Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 17 Researches
6.9
USERS' SCORE
Good
Based on 7 Reviews
8.3
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Selenium (as L-selenomethionine)
200 mcg
364%
Top Medical Research Studies
9
Selenium aids Graves' orbitopathy treatment
We explored how selenium supplementation might help individuals suffering from Graves' orbitopathy, an autoimmune disorder linked to thyroid dysfunction. Our approach involved a systematic review and meta-analysis that assessed results from four randomized controlled trials.
The findings revealed that selenium supplementation had a significant positive impact on various aspects of Graves' orbitopathy. Over a period of six months, patients taking selenium showed a notable reduction in clinical activity scores, which reflect the severity of eye symptoms. Furthermore, their quality of life also improved significantly.
We observed improvements not only in the overall quality of life specific to eye conditions, but also in visual and psychological functioning scores. Additionally, selenium appeared to reduce the width of the eyelids, providing further benefits for eye-related symptoms. However, we found no significant changes in other areas, such as eye bulging or muscle movement abilities.
Importantly, selenium supplementation was deemed safe with minor side effects reported, suggesting it could be a viable option for managing Graves' orbitopathy. While our results are promising, we believe further research is needed to thoroughly validate the long-term effectiveness and safety of selenium treatment for this condition.
The findings revealed that selenium supplementation had a significant positive impact on various aspects of Graves' orbitopathy. Over a period of six months, patients taking selenium showed a notable reduction in clinical activity scores, which reflect the severity of eye symptoms. Furthermore, their quality of life also improved significantly.
We observed improvements not only in the overall quality of life specific to eye conditions, but also in visual and psychological functioning scores. Additionally, selenium appeared to reduce the width of the eyelids, providing further benefits for eye-related symptoms. However, we found no significant changes in other areas, such as eye bulging or muscle movement abilities.
Importantly, selenium supplementation was deemed safe with minor side effects reported, suggesting it could be a viable option for managing Graves' orbitopathy. While our results are promising, we believe further research is needed to thoroughly validate the long-term effectiveness and safety of selenium treatment for this condition.
Read More
0
We aimed to explore how selenium affects autoimmune thyroid disease (AITD), specifically looking at three conditions: autoimmune thyroiditis (AIT), autoimmune hyperthyroidism (AIH), and Graves' disease (GD). Using a research method called Mendelian randomization, we analyzed genetic data to establish potential causal links between selenium levels and these autoimmune disorders.
Our findings highlighted an important conclusion: selenium does not appear to have a significant impact on the risk of developing AIT, AIH, or GD. The statistical analysis revealed no causal relationship, and we found that the odds ratios for each condition were close to one, indicating no discernible benefit from selenium.
Given these results, it is clear that indiscriminate supplementation of selenium for individuals with autoimmune thyroid conditions is not supported. Patients should avoid unnecessary selenium intake unless they are specifically deficient in this nutrient.
Our findings highlighted an important conclusion: selenium does not appear to have a significant impact on the risk of developing AIT, AIH, or GD. The statistical analysis revealed no causal relationship, and we found that the odds ratios for each condition were close to one, indicating no discernible benefit from selenium.
Given these results, it is clear that indiscriminate supplementation of selenium for individuals with autoimmune thyroid conditions is not supported. Patients should avoid unnecessary selenium intake unless they are specifically deficient in this nutrient.
Read More
9
We explored the effects of selenium supplements on patients with Hashimoto's thyroiditis, an autoimmune disorder that can affect thyroid function. Through a structured analysis of studies, we focused on how selenium could potentially lower the levels of thyroid autoantibodies.
Our research involved a careful review of data from reputable databases, including PubMed and Cochrane, which identified several studies examining the effectiveness of selenium, Vitamin D, and Myo-inositol. Among these, the results showed that selenium supplementation significantly reduced both thyroid peroxidase autoantibodies (TPOAb) and thyroglobulin autoantibodies (TgAb) when compared to a placebo group.
Interestingly, other supplements like Myo-inositol and Vitamin D, both individually and in combination with selenium, did not show a significant effect in reducing the autoantibody levels. Based on these findings, it appears that incorporating selenium into treatment regimens may offer a beneficial adjunct for those managing Hashimoto's thyroiditis.
