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Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Vitamin D3 (as cholecalciferol)
125 mcg (5000 IU)
625%
The product is found useful for the following medical conditions
Common Cold details
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.4
USERS' SCORE
Excellent
Based on 9 Reviews
9
8
Vitamin D3 improves cold symptoms
Intake of 25-Hydroxyvitamin D3 Reduces Duration and Severity of Upper Respiratory Tract Infection: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Comparison Study.
Most Relevant Research
We conducted a thorough investigation into how 25-hydroxyvitamin D3, commonly referred to as vitamin D3, impacts upper respiratory tract infections (URTIs), particularly the common cold. This study was carried out as a randomized, double-blind, placebo-controlled trial, engaging 428 participants, all aged between 45 and 74, across three clinics in Japan.
Participants were divided into two groups, with one receiving a daily dose of 10 μg of vitamin D3, while the other took a placebo for 16 weeks. Our findings highlighted that those who took vitamin D3 experienced a reduction in the duration of their upper respiratory symptoms, as well as a decrease in severity and improvement in their quality of life during illness.
Overall, our results indicate that supplementing with vitamin D3 might be a proactive step in handling the discomforts associated with common colds. This simple addition to one's daily routine could lead to a notably better experience when facing URTIs, providing a hopeful outlook for those looking for relief from their symptoms.
Participants were divided into two groups, with one receiving a daily dose of 10 μg of vitamin D3, while the other took a placebo for 16 weeks. Our findings highlighted that those who took vitamin D3 experienced a reduction in the duration of their upper respiratory symptoms, as well as a decrease in severity and improvement in their quality of life during illness.
Overall, our results indicate that supplementing with vitamin D3 might be a proactive step in handling the discomforts associated with common colds. This simple addition to one's daily routine could lead to a notably better experience when facing URTIs, providing a hopeful outlook for those looking for relief from their symptoms.
9.5
Improved immunity
Most Useful Review
I recommend Solgar’s Vitamin D3. The 5000 IU dosage in tasteless, easy-to-swallow capsules has helped my immune system significantly; I rarely catch common colds now. It supports my skeletal health by promoting calcium absorption, and I'm very satisfied with the results.
Allergies details
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.4
USERS' SCORE
Good
Based on 8 Reviews
8.8
8
Vitamin D3 impacts allergy severity
Correlation Between a Deficiency of D3 Levels and the Development of Allergic Rhinitis.
Most Relevant Research
We explored the relationship between vitamin D3 levels and allergic rhinitis (AR), a common condition characterized by sneezing, runny noses, and itchy eyes. In our research, we included two groups: thirty individuals with AR between the ages of 18 and 35 who had low levels of vitamin D3 and a control group of thirty people with sufficient vitamin D3 levels.
Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.
Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.
Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.
Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.
9.5
Immunity improved
Most Useful Review
Quality vitamins with the right dosage. I take iodine as prescribed, alongside vitamin D. The capsules are small, and I experience no allergies with these vitamins. After taking one daily, my joint pain ceased, I felt better, and my immunity improved. Tests indicated no vitamin D deficiency.
Osteoporosis details
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.4
USERS' SCORE
Good
Based on 11 Reviews
8.8
9
Vitamin D derivatives enhance bone health
Synthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities.
Most Relevant Research
We looked into the potential effects of vitamin D3, particularly its derivatives, on osteoporosis. Recent research highlights how modifications to the A-ring of 1α,25-dihydroxyvitamin D can enhance its binding to the vitamin D receptor. This change not only boosts the vitamin's effectiveness but also helps it resist breakdown in the body, making it stay active for longer periods.
One standout example is a derivative known as AH-1, which demonstrated significant benefits for bone health in an osteoporosis model using ovariectomized rats. When given at a low dosage, AH-1 outperformed natural vitamin D, suggesting a promising path for improving osteoporosis treatment.
We also noted that while traditional vitamin D has its benefits, these newly developed analogs could lead to treatments that target osteoporosis more effectively, providing options without the side effects commonly associated with vitamin D therapy. This research emphasizes the importance of vitamin D derivatives as we seek better solutions for managing bone health.
One standout example is a derivative known as AH-1, which demonstrated significant benefits for bone health in an osteoporosis model using ovariectomized rats. When given at a low dosage, AH-1 outperformed natural vitamin D, suggesting a promising path for improving osteoporosis treatment.
