SCIENTIFIC SCORE
Questionable
Based on 30 Researches
6.3
USERS' SCORE
Good
Based on 1 Review
8.3
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3
25 mcg (1,000 IU)
125%
Top Medical Research Studies
9
Vitamin D3 alleviates MS symptoms
Immunoregulatory Effect of Calcitriol on Experimental Autoimmune Encephalomyelitis (EAE) Mice.
Study focuses on vitamin D3 effects
We investigated the influence of calcitriol, the active form of vitamin D, on experimental autoimmune encephalomyelitis (EAE), an animal model akin to multiple sclerosis. Our study involved twenty-eight mice divided into four groups, allowing us to compare outcomes between those with and without EAE, as well as those receiving calcitriol treatment.
We found that, in mice with EAE, inflammation indicators such as interleukin-17 (IL-17) significantly increased, while transforming growth factor beta (TGF-β) levels decreased compared to healthy controls. Upon treating the EAE group with calcitriol, we observed a reversal of these changes, suggesting a substantial immunomodulatory effect, which eased symptoms typically associated with EAE.
Notably, we also noticed that calcitriol enhanced gene expression for interleukin-9 (IL-9) in both healthy and EAE mice. Overall, our findings support the notion that calcitriol holds promise as a potential treatment to alleviate the symptoms of multiple sclerosis through its anti-inflammatory properties.
We found that, in mice with EAE, inflammation indicators such as interleukin-17 (IL-17) significantly increased, while transforming growth factor beta (TGF-β) levels decreased compared to healthy controls. Upon treating the EAE group with calcitriol, we observed a reversal of these changes, suggesting a substantial immunomodulatory effect, which eased symptoms typically associated with EAE.
Notably, we also noticed that calcitriol enhanced gene expression for interleukin-9 (IL-9) in both healthy and EAE mice. Overall, our findings support the notion that calcitriol holds promise as a potential treatment to alleviate the symptoms of multiple sclerosis through its anti-inflammatory properties.
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8
Vitamin D linked to MS activity
Vitamin D affects the risk of disease activity in multiple sclerosis.
High relevance for MS research
We explored how vitamin D (VitD) levels relate to the activity of multiple sclerosis (MS) in patients about to start treatment. By measuring serum levels of a specific form of VitD in 230 untreated individuals with relapsing-remitting MS, we aimed to see if higher VitD could reduce disease activity over the subsequent two years.
Our findings revealed that lower VitD levels were linked to a greater likelihood of disease activity, specifically noting that patients with VitD levels below 20 ng/mL faced more than double the risk of experiencing such activity. Interestingly, we found that genetic factors also played a role; those with a genetic predisposition to higher VitD levels were more likely to have a delayed onset of MS and a better chance of maintaining a status known as No-Evidence of Disease Activity-3 (NEDA-3).
Through further analysis using Mendelian randomization, we confirmed that there is a causal relationship between VitD levels and disease activity in MS. This research highlights the potential benefits of monitoring and possibly supplementing VitD for patients, prompting a greater interest in lifestyle changes that could help manage the disease.
Our findings revealed that lower VitD levels were linked to a greater likelihood of disease activity, specifically noting that patients with VitD levels below 20 ng/mL faced more than double the risk of experiencing such activity. Interestingly, we found that genetic factors also played a role; those with a genetic predisposition to higher VitD levels were more likely to have a delayed onset of MS and a better chance of maintaining a status known as No-Evidence of Disease Activity-3 (NEDA-3).
Through further analysis using Mendelian randomization, we confirmed that there is a causal relationship between VitD levels and disease activity in MS. This research highlights the potential benefits of monitoring and possibly supplementing VitD for patients, prompting a greater interest in lifestyle changes that could help manage the disease.
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8
Vitamin D3 influences MS immune response
The immune cell transcriptome is modulated by vitamin D supplementation in people with a first demyelinating event participating in a randomized placebo-controlled trial.
