Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 18 Researches
6.7
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.9
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3
25 mcg (1,000 IU)
125%
Top Medical Research Studies
7
Vitamin D's role in heart health
We examined how low levels of vitamin D (Vit D) could impact the severity of heart disease, specifically looking at myocardial ischemia. Our study involved two hundred patients who underwent myocardial perfusion imaging at Namazi Hospital in Shiraz, Iran, in 2019. We assessed both the severity of ischemia in patients and their vitamin D levels.
The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.
Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.
The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.
Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.
Read More
8
We explored the relationship between vitamin D deficiency and heart disease, particularly how it interacts with a condition called hyperhomocysteinemia, which is known to promote heart issues. In our study, we examined both animal models (rats fed a diet to induce hyperhomocysteinemia) and heart cells under lab conditions to understand this interaction better.
Our findings revealed that hyperhomocysteinemia significantly lowered levels of vitamin D, specifically 1,25(OH)D, in the blood and heart tissues. We also noted an increase in the expression of an enzyme (CYP24A1) that breaks down vitamin D, indicating a disruption in its availability. Moreover, the presence of elevated homocysteine was linked to a decrease in vitamin D receptor (VDR) expression in heart tissues, complicating the heart's ability to respond to vitamin D’s effects.
By manipulating levels of VDR, we demonstrated that reducing VDR led to more heart cell growth, which is a sign of heart hypertrophy. Conversely, when VDR was overexpressed, we observed a decrease in hypertrophy, showing that vitamin D plays a protective role against heart enlargement during hyperhomocysteinemia. Additionally, a specific microRNA (miR-125b-5p) was found to repress VDR and contribute to heart cell growth, highlighting the complex regulatory network involved.
Our study concluded that vitamin D deficiency and reduced VDR contribute to heart issues associated with high levels of homocysteine by activating harmful cellular pathways. This underscores the potential significance of monitoring and supporting vitamin D levels, especially in individuals suffering from hyperhomocysteinemia.
Our findings revealed that hyperhomocysteinemia significantly lowered levels of vitamin D, specifically 1,25(OH)D, in the blood and heart tissues. We also noted an increase in the expression of an enzyme (CYP24A1) that breaks down vitamin D, indicating a disruption in its availability. Moreover, the presence of elevated homocysteine was linked to a decrease in vitamin D receptor (VDR) expression in heart tissues, complicating the heart's ability to respond to vitamin D’s effects.
By manipulating levels of VDR, we demonstrated that reducing VDR led to more heart cell growth, which is a sign of heart hypertrophy. Conversely, when VDR was overexpressed, we observed a decrease in hypertrophy, showing that vitamin D plays a protective role against heart enlargement during hyperhomocysteinemia. Additionally, a specific microRNA (miR-125b-5p) was found to repress VDR and contribute to heart cell growth, highlighting the complex regulatory network involved.
Our study concluded that vitamin D deficiency and reduced VDR contribute to heart issues associated with high levels of homocysteine by activating harmful cellular pathways. This underscores the potential significance of monitoring and supporting vitamin D levels, especially in individuals suffering from hyperhomocysteinemia.
Read More
8
Vitamin D improves heart health
We conducted a double-blind, randomized clinical trial to explore how treating vitamin D deficiency affects heart health, specifically in patients with ischemic heart disease (IHD). In our study, we involved 44 patients aged between 40 and 65 who were dealing with low vitamin D levels. They were divided into two groups—one receiving vitamin D supplements and the other a placebo.
Over five weeks, patients in the intervention group received weekly doses of 50,000 units of vitamin D. We measured changes in their lipid profiles, which includes important markers like cholesterol and triglycerides, as well as C-reactive protein (CRP), an indicator of inflammation.
Our findings revealed that vitamin D supplementation led to significant improvements. Patients in the intervention group showed an increase in good cholesterol (HDL) and a decrease in triglycerides, which are both beneficial for heart health. While the placebo group also experienced some minor improvements, the notable changes were primarily in the group receiving vitamin D.
Overall, these results suggest that addressing vitamin D deficiency can have positive effects on lipid levels in IHD patients. This is an encouraging insight for healthcare providers looking to manage heart disease risk more effectively.