We also noted that while traditional vitamin D has its benefits, these newly developed analogs could lead to treatments that target osteoporosis more effectively, providing options without the side effects commonly associated with vitamin D therapy. This research emphasizes the importance of vitamin D derivatives as we seek better solutions for managing bone health.
9.5
Bones improved
Most Useful Review
While I cannot medically prove it, my Solgar Vitamin D3 supplement has significantly contributed to my osteoporosis dropping to osteopenia. I've taken this supplement for about six years, with consistent improvements in my bone density exams every two years.
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
5
USERS' SCORE
Good
Based on 9 Reviews
8.7
2
Vitamin D3 ineffective for CFS
Effect of intermittent vitamin D3 on vascular function and symptoms in chronic fatigue syndrome--a randomised controlled trial.
Most Relevant Research
We conducted a thorough investigation into whether high-dose intermittent vitamin D3 could alleviate symptoms of chronic fatigue syndrome (CFS) and improve vascular health. This double-blind, randomized placebo-controlled trial involved patients meeting established criteria for CFS. Participants received either 100,000 units of vitamin D3 or a placebo every two months for six months.
Over the course of the study, we measured key outcomes such as arterial stiffness, blood pressure, cholesterol levels, and fatigue levels through various tests. Surprisingly, our findings showed that vitamin D3 treatment did not lead to any significant improvements in these areas. We observed only a slight increase in vitamin D levels in the treatment group, but this did not translate into better vascular health or reduced fatigue.
In conclusion, we honestly found that high-dose vitamin D3 did not offer any notable benefits for patients struggling with chronic fatigue syndrome. This study highlights the complexities of treating CFS and suggests that vitamin D3 may not be the solution some had hoped for.
Over the course of the study, we measured key outcomes such as arterial stiffness, blood pressure, cholesterol levels, and fatigue levels through various tests. Surprisingly, our findings showed that vitamin D3 treatment did not lead to any significant improvements in these areas. We observed only a slight increase in vitamin D levels in the treatment group, but this did not translate into better vascular health or reduced fatigue.
In conclusion, we honestly found that high-dose vitamin D3 did not offer any notable benefits for patients struggling with chronic fatigue syndrome. This study highlights the complexities of treating CFS and suggests that vitamin D3 may not be the solution some had hoped for.
9.5
Weight stabilisation
Most Useful Review
On my doctor's advice, I've been taking vitamin D regularly as it isn't produced naturally in my body. After previously using Russian alternatives that increased my appetite dramatically, I switched to Solgar. I've been taking it for over two years, and my weight is stabilised. My health is excellent now, with no fatigue or mood swings.
Depression details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.2
USERS' SCORE
Good
Based on 8 Reviews
8.7
9
Vitamin D3 improves depressive symptoms
Effects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial.
Most Relevant Research
We conducted a double-blind randomized clinical trial to explore the effects of vitamin D3 supplementation on depression. Our study involved 56 adults with mild to moderate depression, who were assigned to either a vitamin D group or a placebo group. Over the course of eight weeks, the vitamin D group received a high dose of 50,000 IU cholecalciferol every two weeks, while the control group received a placebo.
After the treatment period, we observed that the participants who received the vitamin D3 experienced a significant reduction in depression severity, as measured by the Beck Depression Inventory-II. Interestingly, this improvement in mood occurred independently of any changes in inflammatory biomarkers like IL-1β, IL-6, and hs-CRP, which we also assessed during the study.
This indicates that while vitamin D supplementation may positively impact depressive symptoms, its effects are not directly linked to the inflammatory markers we evaluated. Our findings suggest that vitamin D3 could be a helpful addition to depression treatment strategies, particularly in individuals with low vitamin D levels.
After the treatment period, we observed that the participants who received the vitamin D3 experienced a significant reduction in depression severity, as measured by the Beck Depression Inventory-II. Interestingly, this improvement in mood occurred independently of any changes in inflammatory biomarkers like IL-1β, IL-6, and hs-CRP, which we also assessed during the study.
This indicates that while vitamin D supplementation may positively impact depressive symptoms, its effects are not directly linked to the inflammatory markers we evaluated. Our findings suggest that vitamin D3 could be a helpful addition to depression treatment strategies, particularly in individuals with low vitamin D levels.
