Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.4
USERS' SCORE
Good
Based on 3 Reviews
8.4
Supplement Facts
Serving Size:  1 Vegetable Capsule
Amount Per Serving
%DV
Vitamin D3 (as cholecalciferol)
125 mcg (5000 IU)
625%

Top Medical Research Studies

9
Vitamin D lowers cholesterol levels
We investigated how vitamin D3 supplementation impacts cholesterol levels in pediatric patients with obesity. During our study, we divided 723 children into two groups: one received vitamin D3 supplements, while the other received a placebo. This allowed us to comprehensively assess the relationship between vitamin D and metabolic health, especially focusing on high cholesterol.

What we found was promising. After introducing vitamin D3 to the participants, we observed a significant drop in various lipid levels among those who received the supplements compared to those who were on the placebo. Specifically, there were notable reductions in total cholesterol, triglycerides, and low-density lipoprotein (LDL), alongside improvements in high-density lipoprotein (HDL).

Our results highlight that vitamin D3 not only boosted vitamin D levels but also positively influenced cholesterol metabolism. This suggests that supplementing with vitamin D could be a helpful strategy for managing high cholesterol, particularly in children struggling with obesity. Overall, our findings underscore the potential of vitamin D in improving metabolic health in younger populations.
8
Vitamin D improves triglycerides and HDL-C
We wanted to understand how vitamin D supplementation affects cholesterol levels, especially in women who are overweight or obese. Our analysis involved reviewing multiple randomized controlled trials, allowing us to look closely at the changes potential vitamin D can bring to lipid profiles.

We found that taking vitamin D led to significant reductions in triglyceride levels and total cholesterol. Specifically, triglycerides dropped by about 6.13 mg/dL, while total cholesterol saw a decrease of 4.45 mg/dL. Interestingly, we also noticed that vitamin D supplementation was linked to an increase in levels of high-density lipoprotein cholesterol (HDL-C), which is often referred to as the "good" cholesterol.

However, it's worth noting that despite these positive changes, vitamin D did not significantly impact low-density lipoprotein cholesterol (LDL-C), often known as the "bad" cholesterol. Therefore, while vitamin D can help with some lipid profile issues, its effect on LDL-C isn’t as pronounced.

Overall, we are encouraged by the results indicating that vitamin D can play a beneficial role in managing triglycerides and cholesterol levels among overweight or obese women, but we acknowledge that more research is needed to fully understand its effects on LDL-C.
8
Vitamin D associated with cholesterol improvement
Our investigation centered around the link between vitamin D levels and cholesterol, particularly focusing on high cholesterol. We analyzed data from nearly 48,000 outpatients to see how two forms of vitamin D—25-hydroxyvitamin D and 1,25-dihydroxyvitamin D—relate to various cholesterol parameters, such as LDL (the "bad" cholesterol), HDL (the "good" cholesterol), and total cholesterol levels.

We discovered that higher levels of 25(OH)D are connected with lower LDL and total cholesterol levels across the board. This relationship was especially strong among men over 50. Interestingly, the pattern varied for women; they showed a positive correlation with LDL and total cholesterol before age 50, but a negative association afterwards.

HDL levels consistently improved with higher 25(OH)D levels in all age groups, demonstrating the strongest link in postmenopausal women. However, the other form, 1,25(OH)D, only positively associated with HDL in people over 50 and didn't show significant effects on LDL or total cholesterol in any age category.

Overall, we pointed out that elevated levels of 25(OH)D can contribute to better cholesterol profiles, marked by lower levels of LDL and total cholesterol as well as higher HDL levels. This effect was particularly notable in those over 50 and postmenopausal women, highlighting the potential role of vitamin D in managing cholesterol levels.