Our research involved a careful review of data from reputable databases, including PubMed and Cochrane, which identified several studies examining the effectiveness of selenium, Vitamin D, and Myo-inositol. Among these, the results showed that selenium supplementation significantly reduced both thyroid peroxidase autoantibodies (TPOAb) and thyroglobulin autoantibodies (TgAb) when compared to a placebo group.
Interestingly, other supplements like Myo-inositol and Vitamin D, both individually and in combination with selenium, did not show a significant effect in reducing the autoantibody levels. Based on these findings, it appears that incorporating selenium into treatment regimens may offer a beneficial adjunct for those managing Hashimoto's thyroiditis.
Read More
Most Useful Reviews
9
Decreased antibodies
14 people found this helpful
Good analyses! After the course of selenium, my antibodies decreased with autoimmune thyroiditis!
Read More
9
Maintains immunity
1 people found this helpful
An excellent supplement from a superb manufacturer. I consistently buy selenium and take it as directed by my endocrinologist. It’s vital for maintaining my immunity and thyroid health, and I’m very pleased with the results.
Read More
7.5
Improved well-being
1 people found this helpful
Excellent! I ordered it for my mother along with zinc. She has shown noticeable progress, with reduced hot flushes and improved well-being.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 17 Researches
6.9
- All Researches
9
We explored the effects of selenium supplements on patients with Hashimoto's thyroiditis, an autoimmune disorder that can affect thyroid function. Through a structured analysis of studies, we focused on how selenium could potentially lower the levels of thyroid autoantibodies.
Our research involved a careful review of data from reputable databases, including PubMed and Cochrane, which identified several studies examining the effectiveness of selenium, Vitamin D, and Myo-inositol. Among these, the results showed that selenium supplementation significantly reduced both thyroid peroxidase autoantibodies (TPOAb) and thyroglobulin autoantibodies (TgAb) when compared to a placebo group.
Interestingly, other supplements like Myo-inositol and Vitamin D, both individually and in combination with selenium, did not show a significant effect in reducing the autoantibody levels. Based on these findings, it appears that incorporating selenium into treatment regimens may offer a beneficial adjunct for those managing Hashimoto's thyroiditis.
Our research involved a careful review of data from reputable databases, including PubMed and Cochrane, which identified several studies examining the effectiveness of selenium, Vitamin D, and Myo-inositol. Among these, the results showed that selenium supplementation significantly reduced both thyroid peroxidase autoantibodies (TPOAb) and thyroglobulin autoantibodies (TgAb) when compared to a placebo group.
Interestingly, other supplements like Myo-inositol and Vitamin D, both individually and in combination with selenium, did not show a significant effect in reducing the autoantibody levels. Based on these findings, it appears that incorporating selenium into treatment regimens may offer a beneficial adjunct for those managing Hashimoto's thyroiditis.
Read More
9
Selenium aids Graves' orbitopathy treatment
We explored how selenium supplementation might help individuals suffering from Graves' orbitopathy, an autoimmune disorder linked to thyroid dysfunction. Our approach involved a systematic review and meta-analysis that assessed results from four randomized controlled trials.
The findings revealed that selenium supplementation had a significant positive impact on various aspects of Graves' orbitopathy. Over a period of six months, patients taking selenium showed a notable reduction in clinical activity scores, which reflect the severity of eye symptoms. Furthermore, their quality of life also improved significantly.
We observed improvements not only in the overall quality of life specific to eye conditions, but also in visual and psychological functioning scores. Additionally, selenium appeared to reduce the width of the eyelids, providing further benefits for eye-related symptoms. However, we found no significant changes in other areas, such as eye bulging or muscle movement abilities.
Importantly, selenium supplementation was deemed safe with minor side effects reported, suggesting it could be a viable option for managing Graves' orbitopathy. While our results are promising, we believe further research is needed to thoroughly validate the long-term effectiveness and safety of selenium treatment for this condition.
The findings revealed that selenium supplementation had a significant positive impact on various aspects of Graves' orbitopathy. Over a period of six months, patients taking selenium showed a notable reduction in clinical activity scores, which reflect the severity of eye symptoms. Furthermore, their quality of life also improved significantly.
We observed improvements not only in the overall quality of life specific to eye conditions, but also in visual and psychological functioning scores. Additionally, selenium appeared to reduce the width of the eyelids, providing further benefits for eye-related symptoms. However, we found no significant changes in other areas, such as eye bulging or muscle movement abilities.