9.5
Boosted energy
Most Useful Review
The best vitamin D3! It strengthens the immune system, combats depression, and improves sleep, making one feel lively and energetic. After just a few days, I experienced an energy boost and found it easier to wake up. Since balancing my D3 levels with this product, I haven't caught a single cold. Truly an excellent result!
Heartburn details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.7
9.5
No heartburn experienced
Most Useful Review
Perfect! I have tried vitamin D3 from various companies, but I prefer Solgar. Unlike others, I did not experience heartburn. My sleep has improved, and I've noticed a boost in my energy levels. The capsules are convenient, and the dosage is excellent. This brand is highly commendable. I will recommend it to my family and friends and will definitely purchase more.
Cancer details
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.5
USERS' SCORE
Good
Based on 5 Reviews
8.6
8
Vitamin D3 offers anti-cancer benefits
Liposomal encapsulation of cholecalciferol mitigates toxicity and delays tumor growth.
Most Relevant Research
We investigated the potential of vitamin D3, also known as cholecalciferol, in combating cancer while addressing concerns about its toxicity at higher doses. This study focused on enhancing the effectiveness of vitamin D3 through a clever method called liposomal encapsulation, which helps minimize side effects.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
8.8
Positive lab results
Most Useful Review
I've been taking these capsules for several months, and recent lab results showed my Vitamin D levels increased from 19 to 35.5. I take one capsule with my morning medications and am pleased with the outcome. As a cancer patient, I've been advised that maintaining good Vitamin D levels is essential, so I'll continue using this brand.
Headache details
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.6
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Vitamin D3 aids migraine relief
Vitamin D3 might improve headache characteristics and protect against inflammation in migraine: a randomized clinical trial.
Most Relevant Research
We conducted a rigorous study to explore how vitamin D3 supplementation might influence headaches in people suffering from migraines. By utilizing a well-structured, placebo-controlled, double-blind design, we included 80 participants with episodic migraines, assigning them either a daily dose of vitamin D3 or a placebo for 12 weeks.
After the study, we observed significant improvements in those receiving vitamin D3. Participants reported fewer headache days each month, shorter headache durations, and less severe pain overall. They also used fewer pain relievers compared to those on placebo, showcasing the potential benefit of vitamin D3 in managing migraine symptoms.
Our findings suggest that vitamin D3 not only aids in reducing headache frequency but may also play a role in addressing inflammation, as evidenced by reduced levels of certain inflammatory markers in the blood. This highlights its possible therapeutic value for migraine sufferers, indicating that a daily dose could make a meaningful difference in their lives.
After the study, we observed significant improvements in those receiving vitamin D3. Participants reported fewer headache days each month, shorter headache durations, and less severe pain overall. They also used fewer pain relievers compared to those on placebo, showcasing the potential benefit of vitamin D3 in managing migraine symptoms.
Our findings suggest that vitamin D3 not only aids in reducing headache frequency but may also play a role in addressing inflammation, as evidenced by reduced levels of certain inflammatory markers in the blood. This highlights its possible therapeutic value for migraine sufferers, indicating that a daily dose could make a meaningful difference in their lives.
9.5
Effective for headaches
Most Useful Review
Good composition and fast delivery. The capsules, although slightly large, are easy to swallow and taste of citrus. I take one daily with meals, along with other supplements. After 10 days, I've noticed a remarkable improvement; my energy is up, headaches have stopped, and my mood is consistently excellent. This product is ideal for those interested in sports or following a diet, as omega-3 helps replenish the body's needs.
High Cholesterol details
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.6
USERS' SCORE
Good
Based on 3 Reviews
8.6
9
Vitamin D3 lowers cholesterol levels
Vitamin D Supplementation Reduces Hyperlipidemia and Improves Bone Mass in Pediatric Obesity.
Most Relevant Research
We investigated how vitamin D3 supplements impact cholesterol levels in pediatric patients suffering from obesity. The study involved 723 children over two years, with 283 receiving vitamin D3 and 440 on a placebo.
After closely examining the children’s cholesterol, triglycerides, and glucose levels, we found a strong relationship between these factors and their vitamin D3 levels. Following the supplementation, the group taking vitamin D3 experienced some notable improvements.
Specifically, we saw significant decreases in total cholesterol, HDL cholesterol, and triglycerides in the vitamin D3 group when compared to those who received the placebo. This indicates that vitamin D3 could play a beneficial role in managing high cholesterol and improving overall metabolic health in children coping with obesity.
