' 
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.8
USERS' SCORE
Good
Based on 2 Reviews
8.2
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3
25 mcg (1,000 IU)
125%
Top Medical Research Studies
8
Vitamin D may reduce prostate cancer mortality
Intratumoral vitamin D signaling and lethal prostate cancer.
Direct effects on prostate cancer
We set out to understand how vitamin D signaling within prostate cancer tumors might impact patient outcomes, particularly the risk of developing lethal forms of the disease. In our exploration, we analyzed data from 404 men with primary prostate cancer over a long follow-up period, assessing specific gene expressions linked to vitamin D in their tumor tissues.
Our findings revealed a noteworthy trend: the activation of vitamin D signaling in tumors was associated with a lower chance of progressing to lethal prostate cancer. Specifically, men with higher scores indicating active vitamin D signaling had a significantly reduced risk of metastasis or prostate cancer-related death compared to those with lower scores.
Interestingly, this protective association appeared to be stronger in individuals with predicted higher levels of vitamin D in their blood and those who had a body mass index of 25 or higher. With our research providing a clearer picture of how vitamin D functions within tumors, we believe there’s a solid basis for considering vitamin D interventions as potential strategies to enhance survival outcomes for prostate cancer patients.
Our findings revealed a noteworthy trend: the activation of vitamin D signaling in tumors was associated with a lower chance of progressing to lethal prostate cancer. Specifically, men with higher scores indicating active vitamin D signaling had a significantly reduced risk of metastasis or prostate cancer-related death compared to those with lower scores.
Interestingly, this protective association appeared to be stronger in individuals with predicted higher levels of vitamin D in their blood and those who had a body mass index of 25 or higher. With our research providing a clearer picture of how vitamin D functions within tumors, we believe there’s a solid basis for considering vitamin D interventions as potential strategies to enhance survival outcomes for prostate cancer patients.
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9
Vitamin D3 may prevent prostate cancer
1,25-Dihydroxyvitamin D Suppresses Prognostic Survival Biomarkers Associated with Cell Cycle and Actin Organization in a Non-Malignant African American Prostate Cell Line.
Highly relevant to prostate cancer
We explored how vitamin D3, specifically the metabolite 1α,25(OH)D, influences the behavior of non-cancerous prostate cells derived from African American men. In our study, we treated the RC-77N/E cell line with vitamin D3 and observed significant changes in gene expression after just 24 hours.
Our analysis revealed that 1α,25(OH)D affected 1,601 genes, highlighting its potential to suppress pathways linked to prostate cancer progression and cell proliferation. This points to the ability of vitamin D3 to help maintain non-malignant cell characteristics.
Additionally, we identified two specific genes, Anillin and Epithelial Cell Transforming 2, which were significantly downregulated by vitamin D3 treatment and correlated with better overall survival in prostate cancer patients. This suggests that these genes could serve as valuable biomarkers for assessing the risk of disease in affected individuals.
Given these promising findings, we believe that 1α,25(OH)D not only plays a vital role in regulating prostate health but could also be used as part of a preventative strategy or as an adjunct therapy, particularly for African American men who are disproportionately affected by prostate cancer.
Our analysis revealed that 1α,25(OH)D affected 1,601 genes, highlighting its potential to suppress pathways linked to prostate cancer progression and cell proliferation. This points to the ability of vitamin D3 to help maintain non-malignant cell characteristics.
Additionally, we identified two specific genes, Anillin and Epithelial Cell Transforming 2, which were significantly downregulated by vitamin D3 treatment and correlated with better overall survival in prostate cancer patients. This suggests that these genes could serve as valuable biomarkers for assessing the risk of disease in affected individuals.
Given these promising findings, we believe that 1α,25(OH)D not only plays a vital role in regulating prostate health but could also be used as part of a preventative strategy or as an adjunct therapy, particularly for African American men who are disproportionately affected by prostate cancer.
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8
Vitamin D and prostate cancer outcomes
Disentangling discordant vitamin D associations with prostate cancer incidence and fatality in a large, nested case-control study.
Direct investigation of vitamin D
We explored the connection between vitamin D levels and their effects on prostate cancer risk and survival. Utilizing data from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, we looked closer at nearly 1,000 prostate cancer cases and their corresponding controls, analyzing the role of vitamin D alongside other vitamins like E and A.
Our findings suggest an interesting duality: higher vitamin D levels may increase the risk of developing prostate cancer, yet they also appear to support better survival among those diagnosed with the disease. Importantly, we found no evidence of biases that could distort these associations, suggesting that the relationship we observed is quite valid.
This research provides a critical insight into how vitamin D might play a beneficial role in surviving prostate cancer, warranting further investigation through controlled trials. Thus, while more research is needed, our results open the door for considering vitamin D as a potential factor in improving outcomes for prostate cancer patients.
Our findings suggest an interesting duality: higher vitamin D levels may increase the risk of developing prostate cancer, yet they also appear to support better survival among those diagnosed with the disease. Importantly, we found no evidence of biases that could distort these associations, suggesting that the relationship we observed is quite valid.
