Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Selenium (as L-selenomethionine)
200 mcg
364%
The product is found useful for the following medical conditions
Cold Sores details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8.8
10
No more colds!
Most Useful Review
Since I began taking Selenium alongside zinc, I have not experienced any further colds!
Hypothyroidism details
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.6
USERS' SCORE
Good
Based on 8 Reviews
8.8
8
Selenium benefits Hashimoto's patients
Selenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
Most Relevant Research
We explored the effects of selenium supplementation in patients suffering from Hashimoto thyroiditis (HT), a leading cause of hypothyroidism. By analyzing multiple randomized controlled trials, we aimed to see how selenium might impact thyroid function, particularly focusing on thyroid-stimulating hormone (TSH) levels and thyroid antibodies.
Our analysis included results from 35 studies, where we observed that selenium supplementation led to a notable decrease in TSH levels among patients not undergoing thyroid hormone replacement therapy. This suggests that selenium may help manage thyroid function in specific populations.
Additionally, we found that selenium also reduced levels of thyroid peroxidase antibodies (TPOAb) and malondialdehyde (MDA), which indicates improved thyroid health and reduced oxidative stress. Interestingly, we observed that these benefits occurred irrespective of whether patients were receiving thyroid hormone therapy.
However, we did not find significant changes in other thyroid hormones or immune markers, indicating that while selenium can be effective in some areas, its benefits may not extend across all measures of thyroid health. Overall, our findings support the safe use of selenium in lowering TSH and certain antibodies in HT patients not on hormone therapy.
Our analysis included results from 35 studies, where we observed that selenium supplementation led to a notable decrease in TSH levels among patients not undergoing thyroid hormone replacement therapy. This suggests that selenium may help manage thyroid function in specific populations.
Additionally, we found that selenium also reduced levels of thyroid peroxidase antibodies (TPOAb) and malondialdehyde (MDA), which indicates improved thyroid health and reduced oxidative stress. Interestingly, we observed that these benefits occurred irrespective of whether patients were receiving thyroid hormone therapy.
However, we did not find significant changes in other thyroid hormones or immune markers, indicating that while selenium can be effective in some areas, its benefits may not extend across all measures of thyroid health. Overall, our findings support the safe use of selenium in lowering TSH and certain antibodies in HT patients not on hormone therapy.
10
Reversed hypothyroidism
Most Useful Review
This product has reversed my hypothyroidism, combined with Vitamin C and zinc.
Sleep Apnea details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 8 Reviews
8.8
9.5
Enhanced overall health
Most Useful Review
After I started taking selenium, my health significantly improved, and my sleep returned to normal; I wake up on time. It's challenging to express all the sensations, but what's most important is that thinking has become clearer, the constant headaches have lessened, and my overall state of health has improved with a noticeable decrease in pressure in my throat. I observed improvements in the condition of my facial skin, as small spots on my forehead and chin disappeared. Additionally, I felt the effects almost within days of starting the medication. The impact of the drug has enhanced my quality of life, including reduced hair loss. I experienced no side effects. Generally, I recommend it to everyone!
Swollen Lymph Nodes details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.8
9.5
Nodes decreased significantly
Most Useful Review
Selenium is an element that helps to maintain the normal functioning of the thyroid gland. After taking it, my TSH returned to normal, and the enlarged nodes decreased on the ultrasound while the smaller ones vanished! To support my thyroid gland, I take a course once a year for a month. I am very pleased with the results.
Hashimoto details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8.7
8.8
Effective for antibodies
Most Useful Review
I have been using this product successfully as part of a strategy to reduce Anti-TPO antibodies and manage Hashimoto's thyroiditis. However, one must be cautious with dosages and administration times, as too much selenium can be harmful.
Nausea details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.7
9.5
No nausea experienced
Most Useful Review
Selenium is very comfortable for me—just dry selenium. This form does not cause discomfort, nausea, or other unwanted side effects. Excellent quality from Solgar. I take a dosage of 200mcg as prescribed by my doctor, followed by a break, and after 6-8 months, I switch to a maintenance dosage of 100mcg along with Vitamin E, also from Solgar. I have noticed positive results. It is a standard tablet, rather than a capsule, and can be divided easily.