Direct assessment of immune impact
We conducted a thorough investigation into the potential benefits of vitamin D3 supplementation for individuals who have experienced a first demyelinating event, which can be an early indication of multiple sclerosis (MS). Our study was a part of the PrevANZ trial and involved randomizing participants to receive varying doses of vitamin D—1000, 5000, or 10,000 international units—or a placebo, over a period of 12 weeks.
We focused on how these vitamin D3 supplements affected the gene expression of immune cells. After analyzing blood samples from 55 participants both at the beginning and end of the study, we observed that higher doses of vitamin D significantly influenced immune cell activity. Specifically, we found pathways linked to antigen presentation and viral responses became more active, while pathways associated with energy production and certain immune signals, like tumor necrosis factor-alpha and interleukin-17, were less active.
Overall, the results indicate that vitamin D3 supplementation can lead to an anti-inflammatory shift in immune gene expression, suggesting a potential protective role in the development of MS. This study supports the hypothesis that vitamin D3 could be an effective strategy, showing a dose-dependent relationship in immune response modulation.
We focused on how these vitamin D3 supplements affected the gene expression of immune cells. After analyzing blood samples from 55 participants both at the beginning and end of the study, we observed that higher doses of vitamin D significantly influenced immune cell activity. Specifically, we found pathways linked to antigen presentation and viral responses became more active, while pathways associated with energy production and certain immune signals, like tumor necrosis factor-alpha and interleukin-17, were less active.
Overall, the results indicate that vitamin D3 supplementation can lead to an anti-inflammatory shift in immune gene expression, suggesting a potential protective role in the development of MS. This study supports the hypothesis that vitamin D3 could be an effective strategy, showing a dose-dependent relationship in immune response modulation.
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Most Useful Reviews
6.8
Supports health benefits
No vitamin enhances health like vitamin D (vitamin D3 or cholecalciferol). Research indicates it may play a significant role in preventing SARS and upper respiratory infections. Studies show that individuals with higher vitamin D levels have a lower risk of heart attack, certain cancers, diabetes, and multiple sclerosis. I purchased vitamin D3 to take during the pandemic. The capsules are small, easy to swallow, and should be taken with fatty foods.
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Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 30 Researches
6.3
- All Researches
9
Vitamin D may help MS treatment
Targeting aryl hydrocarbon receptor functionally restores tolerogenic dendritic cells derived from patients with multiple sclerosis.
Focus on combined therapies
We evaluated how vitamin D affects multiple sclerosis (MS) by exploring the properties of immune cells in treatment-naive MS patients compared to healthy donors. Our research revealed that patients’ immune cells had heightened proinflammatory features, particularly related to key pathways involving the aryl hydrocarbon receptor (AhR) and NF-κB. This imbalance may contribute to the difficulties in managing MS effectively.
We discovered that dendritic cells derived from MS patients showed reduced tolerogenic capabilities. However, when we applied vitamin D3 and directly activated the AhR, we were able to restore these properties. Furthermore, combining vitamin D3 with a drug known as dimethyl fumarate (DMF) not only enhanced the tolerogenic effects but also provided a more effective treatment option in experiments on mice.
Our findings suggest that a combined therapy utilizing DMF and vitamin D3-tolerogenic dendritic cells has great potential in improving treatment for MS. However, it is worth noting that the analysis focuses on the combination therapy rather than isolating the effects of vitamin D alone.
We discovered that dendritic cells derived from MS patients showed reduced tolerogenic capabilities. However, when we applied vitamin D3 and directly activated the AhR, we were able to restore these properties. Furthermore, combining vitamin D3 with a drug known as dimethyl fumarate (DMF) not only enhanced the tolerogenic effects but also provided a more effective treatment option in experiments on mice.
Our findings suggest that a combined therapy utilizing DMF and vitamin D3-tolerogenic dendritic cells has great potential in improving treatment for MS. However, it is worth noting that the analysis focuses on the combination therapy rather than isolating the effects of vitamin D alone.
Read More
9
Vitamin D3 alleviates MS symptoms
Immunoregulatory Effect of Calcitriol on Experimental Autoimmune Encephalomyelitis (EAE) Mice.