Most Useful Reviews

9
Relieved Pain
1 people found this helpful
After testing, I was pleasantly surprised that my vitamin D levels increased. I no longer experience dental or back pain, both of which were signs of my poor bone mass linked to vitamin D deficiency and high cholesterol.
7.5
Effective Vitamin Increase
1 people found this helpful
My Vit D levels rose from 7 to 20, and it does not raise cholesterol levels, which is crucial after 40.
7.5
Improved Vitamin Levels
1 people found this helpful
I have taken this for a year as prescribed, raising my Vit D from 7 to 30, which is excellent progress! Due to high cholesterol, I was recommended vegetarian capsules.

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.4
  • All Researches
9
Vitamin D lowers cholesterol levels
We investigated how vitamin D3 supplementation impacts cholesterol levels in pediatric patients with obesity. During our study, we divided 723 children into two groups: one received vitamin D3 supplements, while the other received a placebo. This allowed us to comprehensively assess the relationship between vitamin D and metabolic health, especially focusing on high cholesterol.

What we found was promising. After introducing vitamin D3 to the participants, we observed a significant drop in various lipid levels among those who received the supplements compared to those who were on the placebo. Specifically, there were notable reductions in total cholesterol, triglycerides, and low-density lipoprotein (LDL), alongside improvements in high-density lipoprotein (HDL).

Our results highlight that vitamin D3 not only boosted vitamin D levels but also positively influenced cholesterol metabolism. This suggests that supplementing with vitamin D could be a helpful strategy for managing high cholesterol, particularly in children struggling with obesity. Overall, our findings underscore the potential of vitamin D in improving metabolic health in younger populations.
We explored the impact of vitamin D3 on cholesterol levels, specifically in individuals taking olanzapine, an antipsychotic medication known to cause dyslipidemia, a condition characterized by abnormal lipid levels. By analyzing various sources including the FDA Adverse Event Reporting System and electronic medical records, we aimed to uncover whether vitamin D3 supplementation could alleviate the cholesterol imbalances caused by olanzapine.

Our findings revealed that vitamin D3 has a beneficial effect, helping to reduce the unfavorable changes in cholesterol levels typically induced by olanzapine. In particular, we noted that while olanzapine raised low-density lipoprotein (LDL) cholesterol and lowered high-density lipoprotein (HDL) cholesterol, vitamin D3 supplementation appeared to help restore balance in these lipid levels.

Further investigations into cellular mechanisms showed that vitamin D3 may work by inhibiting the cholesterol production process within certain cells. This aligns well with our overall goal of identifying effective treatment strategies that can positively affect cholesterol management in those affected by olanzapine treatment.

In summary, our comprehensive analysis suggests that vitamin D3 supplementation could serve as a promising adjunct therapy for managing cholesterol levels in patients prescribed olanzapine.
We investigated the relationship between serum levels of vitamin D and the risk of high cholesterol, or hyperlipidemia, among adults in a prospective cohort study. This research involved collecting data over three years to understand how vitamin D might influence cholesterol levels, particularly focusing on different ranges of vitamin D sufficiency.

Our findings indicated that individuals with low vitamin D levels faced a significantly higher risk of developing hyperlipidemia. Specifically, those deficient in vitamin D had over 1.5 times the risk compared to those with adequate levels of this essential vitamin.

Additionally, a notable percentage of participants were found to have vitamin D deficiency, particularly among middle-aged and older adults. This suggests a potential link between lifestyle factors accompanying low vitamin D levels and the increased likelihood of high cholesterol.

Overall, these insights point to the promising possibility of improving cholesterol profiles through adequate vitamin D intake, but further research is likely needed to develop clear treatment pathways based solely on vitamin D supplementation.
8
Vitamin D improves triglycerides and HDL-C
We wanted to understand how vitamin D supplementation affects cholesterol levels, especially in women who are overweight or obese. Our analysis involved reviewing multiple randomized controlled trials, allowing us to look closely at the changes potential vitamin D can bring to lipid profiles.