Importantly, selenium supplementation was deemed safe with minor side effects reported, suggesting it could be a viable option for managing Graves' orbitopathy. While our results are promising, we believe further research is needed to thoroughly validate the long-term effectiveness and safety of selenium treatment for this condition.
Read More
9
The study we looked into focused on selenium's impact on autoimmune thyroiditis, particularly Hashimoto's thyroiditis. By analyzing whether selenium supplementation could offer relief or improvement in symptoms, we delved into its potential benefits for patients battling this often frustrating condition.
Through careful examination and relevant data, we observed that selenium may play a significant role in managing autoimmune thyroid disorders. Patients receiving selenium supplements tended to show improved thyroid function and reduced autoimmune response markers. This finding opens the door for a natural approach to complement traditional treatments in dealing with Hashimoto’s.
Overall, we found evidence supporting the use of selenium as a valuable addition to the treatment regimen for patients with autoimmune thyroiditis. This research enhances our understanding of how selenium could provide benefits and encourages further exploration in this area.
Through careful examination and relevant data, we observed that selenium may play a significant role in managing autoimmune thyroid disorders. Patients receiving selenium supplements tended to show improved thyroid function and reduced autoimmune response markers. This finding opens the door for a natural approach to complement traditional treatments in dealing with Hashimoto’s.
Overall, we found evidence supporting the use of selenium as a valuable addition to the treatment regimen for patients with autoimmune thyroiditis. This research enhances our understanding of how selenium could provide benefits and encourages further exploration in this area.
Read More
8
We observed that selenium, an essential micronutrient, significantly impacts thyroid health, especially in the context of autoimmune disorders. When serum selenium levels are low, such as in conditions like autoimmune thyroiditis, glutathione peroxidase activity decreases. This decline can lead to increased oxidative stress, resulting in further damage to thyroid tissue.
Specifically, in cases of Graves' disease, selenium supplementation has been found to help patients achieve euthyroidism more quickly. It also appears to improve overall quality of life and may reduce symptoms associated with the disease, such as less orbital involvement and slowed progression of eye complications. This suggests that selenium not only supports metabolic processes but may also provide therapeutic benefits in specific autoimmune conditions.
However, while some studies do point to selenium's potential advantages, the current body of evidence remains somewhat limited. There is still not enough conclusive data to fully endorse selenium supplementation for all patients with thyroid disorders. We recognize that future research needs to clarify the exact role of selenium in preventing or treating thyroid diseases.
Specifically, in cases of Graves' disease, selenium supplementation has been found to help patients achieve euthyroidism more quickly. It also appears to improve overall quality of life and may reduce symptoms associated with the disease, such as less orbital involvement and slowed progression of eye complications. This suggests that selenium not only supports metabolic processes but may also provide therapeutic benefits in specific autoimmune conditions.
However, while some studies do point to selenium's potential advantages, the current body of evidence remains somewhat limited. There is still not enough conclusive data to fully endorse selenium supplementation for all patients with thyroid disorders. We recognize that future research needs to clarify the exact role of selenium in preventing or treating thyroid diseases.
Read More
8
We explored the effects of selenium treatment on immune dysregulation in lupus, a common autoimmune disorder. In our study, we compared mice with lupus to healthy control mice using advanced single-cell RNA sequencing techniques. This research aimed to clarify whether selenium could help improve gut health and alleviate symptoms associated with lupus.
Our findings revealed a significant decrease in specific immune cells known as CD8αα + intraepithelial lymphocytes (IELs) in the lupus mice. At the same time, we observed an increase in another type of immune cell, CD8αβ + IELs, which displayed enhanced activity. Notably, selenium treatment effectively reversed the loss of a particular subset of immune cells known as γδT. This treatment also improved the gut barrier, which is crucial for immune health, and helped alleviate some lupus symptoms.
As we analyzed the data, it became clear that selenium not only supports the immune system by restoring certain cell types but also reduces oxidative stress in the gut. By enhancing the gut's immunological environment, selenium may provide new avenues for managing lupus and other autoimmune disorders.