Study focuses on vitamin D3 effects
We investigated the influence of calcitriol, the active form of vitamin D, on experimental autoimmune encephalomyelitis (EAE), an animal model akin to multiple sclerosis. Our study involved twenty-eight mice divided into four groups, allowing us to compare outcomes between those with and without EAE, as well as those receiving calcitriol treatment.
We found that, in mice with EAE, inflammation indicators such as interleukin-17 (IL-17) significantly increased, while transforming growth factor beta (TGF-β) levels decreased compared to healthy controls. Upon treating the EAE group with calcitriol, we observed a reversal of these changes, suggesting a substantial immunomodulatory effect, which eased symptoms typically associated with EAE.
Notably, we also noticed that calcitriol enhanced gene expression for interleukin-9 (IL-9) in both healthy and EAE mice. Overall, our findings support the notion that calcitriol holds promise as a potential treatment to alleviate the symptoms of multiple sclerosis through its anti-inflammatory properties.
We found that, in mice with EAE, inflammation indicators such as interleukin-17 (IL-17) significantly increased, while transforming growth factor beta (TGF-β) levels decreased compared to healthy controls. Upon treating the EAE group with calcitriol, we observed a reversal of these changes, suggesting a substantial immunomodulatory effect, which eased symptoms typically associated with EAE.
Notably, we also noticed that calcitriol enhanced gene expression for interleukin-9 (IL-9) in both healthy and EAE mice. Overall, our findings support the notion that calcitriol holds promise as a potential treatment to alleviate the symptoms of multiple sclerosis through its anti-inflammatory properties.
Read More
9
Vitamin D3 may protect against MS
The role of vitamin D through SphK1/S1P in the regulation of MS progression.
Directly addresses vitamin D3 effects
We explored the effects of vitamin D3 on multiple sclerosis (MS) by examining its role in regulating a specific lipid called Sphingosine-1-phosphate (S1P), which is known to contribute to neuroinflammation and the progression of MS. In a series of carefully designed experiments, we looked at both the EAE model in rats, which mimics MS, and PC12 cells to understand how vitamin D3 may offer protective benefits against cellular damage.
Our findings indicated that vitamin D3 could alleviate symptoms of EAE in rats and reduce the severity of their condition. We observed that it also inhibited the expression of SphK1, which is responsible for producing S1P, leading to lower levels of this inflammatory mediator. In the laboratory environment, vitamin D3 significantly reduced cell death induced by S1P in PC12 cells, showing an improvement in cell attachment quality and overall health.
Additionally, vitamin D3 appeared to block pathways that are known to lead to inflammation and cell death. We noticed reductions in certain cytokines and apoptosis markers, which are associated with inflammatory responses. There was also an increase in a protein linked to nerve cell protection, suggesting vitamin D3 has multiple mechanisms through which it operates.
In summary, our research supports the idea that vitamin D3 has a protective effect against MS by lowering S1P levels and influencing several related pathways. This opens up promising avenues for vitamin D3 to be considered in combination therapies aimed at treating this challenging condition.
Our findings indicated that vitamin D3 could alleviate symptoms of EAE in rats and reduce the severity of their condition. We observed that it also inhibited the expression of SphK1, which is responsible for producing S1P, leading to lower levels of this inflammatory mediator. In the laboratory environment, vitamin D3 significantly reduced cell death induced by S1P in PC12 cells, showing an improvement in cell attachment quality and overall health.
Additionally, vitamin D3 appeared to block pathways that are known to lead to inflammation and cell death. We noticed reductions in certain cytokines and apoptosis markers, which are associated with inflammatory responses. There was also an increase in a protein linked to nerve cell protection, suggesting vitamin D3 has multiple mechanisms through which it operates.
In summary, our research supports the idea that vitamin D3 has a protective effect against MS by lowering S1P levels and influencing several related pathways. This opens up promising avenues for vitamin D3 to be considered in combination therapies aimed at treating this challenging condition.
Read More
8
Vitamin D influences MS cytokine balance
Vitamin D supplementation mediates a shift towards anti-inflammatory cytokine response in Multiple Sclerosis.
Study addresses vitamin D in MS.