We found that taking vitamin D led to significant reductions in triglyceride levels and total cholesterol. Specifically, triglycerides dropped by about 6.13 mg/dL, while total cholesterol saw a decrease of 4.45 mg/dL. Interestingly, we also noticed that vitamin D supplementation was linked to an increase in levels of high-density lipoprotein cholesterol (HDL-C), which is often referred to as the "good" cholesterol.

However, it's worth noting that despite these positive changes, vitamin D did not significantly impact low-density lipoprotein cholesterol (LDL-C), often known as the "bad" cholesterol. Therefore, while vitamin D can help with some lipid profile issues, its effect on LDL-C isn’t as pronounced.

Overall, we are encouraged by the results indicating that vitamin D can play a beneficial role in managing triglycerides and cholesterol levels among overweight or obese women, but we acknowledge that more research is needed to fully understand its effects on LDL-C.
8
Ergosterol may improve cholesterol levels
We explored how ergosterol, a precursor of vitamin D, impacts cholesterol levels and vitamin D biosynthesis in ovariectomized (OVX) rats. Our study revealed that daily high ergosterol intake over 14 weeks significantly lowered plasma cholesterol levels, an important finding since high cholesterol can lead to various health issues.

Additionally, we found that treated OVX rats had higher levels of 7-dehydrocholesterol, a precursor to vitamin D, suggesting that ergosterol not only helps decrease cholesterol but may also promote improved vitamin D synthesis. We also observed a slight increase in the active form of vitamin D in these rats.

Perhaps most excitingly, ergosterol contributed to better bone strength, countering some of the effects of OVX-induced bone resorption. This suggests that ergosterol could be a promising option for addressing both dyslipidemia and osteoporosis in postmenopausal women, providing a dual benefit for health.

Overall, our findings support the idea that ergosterol could be an adjunct to traditional treatments for managing cholesterol and promoting vitamin D levels.

User Reviews

USERS' SCORE
Good
Based on 3 Reviews
8.4
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Relieved Pain
1 people found this helpful
After testing, I was pleasantly surprised that my vitamin D levels increased. I no longer experience dental or back pain, both of which were signs of my poor bone mass linked to vitamin D deficiency and high cholesterol.
7.5
Effective Vitamin Increase
1 people found this helpful
My Vit D levels rose from 7 to 20, and it does not raise cholesterol levels, which is crucial after 40.
7.5
Improved Vitamin Levels
1 people found this helpful
I have taken this for a year as prescribed, raising my Vit D from 7 to 30, which is excellent progress! Due to high cholesterol, I was recommended vegetarian capsules.

Frequently Asked Questions

7.5
Effective Vitamin Increase
1 people found this helpful
My Vit D levels rose from 7 to 20, and it does not raise cholesterol levels, which is crucial after 40.
7.5
Improved Vitamin Levels
1 people found this helpful
I have taken this for a year as prescribed, raising my Vit D from 7 to 30, which is excellent progress! Due to high cholesterol, I was recommended vegetarian capsules.
9
Relieved Pain
1 people found this helpful
After testing, I was pleasantly surprised that my vitamin D levels increased. I no longer experience dental or back pain, both of which were signs of my poor bone mass linked to vitamin D deficiency and high cholesterol.
8
Vitamin D improves triglycerides and HDL-C
We wanted to understand how vitamin D supplementation affects cholesterol levels, especially in women who are overweight or obese. Our analysis involved reviewing multiple randomized controlled trials, allowing us to look closely at the changes potential vitamin D can bring to lipid profiles.

We found that taking vitamin D led to significant reductions in triglyceride levels and total cholesterol. Specifically, triglycerides dropped by about 6.13 mg/dL, while total cholesterol saw a decrease of 4.45 mg/dL. Interestingly, we also noticed that vitamin D supplementation was linked to an increase in levels of high-density lipoprotein cholesterol (HDL-C), which is often referred to as the "good" cholesterol.