Prostate Cancer details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
USERS' SCORE
Good
Based on 4 Reviews
8.7
8
Selenium nanoparticles show promise
Intracellular Fate of Sub-Toxic Concentration of Functionalized Selenium Nanoparticles in Aggressive Prostate Cancer Cells.
Most Relevant Research
We explored the impact of selenium nanoparticles, known for their potential anti-cancer properties, on aggressive prostate cancer cells, specifically the PC-3 line. The study focused on understanding how sub-toxic levels of selenium functionalized nanoparticles affect cell proliferation and their intracellular behavior.
By utilizing advanced imaging techniques and careful cryopreparation, we aimed to preserve the integrity of the cancer cells while analyzing the distribution of these nanoparticles within them. Our findings revealed that nanoparticles coated with bovine serum albumin (BSA) reduced the migration capability of the cancer cells more effectively than those coated with chitosan.
This difference may be attributed to the BSA coating's ability to prevent harmful interactions with the cell membranes, which in turn limits the generation of reactive oxygen species that can damage cells. Most intriguingly, we observed that these selenium nanoparticles localized in both the mitochondria and lysosome-related organelles within the cells. The presence of nanoparticles in the mitochondria might explain the significant reduction in the PC-3 cells' ability to proliferate.
Overall, our investigation highlights the promising role selenium nanoparticles can play in cancer treatment strategies, providing valuable insights for further research into their cytotoxic mechanisms against prostate cancer.
By utilizing advanced imaging techniques and careful cryopreparation, we aimed to preserve the integrity of the cancer cells while analyzing the distribution of these nanoparticles within them. Our findings revealed that nanoparticles coated with bovine serum albumin (BSA) reduced the migration capability of the cancer cells more effectively than those coated with chitosan.
This difference may be attributed to the BSA coating's ability to prevent harmful interactions with the cell membranes, which in turn limits the generation of reactive oxygen species that can damage cells. Most intriguingly, we observed that these selenium nanoparticles localized in both the mitochondria and lysosome-related organelles within the cells. The presence of nanoparticles in the mitochondria might explain the significant reduction in the PC-3 cells' ability to proliferate.
Overall, our investigation highlights the promising role selenium nanoparticles can play in cancer treatment strategies, providing valuable insights for further research into their cytotoxic mechanisms against prostate cancer.
9.5
Cancer prevention
Most Useful Review
I take selenium as advised by a German doctor for cancer prevention. Previously, I used inorganic selenium but have now switched to a more affordable Solgar product. I split the pill in half since the recommended dose is 100 mcg, allowing this package to last over a year!
Cancer details
SCIENTIFIC SCORE
Moderately Effective
Based on 27 Researches
8.3
USERS' SCORE
Good
Based on 4 Reviews
8.6
9.5
Selenium drug shows selective toxicity
Selenium Electrophilic Center Responsive to Biological Electron Donors for Efficient Chemotherapy.
Most Relevant Research
We examined how a selenium-containing drug, known as RuSe, targets cancer cells while sparing normal cells. This innovative approach leverages the unique properties of selenium, specifically its electrophilic center, to create oxidative stress within cancer cells. By shuttling electrons from biological electron donors, the drug activates a sequence of events detrimental to cancer survival.
The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.
Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.
The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.
Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.
9.5
Reduces cancer risk
Most Useful Review
Reduced cancer risk. This is an excellent mineral to take. It helps the liver combat toxins and lowers cancer risk by 50%. I love it!
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Good
Based on 3 Reviews
8.6
8
Selenium effects on chronic fatigue
Therapeutic Effect and Metabolic Mechanism of A Selenium-Polysaccharide from Green Tea on Chronic Fatigue Syndrome.
Most Relevant Research
We studied how selenium-polysaccharides (Se-TP) from green tea could improve chronic fatigue syndrome (CFS) in a rat model. Our experiments revealed that Se-TP significantly enhanced levels of certain substances related to fatigue, indicating improved overall condition. However, while the treatment showed promise in restoring some metabolic markers, the overall efficacy in CFS management remains to be fully affirmed. The changes observed were tied to metabolic pathways involved in steroid hormone biosynthesis and other critical processes.
