during collagen-induced arthritis in rats without any synergistic effect. Life Sci. 2023;327:121826. 10.1016/j.lfs.2023.121826
- Marchand NE, Choi MY, Oakes EG, Cook NR, Stevens E, et al. Over-the-counter fish oil supplementation and pro-resolving and pro-inflammatory lipid mediators in rheumatoid arthritis. Prostaglandins Leukot Essent Fatty Acids. 2023;190:102542. 10.1016/j.plefa.2023.102542
- Feng L, Yang Z, Li Y, Hou N, Yang B, et al. Malat1 attenuated the rescuing effects of docosahexaenoic acid on osteoarthritis treatment via repressing its chondroprotective and chondrogenesis activities. Biomed Pharmacother. 2022;154:113608. 10.1016/j.biopha.2022.113608
- Gkiouras K, Grammatikopoulou MG, Myrogiannis I, Papamitsou T, Rigopoulou EI, et al. Efficacy of n-3 fatty acid supplementation on rheumatoid arthritis' disease activity indicators: a systematic review and meta-analysis of randomized placebo-controlled trials. Crit Rev Food Sci Nutr. 2024;64:16. 10.1080/10408398.2022.2104210
- Sigaux J, Bellicha A, Buscail C, Julia C, Flipo RM, et al. Serum Fatty Acid Profiles Are Associated with Disease Activity in Early Rheumatoid Arthritis: Results from the ESPOIR Cohort. Nutrients. 2022;14. 10.3390/nu14142947
- Stonehouse W, Benassi-Evans B, Bednarz J, Vincent AD, Hall S, et al. Krill oil improved osteoarthritic knee pain in adults with mild to moderate knee osteoarthritis: a 6-month multicenter, randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2022;116:672. 10.1093/ajcn/nqac125