This research provides a critical insight into how vitamin D might play a beneficial role in surviving prostate cancer, warranting further investigation through controlled trials. Thus, while more research is needed, our results open the door for considering vitamin D as a potential factor in improving outcomes for prostate cancer patients.
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Most Useful Reviews
5
Boosted immunity
VITAMIN D3 IS ESSENTIAL for immunity and bones! After discovering my low vitamin D3 levels, I tried this supplement. Within three months, my levels normalised, and I felt a significant improvement in my energy, mood, and overall well-being. This product is reputable and effectively enhances calcium absorption and bone strength, and I've read that it may even reduce the risk of viral infections. It's crucial for maintaining good health, especially during winter when sunlight exposure is limited. I highly recommend it for people looking to bolster their bodies.
Read More
8
Good for cancer
I bought it as it's beneficial for cancer patients.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.8
- All Researches
9
Vitamin D enhances chemoresistance treatment
A vitamin D-based strategy overcomes chemoresistance in prostate cancer.
Study highlights vitamin D's potential
This study sought to uncover how vitamin D can help overcome challenges faced in treating castration-resistant prostate cancer (CRPC). We evaluated the powerful effects of certain vitamin D analogs in combination with the standard chemotherapy drug docetaxel, which often sees diminished effectiveness due to cancer cells developing resistance.
Our findings indicate that a specific vitamin D analog, Xe4MeCF3, outperforms natural vitamin D in activating the vitamin D receptor, which plays a crucial role in regulating cell growth and health. Notably, we observed that this compound not only helps restore sensitivity to docetaxel in lab-grown cancer spheroids but also reduces tumor growth in models derived from CRPC patients showing resistance to treatments.
This suggests a promising new avenue for enhancing the effectiveness of existing treatments for prostate cancer, especially for those who have not responded well to current options. By targeting key signaling pathways in cancer cells, vitamin D analogs like Xe4MeCF3 could significantly improve patient outcomes in the fight against this challenging disease.
Our findings indicate that a specific vitamin D analog, Xe4MeCF3, outperforms natural vitamin D in activating the vitamin D receptor, which plays a crucial role in regulating cell growth and health. Notably, we observed that this compound not only helps restore sensitivity to docetaxel in lab-grown cancer spheroids but also reduces tumor growth in models derived from CRPC patients showing resistance to treatments.
This suggests a promising new avenue for enhancing the effectiveness of existing treatments for prostate cancer, especially for those who have not responded well to current options. By targeting key signaling pathways in cancer cells, vitamin D analogs like Xe4MeCF3 could significantly improve patient outcomes in the fight against this challenging disease.
Read More
9
Vitamin D3 may prevent prostate cancer
1,25-Dihydroxyvitamin D Suppresses Prognostic Survival Biomarkers Associated with Cell Cycle and Actin Organization in a Non-Malignant African American Prostate Cell Line.
Highly relevant to prostate cancer
We explored how vitamin D3, specifically the metabolite 1α,25(OH)D, influences the behavior of non-cancerous prostate cells derived from African American men. In our study, we treated the RC-77N/E cell line with vitamin D3 and observed significant changes in gene expression after just 24 hours.
Our analysis revealed that 1α,25(OH)D affected 1,601 genes, highlighting its potential to suppress pathways linked to prostate cancer progression and cell proliferation. This points to the ability of vitamin D3 to help maintain non-malignant cell characteristics.
Additionally, we identified two specific genes, Anillin and Epithelial Cell Transforming 2, which were significantly downregulated by vitamin D3 treatment and correlated with better overall survival in prostate cancer patients. This suggests that these genes could serve as valuable biomarkers for assessing the risk of disease in affected individuals.
Given these promising findings, we believe that 1α,25(OH)D not only plays a vital role in regulating prostate health but could also be used as part of a preventative strategy or as an adjunct therapy, particularly for African American men who are disproportionately affected by prostate cancer.
Our analysis revealed that 1α,25(OH)D affected 1,601 genes, highlighting its potential to suppress pathways linked to prostate cancer progression and cell proliferation. This points to the ability of vitamin D3 to help maintain non-malignant cell characteristics.
Additionally, we identified two specific genes, Anillin and Epithelial Cell Transforming 2, which were significantly downregulated by vitamin D3 treatment and correlated with better overall survival in prostate cancer patients. This suggests that these genes could serve as valuable biomarkers for assessing the risk of disease in affected individuals.
Given these promising findings, we believe that 1α,25(OH)D not only plays a vital role in regulating prostate health but could also be used as part of a preventative strategy or as an adjunct therapy, particularly for African American men who are disproportionately affected by prostate cancer.
Read More
9
Vitamin D3 enhances cancer treatment
1α,25-Dihydroxyvitamin D synergistically enhances anticancer effects of ginsenoside Rh2 in human prostate cancer cells.
Study shows synergistic effects
We explored how vitamin D3, specifically 1α,25-dihydroxyvitamin D (often called calcitriol), influences the effects of ginsenoside Rh2 on prostate cancer cells. The study focused on both androgen-dependent LNCaP and androgen-independent C4-2 cell lines to analyze if this combination could enhance cancer-fighting properties.