8.8
Enhanced well-being
Most Useful Review
The product is of excellent quality, both in formulation and packaging. The brand pays attention to detail, evident in each product. The tablets are standard-sized and easy to swallow. Selenium is a powerful antioxidant, essential for maintaining immunity and protecting cells from oxidative stress. After a few weeks, I noticed improvements in my overall well-being, reduced fatigue, and enhanced skin quality. This is a great way to boost selenium levels, especially for those who lack it in their diet, particularly during winter.
Hyperthyroidism details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Boosted immunity
Most Useful Review
This product helped with hyperthyroidism perfectly, boosting my immunity. Since using it, my hair has stopped falling out. I took it alongside D3, magnesium citrate, and calcium, all from Solgar, with great effect!
Autoimmune Disorder details
SCIENTIFIC SCORE
Questionable
Based on 17 Researches
6.9
USERS' SCORE
Good
Based on 7 Reviews
8.5
9
Selenium aids Graves' orbitopathy treatment
The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.
Most Relevant Research
We explored how selenium supplementation might help individuals suffering from Graves' orbitopathy, an autoimmune disorder linked to thyroid dysfunction. Our approach involved a systematic review and meta-analysis that assessed results from four randomized controlled trials.
The findings revealed that selenium supplementation had a significant positive impact on various aspects of Graves' orbitopathy. Over a period of six months, patients taking selenium showed a notable reduction in clinical activity scores, which reflect the severity of eye symptoms. Furthermore, their quality of life also improved significantly.
We observed improvements not only in the overall quality of life specific to eye conditions, but also in visual and psychological functioning scores. Additionally, selenium appeared to reduce the width of the eyelids, providing further benefits for eye-related symptoms. However, we found no significant changes in other areas, such as eye bulging or muscle movement abilities.
Importantly, selenium supplementation was deemed safe with minor side effects reported, suggesting it could be a viable option for managing Graves' orbitopathy. While our results are promising, we believe further research is needed to thoroughly validate the long-term effectiveness and safety of selenium treatment for this condition.
The findings revealed that selenium supplementation had a significant positive impact on various aspects of Graves' orbitopathy. Over a period of six months, patients taking selenium showed a notable reduction in clinical activity scores, which reflect the severity of eye symptoms. Furthermore, their quality of life also improved significantly.
We observed improvements not only in the overall quality of life specific to eye conditions, but also in visual and psychological functioning scores. Additionally, selenium appeared to reduce the width of the eyelids, providing further benefits for eye-related symptoms. However, we found no significant changes in other areas, such as eye bulging or muscle movement abilities.
Importantly, selenium supplementation was deemed safe with minor side effects reported, suggesting it could be a viable option for managing Graves' orbitopathy. While our results are promising, we believe further research is needed to thoroughly validate the long-term effectiveness and safety of selenium treatment for this condition.
9.5
Decreased antibodies
Most Useful Review
Good analyses! After the course of selenium, my antibodies decreased with autoimmune thyroiditis!
Heart Disease details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 8 Reviews
8.5
9.5
Supports heart health
Most Useful Review
This product is excellent; I’ve been taking it for a long time with other supplements to boost my immune system. Recently, I’ve increased my dosage due to my hypothyroidism. I discovered that selenium is concentrated in the thyroid as it is essential for metabolic processes. Various studies have shown that selenium supplementation improves thyroid structure and can lead to quicker remission in certain diseases.
Hypertension details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.5
8.8
Necessary for recovery
Most Useful Review
Excellent! Crucial for arrhythmia, ischaemic heart disease, hypertension, atherosclerosis, and during recovery after a myocardial infarction. Selenium normalises fat metabolism and cholesterol levels in the blood, protects blood vessels and heart muscle from damage, and reduces the chances of developing hypertension.
Acne details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.4
7.5
Effective acne treatment
Most Useful Review
The quality is good, the ingredients are beneficial, and the packaging is very useful. I purchased it for my son to help with his acne, and I find it to be an important supplement. The flavour has no aftertaste, and there are no side effects.
