Solgar Vitamin B6

We conducted an intriguing study that looked into how vitamin B6 affects cognitive function in patients with Neuromyelitis Optica Spectrum Disorder (NMOSD). This autoimmune disorder often brings along cognitive challenges, so understanding potential dietary influences could be beneficial.

By surveying 24 NMOSD patients at Sina Hospital in Tehran, we gathered detailed dietary habits through a comprehensive food frequency questionnaire. The cognitive abilities of participants were assessed using the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) battery, which allowed us to evaluate their mental performance thoroughly.

Our findings were particularly interesting: we observed a positive correlation between the amount of dietary vitamin B6 consumed and cognitive function. Specifically, higher intake was linked to better performance in verbal and learning memory, as well as working memory and processing speed. This suggests that boosting vitamin B6 intake might help enhance cognitive functioning in NMOSD patients, which is encouraging given the prevalence of cognitive issues in this group.

Overall, our study opens up promising pathways for dietary intervention in managing cognitive impairment related to autoimmune disorders like NMOSD.

9.5

Cleared Chronic Fatigue

Most Useful Review

Superb product, with numerous benefits, presented in easy-to-swallow capsules. I've experienced great success over many years using this product alongside equal amounts of vitamin B2, as they complement each other well. I’ve never encountered any side effects, as I also take magnesium and various other supplements to ensure all necessary co-factors are present. It's a safe product with no unnecessary additives, and the value is excellent. After using it, I noticed numerous symptoms of Chronic Fatigue vanish, making it an essential component of my supplement arsenal, particularly if you're a woman, have any autoimmune disorder, diabetes, or stress issues. Well-packaged and sealed in glass bottles. Solgar supplements truly have been a lifesaver at a superb price.

Blood Clot details

SCIENTIFIC SCORE

Moderately Effective

Based on 8 Researches

High homocysteine management strategy

Treatable high homocysteine alone or in concert with five other thrombophilias in 1014 patients with thrombotic events.

Most Relevant Research

We explored the effects of high serum homocysteine levels on blood clot risks within a group of 1,014 patients who experienced thrombotic events. This group underwent a thorough evaluation for various thrombophilic conditions. Notably, we found that 12% of these patients had treatable high homocysteine levels.

Among those with high homocysteine, we examined a treatment regimen that included vitamin B6, alongside L-methyl folate and vitamin B12. After approximately 18 months of this combined treatment, we observed significant reductions in homocysteine levels, with many patients reaching normal levels.

Importantly, when high homocysteine was the only identified thrombophilia, those who achieved normalization of their homocysteine levels reported a remarkable decrease in new thrombotic events. Thus, while vitamin B6 plays a role in lowering homocysteine, its specific isolated impact on blood clotting remains unclear as part of the combined therapy.

Overall, our findings highlight the relevance of managing high homocysteine through vitamin treatment to potentially lower the risk of blood clots, especially in individuals with no other identified thrombophilia.

9.5

Blood count improvement

Most Useful Review

My husband's blood count has greatly improved since he started taking this supplement. His specialists are very pleased with the results.

Brain Tumor details

SCIENTIFIC SCORE

Moderately Effective

Based on 2 Researches

Vitamin B6 as glioblastoma target

Vitamin B6 Pathway Maintains Glioblastoma Cell Survival in 3D Spheroid Cultures.

Most Relevant Research

We explored the impact of the vitamin B6 pathway on glioblastoma, a challenging and aggressive brain cancer. Specifically, we assessed how different cell cultures—2D monolayers and 3D spheroids—responded to treatments that alter vitamin B6 levels. Through comprehensive metabolomics analysis, we found notable differences in the levels of vitamin B6-related metabolites between these two culture methods.

Our key finding was that when we used hydralazine, a small molecule known to lower vitamin B6 levels, it induced cell death specifically in the 3D spheroid cultures of glioblastoma. This suggests a potential new therapeutic strategy targeting the vitamin B6 pathway could benefit glioblastoma treatment.

Thus, this study highlights a novel approach to tackle this aggressive cancer by focusing on the metabolic alterations within the tumor microenvironment, particularly through vitamin B6 modulation.

9.5

Enhanced brain performance

Most Useful Review

An excellent preparation for strengthening the heart. It works remarkably well—my brain performance is at its peak.

Anxiety details

SCIENTIFIC SCORE

Possibly Effective

Based on 10 Researches

Vitamin B6 treatment alleviates anxiety

Pyridoxal 5'-phosphate alleviates prenatal pyridaben exposure-induced anxiety-like behaviors in offspring.

Most Relevant Research

We investigated the impact of prenatal exposure to pyridaben, a common pesticide, on anxiety-like behaviors in offspring. Pregnant mice were given pyridaben, and later, we observed that the exposed offspring displayed increased anxiety levels at five weeks of age.

Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.

To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.

Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.

7.5

Reduced panic attacks

Most Useful Review

Good, I read extensively about this before, but unexpectedly realised that panic attacks affected me too. To be honest, I hadn’t taken B vitamins before, except during pregnancy. I bought some and started taking them immediately. As a result, thanks to the medication, I felt lighter and free of anxiety. I can’t say that the panic attacks have vanished completely, but it has improved significantly and the spasms have become less frequent. I’m still taking it, but we shall see.