Our findings suggest that vitamin D3 is a valuable addition to strategies aimed at improving lipid levels and encouraging healthy lifestyles in young patients struggling with excessive weight. Overall, supplementing with vitamin D3 appears to offer an effective approach to tackling high cholesterol in this at-risk population.
After closely examining the children’s cholesterol, triglycerides, and glucose levels, we found a strong relationship between these factors and their vitamin D3 levels. Following the supplementation, the group taking vitamin D3 experienced some notable improvements.
Specifically, we saw significant decreases in total cholesterol, HDL cholesterol, and triglycerides in the vitamin D3 group when compared to those who received the placebo. This indicates that vitamin D3 could play a beneficial role in managing high cholesterol and improving overall metabolic health in children coping with obesity.
Our findings suggest that vitamin D3 is a valuable addition to strategies aimed at improving lipid levels and encouraging healthy lifestyles in young patients struggling with excessive weight. Overall, supplementing with vitamin D3 appears to offer an effective approach to tackling high cholesterol in this at-risk population.
9.5
Relieved Pain
Most Useful Review
After testing, I was pleasantly surprised that my vitamin D levels increased. I no longer experience dental or back pain, both of which were signs of my poor bone mass linked to vitamin D deficiency and high cholesterol.
Influenza details
SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.8
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Vitamin D3 may reduce influenza severity
Oral Supplementation of the Vitamin D Metabolite 25(OH)D Against Influenza Virus Infection in Mice.
Most Relevant Research
We aimed to understand how oral supplementation of 25-hydroxyvitamin D, a key metabolite of vitamin D3, influences influenza A virus infection in mice. In our study, mice were given a diet enriched with a high dose of 25(OH)D before they were exposed to the influenza virus.
The results were promising. Mice that received the vitamin D3 supplement showed significantly lower viral levels in their lungs compared to mice that were fed a standard diet. Furthermore, we noticed a decrease in certain pro-inflammatory cytokines, namely IL-5 and IFN-γ, which are involved in the body's inflammatory response to infection. Importantly, we found that the anti-inflammatory cytokines did not see a significant increase.
These findings suggest that 25(OH)D can help to suppress excessive inflammatory responses and may reduce both the replication of the virus and the overall severity of influenza in this mouse model. It opens the door to further exploration on vitamin D3's role in combating influenza in humans.
The results were promising. Mice that received the vitamin D3 supplement showed significantly lower viral levels in their lungs compared to mice that were fed a standard diet. Furthermore, we noticed a decrease in certain pro-inflammatory cytokines, namely IL-5 and IFN-γ, which are involved in the body's inflammatory response to infection. Importantly, we found that the anti-inflammatory cytokines did not see a significant increase.
These findings suggest that 25(OH)D can help to suppress excessive inflammatory responses and may reduce both the replication of the virus and the overall severity of influenza in this mouse model. It opens the door to further exploration on vitamin D3's role in combating influenza in humans.
9.5
Boosted immunity
Most Useful Review
Excellent quality product; it significantly contributes to immunity and combating influenza and other viruses.
Insomnia details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.7
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Vitamin D3 improves adolescent insomnia
High-dose Vitamin D Supplementation and Improvement in Cognitive Abilities, Insomnia, and Daytime Sleepiness in Adolescent Girls.
Most Relevant Research
We studied how high-dose vitamin D3 supplementation might affect insomnia in adolescent girls. Over nine weeks, 940 participants received a weekly dose of 50,000 IU of vitamin D3 while we tracked changes in their sleep patterns.
Interestingly, we observed a notable reduction in insomnia rates after the treatment. The number of girls reporting insomnia dropped from 15.0% to 11.3%, indicating that this vitamin can potentially improve sleep quality.
We also noticed a slight decrease in daytime sleepiness, with cases falling from 15.6% to 14.7%. Furthermore, those experiencing both insomnia and sleepiness saw a decline from 8.0% to 6.1%.
These findings suggest that high-dose vitamin D can play a significant role in alleviating sleep issues among adolescent girls. However, further studies are needed to see if these effects are consistent across diverse age and gender groups.
Interestingly, we observed a notable reduction in insomnia rates after the treatment. The number of girls reporting insomnia dropped from 15.0% to 11.3%, indicating that this vitamin can potentially improve sleep quality.
