Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
USERS' SCORE
Good
Based on 8 Reviews
8.1
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Selenium (as L-selenomethionine)
200 mcg
364%
Top Medical Research Studies
9
Selenium nanoparticles support heart health
We explored how selenium nanoparticles (SeNPs) could help reduce damage from heart attacks, specifically ischemia/reperfusion injury (I/RI). Using a method to create these nanoparticles, we found they possess remarkable properties that combat oxidative stress and inflammation.
SeNPs seem to disrupt harmful cellular cycles, thereby protecting heart cells. Notably, they improved heart function and reduced cell death and scar tissue in tests. Overall, these findings suggest that SeNPs could be a valuable approach in managing heart conditions after a heart attack.
SeNPs seem to disrupt harmful cellular cycles, thereby protecting heart cells. Notably, they improved heart function and reduced cell death and scar tissue in tests. Overall, these findings suggest that SeNPs could be a valuable approach in managing heart conditions after a heart attack.
Read More
8
We explored the use of selenium-loaded porous silica nanospheres (Se@PSN) as a promising treatment for myocardial infarction (MI). This innovative approach targets harmful reactive oxygen species (ROS), which damage heart cells. By improving antioxidant activity and supporting mitochondrial function, Se@PSN help reduce heart tissue damage and maintain cardiac function after a heart attack. The findings suggest that Se@PSN could be a significant advancement for MI treatments and may offer hope in the clinical realm.
Read More
9.5
We looked into how dietary selenium and zinc affect the risk of dilated cardiomyopathy (DCMP) in children. In this case-control study, 36 patients with DCMP were compared to 72 healthy children, assessing their dietary intakes using a food frequency questionnaire.
Our findings revealed that sufficient intake of selenium and zinc significantly lowered the risk of DCMP, suggesting that these nutrients play a protective role. Addressing nutritional deficiencies could improve heart health in affected children, although more research is needed to explore the underlying mechanisms.
Our findings revealed that sufficient intake of selenium and zinc significantly lowered the risk of DCMP, suggesting that these nutrients play a protective role. Addressing nutritional deficiencies could improve heart health in affected children, although more research is needed to explore the underlying mechanisms.
Read More
Most Useful Reviews
9
Supports heart health
2 people found this helpful
This product is excellent; I’ve been taking it for a long time with other supplements to boost my immune system. Recently, I’ve increased my dosage due to my hypothyroidism. I discovered that selenium is concentrated in the thyroid as it is essential for metabolic processes. Various studies have shown that selenium supplementation improves thyroid structure and can lead to quicker remission in certain diseases.
Read More
7.5
Boosts immunity
2 people found this helpful
Selenium is crucial for the thyroid gland, complementing iodine and supporting liver, heart, arteries, nerves, and brain health. It significantly improves blood sugar levels and is vital for fertility and sexual health. Most people are deficient in this essential mineral. I recommend this product as it offers a good combination of selenium along with a focus on healthy eating and exercise.
Read More
7.5
Prevents cell damage
2 people found this helpful
Selenium helps maintain normal thyroid gland function and improves hormone production. It prevents cell destruction, addresses inflammation, and supports the immune system. Those with Alzheimer’s disease frequently exhibit reduced selenium levels. Furthermore, selenium mitigates the risk of heart disease by tackling inflammatory processes. I take it as prescribed by my gynaecologist.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
- All Researches
9.5
We looked into how dietary selenium and zinc affect the risk of dilated cardiomyopathy (DCMP) in children. In this case-control study, 36 patients with DCMP were compared to 72 healthy children, assessing their dietary intakes using a food frequency questionnaire.
Our findings revealed that sufficient intake of selenium and zinc significantly lowered the risk of DCMP, suggesting that these nutrients play a protective role. Addressing nutritional deficiencies could improve heart health in affected children, although more research is needed to explore the underlying mechanisms.
Our findings revealed that sufficient intake of selenium and zinc significantly lowered the risk of DCMP, suggesting that these nutrients play a protective role. Addressing nutritional deficiencies could improve heart health in affected children, although more research is needed to explore the underlying mechanisms.
Read More
9
Selenium nanoparticles support heart health
We explored how selenium nanoparticles (SeNPs) could help reduce damage from heart attacks, specifically ischemia/reperfusion injury (I/RI). Using a method to create these nanoparticles, we found they possess remarkable properties that combat oxidative stress and inflammation.
SeNPs seem to disrupt harmful cellular cycles, thereby protecting heart cells. Notably, they improved heart function and reduced cell death and scar tissue in tests. Overall, these findings suggest that SeNPs could be a valuable approach in managing heart conditions after a heart attack.
SeNPs seem to disrupt harmful cellular cycles, thereby protecting heart cells. Notably, they improved heart function and reduced cell death and scar tissue in tests. Overall, these findings suggest that SeNPs could be a valuable approach in managing heart conditions after a heart attack.
Read More
9
We explored how a high selenium diet impacts heart health, especially under stress conditions like systolic overload. Using male mice, we compared those on a high selenium diet with those on a normal diet.
While high selenium didn’t change heart function under normal conditions, it significantly protected against heart issues caused by overload, reducing inflammation and heart muscle growth.
This suggests that a high selenium diet can be beneficial in combating certain heart problems, providing a proactive step for heart health.