Our findings revealed a significant decrease in specific immune cells known as CD8αα + intraepithelial lymphocytes (IELs) in the lupus mice. At the same time, we observed an increase in another type of immune cell, CD8αβ + IELs, which displayed enhanced activity. Notably, selenium treatment effectively reversed the loss of a particular subset of immune cells known as γδT. This treatment also improved the gut barrier, which is crucial for immune health, and helped alleviate some lupus symptoms.
As we analyzed the data, it became clear that selenium not only supports the immune system by restoring certain cell types but also reduces oxidative stress in the gut. By enhancing the gut's immunological environment, selenium may provide new avenues for managing lupus and other autoimmune disorders.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Decreased antibodies
14 people found this helpful
Good analyses! After the course of selenium, my antibodies decreased with autoimmune thyroiditis!
Read More
9
Maintains immunity
1 people found this helpful
An excellent supplement from a superb manufacturer. I consistently buy selenium and take it as directed by my endocrinologist. It’s vital for maintaining my immunity and thyroid health, and I’m very pleased with the results.
Read More
7.5
Improved well-being
1 people found this helpful
Excellent! I ordered it for my mother along with zinc. She has shown noticeable progress, with reduced hot flushes and improved well-being.
Read More
7.5
Improved health
10 people found this helpful
Unexpectedly, selenium improved my energy and vivacity greatly. While treating my occult anaemia, I experienced constant seizures at the corners of my lips despite taking sorbifer and other group B vitamins. Remarkably, after a few days on selenium, those seizures vanished. I can’t explain how selenium connects with anaemia, but my health has significantly improved. I’ve ordered more.
Read More
8
Feeling normal
This product is great, particularly for those with thyroid disorders, given selenium's scarcity in our soils. I feel it helps me feel more normal despite its smell. It’s easy to swallow, which I appreciate.
Read More
Frequently Asked Questions
7.5
Improved health
10 people found this helpful
Unexpectedly, selenium improved my energy and vivacity greatly. While treating my occult anaemia, I experienced constant seizures at the corners of my lips despite taking sorbifer and other group B vitamins. Remarkably, after a few days on selenium, those seizures vanished. I can’t explain how selenium connects with anaemia, but my health has significantly improved. I’ve ordered more.
7.5
Improved well-being
1 people found this helpful
Excellent! I ordered it for my mother along with zinc. She has shown noticeable progress, with reduced hot flushes and improved well-being.
7.5
Easier swallowing
2 people found this helpful
These vitamins are excellent, and the dosage is convenient! After a week, I noticed it became easier to swallow, as selenium is crucial to prevent the thyroid gland from enlarging. The delivery was quick too! I’m pleased with this vitamin range. Stay healthy and choose the best for your body!
9
Decreased antibodies
14 people found this helpful
Good analyses! After the course of selenium, my antibodies decreased with autoimmune thyroiditis!
9
Maintains immunity
1 people found this helpful
An excellent supplement from a superb manufacturer. I consistently buy selenium and take it as directed by my endocrinologist. It’s vital for maintaining my immunity and thyroid health, and I’m very pleased with the results.
6
Recommended form
Selenocysteine is better for those with autoimmune thyroiditis, as this form of selenium might not be absorbed due to a gene mutation. It’s wise to opt for selenocysteine instead during treatment.
9
We explored the effects of selenium supplements on patients with Hashimoto's thyroiditis, an autoimmune disorder that can affect thyroid function. Through a structured analysis of studies, we focused on how selenium could potentially lower the levels of thyroid autoantibodies.
Our research involved a careful review of data from reputable databases, including PubMed and Cochrane, which identified several studies examining the effectiveness of selenium, Vitamin D, and Myo-inositol. Among these, the results showed that selenium supplementation significantly reduced both thyroid peroxidase autoantibodies (TPOAb) and thyroglobulin autoantibodies (TgAb) when compared to a placebo group.
Interestingly, other supplements like Myo-inositol and Vitamin D, both individually and in combination with selenium, did not show a significant effect in reducing the autoantibody levels. Based on these findings, it appears that incorporating selenium into treatment regimens may offer a beneficial adjunct for those managing Hashimoto's thyroiditis.
Our research involved a careful review of data from reputable databases, including PubMed and Cochrane, which identified several studies examining the effectiveness of selenium, Vitamin D, and Myo-inositol. Among these, the results showed that selenium supplementation significantly reduced both thyroid peroxidase autoantibodies (TPOAb) and thyroglobulin autoantibodies (TgAb) when compared to a placebo group.