Over five weeks, patients in the intervention group received weekly doses of 50,000 units of vitamin D. We measured changes in their lipid profiles, which includes important markers like cholesterol and triglycerides, as well as C-reactive protein (CRP), an indicator of inflammation.
Our findings revealed that vitamin D supplementation led to significant improvements. Patients in the intervention group showed an increase in good cholesterol (HDL) and a decrease in triglycerides, which are both beneficial for heart health. While the placebo group also experienced some minor improvements, the notable changes were primarily in the group receiving vitamin D.
Overall, these results suggest that addressing vitamin D deficiency can have positive effects on lipid levels in IHD patients. This is an encouraging insight for healthcare providers looking to manage heart disease risk more effectively.
Read More
Most Useful Reviews
9
Improved immunity
1 people found this helpful
VITAMIN D3 is essential for immunity and bone health! After discovering low levels of vitamin D3, I took this for three months. My results normalised, and I felt a boost in energy and mood. Solgar's quality is reliable, and studies confirm D3's role in reducing risks of heart disease and other ailments. It works with K2 and fatty foods for optimal absorption. With winter sun exposure lacking, I find supplementation vital, especially for those facing heart disease risks. I genuinely recommend this product!
Read More
7.5
Reduced heart risk
8 people found this helpful
No vitamin enhances health like vitamin D3. It may prevent SARS and respiratory infections, and studies show higher vitamin D levels reduce heart disease risks. I bought vitamin D3 during the pandemic as regular capsules are small and easy to swallow. It's advisable to take them with fatty foods for optimum effect. If my review was helpful, please click Yes. Thank you!
Read More
7.5
Cancer risk reduction
6 people found this helpful
The composition of lanolin is good. I believe no vitamin is as effective as vitamin D3 for health. It may help prevent SARS and has shown that those with higher vitamin D levels have a reduced risk of heart disease and several types of cancer. I purchased D3 during the pandemic; the small tablets are easy to take and should be consumed with fatty foods. My usual dosage was 1000 units. If helpful, please click Yes. Thank you!
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 18 Researches
6.7
- All Researches
8
We conducted a study to explore how vitamin D3, combined with SGLT2 inhibitors, could influence heart health in hypertensive obese patients suffering from obstructive sleep apnea (OSA). This combination therapy was assessed for its effects on various health parameters and the quality of life of the participants.
In our investigation, patients were randomly assigned to receive either Dapagliflozin, vitamin D3, a combination of both, or no treatment at all over 16 weeks. We closely looked at measurements such as weight, blood pressure, blood sugar levels, liver health, and heart function among others.
Our findings were promising, revealing beneficial effects of combining vitamin D3 with SGLT2 inhibitors. Participants who received this combination reported improvements in their cardio-metabolic health and overall quality of life, suggesting a potential new approach to managing heart disease in this specific group of patients.
It is important to note that while this study highlights the synergistic benefits of vitamin D3 and SGLT2 inhibitors, the isolated impact of vitamin D itself on heart disease remains somewhat unclear. This complexity underscores the need for further research to fully understand vitamin D's role in cardiovascular health.
In our investigation, patients were randomly assigned to receive either Dapagliflozin, vitamin D3, a combination of both, or no treatment at all over 16 weeks. We closely looked at measurements such as weight, blood pressure, blood sugar levels, liver health, and heart function among others.
Our findings were promising, revealing beneficial effects of combining vitamin D3 with SGLT2 inhibitors. Participants who received this combination reported improvements in their cardio-metabolic health and overall quality of life, suggesting a potential new approach to managing heart disease in this specific group of patients.
It is important to note that while this study highlights the synergistic benefits of vitamin D3 and SGLT2 inhibitors, the isolated impact of vitamin D itself on heart disease remains somewhat unclear. This complexity underscores the need for further research to fully understand vitamin D's role in cardiovascular health.
Read More
8
We explored the relationship between vitamin D deficiency and heart disease, particularly how it interacts with a condition called hyperhomocysteinemia, which is known to promote heart issues. In our study, we examined both animal models (rats fed a diet to induce hyperhomocysteinemia) and heart cells under lab conditions to understand this interaction better.
Our findings revealed that hyperhomocysteinemia significantly lowered levels of vitamin D, specifically 1,25(OH)D, in the blood and heart tissues. We also noted an increase in the expression of an enzyme (CYP24A1) that breaks down vitamin D, indicating a disruption in its availability. Moreover, the presence of elevated homocysteine was linked to a decrease in vitamin D receptor (VDR) expression in heart tissues, complicating the heart's ability to respond to vitamin D’s effects.