However, it's worth noting that despite these positive changes, vitamin D did not significantly impact low-density lipoprotein cholesterol (LDL-C), often known as the "bad" cholesterol. Therefore, while vitamin D can help with some lipid profile issues, its effect on LDL-C isn’t as pronounced.

Overall, we are encouraged by the results indicating that vitamin D can play a beneficial role in managing triglycerides and cholesterol levels among overweight or obese women, but we acknowledge that more research is needed to fully understand its effects on LDL-C.
9
Vitamin D lowers cholesterol levels
We investigated how vitamin D3 supplementation impacts cholesterol levels in pediatric patients with obesity. During our study, we divided 723 children into two groups: one received vitamin D3 supplements, while the other received a placebo. This allowed us to comprehensively assess the relationship between vitamin D and metabolic health, especially focusing on high cholesterol.

What we found was promising. After introducing vitamin D3 to the participants, we observed a significant drop in various lipid levels among those who received the supplements compared to those who were on the placebo. Specifically, there were notable reductions in total cholesterol, triglycerides, and low-density lipoprotein (LDL), alongside improvements in high-density lipoprotein (HDL).

Our results highlight that vitamin D3 not only boosted vitamin D levels but also positively influenced cholesterol metabolism. This suggests that supplementing with vitamin D could be a helpful strategy for managing high cholesterol, particularly in children struggling with obesity. Overall, our findings underscore the potential of vitamin D in improving metabolic health in younger populations.
5
Vitamin D's link to cholesterol levels
We examined the connection between vitamin D levels and high cholesterol in a diverse group of over 2,000 Chinese adults. Through careful measurement of serum vitamin D and various blood lipid markers, we found that nearly 42% of participants had high cholesterol, with about 20% suffering from vitamin D deficiency. An intriguing detail emerged: those individuals with low vitamin D levels were more likely to experience high cholesterol.

Specifically, 23.68% of participants with vitamin D deficiency also showed signs of hyperlipidemia, compared to 17.11% of those with adequate vitamin D levels. Our analysis indicated that lower levels of vitamin D significantly increased the risk of high cholesterol, suggesting that having enough vitamin D might be important for heart health. However, we need to highlight that while there is a notable correlation, we did not investigate the direct effects of vitamin D treatment on cholesterol levels.

Overall, although we observed a relationship between vitamin D deficiency and higher risks of cholesterol abnormalities, no clear benefit of vitamin D treatment specifically for high cholesterol was documented in this study. Thus, while maintaining healthy vitamin D levels seems to be crucial for overall wellness, its direct role in treating high cholesterol remains unclear.