Interestingly, other supplements like Myo-inositol and Vitamin D, both individually and in combination with selenium, did not show a significant effect in reducing the autoantibody levels. Based on these findings, it appears that incorporating selenium into treatment regimens may offer a beneficial adjunct for those managing Hashimoto's thyroiditis.
9
Selenium aids Graves' orbitopathy treatment
We explored how selenium supplementation might help individuals suffering from Graves' orbitopathy, an autoimmune disorder linked to thyroid dysfunction. Our approach involved a systematic review and meta-analysis that assessed results from four randomized controlled trials.
The findings revealed that selenium supplementation had a significant positive impact on various aspects of Graves' orbitopathy. Over a period of six months, patients taking selenium showed a notable reduction in clinical activity scores, which reflect the severity of eye symptoms. Furthermore, their quality of life also improved significantly.
We observed improvements not only in the overall quality of life specific to eye conditions, but also in visual and psychological functioning scores. Additionally, selenium appeared to reduce the width of the eyelids, providing further benefits for eye-related symptoms. However, we found no significant changes in other areas, such as eye bulging or muscle movement abilities.
Importantly, selenium supplementation was deemed safe with minor side effects reported, suggesting it could be a viable option for managing Graves' orbitopathy. While our results are promising, we believe further research is needed to thoroughly validate the long-term effectiveness and safety of selenium treatment for this condition.
The findings revealed that selenium supplementation had a significant positive impact on various aspects of Graves' orbitopathy. Over a period of six months, patients taking selenium showed a notable reduction in clinical activity scores, which reflect the severity of eye symptoms. Furthermore, their quality of life also improved significantly.
We observed improvements not only in the overall quality of life specific to eye conditions, but also in visual and psychological functioning scores. Additionally, selenium appeared to reduce the width of the eyelids, providing further benefits for eye-related symptoms. However, we found no significant changes in other areas, such as eye bulging or muscle movement abilities.
Importantly, selenium supplementation was deemed safe with minor side effects reported, suggesting it could be a viable option for managing Graves' orbitopathy. While our results are promising, we believe further research is needed to thoroughly validate the long-term effectiveness and safety of selenium treatment for this condition.
7
We conducted a study to evaluate the impact of selenium supplementation on patients with inactive moderate-to-severe Graves' orbitopathy, a condition that affects the eyes and is related to an autoimmune disorder. In a controlled setting, participants were randomly assigned to either a selenium group or a placebo group, and each received treatment for six months.
Throughout the study, we conducted comprehensive eye exams and evaluated various factors such as eyelid aperture, quality of life related to Graves' disease, and serum selenium levels. What we found was quite striking—participants who received selenium showed a notable improvement in their eyelid aperture compared to those who received the placebo.
Specifically, the selenium group had a mean change of -1.4 mm in palpebral aperture, while the placebo group saw only a minor change. However, other measures like proptosis and ocular motility didn't significantly change for either group. Interestingly, even though the selenium group didn’t show notable improvements in all aspects, they did experience some positive changes, which might encourage further exploration into selenium's role in autoimmune-related eye conditions.
It's important to note that while some participants in the placebo group did experience changes, overall, selenium demonstrated a distinct benefit for eyelid aperture in patients with adequate baseline selenium levels, suggesting a potential area for further research in managing symptoms of Graves' orbitopathy.
Throughout the study, we conducted comprehensive eye exams and evaluated various factors such as eyelid aperture, quality of life related to Graves' disease, and serum selenium levels. What we found was quite striking—participants who received selenium showed a notable improvement in their eyelid aperture compared to those who received the placebo.
Specifically, the selenium group had a mean change of -1.4 mm in palpebral aperture, while the placebo group saw only a minor change. However, other measures like proptosis and ocular motility didn't significantly change for either group. Interestingly, even though the selenium group didn’t show notable improvements in all aspects, they did experience some positive changes, which might encourage further exploration into selenium's role in autoimmune-related eye conditions.
It's important to note that while some participants in the placebo group did experience changes, overall, selenium demonstrated a distinct benefit for eyelid aperture in patients with adequate baseline selenium levels, suggesting a potential area for further research in managing symptoms of Graves' orbitopathy.