By manipulating levels of VDR, we demonstrated that reducing VDR led to more heart cell growth, which is a sign of heart hypertrophy. Conversely, when VDR was overexpressed, we observed a decrease in hypertrophy, showing that vitamin D plays a protective role against heart enlargement during hyperhomocysteinemia. Additionally, a specific microRNA (miR-125b-5p) was found to repress VDR and contribute to heart cell growth, highlighting the complex regulatory network involved.
Our study concluded that vitamin D deficiency and reduced VDR contribute to heart issues associated with high levels of homocysteine by activating harmful cellular pathways. This underscores the potential significance of monitoring and supporting vitamin D levels, especially in individuals suffering from hyperhomocysteinemia.
Our findings revealed that hyperhomocysteinemia significantly lowered levels of vitamin D, specifically 1,25(OH)D, in the blood and heart tissues. We also noted an increase in the expression of an enzyme (CYP24A1) that breaks down vitamin D, indicating a disruption in its availability. Moreover, the presence of elevated homocysteine was linked to a decrease in vitamin D receptor (VDR) expression in heart tissues, complicating the heart's ability to respond to vitamin D’s effects.
By manipulating levels of VDR, we demonstrated that reducing VDR led to more heart cell growth, which is a sign of heart hypertrophy. Conversely, when VDR was overexpressed, we observed a decrease in hypertrophy, showing that vitamin D plays a protective role against heart enlargement during hyperhomocysteinemia. Additionally, a specific microRNA (miR-125b-5p) was found to repress VDR and contribute to heart cell growth, highlighting the complex regulatory network involved.
Our study concluded that vitamin D deficiency and reduced VDR contribute to heart issues associated with high levels of homocysteine by activating harmful cellular pathways. This underscores the potential significance of monitoring and supporting vitamin D levels, especially in individuals suffering from hyperhomocysteinemia.
Read More
8
Vitamin D improves heart health
We conducted a double-blind, randomized clinical trial to explore how treating vitamin D deficiency affects heart health, specifically in patients with ischemic heart disease (IHD). In our study, we involved 44 patients aged between 40 and 65 who were dealing with low vitamin D levels. They were divided into two groups—one receiving vitamin D supplements and the other a placebo.
Over five weeks, patients in the intervention group received weekly doses of 50,000 units of vitamin D. We measured changes in their lipid profiles, which includes important markers like cholesterol and triglycerides, as well as C-reactive protein (CRP), an indicator of inflammation.
Our findings revealed that vitamin D supplementation led to significant improvements. Patients in the intervention group showed an increase in good cholesterol (HDL) and a decrease in triglycerides, which are both beneficial for heart health. While the placebo group also experienced some minor improvements, the notable changes were primarily in the group receiving vitamin D.
Overall, these results suggest that addressing vitamin D deficiency can have positive effects on lipid levels in IHD patients. This is an encouraging insight for healthcare providers looking to manage heart disease risk more effectively.
Over five weeks, patients in the intervention group received weekly doses of 50,000 units of vitamin D. We measured changes in their lipid profiles, which includes important markers like cholesterol and triglycerides, as well as C-reactive protein (CRP), an indicator of inflammation.
Our findings revealed that vitamin D supplementation led to significant improvements. Patients in the intervention group showed an increase in good cholesterol (HDL) and a decrease in triglycerides, which are both beneficial for heart health. While the placebo group also experienced some minor improvements, the notable changes were primarily in the group receiving vitamin D.
Overall, these results suggest that addressing vitamin D deficiency can have positive effects on lipid levels in IHD patients. This is an encouraging insight for healthcare providers looking to manage heart disease risk more effectively.
Read More
8
Vitamin D3 shows potential heart protection
We explored the effects of vitamin D3 and paricalcitol on heart health, particularly in the context of doxorubicin-induced cardiotoxicity. In our study, we worked with male Wistar rats divided into various groups, some receiving doxorubicin, a drug known for its heart-damaging potential. Others were treated with vitamin D3 or paricalcitol, both thought to have protective qualities against heart injury.