References

  1. Liu ZY, Liu S, Yao X, Wang CY, Song Y, et al. A cohort study of serum 25-hydroxyvitamin D levels and the risk of hyperlipidaemia in adults. Front Nutr. 2024;11:1492621. doi:10.3389/fnut.2024.1492621
  2. Hu L, Velu P, Prabahar K, Hernández-Wolters B, Kord-Varkaneh H, et al. Effect of Vitamin D Supplementation on Lipid Profile in Overweight or Obese Women: A Meta-analysis and Systematic Review of Randomized Controlled Trials. Nutr Rev. 2025. doi:10.1093/nutrit/nuae226
  3. Kuwabara N, Kanda J, Sato S, Nakagawa S. Impact of Daily High Ergosterol Intake for 14 Weeks in Ovariectomized Rats on Cholesterol and Vitamin D Biosynthesis Pathways. Biol Pharm Bull. 2025;48:39. doi:10.1248/bpb.b24-00536
  4. Wang F, Bei L, Zhang X, Fu Y. Vitamin D Supplementation Reduces Hyperlipidemia and Improves Bone Mass in Pediatric Obesity. Crit Rev Immunol. 2025;45:31. doi:10.1615/CritRevImmunol.2024052129
  5. Li X, Liu Y, Wang J, Chen X, Reichetzeder C, et al. Vitamin D Is Associated with Lipid Metabolism: A Sex- and Age-Dependent Analysis of a Large Outpatient Cohort. Nutrients. 2024;16. doi:10.3390/nu16223936
  6. Hu T, Zhang Y, Chen Z, Su J. Relationship between serum vitamin D levels and the atherogenic index of plasma: a study based on NHANES database 2011-2018. Front Nutr. 2024;11:1468284. doi:10.3389/fnut.2024.1468284
  7. Xu H, Qiu S, Lin P, Liao X, Lin Y, et al. Vitamin D has therapeutic effects on obesity and hyperandrogenemia in PCOS mouse model induced by low dose DHEA and high-fat diet. BMC Womens Health. 2024;24:601. doi:10.1186/s12905-024-03445-w
  8. Sadeghi M, Momeni A, Mirsaeidi FS, Jamalian M, Amirpour A, et al. The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial. Adv Biomed Res. 2024;13:79. doi:10.4103/abr.abr_380_23
  9. Wang J, Shi T, Xu L, Li Y, Mi W, et al. Correlation between hyperlipidemia and serum vitamin D levels in an adult Chinese cohort. Front Nutr. 2024;11:1302260. doi:10.3389/fnut.2024.1302260
  10. Xu W, Wang L, Yang L, Li X, Li C, et al. [Vitamin D3 alleviates the gastritis that associated with Helicobacter pylori infection in mice with hypercholesterolemia by enhancing the activity of vitamin D receptors in the liver tissue and blocking the signaling pathway of JAK/STAT3]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2024;40:520.
  11. Papakonstantinou E, Zacharodimos N, Georgiopoulos G, Athanasaki C, Bothou DL, et al. Two-Month Consumption of Orange Juice Enriched with Vitamin D3 and Probiotics Decreases Body Weight, Insulin Resistance, Blood Lipids, and Arterial Blood Pressure in High-Cardiometabolic-Risk Patients on a Westernized Type Diet: Results from a Randomized Clinical Trial. Nutrients. 2024;16. doi:10.3390/nu16091331
  12. Oczkowicz M, Szymczyk B, Świątkiewicz M, Wierzbicka A, Steg A, et al. Effect of vitamin D3 supplementation on blood parameters and liver gene expression in female rats. Mol Biol Rep. 2024;51:456. doi:10.1007/s11033-024-09408-6
  13. Yang HE, Lee BW, Choi IJ, Oh JY, An EJ. Age-dependent effect of vitamin D supplementation on musculoskeletal health in chronic spinal cord injury patients: A pilot study. J Spinal Cord Med. 2025;48:93. doi:10.1080/10790268.2023.2257850
  14. Habiba E, Ali S, Ghanem Y, Sharaki O, Hewedy W. Effect of oral versus parenteral vitamin D3 supplementation on nuclear factor-κB and platelet aggregation in type 2 diabetic patients. Can J Physiol Pharmacol. 2023;101:610. doi:10.1139/cjpp-2022-0359
  15. Sandgruber F, Höger AL, Kunze J, Schenz B, Griehl C, et al. Impact of Regular Intake of Microalgae on Nutrient Supply and Cardiovascular Risk Factors: Results from the NovAL Intervention Study. Nutrients. 2023;15. doi:10.3390/nu15071645
  16. Zhou Z, Nagashima T, Toda C, Kobayashi M, Suzuki T, et al. Vitamin D supplementation is effective for olanzapine-induced dyslipidemia. Front Pharmacol. 2023;14:1135516. doi:10.3389/fphar.2023.1135516
  17. Hariri Z, Kord-Varkaneh H, Alyahya N, Prabahar K, Găman MA, et al. Higher Dietary Vitamin D Intake Influences the Lipid Profile and hs-CRP Concentrations: Cross-Sectional Assessment Based on The National Health and Nutrition Examination Survey. Life (Basel). 2023;13. doi:10.3390/life13020581
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