8
We conducted a fascinating study exploring how selenium, a powerful antioxidant, can impact autoimmune disorders, particularly Type 1 diabetes mellitus (T1DM). Our focus was on mesenchymal stem cell-derived exosomes (MSCs-Exs) and how loading them with either selenium or nano selenium might enhance their therapeutic effects.
During a four-week experiment with six groups of rats, including healthy and diabetic subjects, we observed significant benefits in the groups treated with MSCs-Exs loaded with selenium. Both selenium-treated groups showed remarkable improvements in pancreatic function and exhibited properties that promote healing, reduce inflammation, enhance immunity, and prevent cell death.
Notably, the group receiving nano selenium-loaded exosomes demonstrated even greater benefits in managing the complications associated with diabetes. These findings suggest that combining selenium with exosome therapy may represent a promising new approach to tackling T1DM while also broadening our understanding of selenium's role in autoimmune disorders.
During a four-week experiment with six groups of rats, including healthy and diabetic subjects, we observed significant benefits in the groups treated with MSCs-Exs loaded with selenium. Both selenium-treated groups showed remarkable improvements in pancreatic function and exhibited properties that promote healing, reduce inflammation, enhance immunity, and prevent cell death.
Notably, the group receiving nano selenium-loaded exosomes demonstrated even greater benefits in managing the complications associated with diabetes. These findings suggest that combining selenium with exosome therapy may represent a promising new approach to tackling T1DM while also broadening our understanding of selenium's role in autoimmune disorders.
0
We aimed to explore how selenium affects autoimmune thyroid disease (AITD), specifically looking at three conditions: autoimmune thyroiditis (AIT), autoimmune hyperthyroidism (AIH), and Graves' disease (GD). Using a research method called Mendelian randomization, we analyzed genetic data to establish potential causal links between selenium levels and these autoimmune disorders.
Our findings highlighted an important conclusion: selenium does not appear to have a significant impact on the risk of developing AIT, AIH, or GD. The statistical analysis revealed no causal relationship, and we found that the odds ratios for each condition were close to one, indicating no discernible benefit from selenium.
Given these results, it is clear that indiscriminate supplementation of selenium for individuals with autoimmune thyroid conditions is not supported. Patients should avoid unnecessary selenium intake unless they are specifically deficient in this nutrient.
Our findings highlighted an important conclusion: selenium does not appear to have a significant impact on the risk of developing AIT, AIH, or GD. The statistical analysis revealed no causal relationship, and we found that the odds ratios for each condition were close to one, indicating no discernible benefit from selenium.
Given these results, it is clear that indiscriminate supplementation of selenium for individuals with autoimmune thyroid conditions is not supported. Patients should avoid unnecessary selenium intake unless they are specifically deficient in this nutrient.
We conducted a triple-blind randomized clinical trial with 60 patients who have multiple sclerosis (MS) to investigate the effects of crocin-selenium nanoparticles (Cor@SeNs) on cognitive function and oxidative stress markers. Participants were divided evenly into a group receiving the Cor@SeNs capsules and a placebo group for 12 weeks.
We evaluated cognitive performance using a specific assessment tool for MS and measured serum antioxidants to see how well the intervention worked. The results showed an increase in total antioxidant capacity in the Cor@SeNs group, suggesting some benefit from selenium and crocin combined.
Furthermore, we noted improvements in cognitive tests across both groups, although the Cor@SeNs group showed slightly greater enhancements in cognitive function and antioxidant levels. While these changes were promising, they were not statistically significant enough to conclude definitive benefits.
Our study is unique, being one of the first to look at this specific combination of ingredients at low doses. Future research with different dosages and longer durations could further clarify these findings.
We evaluated cognitive performance using a specific assessment tool for MS and measured serum antioxidants to see how well the intervention worked. The results showed an increase in total antioxidant capacity in the Cor@SeNs group, suggesting some benefit from selenium and crocin combined.
Furthermore, we noted improvements in cognitive tests across both groups, although the Cor@SeNs group showed slightly greater enhancements in cognitive function and antioxidant levels. While these changes were promising, they were not statistically significant enough to conclude definitive benefits.
Our study is unique, being one of the first to look at this specific combination of ingredients at low doses. Future research with different dosages and longer durations could further clarify these findings.