Cardiovascular Disease details
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8
USERS' SCORE
Good
Based on 7 Reviews
8.4
8
Selenium aids heart recovery post-MI
Selenium-loaded porous silica nanospheres improve cardiac repair after myocardial infarction by enhancing antioxidant activity and mitophagy.
Most Relevant Research
This study focused on how selenium-loaded porous silica nanospheres (Se@PSN) could help repair the heart following a myocardial infarction (MI). These tiny particles are designed to neutralize harmful molecules called reactive oxygen species, which play a significant role in heart damage during MI.
We found that Se@PSN not only reduces cellular damage but also promotes the production of protective antioxidant proteins. By enhancing mitochondrial function, these nanospheres could potentially preserve heart function after an MI, demonstrating promising results for future treatments.
We found that Se@PSN not only reduces cellular damage but also promotes the production of protective antioxidant proteins. By enhancing mitochondrial function, these nanospheres could potentially preserve heart function after an MI, demonstrating promising results for future treatments.
9.5
Reduces thyroid antibodies
Most Useful Review
I have been using this form of selenium for autoimmune thyroid disease for three years now, and it has significantly reduced my thyroid antibodies while improving my overall well-being. Truly excellent!
Chronic Cough details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.4
8
Positive health impact
Most Useful Review
Selenium can be toxic in large quantities, but when taken in the recommended daily amounts, it positively affects various bodily processes. It helps combat atherosclerosis, has anti-cancer properties, reduces infertility risks, alleviates chronic fatigue syndrome, enhances lifespan, eases asthma symptoms, and bolsters the immune system. I recommend taking it in courses.
Pelvic Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.7
6
Hair loss concern
Most Useful Review
I purchased this product after reading rave reviews regarding its effects on hair. Unfortunately, upon commencing intake, I began to experience pain under my left rib. I became cautious, considering I was also on other supplements, but it seemed the discomfort arose after consuming selenium. My hair also started to thin. To confirm, I ordered a laboratory test that revealed a selenium overdose in my body, despite taking only one pill daily for a couple of weeks. Once I discontinued it, the pain subsided. It's important to get tested before starting any new supplements.
Hair Loss details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Medium or Average
Based on 6 Reviews
6.9
8
Selenium aids hair loss in PCOS
Selenium Supplementation and the Effects on Reproductive Outcomes, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome.
Most Relevant Research
We conducted a randomized double-blind, placebo-controlled trial to explore how selenium supplementation may influence hair loss among women with polycystic ovary syndrome (PCOS). In the study, 64 women aged 18-40 received either 200 μg of selenium daily or a placebo for eight weeks.
After the treatment period, we noticed a significant improvement in hair-related issues for those taking selenium. Specifically, alopecia rates dropped from 40.6% in the selenium group to just 9.4% in the placebo group, showing a strong positive effect of the supplement on hair loss. Acne also improved, with a reduction from 46.9% to 12.5%.
Furthermore, women who took selenium supplements exhibited decreased levels of dehydroepiandrosterone (DHEA), hirsutism, and markers of inflammation and oxidative stress. However, it’s important to note that selenium did not show significant effects on some hormonal profiles and other biomarkers. Overall, our findings suggest that selenium can be beneficial for women with PCOS, particularly regarding hair loss and related symptoms.
After the treatment period, we noticed a significant improvement in hair-related issues for those taking selenium. Specifically, alopecia rates dropped from 40.6% in the selenium group to just 9.4% in the placebo group, showing a strong positive effect of the supplement on hair loss. Acne also improved, with a reduction from 46.9% to 12.5%.
Furthermore, women who took selenium supplements exhibited decreased levels of dehydroepiandrosterone (DHEA), hirsutism, and markers of inflammation and oxidative stress. However, it’s important to note that selenium did not show significant effects on some hormonal profiles and other biomarkers. Overall, our findings suggest that selenium can be beneficial for women with PCOS, particularly regarding hair loss and related symptoms.
9.5
Reduced hair loss
Most Useful Review
Excellent product. Very high quality. It has made a significant difference in reducing hair loss and normalising thyroid hormones. Definitely recommend!