We also noticed a slight decrease in daytime sleepiness, with cases falling from 15.6% to 14.7%. Furthermore, those experiencing both insomnia and sleepiness saw a decline from 8.0% to 6.1%.
These findings suggest that high-dose vitamin D can play a significant role in alleviating sleep issues among adolescent girls. However, further studies are needed to see if these effects are consistent across diverse age and gender groups.
9.5
Reduced insomnia symptoms
Most Useful Review
Vitamin D3 is irreplaceable for those lacking sunlight. It provides energy and has eliminated my irritability. I've noticed a significant reduction in insomnia since I began taking it two months ago, and I plan to continue.
Kidney Stones details
SCIENTIFIC SCORE
Likely Ineffective
Based on 4 Researches
4.3
USERS' SCORE
Good
Based on 2 Reviews
8.6
4
Vitamin D3 does not prevent stones
Effect of two vitamin D repletion protocols on 24-h urine calcium in patients with recurrent calcium kidney stones and vitamin D deficiency: a randomized clinical trial.
Most Relevant Research
We assessed how two different vitamin D3 repletion protocols affect patients with recurrent calcium kidney stones and vitamin D deficiency. This was a controlled clinical trial involving 62 participants who had low levels of vitamin D and were prone to kidney stones. We administered either 2000 IU of cholecalciferol daily for 12 weeks or 50,000 IU weekly for 8 weeks.
Both treatment approaches resulted in a significant increase in 24-hour urine calcium levels; however, there was no difference between the two methods. Importantly, neither regimen increased the supersaturation of calcium oxalate or calcium phosphate, which are substances that can contribute to the formation of kidney stones.
We also observed a notable increase in serum levels of 25-hydroxyvitamin D, particularly in the weekly high-dose group, and a decline in serum parathyroid hormone in both groups. Despite these changes, it's crucial to highlight that our findings indicate no significant advantages in preventing kidney stones from vitamin D3 treatment alone.
Both treatment approaches resulted in a significant increase in 24-hour urine calcium levels; however, there was no difference between the two methods. Importantly, neither regimen increased the supersaturation of calcium oxalate or calcium phosphate, which are substances that can contribute to the formation of kidney stones.
We also observed a notable increase in serum levels of 25-hydroxyvitamin D, particularly in the weekly high-dose group, and a decline in serum parathyroid hormone in both groups. Despite these changes, it's crucial to highlight that our findings indicate no significant advantages in preventing kidney stones from vitamin D3 treatment alone.
9
Vitamin D dosage
Most Useful Review
Different doctors have varying views on vitamin D. One therapist believes sun exposure is sufficient, while another insists on strictly two drops of Aquadetrim. However, my trusted endocrinologist, whom I have seen for five years, claims we are all deficient and can safely take up to 10,000 IU without risk of overdose or kidney stones. I ordered vitamin D with a dosage of 5,000 IU, as I have not previously taken it separately.
Leg Cramps details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
8.8
Reduced leg cramps
Most Useful Review
Vitamin D3 5000 Hello! I’m 59 and had never taken this vitamin until now, as doctors never prescribed it. After watching a video explaining its necessity, I realised my leg cramps and joint pain were concerning. I started taking it, especially in the autumn and winter when there’s less sunlight. After a week and a half, my sleep improved, and the pain in my legs lessened. A month later, I no longer suffered from hip joint and muscle pain, and even my rheumatoid arthritis finger joint hurt less. I'm absolutely thrilled!
Menopause details
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6
USERS' SCORE
Good
Based on 2 Reviews
8.6
7
Vitamin D3 in menopause management
Utilizing a Combination of Supplements Comprising Boric Acid, Magnesium, Vitamin D3, and Extra Virgin Olive Oil to Improve Metabolism in Menopausal Ovariectomized Rats.
Most Relevant Research
In this study, we explored how vitamin D3, among other supplements, affects metabolic health during menopause. The research utilized a group of ovariectomized female rats, which serve as a model for menopausal conditions in women. These rats were divided into several groups, including a control group and various groups that received different treatments, including vitamin D3.