8
We delved into how selenium supplementation might impact Hashimoto thyroiditis (HT), a common autoimmune disorder linked to hypothyroidism. Through a systematic review and meta-analysis of various randomized controlled trials, we assessed selenium's influence on several health measures, including thyroid hormone levels and antibodies in patients suffering from HT.
Our analysis involved screening a total of 687 records, leading us to include 35 relevant studies in our findings. Notably, we discovered that selenium supplementation significantly reduced thyroid-stimulating hormone (TSH) levels in patients who were not undergoing thyroid hormone replacement therapy. It also effectively lowered thyroid peroxidase antibodies (TPOAb) and malondialdehyde (MDA), which suggests an overall improvement in the autoimmune response.
While selenium showed promise in lowering TSH, TPOAb, and MDA levels, our exploration revealed that there were no notable changes in other thyroid hormone levels like fT4, T3, or thyroid volume. Furthermore, we observed that adverse effects were similar between those receiving selenium and those on a placebo, indicating that it's safe for use. Overall, our findings point to selenium as a beneficial addition to the management of HT for individuals not on hormone replacement therapies.
Our analysis involved screening a total of 687 records, leading us to include 35 relevant studies in our findings. Notably, we discovered that selenium supplementation significantly reduced thyroid-stimulating hormone (TSH) levels in patients who were not undergoing thyroid hormone replacement therapy. It also effectively lowered thyroid peroxidase antibodies (TPOAb) and malondialdehyde (MDA), which suggests an overall improvement in the autoimmune response.
While selenium showed promise in lowering TSH, TPOAb, and MDA levels, our exploration revealed that there were no notable changes in other thyroid hormone levels like fT4, T3, or thyroid volume. Furthermore, we observed that adverse effects were similar between those receiving selenium and those on a placebo, indicating that it's safe for use. Overall, our findings point to selenium as a beneficial addition to the management of HT for individuals not on hormone replacement therapies.
7
We investigated how selenium levels in pregnant women relate to thyroid health and potential autoimmune disorders. In our study, we looked at a group of 367 expectant mothers in South Korea and divided them into three selenium categories: deficient, suboptimal, and optimal. This allowed us to explore how these levels might influence thyroid function and the risk of conditions like severe preeclampsia.
Our findings revealed that a notable percentage of participants experienced mild selenium deficiency, with 8% classified as deficient. We observed that lower selenium levels were linked to higher instances of autoimmune thyroid markers, indicating a potential connection between selenium deficiency and thyroid issues. For instance, women with deficient selenium levels showed higher rates of positive anti-thyroid peroxidase antibody results compared to those with optimal levels.
Furthermore, we noted an increased risk of severe preeclampsia among women not taking selenium supplements, especially in those with twin pregnancies. This suggests that adequate selenium intake might be crucial not just for thyroid health, but also for a smoother pregnancy experience.
Overall, our study underscores the importance of monitoring and potentially supplementing selenium during pregnancy to manage thyroid health and reduce the risk of complications. Guidelines on selenium intake during pregnancy could be beneficial for both mothers and their babies.
Our findings revealed that a notable percentage of participants experienced mild selenium deficiency, with 8% classified as deficient. We observed that lower selenium levels were linked to higher instances of autoimmune thyroid markers, indicating a potential connection between selenium deficiency and thyroid issues. For instance, women with deficient selenium levels showed higher rates of positive anti-thyroid peroxidase antibody results compared to those with optimal levels.
Furthermore, we noted an increased risk of severe preeclampsia among women not taking selenium supplements, especially in those with twin pregnancies. This suggests that adequate selenium intake might be crucial not just for thyroid health, but also for a smoother pregnancy experience.
Overall, our study underscores the importance of monitoring and potentially supplementing selenium during pregnancy to manage thyroid health and reduce the risk of complications. Guidelines on selenium intake during pregnancy could be beneficial for both mothers and their babies.