After administering doxorubicin, we observed significant changes in a range of biochemical markers and physiological indicators, including ECG readings and scintigraphy results. The findings suggested that both vitamin D3 and paricalcitol demonstrate potential cardioprotective effects by reducing inflammation and oxidative stress linked to heart damage.
This study shines a light on the possible benefits of vitamin D3 in protecting the heart during chemotherapy treatments. However, readers should note that while our findings are promising, they stem from an animal model, and further research is needed to confirm these effects in humans.
After administering doxorubicin, we observed significant changes in a range of biochemical markers and physiological indicators, including ECG readings and scintigraphy results. The findings suggested that both vitamin D3 and paricalcitol demonstrate potential cardioprotective effects by reducing inflammation and oxidative stress linked to heart damage.
This study shines a light on the possible benefits of vitamin D3 in protecting the heart during chemotherapy treatments. However, readers should note that while our findings are promising, they stem from an animal model, and further research is needed to confirm these effects in humans.
Read More
8
We examined how vitamin D3 could play a role in protecting the heart from damage caused by cisplatin, a chemotherapy drug. In our research, we worked with male Balb-c mice, dividing them into several groups to evaluate different treatment approaches. Some groups received vitamin D3 before or after cisplatin injection, while others acted as controls.
Our findings revealed that cisplatin significantly raised markers indicating heart damage and increased oxidative stress levels. In contrast, when we administered vitamin D3, whether as a preventive measure or treatment after cisplatin exposure, it showed promising results. It was able to improve heart tissue structure and biochemical indicators associated with heart injury, suggesting that vitamin D3 may mitigate some of the cardiac risks linked with chemotherapy.
However, while vitamin D3 showed a protective effect in the groups that received it before cisplatin treatment, the benefits were only partial when given afterward. This highlights the potential of vitamin D3 in supporting heart health during cancer treatment, although more research is necessary to understand its full capabilities and best applications.
Our findings revealed that cisplatin significantly raised markers indicating heart damage and increased oxidative stress levels. In contrast, when we administered vitamin D3, whether as a preventive measure or treatment after cisplatin exposure, it showed promising results. It was able to improve heart tissue structure and biochemical indicators associated with heart injury, suggesting that vitamin D3 may mitigate some of the cardiac risks linked with chemotherapy.
However, while vitamin D3 showed a protective effect in the groups that received it before cisplatin treatment, the benefits were only partial when given afterward. This highlights the potential of vitamin D3 in supporting heart health during cancer treatment, although more research is necessary to understand its full capabilities and best applications.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved immunity
1 people found this helpful
VITAMIN D3 is essential for immunity and bone health! After discovering low levels of vitamin D3, I took this for three months. My results normalised, and I felt a boost in energy and mood. Solgar's quality is reliable, and studies confirm D3's role in reducing risks of heart disease and other ailments. It works with K2 and fatty foods for optimal absorption. With winter sun exposure lacking, I find supplementation vital, especially for those facing heart disease risks. I genuinely recommend this product!
Read More
7.5
Reduced heart risk
8 people found this helpful
No vitamin enhances health like vitamin D3. It may prevent SARS and respiratory infections, and studies show higher vitamin D levels reduce heart disease risks. I bought vitamin D3 during the pandemic as regular capsules are small and easy to swallow. It's advisable to take them with fatty foods for optimum effect. If my review was helpful, please click Yes. Thank you!
Read More
7.5
Cancer risk reduction
6 people found this helpful
The composition of lanolin is good. I believe no vitamin is as effective as vitamin D3 for health. It may help prevent SARS and has shown that those with higher vitamin D levels have a reduced risk of heart disease and several types of cancer. I purchased D3 during the pandemic; the small tablets are easy to take and should be consumed with fatty foods. My usual dosage was 1000 units. If helpful, please click Yes. Thank you!
Read More
7.5
Heart disease prevention
No vitamin improves well-being like vitamin D3. Current research indicates it may prevent SARS and upper respiratory infections, with studies showing higher vitamin D levels correspond to a lower risk of heart disease. I got vitamin D3 during the pandemic, and I'm pleased with its small, easy-to-swallow tablets. It's important to take it with fatty foods. My dosage was 1000 units. If my review helped, please click Yes. Thank you!
