5/26/2025
Last update
5/26/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 7 Reviews
8.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%
Top Medical Research Studies
8
We explored the effects of vitamin B6, specifically its active form called pyridoxal phosphate (PLP), on allergic responses. Our research focused on how this vitamin might influence interleukin-33 (IL-33), a key cytokine involved in type 2 inflammation, typically seen in asthma and other allergic conditions.
We found that healthy individuals had higher levels of PLP in their blood compared to asthma patients. Notably, lower PLP levels correlated with worse lung function and increased inflammation in those with asthma. In tests using mouse models of lung inflammation, we observed that PLP significantly reduced the type 2 immune response, suggesting a protective role against allergic reactions.
Delving deeper, we identified that the conversion of pyridoxal to PLP was critical for regulating IL-33 stability. Moreover, we found that a protein called MDM2 contributed to IL-33's stability by facilitating its degradation. Using PLP helped to decrease IL-33 levels in the lungs and enhance the regulation of this protein, providing a potential new avenue for allergy treatment.
Additionally, inhalation of PLP showed promise in mitigating asthma-related symptoms in mouse models. Overall, our findings indicate that vitamin B6 could serve as a beneficial strategy in managing type 2 inflammation and offer new hope for developing effective treatments for allergy-related diseases.
We found that healthy individuals had higher levels of PLP in their blood compared to asthma patients. Notably, lower PLP levels correlated with worse lung function and increased inflammation in those with asthma. In tests using mouse models of lung inflammation, we observed that PLP significantly reduced the type 2 immune response, suggesting a protective role against allergic reactions.
Delving deeper, we identified that the conversion of pyridoxal to PLP was critical for regulating IL-33 stability. Moreover, we found that a protein called MDM2 contributed to IL-33's stability by facilitating its degradation. Using PLP helped to decrease IL-33 levels in the lungs and enhance the regulation of this protein, providing a potential new avenue for allergy treatment.
Additionally, inhalation of PLP showed promise in mitigating asthma-related symptoms in mouse models. Overall, our findings indicate that vitamin B6 could serve as a beneficial strategy in managing type 2 inflammation and offer new hope for developing effective treatments for allergy-related diseases.
Read More
7
We dove deep into the question of whether vitamin B6 has any impact on allergic reactions associated with Dengzhan Xixin, a medication given through injections. Our analysis was based on a nested case-control study, leveraging data from 20 hospitals across China. The participants included patients who received dexamethasone due to suspected allergic reactions after being administered Dengzhan Xixin, allowing us to compare them with those who did not experience such reactions.
Surprisingly, our findings linked the use of vitamin B6 to heightened risks of allergic reactions when combined with Dengzhan Xixin. Specifically, when patients received vitamin B6 or ambroxol alongside the medication, the likelihood of experiencing an allergic reaction increased significantly. The data suggested that the condition upon admission was also an important factor associated with these reactions.
While this study sheds light on potential risk factors for allergic reactions, the relationship between vitamin B6 and these allergies doesn’t position it as a clear solution for managing allergy symptoms. Further exploration and research are needed to confirm these findings and understand them in greater depth. Ultimately, our work pushes forward the conversation about safety in clinical practices surrounding Dengzhan Xixin and its use in treatments.
Surprisingly, our findings linked the use of vitamin B6 to heightened risks of allergic reactions when combined with Dengzhan Xixin. Specifically, when patients received vitamin B6 or ambroxol alongside the medication, the likelihood of experiencing an allergic reaction increased significantly. The data suggested that the condition upon admission was also an important factor associated with these reactions.
While this study sheds light on potential risk factors for allergic reactions, the relationship between vitamin B6 and these allergies doesn’t position it as a clear solution for managing allergy symptoms. Further exploration and research are needed to confirm these findings and understand them in greater depth. Ultimately, our work pushes forward the conversation about safety in clinical practices surrounding Dengzhan Xixin and its use in treatments.
Read More
Most Useful Reviews
9
Trusted high quality
Bestseller! The Solgar brand needs no introduction—it's one of the finest supplements on iHerb. As someone with allergies, I can attest to its quality; I’ve never experienced negative reactions. This vitamin B6, at an optimal 25 mg dosage for adults, is highly effective for prevention. I usually take it separately, as I prefer controlling dosage. It's wise to take it with food, and it's best in the afternoon or at night. I highly recommend it due to its superior quality.
Read More
9
Child's allergies managed
We give this to our child for seasonal allergies. Everything suits me.
Read More
9
Moderate and effective
Good dosage. This B6 is the only moderate dosage available on the site. I take it in courses with magnesium for neurological needs. Vitamin B6 is vital for metabolism and heart health, so I chose this one and have no regrets. No allergies, no overdose.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
- All Researches
8
We explored the effects of vitamin B6, specifically its active form called pyridoxal phosphate (PLP), on allergic responses. Our research focused on how this vitamin might influence interleukin-33 (IL-33), a key cytokine involved in type 2 inflammation, typically seen in asthma and other allergic conditions.