The findings indicated that administering vitamin D3, along with boric acid, magnesium, and extra virgin olive oil, led to notable improvements in metabolic parameters. We observed benefits in areas such as inflammation and oxidative stress, which are crucial for managing health during menopause. However, while vitamin D3 showed positive effects, the study highlighted that the combination of all supplements had a more significant impact than vitamin D3 alone.
Ultimately, while vitamin D3 contributes positively to metabolic health in menopause, the full extent of its isolated benefits remains unclear without further studies. Thus, we recognize the need for additional research to fully understand how effective vitamin D3 can be independently in this context.
The findings indicated that administering vitamin D3, along with boric acid, magnesium, and extra virgin olive oil, led to notable improvements in metabolic parameters. We observed benefits in areas such as inflammation and oxidative stress, which are crucial for managing health during menopause. However, while vitamin D3 showed positive effects, the study highlighted that the combination of all supplements had a more significant impact than vitamin D3 alone.
Ultimately, while vitamin D3 contributes positively to metabolic health in menopause, the full extent of its isolated benefits remains unclear without further studies. Thus, we recognize the need for additional research to fully understand how effective vitamin D3 can be independently in this context.
9.5
Relieved back pain
Most Useful Review
Briefly about my case: I discovered iHerb from a client while dealing with menopause that caused discomfort in my lower back. Until 50, I had no issues. Despite trying yoga, anti-inflammatories, and injections with no success. After taking Vitamin D3 (1,000 IU) each morning, I noticed I began to forget about the back pain. I plan to test my vitamin D levels and will continue taking it. Remarkably effective within two weeks. I recommend it.
Prostate Cancer details
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.7
USERS' SCORE
Good
Based on 3 Reviews
8.6
9
Vitamin D3 may prevent prostate cancer
1,25-Dihydroxyvitamin D Suppresses Prognostic Survival Biomarkers Associated with Cell Cycle and Actin Organization in a Non-Malignant African American Prostate Cell Line.
Most Relevant Research
We explored how vitamin D3, specifically the metabolite 1α,25(OH)D, influences the behavior of non-cancerous prostate cells derived from African American men. In our study, we treated the RC-77N/E cell line with vitamin D3 and observed significant changes in gene expression after just 24 hours.
Our analysis revealed that 1α,25(OH)D affected 1,601 genes, highlighting its potential to suppress pathways linked to prostate cancer progression and cell proliferation. This points to the ability of vitamin D3 to help maintain non-malignant cell characteristics.
Additionally, we identified two specific genes, Anillin and Epithelial Cell Transforming 2, which were significantly downregulated by vitamin D3 treatment and correlated with better overall survival in prostate cancer patients. This suggests that these genes could serve as valuable biomarkers for assessing the risk of disease in affected individuals.
Given these promising findings, we believe that 1α,25(OH)D not only plays a vital role in regulating prostate health but could also be used as part of a preventative strategy or as an adjunct therapy, particularly for African American men who are disproportionately affected by prostate cancer.
Our analysis revealed that 1α,25(OH)D affected 1,601 genes, highlighting its potential to suppress pathways linked to prostate cancer progression and cell proliferation. This points to the ability of vitamin D3 to help maintain non-malignant cell characteristics.
Additionally, we identified two specific genes, Anillin and Epithelial Cell Transforming 2, which were significantly downregulated by vitamin D3 treatment and correlated with better overall survival in prostate cancer patients. This suggests that these genes could serve as valuable biomarkers for assessing the risk of disease in affected individuals.
Given these promising findings, we believe that 1α,25(OH)D not only plays a vital role in regulating prostate health but could also be used as part of a preventative strategy or as an adjunct therapy, particularly for African American men who are disproportionately affected by prostate cancer.
8.8
Boosts immunity
Most Useful Review
The best vitamin D3. The ideal dose to enhance immunity with immediate effects. It also supports prostate cancer. If you need to take daily sunbaths, its ingredients and quality make it highly recommended.
Multiple Sclerosis details
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.6
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
Vitamin D3 alleviates MS symptoms
Immunoregulatory Effect of Calcitriol on Experimental Autoimmune Encephalomyelitis (EAE) Mice.
Most Relevant Research
We investigated the influence of calcitriol, the active form of vitamin D, on experimental autoimmune encephalomyelitis (EAE), an animal model akin to multiple sclerosis. Our study involved twenty-eight mice divided into four groups, allowing us to compare outcomes between those with and without EAE, as well as those receiving calcitriol treatment.