References
- Souza LSL, Campos RO, Braga JS, Jesus JDS, Ramos HE, et al. Selenium nutritional status and thyroid dysfunction. Arch Endocrinol Metab. 2025;69:e230348. 10.20945/2359-4292-2023-0348
- Wang Q, Wu Y, Ouyang L, Min X, Zheng M, et al. Single-cell analyses of intestinal epithelium reveal the dysregulation of gut immune microenvironment in systemic lupus erythematosus. J Transl Med. 2025;23:118. 10.1186/s12967-025-06147-5
- Peng B, Wang W, Gu Q, Wang P, Teng W, et al. Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis. Front Endocrinol (Lausanne). 2024;15:1445878. 10.3389/fendo.2024.1445878
- Wahl L, Samson Chillon T, Seemann P, Ohrndorf S, Ochwadt R, et al. Serum selenium, selenoprotein P and glutathione peroxidase 3 in rheumatoid, psoriatic, juvenile idiopathic arthritis, and osteoarthritis. J Nutr Biochem. 2025;135:109776. 10.1016/j.jnutbio.2024.109776
- Sharabati I, Qafesha RM, Hindawi MD, Amro S, Ayesh BM. The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials. Clin Endocrinol (Oxf). 2024;101:669. 10.1111/cen.15128
- Chung CW, Kim K, Park SK, Ju DL, Park YJ, et al. Selenium levels and their association with thyroid autoimmunity and severe preeclampsia in pregnancy: Insights from a prospective ideal breast milk cohort study. Eur Thyroid J. 2024;13. 10.1530/ETJ-24-0007
- Hu C, Yu YF, Tong KK, Hu G, Wu JY, et al. A Mendelian randomization study of the effect of selenium on autoimmune thyroid disease. Eur Rev Med Pharmacol Sci. 2024;28:2988. 10.26355/eurrev_202404_36011
- Khalil DY, Hussein RH, El-Kholy WM. Mesenchymal Stem Cell-Derived Exosomes Loaded with Selenium or Nano Selenium as a Novel Therapeutic Paradigm for Streptozotocin-Induced Type 1 Diabetes in Rats. Biology (Basel). 2024;13. 10.3390/biology13040253
- Potita P, Pruksakorn V, Srichomkwun P, Kingpetch K, Saonanon P. Selenium supplementation in inactive moderate to severe Graves' orbitopathy patients: a randomized controlled trial. Orbit. 2024;43:329. 10.1080/01676830.2024.2315566
- Duntas LH. Reassessing Selenium for the Management of Hashimoto's Thyroiditis: The Selini Shines Bright for Autoimmune Thyroiditis Patients. Thyroid. 2024;34:292. 10.1089/thy.2024.0078
- Wang S, Chen P, He Y, Wei J, Tian L, et al. A follow-up study on factors affecting the recovery of patients with hypothyroidism in different selenium environments. BMC Endocr Disord. 2024;24:14. 10.1186/s12902-024-01536-1
- Huwiler VV, Maissen-Abgottspon S, Stanga Z, Mühlebach S, Trepp R, et al. Selenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Thyroid. 2024;34:295. 10.1089/thy.2023.0556
- Wang C, Qiao J, Liu S, Piao S, Zhou Y, et al. Selenium in the treatment of mild-to-moderate Graves' orbitopathy: a 5-year prospective controlled cohort study. Endocrine. 2024;84:1072. 10.1007/s12020-023-03672-5
- Yavari M, Akbari M, Ramezani Ahmadi A, Siavash Dastjerdi M, Hashemi MS. Investigating the effect of combined use of selenium and Myo-inositol supplements on thyroid function and autoimmune characteristics in thyroid disorders: a systematic review and meta-analysis. Expert Rev Endocrinol Metab. 2024;19:269. 10.1080/17446651.2023.2295487
- Foos W, Maliakkal Hernandez J, Mansour TN. Selenium supplementation in thyroid eye disease: an updated review from a clinical ophthalmic perspective. Orbit. 2024;43:790. 10.1080/01676830.2023.2276783
- Rezaeimanesh N, Rafiee P, Saeedi R, Khosravian P, Sahraian MA, et al. The effect of crocin-selenium nanoparticles on the cognition and oxidative stress markers of multiple sclerosis patients: a randomized triple-blinded placebo-controlled clinical trial. Biometals. 2024;37:305. 10.1007/s10534-023-00548-z
- Chen X, Yang Y, Chen J, He Y, Huang Y, et al. Dual-driven selenium Janus single-atom nanomotors for autonomous regulating mitochondrial oxygen imbalance to catalytic therapy of rheumatoid arthritis. Redox Biol. 2025;81:103574. 10.1016/j.redox.2025.103574