We explored the potential impact of Vitamin D supplementation on patients newly diagnosed with Multiple Sclerosis (MS). Our study involved 16 drug-naïve patients who were monitored over a year. We measured the levels of 25-hydroxy-vitamin D in their blood and evaluated how this vitamin affects the balance between pro-inflammatory and anti-inflammatory cytokines, which play significant roles in MS.
Our findings showed that these patients initially had low vitamin D levels and high levels of pro-inflammatory cytokines. Over the course of the study, participants who received vitamin D supplementation demonstrated a notable decrease in pro-inflammatory cytokine levels. Additionally, the ratio of pro-inflammatory to anti-inflammatory cytokines improved, suggesting that vitamin D may help shift the immune response towards a more protective profile.
Interestingly, while some patients also received immunotherapy, our data indicated that Vitamin D supplementation might independently contribute to better immune regulation. Patients with higher pro-inflammatory cytokine ratios appeared more susceptible to relapses, emphasizing the potential role of Vitamin D in managing MS symptoms.
This research supports the idea that having adequate levels of Vitamin D could be vital for those facing MS, as it may offer a protective mechanism through improving immune responses. Ultimately, vitamin D supplementation could be an essential component of a comprehensive treatment plan for MS patients.
Our findings showed that these patients initially had low vitamin D levels and high levels of pro-inflammatory cytokines. Over the course of the study, participants who received vitamin D supplementation demonstrated a notable decrease in pro-inflammatory cytokine levels. Additionally, the ratio of pro-inflammatory to anti-inflammatory cytokines improved, suggesting that vitamin D may help shift the immune response towards a more protective profile.
Interestingly, while some patients also received immunotherapy, our data indicated that Vitamin D supplementation might independently contribute to better immune regulation. Patients with higher pro-inflammatory cytokine ratios appeared more susceptible to relapses, emphasizing the potential role of Vitamin D in managing MS symptoms.
This research supports the idea that having adequate levels of Vitamin D could be vital for those facing MS, as it may offer a protective mechanism through improving immune responses. Ultimately, vitamin D supplementation could be an essential component of a comprehensive treatment plan for MS patients.
Read More
8
GLP-1 medications enhance vitamin D
Glucagon-like peptide-1 agonist safety and efficacy in a multiple sclerosis cohort.
Moderate relevance regarding findings
We investigated how glucagon-like peptide-1 agonists (GLP-1s) impact people with multiple sclerosis (MS), particularly focusing on weight loss and vitamin D levels. Our research examined individuals with MS who used GLP-1 medications over an extended period from 2006 to 2024.
The findings were promising. We observed that after initiating GLP-1 treatment, participants experienced a significant decrease in body mass index (BMI) by an average of 3.7%. Moreover, there was an increase in vitamin D levels, with an average rise of 8.1 ng/mL. However, there were no notable changes in disability status or walking speed.
Importantly, we found that patients did not experience any hospitalizations or deaths during the study period following GLP-1 usage. This suggests that GLP-1 medications are not only safe for people with MS but also effective in boosting vitamin D levels, which may play a role in managing MS symptoms.
The findings were promising. We observed that after initiating GLP-1 treatment, participants experienced a significant decrease in body mass index (BMI) by an average of 3.7%. Moreover, there was an increase in vitamin D levels, with an average rise of 8.1 ng/mL. However, there were no notable changes in disability status or walking speed.
Importantly, we found that patients did not experience any hospitalizations or deaths during the study period following GLP-1 usage. This suggests that GLP-1 medications are not only safe for people with MS but also effective in boosting vitamin D levels, which may play a role in managing MS symptoms.
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User Reviews
USERS' SCORE
Good
Based on 1 Review
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
6.8
Supports health benefits
No vitamin enhances health like vitamin D (vitamin D3 or cholecalciferol). Research indicates it may play a significant role in preventing SARS and upper respiratory infections. Studies show that individuals with higher vitamin D levels have a lower risk of heart attack, certain cancers, diabetes, and multiple sclerosis. I purchased vitamin D3 to take during the pandemic. The capsules are small, easy to swallow, and should be taken with fatty foods.
Read More
Frequently Asked Questions
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