Read More
7.5
Skin benefits noted
Excellent quality and beneficial ingredients. I found it useful for heart health and noticed antioxidant benefits for the skin as well.
Read More
Frequently Asked Questions
9
Improved immunity
1 people found this helpful
VITAMIN D3 is essential for immunity and bone health! After discovering low levels of vitamin D3, I took this for three months. My results normalised, and I felt a boost in energy and mood. Solgar's quality is reliable, and studies confirm D3's role in reducing risks of heart disease and other ailments. It works with K2 and fatty foods for optimal absorption. With winter sun exposure lacking, I find supplementation vital, especially for those facing heart disease risks. I genuinely recommend this product!
7.5
Reduced heart risk
8 people found this helpful
No vitamin enhances health like vitamin D3. It may prevent SARS and respiratory infections, and studies show higher vitamin D levels reduce heart disease risks. I bought vitamin D3 during the pandemic as regular capsules are small and easy to swallow. It's advisable to take them with fatty foods for optimum effect. If my review was helpful, please click Yes. Thank you!
7.5
Heart disease prevention
No vitamin improves well-being like vitamin D3. Current research indicates it may prevent SARS and upper respiratory infections, with studies showing higher vitamin D levels correspond to a lower risk of heart disease. I got vitamin D3 during the pandemic, and I'm pleased with its small, easy-to-swallow tablets. It's important to take it with fatty foods. My dosage was 1000 units. If my review helped, please click Yes. Thank you!
7.5
Skin benefits noted
Excellent quality and beneficial ingredients. I found it useful for heart health and noticed antioxidant benefits for the skin as well.
0
Negative side effects
Unfortunately, after taking Vitamin D3 due to a fracture, I experienced rapid heartbeat, nocturia, and severe pain in my body, including the fracture area. I've never had these issues with other brands. The quality seems questionable, particularly with the inclusion of deep-sea fish. Despite a low dosage, these side effects were significant and concerning, particularly regarding heart disease.
7.5
Cancer risk reduction
6 people found this helpful
The composition of lanolin is good. I believe no vitamin is as effective as vitamin D3 for health. It may help prevent SARS and has shown that those with higher vitamin D levels have a reduced risk of heart disease and several types of cancer. I purchased D3 during the pandemic; the small tablets are easy to take and should be consumed with fatty foods. My usual dosage was 1000 units. If helpful, please click Yes. Thank you!
4
We investigated the relationship between vitamin D levels and exercise capacity in adults with congenital heart disease (CHD). In our study, we examined 55 CHD patients and 55 healthy peers, looking at how their vitamin D levels correlated with various health metrics, including their ability to exercise.
Despite the common concern about vitamin D deficiency, we found that levels were similar between CHD patients and healthy controls, though both groups exhibited high rates of vitamin D insufficiency. While vitamin D levels didn't significantly correlate with many factors such as age, body mass index, or blood pressure, we did observe a noteworthy connection between vitamin D levels and exercise performance.
Specifically, lower vitamin D levels were linked to reduced exercise capacity among CHD patients. This suggests that while vitamin D may not drastically affect heart disease outcomes on its own, it plays a role in physical performance. The findings highlight the need for further research into whether supplementing vitamin D might enhance exercise capacity in individuals with vitamin D insufficiency and CHD.
Despite the common concern about vitamin D deficiency, we found that levels were similar between CHD patients and healthy controls, though both groups exhibited high rates of vitamin D insufficiency. While vitamin D levels didn't significantly correlate with many factors such as age, body mass index, or blood pressure, we did observe a noteworthy connection between vitamin D levels and exercise performance.
Specifically, lower vitamin D levels were linked to reduced exercise capacity among CHD patients. This suggests that while vitamin D may not drastically affect heart disease outcomes on its own, it plays a role in physical performance. The findings highlight the need for further research into whether supplementing vitamin D might enhance exercise capacity in individuals with vitamin D insufficiency and CHD.
7
Vitamin D's role in heart health
We examined how low levels of vitamin D (Vit D) could impact the severity of heart disease, specifically looking at myocardial ischemia. Our study involved two hundred patients who underwent myocardial perfusion imaging at Namazi Hospital in Shiraz, Iran, in 2019. We assessed both the severity of ischemia in patients and their vitamin D levels.
The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.
Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.
The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.
Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.
