' 
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 5 Reviews
8.4
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3
25 mcg (1,000 IU)
125%
Top Medical Research Studies
8
Genetic factors in cold sores
Associations between host genetic variants and Herpes Simplex Labialis in the TwinsUK cohort.
Genetic variant relevance acknowledged
We explored how a specific genetic variant associated with vitamin D might influence the occurrence of cold sores, also known as Herpes Simplex Labialis (HSL). Our research involved nearly 1,800 participants from the TwinsUK registry, with a focus on a group of 595 that completed both blood tests and questionnaires regarding their cold sore experiences.
From the participants surveyed, 235 reported having experienced cold sores at least once, and out of these, 160 indicated that they had recurrent episodes. While we investigated several genetic variants, including three commonly discussed in relation to cold sores, we found no significant links between these particular SNPs and the occurrence or recurrence of cold sores.
However, our analysis did reveal a noteworthy association with a genetic variation in the Vitamin D Receptor (VDR) gene. This variant was significantly correlated with both the history of cold sore outbreaks and their frequency. While this suggests a potential relationship between vitamin D-related genetics and cold sore experiences, it does not mean that vitamin D treatment has a proven direct effect on reducing these occurrences.
Overall, our findings provide an intriguing glimpse into the genetic factors that may play a role in cold sore reactivation, especially as it pertains to the VDR gene. Yet, since we didn't explore the direct effects of vitamin D supplementation, more research would be needed to conclusively determine how vitamin D treatment might influence cold sore frequency.
From the participants surveyed, 235 reported having experienced cold sores at least once, and out of these, 160 indicated that they had recurrent episodes. While we investigated several genetic variants, including three commonly discussed in relation to cold sores, we found no significant links between these particular SNPs and the occurrence or recurrence of cold sores.
However, our analysis did reveal a noteworthy association with a genetic variation in the Vitamin D Receptor (VDR) gene. This variant was significantly correlated with both the history of cold sore outbreaks and their frequency. While this suggests a potential relationship between vitamin D-related genetics and cold sore experiences, it does not mean that vitamin D treatment has a proven direct effect on reducing these occurrences.
Overall, our findings provide an intriguing glimpse into the genetic factors that may play a role in cold sore reactivation, especially as it pertains to the VDR gene. Yet, since we didn't explore the direct effects of vitamin D supplementation, more research would be needed to conclusively determine how vitamin D treatment might influence cold sore frequency.
Read More
Most Useful Reviews
9.5
Immunity improvement
This product is fantastic! After a month of use, I noticed a significant boost in my mood and energy levels. My general health has improved dramatically, and I believe my immunity is much stronger, especially during this flu season. I’ll continue using it and have recommended it to my family and friends. The results are genuinely stunning!
Read More
8.8
Cold resistance
After struggling with low immunity and frequent illnesses, I discovered vitamin D3. I ordered it online and have been taking it for six months. While I still had a few mild symptoms, I managed them without bed rest. My mood has also improved, and I’ve noticed fewer cold sores. I plan to continue this for preventive care.
Read More
9.5
Effective vitamin D
I usually take one capsule every few days for prevention. If I sense an illness coming, I increase my dosage, which swiftly alleviates symptoms. I've been healthy for nearly a year, which is a significant change from previous seasons. My child also benefits from vitamin D drops, resulting in fewer cold sores.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
- All Researches
8
Genetic factors in cold sores
Associations between host genetic variants and Herpes Simplex Labialis in the TwinsUK cohort.
Genetic variant relevance acknowledged
We explored how a specific genetic variant associated with vitamin D might influence the occurrence of cold sores, also known as Herpes Simplex Labialis (HSL). Our research involved nearly 1,800 participants from the TwinsUK registry, with a focus on a group of 595 that completed both blood tests and questionnaires regarding their cold sore experiences.
From the participants surveyed, 235 reported having experienced cold sores at least once, and out of these, 160 indicated that they had recurrent episodes. While we investigated several genetic variants, including three commonly discussed in relation to cold sores, we found no significant links between these particular SNPs and the occurrence or recurrence of cold sores.
However, our analysis did reveal a noteworthy association with a genetic variation in the Vitamin D Receptor (VDR) gene. This variant was significantly correlated with both the history of cold sore outbreaks and their frequency. While this suggests a potential relationship between vitamin D-related genetics and cold sore experiences, it does not mean that vitamin D treatment has a proven direct effect on reducing these occurrences.
Overall, our findings provide an intriguing glimpse into the genetic factors that may play a role in cold sore reactivation, especially as it pertains to the VDR gene. Yet, since we didn't explore the direct effects of vitamin D supplementation, more research would be needed to conclusively determine how vitamin D treatment might influence cold sore frequency.
From the participants surveyed, 235 reported having experienced cold sores at least once, and out of these, 160 indicated that they had recurrent episodes. While we investigated several genetic variants, including three commonly discussed in relation to cold sores, we found no significant links between these particular SNPs and the occurrence or recurrence of cold sores.
However, our analysis did reveal a noteworthy association with a genetic variation in the Vitamin D Receptor (VDR) gene. This variant was significantly correlated with both the history of cold sore outbreaks and their frequency. While this suggests a potential relationship between vitamin D-related genetics and cold sore experiences, it does not mean that vitamin D treatment has a proven direct effect on reducing these occurrences.
Overall, our findings provide an intriguing glimpse into the genetic factors that may play a role in cold sore reactivation, especially as it pertains to the VDR gene. Yet, since we didn't explore the direct effects of vitamin D supplementation, more research would be needed to conclusively determine how vitamin D treatment might influence cold sore frequency.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Immunity improvement
This product is fantastic! After a month of use, I noticed a significant boost in my mood and energy levels. My general health has improved dramatically, and I believe my immunity is much stronger, especially during this flu season. I’ll continue using it and have recommended it to my family and friends. The results are genuinely stunning!
Read More
8.8
Cold resistance
After struggling with low immunity and frequent illnesses, I discovered vitamin D3. I ordered it online and have been taking it for six months. While I still had a few mild symptoms, I managed them without bed rest. My mood has also improved, and I’ve noticed fewer cold sores. I plan to continue this for preventive care.
Read More
9.5
Effective vitamin D
I usually take one capsule every few days for prevention. If I sense an illness coming, I increase my dosage, which swiftly alleviates symptoms. I've been healthy for nearly a year, which is a significant change from previous seasons. My child also benefits from vitamin D drops, resulting in fewer cold sores.
Read More
8.8
Reduced cold sores
I've reordered multiple times and haven’t suffered from cold sores or illnesses since I started using this product. It seems to work well for me.
2.5
Mood improvement
I find that vitamin D3 enhances my mood and stress resilience, yet it caused subcutaneous acne, which worries me. Unfortunately, I’ll need to stop taking it due to this issue. Others might not experience the same problem, so it might be worth trying from a different brand.
