Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
100 mg
5,882%
Top Medical Research Studies
8
We explored the impact of the vitamin B6 pathway on glioblastoma, a challenging and aggressive brain cancer. Specifically, we assessed how different cell cultures—2D monolayers and 3D spheroids—responded to treatments that alter vitamin B6 levels. Through comprehensive metabolomics analysis, we found notable differences in the levels of vitamin B6-related metabolites between these two culture methods.
Our key finding was that when we used hydralazine, a small molecule known to lower vitamin B6 levels, it induced cell death specifically in the 3D spheroid cultures of glioblastoma. This suggests a potential new therapeutic strategy targeting the vitamin B6 pathway could benefit glioblastoma treatment.
Thus, this study highlights a novel approach to tackle this aggressive cancer by focusing on the metabolic alterations within the tumor microenvironment, particularly through vitamin B6 modulation.
Our key finding was that when we used hydralazine, a small molecule known to lower vitamin B6 levels, it induced cell death specifically in the 3D spheroid cultures of glioblastoma. This suggests a potential new therapeutic strategy targeting the vitamin B6 pathway could benefit glioblastoma treatment.
Thus, this study highlights a novel approach to tackle this aggressive cancer by focusing on the metabolic alterations within the tumor microenvironment, particularly through vitamin B6 modulation.
Read More
8
Pyridoxine promotes glioblastoma apoptosis
We explored the impact of vitamin B6, also known as pyridoxine, on the viability and progression of human glioblastoma cells, specifically the U-87 MG cell line. The study involved treating these cells with increasing concentrations of vitamin B6 and monitoring changes over 24 to 72 hours.
Our findings demonstrated that higher doses of pyridoxine resulted in a significant decrease in cell viability, suggesting that it may effectively hinder the growth of glioblastoma. We observed that this reduction in cell viability was likely linked to a slower cell cycle progression and an increase in active caspase 3, a marker of apoptosis or programmed cell death.
Interestingly, while vitamin B6 appeared to enhance the apoptosis process, the levels of Bcl-2, a protein that usually helps cells survive, did not change significantly. Furthermore, when we introduced cobalamin (vitamin B12) alongside pyridoxine, we found that it seemed to counteract some of pyridoxine's harmful effects in terms of cell viability.
Overall, the results imply that vitamin B6 supplementation could potentially be used to promote apoptosis in glioblastoma cells, possibly making it a valuable addition to current cancer therapies.
Our findings demonstrated that higher doses of pyridoxine resulted in a significant decrease in cell viability, suggesting that it may effectively hinder the growth of glioblastoma. We observed that this reduction in cell viability was likely linked to a slower cell cycle progression and an increase in active caspase 3, a marker of apoptosis or programmed cell death.
Interestingly, while vitamin B6 appeared to enhance the apoptosis process, the levels of Bcl-2, a protein that usually helps cells survive, did not change significantly. Furthermore, when we introduced cobalamin (vitamin B12) alongside pyridoxine, we found that it seemed to counteract some of pyridoxine's harmful effects in terms of cell viability.
Overall, the results imply that vitamin B6 supplementation could potentially be used to promote apoptosis in glioblastoma cells, possibly making it a valuable addition to current cancer therapies.
Read More
Most Useful Reviews
9
Enhanced brain performance
An excellent preparation for strengthening the heart. It works remarkably well—my brain performance is at its peak.
Read More
7.5
Promotes brain health
Vitamin B6 is beneficial for improving health. I find it useful for promoting my brain health.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
- All Researches
8
We explored the impact of the vitamin B6 pathway on glioblastoma, a challenging and aggressive brain cancer. Specifically, we assessed how different cell cultures—2D monolayers and 3D spheroids—responded to treatments that alter vitamin B6 levels. Through comprehensive metabolomics analysis, we found notable differences in the levels of vitamin B6-related metabolites between these two culture methods.
Our key finding was that when we used hydralazine, a small molecule known to lower vitamin B6 levels, it induced cell death specifically in the 3D spheroid cultures of glioblastoma. This suggests a potential new therapeutic strategy targeting the vitamin B6 pathway could benefit glioblastoma treatment.
Thus, this study highlights a novel approach to tackle this aggressive cancer by focusing on the metabolic alterations within the tumor microenvironment, particularly through vitamin B6 modulation.
Our key finding was that when we used hydralazine, a small molecule known to lower vitamin B6 levels, it induced cell death specifically in the 3D spheroid cultures of glioblastoma. This suggests a potential new therapeutic strategy targeting the vitamin B6 pathway could benefit glioblastoma treatment.
Thus, this study highlights a novel approach to tackle this aggressive cancer by focusing on the metabolic alterations within the tumor microenvironment, particularly through vitamin B6 modulation.
Read More
8
Pyridoxine promotes glioblastoma apoptosis
We explored the impact of vitamin B6, also known as pyridoxine, on the viability and progression of human glioblastoma cells, specifically the U-87 MG cell line. The study involved treating these cells with increasing concentrations of vitamin B6 and monitoring changes over 24 to 72 hours.
Our findings demonstrated that higher doses of pyridoxine resulted in a significant decrease in cell viability, suggesting that it may effectively hinder the growth of glioblastoma. We observed that this reduction in cell viability was likely linked to a slower cell cycle progression and an increase in active caspase 3, a marker of apoptosis or programmed cell death.
Interestingly, while vitamin B6 appeared to enhance the apoptosis process, the levels of Bcl-2, a protein that usually helps cells survive, did not change significantly. Furthermore, when we introduced cobalamin (vitamin B12) alongside pyridoxine, we found that it seemed to counteract some of pyridoxine's harmful effects in terms of cell viability.
Overall, the results imply that vitamin B6 supplementation could potentially be used to promote apoptosis in glioblastoma cells, possibly making it a valuable addition to current cancer therapies.
Our findings demonstrated that higher doses of pyridoxine resulted in a significant decrease in cell viability, suggesting that it may effectively hinder the growth of glioblastoma. We observed that this reduction in cell viability was likely linked to a slower cell cycle progression and an increase in active caspase 3, a marker of apoptosis or programmed cell death.
Interestingly, while vitamin B6 appeared to enhance the apoptosis process, the levels of Bcl-2, a protein that usually helps cells survive, did not change significantly. Furthermore, when we introduced cobalamin (vitamin B12) alongside pyridoxine, we found that it seemed to counteract some of pyridoxine's harmful effects in terms of cell viability.
Overall, the results imply that vitamin B6 supplementation could potentially be used to promote apoptosis in glioblastoma cells, possibly making it a valuable addition to current cancer therapies.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Enhanced brain performance
An excellent preparation for strengthening the heart. It works remarkably well—my brain performance is at its peak.
Read More
7.5
Promotes brain health
Vitamin B6 is beneficial for improving health. I find it useful for promoting my brain health.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Moosa NY, Azeem SA, Lodge JK, Cheung W, Ahmed SU. Vitamin B6 Pathway Maintains Glioblastoma Cell Survival in 3D Spheroid Cultures. Int J Mol Sci. 2024;25. doi:10.3390/ijms251910428
- Martínez-Mendiola CA, Estrada JA, Zapi-Colín LÁ, Contreras-Chávez GG, Contreras I. Effect of pyridoxine or cobalamin supplementation on apoptosis and cell cycle progression in a human glioblastoma cell line. Int J Neurosci. 2024;134:1320. doi:10.1080/00207454.2023.2263815