Through various assays, we measured cell viability, proliferation, and the expression of key proteins involved in cancer growth and death. Our findings revealed that when we combined just 10 nM of vitamin D3 with ginsenoside Rh2, there was a marked improvement in reducing cell viability, with some treatments achieving up to an 80% decrease.
Moreover, we noticed that this collaboration also better suppressed the androgen receptor, which plays a significant role in prostate cancer development, while boosting the pro-apoptotic effects of Rh2. This combination suggests that vitamin D3 can potentiate the anticancer potential of Rh2, potentially lowering the required doses of the active vitamin D and minimizing side effects.
Through various assays, we measured cell viability, proliferation, and the expression of key proteins involved in cancer growth and death. Our findings revealed that when we combined just 10 nM of vitamin D3 with ginsenoside Rh2, there was a marked improvement in reducing cell viability, with some treatments achieving up to an 80% decrease.
Moreover, we noticed that this collaboration also better suppressed the androgen receptor, which plays a significant role in prostate cancer development, while boosting the pro-apoptotic effects of Rh2. This combination suggests that vitamin D3 can potentiate the anticancer potential of Rh2, potentially lowering the required doses of the active vitamin D and minimizing side effects.
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8
Vitamin D analogs show promise
[New insights of vitamin D-based therapy for prostate cancer].
Significant relevance to treatment
We aimed to understand the role of vitamin D in treating prostate cancer, a serious disease that affects many men worldwide. The study highlights the problematic nature of advanced prostate cancer treatments, as most patients can develop resistance to standard hormone and chemotherapy options.
Our research showed a clear connection between low levels of vitamin D and the severity of prostate cancer, as well as the reduced presence of its receptor in prostate cells. This prompted us to investigate the effects of a vitamin D analog specifically in a mouse model designed for prostate cancer.
We observed that using this vitamin D analog positively impacted the tumor microenvironment in these mice. Moreover, we found that combining this vitamin D treatment with a common chemotherapy drug, docetaxel, helped overcome resistance observed in primary prostate cancer spheroids and in patient-derived xenografts that were resistant to both docetaxel and androgen deprivation.
Thus, our findings indicate that vitamin D analogs could be a promising new strategy for tackling advanced prostate cancer, offering hope for improving treatment outcomes for patients facing this challenging disease.
Our research showed a clear connection between low levels of vitamin D and the severity of prostate cancer, as well as the reduced presence of its receptor in prostate cells. This prompted us to investigate the effects of a vitamin D analog specifically in a mouse model designed for prostate cancer.
We observed that using this vitamin D analog positively impacted the tumor microenvironment in these mice. Moreover, we found that combining this vitamin D treatment with a common chemotherapy drug, docetaxel, helped overcome resistance observed in primary prostate cancer spheroids and in patient-derived xenografts that were resistant to both docetaxel and androgen deprivation.
Thus, our findings indicate that vitamin D analogs could be a promising new strategy for tackling advanced prostate cancer, offering hope for improving treatment outcomes for patients facing this challenging disease.
Read More
8
Liposomal vitamin D efficacy in prostate cancer
Liposomal encapsulation of cholecalciferol mitigates toxicity and delays tumor growth.
Addresses prostate cancer treatment
We investigated how vitamin D, specifically in its liposomal form, impacts prostate cancer using the TRAMP-C1 tumor model. Our findings indicate that liposomal vitamin D (VD-LP) significantly enhances anticancer effects while minimizing toxicity, unlike standard vitamin D therapies.
By preparing VD-LP using a film-hydration method, we ensured it was stable and effectively encapsulated, which set the stage for its evaluation in various cancer cell lines, including those representing prostate cancer.
When tested, VD-LP not only delayed tumor growth but also showed improved survival rates, all without triggering harmful levels of calcium in the blood. This is a crucial finding, as hypercalcemia can limit the use of vitamin D in clinical settings.
Overall, the study suggests that liposomal encapsulation of vitamin D could be a promising avenue for enhancing treatment strategies against prostate cancer, providing considerable hope for safer therapeutic options.
By preparing VD-LP using a film-hydration method, we ensured it was stable and effectively encapsulated, which set the stage for its evaluation in various cancer cell lines, including those representing prostate cancer.
When tested, VD-LP not only delayed tumor growth but also showed improved survival rates, all without triggering harmful levels of calcium in the blood. This is a crucial finding, as hypercalcemia can limit the use of vitamin D in clinical settings.
Overall, the study suggests that liposomal encapsulation of vitamin D could be a promising avenue for enhancing treatment strategies against prostate cancer, providing considerable hope for safer therapeutic options.
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User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
5
Boosted immunity
VITAMIN D3 IS ESSENTIAL for immunity and bones! After discovering my low vitamin D3 levels, I tried this supplement. Within three months, my levels normalised, and I felt a significant improvement in my energy, mood, and overall well-being. This product is reputable and effectively enhances calcium absorption and bone strength, and I've read that it may even reduce the risk of viral infections. It's crucial for maintaining good health, especially during winter when sunlight exposure is limited. I highly recommend it for people looking to bolster their bodies.
Read More
8
Good for cancer
I bought it as it's beneficial for cancer patients.