8
We conducted a study to explore how vitamin D3, combined with SGLT2 inhibitors, could influence heart health in hypertensive obese patients suffering from obstructive sleep apnea (OSA). This combination therapy was assessed for its effects on various health parameters and the quality of life of the participants.
In our investigation, patients were randomly assigned to receive either Dapagliflozin, vitamin D3, a combination of both, or no treatment at all over 16 weeks. We closely looked at measurements such as weight, blood pressure, blood sugar levels, liver health, and heart function among others.
Our findings were promising, revealing beneficial effects of combining vitamin D3 with SGLT2 inhibitors. Participants who received this combination reported improvements in their cardio-metabolic health and overall quality of life, suggesting a potential new approach to managing heart disease in this specific group of patients.
It is important to note that while this study highlights the synergistic benefits of vitamin D3 and SGLT2 inhibitors, the isolated impact of vitamin D itself on heart disease remains somewhat unclear. This complexity underscores the need for further research to fully understand vitamin D's role in cardiovascular health.
In our investigation, patients were randomly assigned to receive either Dapagliflozin, vitamin D3, a combination of both, or no treatment at all over 16 weeks. We closely looked at measurements such as weight, blood pressure, blood sugar levels, liver health, and heart function among others.
Our findings were promising, revealing beneficial effects of combining vitamin D3 with SGLT2 inhibitors. Participants who received this combination reported improvements in their cardio-metabolic health and overall quality of life, suggesting a potential new approach to managing heart disease in this specific group of patients.
It is important to note that while this study highlights the synergistic benefits of vitamin D3 and SGLT2 inhibitors, the isolated impact of vitamin D itself on heart disease remains somewhat unclear. This complexity underscores the need for further research to fully understand vitamin D's role in cardiovascular health.
5
We conducted a large-scale study to examine if giving older adults vitamin D on a monthly basis could help reduce major heart-related events like heart attacks and strokes. This randomized, double-blind trial involved over 21,000 participants aged 60 to 84 from Australia, who were assigned to either receive 60,000 IU of vitamin D or a placebo each month for up to five years.
During the study, we found that while there was a hint that vitamin D might lower the occurrence of these serious cardiovascular events, the differences observed were quite small. The confidence intervals surrounding these results suggest that they could just as easily represent no real effect at all.
It's important to note that we observed a significant number of participants successfully completing the study, with 80.2% taking vitamin D and 77.6% receiving the placebo. These findings lead us to believe that more detailed studies could be warranted to verify vitamin D's role, especially for people already using medications to prevent heart disease.
Overall, the evidence doesn't strongly support the idea that vitamin D supplements are a major game changer for heart health, but they may still have a role worth exploring further.
During the study, we found that while there was a hint that vitamin D might lower the occurrence of these serious cardiovascular events, the differences observed were quite small. The confidence intervals surrounding these results suggest that they could just as easily represent no real effect at all.
It's important to note that we observed a significant number of participants successfully completing the study, with 80.2% taking vitamin D and 77.6% receiving the placebo. These findings lead us to believe that more detailed studies could be warranted to verify vitamin D's role, especially for people already using medications to prevent heart disease.
Overall, the evidence doesn't strongly support the idea that vitamin D supplements are a major game changer for heart health, but they may still have a role worth exploring further.