We found that healthy individuals had higher levels of PLP in their blood compared to asthma patients. Notably, lower PLP levels correlated with worse lung function and increased inflammation in those with asthma. In tests using mouse models of lung inflammation, we observed that PLP significantly reduced the type 2 immune response, suggesting a protective role against allergic reactions.
Delving deeper, we identified that the conversion of pyridoxal to PLP was critical for regulating IL-33 stability. Moreover, we found that a protein called MDM2 contributed to IL-33's stability by facilitating its degradation. Using PLP helped to decrease IL-33 levels in the lungs and enhance the regulation of this protein, providing a potential new avenue for allergy treatment.
Additionally, inhalation of PLP showed promise in mitigating asthma-related symptoms in mouse models. Overall, our findings indicate that vitamin B6 could serve as a beneficial strategy in managing type 2 inflammation and offer new hope for developing effective treatments for allergy-related diseases.
We found that healthy individuals had higher levels of PLP in their blood compared to asthma patients. Notably, lower PLP levels correlated with worse lung function and increased inflammation in those with asthma. In tests using mouse models of lung inflammation, we observed that PLP significantly reduced the type 2 immune response, suggesting a protective role against allergic reactions.
Delving deeper, we identified that the conversion of pyridoxal to PLP was critical for regulating IL-33 stability. Moreover, we found that a protein called MDM2 contributed to IL-33's stability by facilitating its degradation. Using PLP helped to decrease IL-33 levels in the lungs and enhance the regulation of this protein, providing a potential new avenue for allergy treatment.
Additionally, inhalation of PLP showed promise in mitigating asthma-related symptoms in mouse models. Overall, our findings indicate that vitamin B6 could serve as a beneficial strategy in managing type 2 inflammation and offer new hope for developing effective treatments for allergy-related diseases.
Read More
7
We dove deep into the question of whether vitamin B6 has any impact on allergic reactions associated with Dengzhan Xixin, a medication given through injections. Our analysis was based on a nested case-control study, leveraging data from 20 hospitals across China. The participants included patients who received dexamethasone due to suspected allergic reactions after being administered Dengzhan Xixin, allowing us to compare them with those who did not experience such reactions.
Surprisingly, our findings linked the use of vitamin B6 to heightened risks of allergic reactions when combined with Dengzhan Xixin. Specifically, when patients received vitamin B6 or ambroxol alongside the medication, the likelihood of experiencing an allergic reaction increased significantly. The data suggested that the condition upon admission was also an important factor associated with these reactions.
While this study sheds light on potential risk factors for allergic reactions, the relationship between vitamin B6 and these allergies doesn’t position it as a clear solution for managing allergy symptoms. Further exploration and research are needed to confirm these findings and understand them in greater depth. Ultimately, our work pushes forward the conversation about safety in clinical practices surrounding Dengzhan Xixin and its use in treatments.
Surprisingly, our findings linked the use of vitamin B6 to heightened risks of allergic reactions when combined with Dengzhan Xixin. Specifically, when patients received vitamin B6 or ambroxol alongside the medication, the likelihood of experiencing an allergic reaction increased significantly. The data suggested that the condition upon admission was also an important factor associated with these reactions.
While this study sheds light on potential risk factors for allergic reactions, the relationship between vitamin B6 and these allergies doesn’t position it as a clear solution for managing allergy symptoms. Further exploration and research are needed to confirm these findings and understand them in greater depth. Ultimately, our work pushes forward the conversation about safety in clinical practices surrounding Dengzhan Xixin and its use in treatments.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Trusted high quality
Bestseller! The Solgar brand needs no introduction—it's one of the finest supplements on iHerb. As someone with allergies, I can attest to its quality; I’ve never experienced negative reactions. This vitamin B6, at an optimal 25 mg dosage for adults, is highly effective for prevention. I usually take it separately, as I prefer controlling dosage. It's wise to take it with food, and it's best in the afternoon or at night. I highly recommend it due to its superior quality.
Read More
9
Child's allergies managed
We give this to our child for seasonal allergies. Everything suits me.
Read More
9
Moderate and effective
Good dosage. This B6 is the only moderate dosage available on the site. I take it in courses with magnesium for neurological needs. Vitamin B6 is vital for metabolism and heart health, so I chose this one and have no regrets. No allergies, no overdose.
Read More
9
Couple's favourite
Satisfied with the vitamins! My husband and I take these together! No allergies—love the Solgar brand.
Read More
9
No complaints
The tablets are small, odourless, and provoke no allergies.
Read More
Frequently Asked Questions
9
Well-tolerated
Good! I take this in combination with other supplements prescribed by my doctor for three months. No allergies.
9
Trusted high quality
Bestseller! The Solgar brand needs no introduction—it's one of the finest supplements on iHerb. As someone with allergies, I can attest to its quality; I’ve never experienced negative reactions. This vitamin B6, at an optimal 25 mg dosage for adults, is highly effective for prevention. I usually take it separately, as I prefer controlling dosage. It's wise to take it with food, and it's best in the afternoon or at night. I highly recommend it due to its superior quality.