We found that, in mice with EAE, inflammation indicators such as interleukin-17 (IL-17) significantly increased, while transforming growth factor beta (TGF-β) levels decreased compared to healthy controls. Upon treating the EAE group with calcitriol, we observed a reversal of these changes, suggesting a substantial immunomodulatory effect, which eased symptoms typically associated with EAE.
Notably, we also noticed that calcitriol enhanced gene expression for interleukin-9 (IL-9) in both healthy and EAE mice. Overall, our findings support the notion that calcitriol holds promise as a potential treatment to alleviate the symptoms of multiple sclerosis through its anti-inflammatory properties.
We found that, in mice with EAE, inflammation indicators such as interleukin-17 (IL-17) significantly increased, while transforming growth factor beta (TGF-β) levels decreased compared to healthy controls. Upon treating the EAE group with calcitriol, we observed a reversal of these changes, suggesting a substantial immunomodulatory effect, which eased symptoms typically associated with EAE.
Notably, we also noticed that calcitriol enhanced gene expression for interleukin-9 (IL-9) in both healthy and EAE mice. Overall, our findings support the notion that calcitriol holds promise as a potential treatment to alleviate the symptoms of multiple sclerosis through its anti-inflammatory properties.
8.3
Enhances health benefits
Most Useful Review
The composition of lanolin is good. No vitamin enhances well-being quite like vitamin D (D3 or cholecalciferol). Research suggests vitamin D is vital in preventing SARS and respiratory infections. Studies indicate those with higher vitamin D levels have a reduced risk of heart attacks, breast and colon cancer, type 1 and type 2 diabetes, hypertension, and complications. I purchased vitamin D3 to use during the pandemic. The tablets are small and easy to swallow and are best consumed with fatty foods. I took a dosage of 5000 units.
Back Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 8 Reviews
8.2
9
Vitamin D3 improves back pain
Vitamin D Supplementation in Patients with Chronic Low Back Pain: An Open Label, Single Arm Clinical Trial.
Most Relevant Research
We sought to understand the role of vitamin D3 supplementation in alleviating chronic low back pain (CLBP). In a single-arm, open-label study at a tertiary care hospital, we worked with 68 patients suffering from CLBP for at least three months, each demonstrating a significant pain level on a visual scale alongside low vitamin D levels.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
9.5
Joint pain improvement
Most Useful Review
I started taking Vitamin D3 at 59 after learning about its importance. I suffered from aching legs and joint inflammation. After just over a week, my sleep improved, and my back pain subsided significantly. After a month, the mobility of my finger joint increased, and the improvement has made me incredibly happy.
Bone Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 8 Reviews
8.2
9.5
Vitamin effectiveness
Most Useful Review
It certainly works. Following an appointment with my endocrinologist, I needed to address a significant vitamin deficiency as my parathyroid hormone was elevated, leading to bone pain. Two months later, my test results were excellent. I will take it with my family during autumn and winter, but at a reduced dose.
Nausea details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.2
9.5
Improved energy levels
Most Useful Review
Good composition and fast delivery. The packaging is high quality and convenient, with no damage. The capsules are slightly large but easy to swallow and taste citrusy. I take one daily with meals alongside other vitamins. After 10 days, I've noticed significant benefits; my energy has increased, headaches have ceased, and my mood is excellent throughout the day. I highly recommend it, especially for those interested in fitness or following a diet, as omega 3 effectively revitalises and replenishes the body.
Arthritis details
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.9
9
Vitamin D3's role in OA prevention
1,25-Dihydroxyvitamin D Deficiency Accelerates Aging-related Osteoarthritis via Downregulation of Sirt1 in Mice.
Most Relevant Research
We explored the link between vitamin D3 and knee osteoarthritis (OA) by examining both young and older mice. Our findings revealed that a deficiency in vitamin D3, specifically the active form known as 1,25(OH)D, significantly sped up the development of age-related OA. This included issues such as cartilage damage and increased chondrocyte senescence.
When we supplemented with vitamin D3, we were pleased to see a reversal of these negative changes in OA phenotypes among the test mice. It not only improved cartilage health but also countered oxidative stress and cell aging associated with OA.
Our research highlights the important role of vitamin D3 in maintaining joint health and its potential to help prevent or slow down the onset of OA through mechanisms involving Sirt1, a gene linked to aging and cellular health. This suggests that ensuring sufficient levels of vitamin D3 could be a useful strategy for those at risk of developing arthritis.