References
- Vanreusel I, Hens W, Van Craenenbroeck EM, Paelinck BP, Segers VFM, et al. Vitamin D levels correlate with exercise capacity in adults with CHD. Cardiol Young. 2025. 10.1017/S1047951125000526
- Loh HH, Tay SP, Koa AJ, Yong MC, Said A, et al. Unveiling the benefits of Vitamin D3 with SGLT-2 inhibitors for hypertensive obese obstructive sleep apnea patients. J Transl Med. 2025;23:296. 10.1186/s12967-025-06312-w
- Qi H, Zhou Y, Hou HT, Wei JH, He GW, et al. Contributing role and molecular basis of Vitamin D/Vitamin D receptor deficiency in hyperhomocysteinemia-induced cardiac hypertrophy. Biochem Pharmacol. 2025;234:116812. 10.1016/j.bcp.2025.116812
- Haghighatafshar M, Shekasteband B, Firuzyar T, Etemadi Z, Farhoudi F, et al. The Impact of Vitamin D Deficiency on Coronary Artery Disease Severity Based on Myocardial Perfusion Imaging: A Cross-Sectional Study. Iran J Med Sci. 2025;50:31. 10.30476/ijms.2024.101112.3372
- Astani A, Maroofi A, Hekmatimoghaddam S, Sarebanhassanabadi M, Safari F. Sirtuin 1 mediates the pro-survival effects of vitamin D in angiotensin II-induced hypertrophy of H9c2 cardiomyoblasts. Mol Biol Rep. 2024;52:96. 10.1007/s11033-024-10168-6
- Algül E, Özbeyaz NB, Şahan HF, Aydinyilmaz F, Erdoğan A, et al. Low vitamin D levels are associated with impaired diastolic function in patients with acute coronary syndrome. Minerva Cardiol Angiol. 2025;73:57. 10.23736/S2724-5683.24.06515-3
- Sun L, Du J. Magnesium status, serum vitamin D concentration and mortality among congestive heart failure patients: a cohort study from NHANES 2007-2018. Magnes Res. 2024;37:61. 10.1684/mrh.2024.0528
- Aleksova A, Janjusevic M, Pani B, Hiche C, Chicco A, et al. The Co-Existence of Hypovitaminosis D and Diabetes Mellitus Triples the Incidence of Severe Coronary Artery Disease in Women. J Clin Med. 2024;13. 10.3390/jcm13226792
- Sadeghi M, Momeni A, Mirsaeidi FS, Jamalian M, Amirpour A, et al. The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial. Adv Biomed Res. 2024;13:79. 10.4103/abr.abr_380_23
- Sato AY, Cregor M, McAndrews K, Schurman CA, Schaible E, et al. Pharmacologic or genetic interference with atrogene signaling protects against glucocorticoid-induced musculoskeletal and cardiac disease. JCI Insight. 2024;9. 10.1172/jci.insight.182664
- Stankiewicz B, Mieszkowski J, Kochanowicz A, Brzezińska P, Niespodziński B, et al. Effect of Single High-Dose Vitamin D Supplementation on Post-Ultra Mountain Running Heart Damage and Iron Metabolism Changes: A Double-Blind Randomized Controlled Trial. Nutrients. 2024;16. 10.3390/nu16152479
- Koroglu R, Koroglu M, Aygun H. Electrocardiographic, biochemical, and scintigraphic evidence for the cardioprotective effect of paricalcitol and vitamin D3 on doxorubicin-induced acute cardiotoxicity in rats. Bratisl Lek Listy. 2024;125:281. 10.4149/BLL_2024_42
- Hao N, Yong H, Zhang F, Liu C, Qiu Y, et al. Aortic calcification accelerates cardiac dysfunction via inducing apoptosis of cardiomyocytes. Int J Med Sci. 2024;21:306. 10.7150/ijms.90324
- Samavati I, Ranjbar A, Haddadi R. Cardioprotective effect of vitamin D3 on cisplatin-induced cardiotoxicity in male mice: role of oxidative stress. Naunyn Schmiedebergs Arch Pharmacol. 2024;397:4761. 10.1007/s00210-023-02848-0
- Ogata S, Manson JE, Kang JH, Buring JE, Lee IM, et al. Marine n-3 Fatty Acids and Prevention of Cardiovascular Disease: A Novel Analysis of the VITAL Trial Using Win Ratio and Hierarchical Composite Outcomes. Nutrients. 2023;15. 10.3390/nu15194235
- Arroyo E, Leber CA, Burney HN, Li Y, Li X, et al. Epimeric vitamin D and cardiovascular structure and function in advanced CKD and after kidney transplantation. Nephrol Dial Transplant. 2024;39:264. 10.1093/ndt/gfad168
- Hasific S, Øvrehus KA, Hosbond S, Lambrechtsen J, Kumarathurai P, et al. Effects of vitamins K2 and D3 supplementation in patients with severe coronary artery calcification: a study protocol for a randomised controlled trial. BMJ Open. 2023;13:e073233. 10.1136/bmjopen-2023-073233
- Thompson B, Waterhouse M, English DR, McLeod DS, Armstrong BK, et al. Vitamin D supplementation and major cardiovascular events: D-Health randomised controlled trial. BMJ. 2023;381:e075230. 10.1136/bmj-2023-075230