9
Child's allergies managed
We give this to our child for seasonal allergies. Everything suits me.
9
Moderate and effective
Good dosage. This B6 is the only moderate dosage available on the site. I take it in courses with magnesium for neurological needs. Vitamin B6 is vital for metabolism and heart health, so I chose this one and have no regrets. No allergies, no overdose.
9
Couple's favourite
Satisfied with the vitamins! My husband and I take these together! No allergies—love the Solgar brand.
8
We explored the effects of vitamin B6, specifically its active form called pyridoxal phosphate (PLP), on allergic responses. Our research focused on how this vitamin might influence interleukin-33 (IL-33), a key cytokine involved in type 2 inflammation, typically seen in asthma and other allergic conditions.
We found that healthy individuals had higher levels of PLP in their blood compared to asthma patients. Notably, lower PLP levels correlated with worse lung function and increased inflammation in those with asthma. In tests using mouse models of lung inflammation, we observed that PLP significantly reduced the type 2 immune response, suggesting a protective role against allergic reactions.
Delving deeper, we identified that the conversion of pyridoxal to PLP was critical for regulating IL-33 stability. Moreover, we found that a protein called MDM2 contributed to IL-33's stability by facilitating its degradation. Using PLP helped to decrease IL-33 levels in the lungs and enhance the regulation of this protein, providing a potential new avenue for allergy treatment.
Additionally, inhalation of PLP showed promise in mitigating asthma-related symptoms in mouse models. Overall, our findings indicate that vitamin B6 could serve as a beneficial strategy in managing type 2 inflammation and offer new hope for developing effective treatments for allergy-related diseases.
We found that healthy individuals had higher levels of PLP in their blood compared to asthma patients. Notably, lower PLP levels correlated with worse lung function and increased inflammation in those with asthma. In tests using mouse models of lung inflammation, we observed that PLP significantly reduced the type 2 immune response, suggesting a protective role against allergic reactions.
Delving deeper, we identified that the conversion of pyridoxal to PLP was critical for regulating IL-33 stability. Moreover, we found that a protein called MDM2 contributed to IL-33's stability by facilitating its degradation. Using PLP helped to decrease IL-33 levels in the lungs and enhance the regulation of this protein, providing a potential new avenue for allergy treatment.
Additionally, inhalation of PLP showed promise in mitigating asthma-related symptoms in mouse models. Overall, our findings indicate that vitamin B6 could serve as a beneficial strategy in managing type 2 inflammation and offer new hope for developing effective treatments for allergy-related diseases.
7
We dove deep into the question of whether vitamin B6 has any impact on allergic reactions associated with Dengzhan Xixin, a medication given through injections. Our analysis was based on a nested case-control study, leveraging data from 20 hospitals across China. The participants included patients who received dexamethasone due to suspected allergic reactions after being administered Dengzhan Xixin, allowing us to compare them with those who did not experience such reactions.
Surprisingly, our findings linked the use of vitamin B6 to heightened risks of allergic reactions when combined with Dengzhan Xixin. Specifically, when patients received vitamin B6 or ambroxol alongside the medication, the likelihood of experiencing an allergic reaction increased significantly. The data suggested that the condition upon admission was also an important factor associated with these reactions.
While this study sheds light on potential risk factors for allergic reactions, the relationship between vitamin B6 and these allergies doesn’t position it as a clear solution for managing allergy symptoms. Further exploration and research are needed to confirm these findings and understand them in greater depth. Ultimately, our work pushes forward the conversation about safety in clinical practices surrounding Dengzhan Xixin and its use in treatments.
Surprisingly, our findings linked the use of vitamin B6 to heightened risks of allergic reactions when combined with Dengzhan Xixin. Specifically, when patients received vitamin B6 or ambroxol alongside the medication, the likelihood of experiencing an allergic reaction increased significantly. The data suggested that the condition upon admission was also an important factor associated with these reactions.
While this study sheds light on potential risk factors for allergic reactions, the relationship between vitamin B6 and these allergies doesn’t position it as a clear solution for managing allergy symptoms. Further exploration and research are needed to confirm these findings and understand them in greater depth. Ultimately, our work pushes forward the conversation about safety in clinical practices surrounding Dengzhan Xixin and its use in treatments.
References
- Zhu S, Zhong S, Cheng K, Zhang LS, Bai JW, et al. Vitamin B6 regulates IL-33 homeostasis to alleviate type 2 inflammation. Cell Mol Immunol. 2023;20:794. 10.1038/s41423-023-01029-6
- Yang W, Cheng H, Xie YM, Yang H, Zhuang Y. [Nested case control study to analyze suspected cases and their related factors of allargic reactions to parenterally administered dengzhan xixin]. Zhongguo Zhong Yao Za Zhi. 2013;38:3024.