When we supplemented with vitamin D3, we were pleased to see a reversal of these negative changes in OA phenotypes among the test mice. It not only improved cartilage health but also countered oxidative stress and cell aging associated with OA.
Our research highlights the important role of vitamin D3 in maintaining joint health and its potential to help prevent or slow down the onset of OA through mechanisms involving Sirt1, a gene linked to aging and cellular health. This suggests that ensuring sufficient levels of vitamin D3 could be a useful strategy for those at risk of developing arthritis.
9.5
Pain relief noted
Most Useful Review
Vitamin D3 5000 has been a revelation for me. At 59, I had never considered this vitamin until I watched a video by a doctor detailing its significance. My symptoms of joint pain, particularly in my legs and fingers affected by arthritis, improved markedly. Within a week and a half, I began to sleep better, and after a month, my hip joints and finger pain subsided significantly. I'm truly delighted with the results and recommend it for its quick and effective outcomes.
Frozen Shoulder details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.8
9.5
Reduced shoulder pain
Most Useful Review
I was prescribed vitamin D3 due to persistent night pain in my shoulder, with my vitamin D level at 19. After less than a month of taking it, the pain no longer troubles me. I would recommend this brand if you're looking to increase your vitamin D levels!
Knee Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.8
1
Vitamin D3 shows no benefit
Effect of Vitamin D Supplementation on Tibial Cartilage Volume and Knee Pain Among Patients With Symptomatic Knee Osteoarthritis: A Randomized Clinical Trial.
Most Relevant Research
We conducted a thorough investigation into the effects of vitamin D3 supplementation on knee pain and cartilage volume in people suffering from knee osteoarthritis, particularly those with low vitamin D levels. This study took place in Tasmania and Victoria, Australia, and was designed as a multicenter, randomized, double-blind, placebo-controlled clinical trial.
Over a span of two years, we divided participants into two groups: one received a monthly dose of oral vitamin D3 (50,000 IU), while the other group received a placebo. Our main focus was to evaluate any changes in tibial cartilage volume, measured through MRI, as well as the participants' knee pain levels as indicated by the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score.
The results showed that, compared to the placebo group, those who received vitamin D3 experienced no significant differences in either tibial cartilage volume or reported knee pain over the two years. This indicates that vitamin D3 supplementation does not provide meaningful benefits for reducing tibial cartilage loss or improving knee pain in patients with symptomatic knee osteoarthritis.
Over a span of two years, we divided participants into two groups: one received a monthly dose of oral vitamin D3 (50,000 IU), while the other group received a placebo. Our main focus was to evaluate any changes in tibial cartilage volume, measured through MRI, as well as the participants' knee pain levels as indicated by the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score.
The results showed that, compared to the placebo group, those who received vitamin D3 experienced no significant differences in either tibial cartilage volume or reported knee pain over the two years. This indicates that vitamin D3 supplementation does not provide meaningful benefits for reducing tibial cartilage loss or improving knee pain in patients with symptomatic knee osteoarthritis.
9.5
Effective joint relief
Most Useful Review
I am 59 and had never taken vitamin D3 until now. After watching a video about its benefits, I realised I had symptoms linked to its deficiency. I started taking it in the autumn and within a week and a half, my knee pain subsided, and I slept better. After a month, my hip joints and muscles were no longer an issue, and even my finger's rheumatoid arthritis pain reduced significantly. I'm thrilled and highly recommend it!
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.3
9
Vitamin D3 modulates autoimmune response
Vitamin D3 attenuates autoimmune thyroiditis by regulating Th17/Treg cell differentiation via YAP/JAK1/STAT1 axis.
Most Relevant Research
We explored how Vitamin D3 impacts autoimmune thyroiditis, a specific autoimmune disorder. In this study, researchers established a mouse model of experimental autoimmune thyroiditis (EAT) to see how Vitamin D3 could influence this condition. After eight weeks of treatment, they assessed thyroid health and immune response through various methods, including staining tissues and measuring hormone levels.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
9.5
Quick recovery
Most Useful Review
Quick result! After my first order during COVID, my vitamin D levels rose from 18 to normal within a month and a half. Despite limited sun exposure, a month of taking this product raised my levels from 27 to 41.