While high selenium didn’t change heart function under normal conditions, it significantly protected against heart issues caused by overload, reducing inflammation and heart muscle growth.
This suggests that a high selenium diet can be beneficial in combating certain heart problems, providing a proactive step for heart health.
Read More
9
Selenium compound shows heart protection
We investigated the effects of a new selenium-containing compound, Se-SAHA, on heart failure caused by isoproterenol. Our study found that Se-SAHA helped protect heart cells from damage, reducing cardiac hypertrophy and fibrosis in lab models.
It effectively lowered harmful reactive oxygen species and increased vital antioxidative enzymes. Additionally, Se-SAHA hindered the buildup of autophagosomes and reversed certain harmful protein expressions linked to heart stress. Overall, these findings suggest that Se-SAHA could play a protective role in heart health by reducing oxidative stress and altering autophagic processes.
It effectively lowered harmful reactive oxygen species and increased vital antioxidative enzymes. Additionally, Se-SAHA hindered the buildup of autophagosomes and reversed certain harmful protein expressions linked to heart stress. Overall, these findings suggest that Se-SAHA could play a protective role in heart health by reducing oxidative stress and altering autophagic processes.
Read More
9
We investigated the use of a new selenium delivery system to combat radiation-induced heart disease, which is a serious concern for cancer patients undergoing thoracic radiation. Our innovative oral microcarriers showed remarkable effects in protecting heart cells from radiation damage by reducing harmful reactive oxygen species.
Not only did this method improve heart function and reduce signs of damage, but it also supported the immune system by increasing beneficial immune cells after radiation exposure. These promising results suggest that selenium could play a key role in helping to manage and prevent heart complications from radiation therapy.
Not only did this method improve heart function and reduce signs of damage, but it also supported the immune system by increasing beneficial immune cells after radiation exposure. These promising results suggest that selenium could play a key role in helping to manage and prevent heart complications from radiation therapy.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Supports heart health
2 people found this helpful
This product is excellent; I’ve been taking it for a long time with other supplements to boost my immune system. Recently, I’ve increased my dosage due to my hypothyroidism. I discovered that selenium is concentrated in the thyroid as it is essential for metabolic processes. Various studies have shown that selenium supplementation improves thyroid structure and can lead to quicker remission in certain diseases.
Read More
7.5
Boosts immunity
2 people found this helpful
Selenium is crucial for the thyroid gland, complementing iodine and supporting liver, heart, arteries, nerves, and brain health. It significantly improves blood sugar levels and is vital for fertility and sexual health. Most people are deficient in this essential mineral. I recommend this product as it offers a good combination of selenium along with a focus on healthy eating and exercise.
Read More
7.5
Prevents cell damage
2 people found this helpful
Selenium helps maintain normal thyroid gland function and improves hormone production. It prevents cell destruction, addresses inflammation, and supports the immune system. Those with Alzheimer’s disease frequently exhibit reduced selenium levels. Furthermore, selenium mitigates the risk of heart disease by tackling inflammatory processes. I take it as prescribed by my gynaecologist.
Read More
9
Enhances wellbeing
1 people found this helpful
I have been using this form of selenium for autoimmune thyroid disease for three years. It significantly reduces thyroid antibodies and enhances my overall wellbeing. Truly excellent!
Read More
7.5
Reduces heart disease
9 people found this helpful
Selenium is an element that helps maintain the normal functioning of the thyroid gland. It promotes improved production of thyroid hormones and prevents cell destruction while eliminating inflammation and strengthening the immune system. Individuals with Alzheimer’s disease often have lower levels of selenium in their blood. Additionally, selenium reduces the risk of heart disease by addressing inflammation and oxidative stress. I take one tablet after breakfast as recommended by my gynaecologist.
Read More
Frequently Asked Questions
7.5
Relieves sickness
We use this selenium as a family and always keep it on hand for viral illnesses. The moment I feel unwell, I start taking selenium with vitamin C, and it helps alleviate my symptoms. If you find my review useful, please like it. Wishing you all good health!
9
Enhances wellbeing
1 people found this helpful
I have been using this form of selenium for autoimmune thyroid disease for three years. It significantly reduces thyroid antibodies and enhances my overall wellbeing. Truly excellent!
7.5
Reduces heart disease
9 people found this helpful
Selenium is an element that helps maintain the normal functioning of the thyroid gland. It promotes improved production of thyroid hormones and prevents cell destruction while eliminating inflammation and strengthening the immune system. Individuals with Alzheimer’s disease often have lower levels of selenium in their blood. Additionally, selenium reduces the risk of heart disease by addressing inflammation and oxidative stress. I take one tablet after breakfast as recommended by my gynaecologist.
7.5
Prevents cell damage
2 people found this helpful
Selenium helps maintain normal thyroid gland function and improves hormone production. It prevents cell destruction, addresses inflammation, and supports the immune system. Those with Alzheimer’s disease frequently exhibit reduced selenium levels. Furthermore, selenium mitigates the risk of heart disease by tackling inflammatory processes. I take it as prescribed by my gynaecologist.
9
Supports heart health
2 people found this helpful
This product is excellent; I’ve been taking it for a long time with other supplements to boost my immune system. Recently, I’ve increased my dosage due to my hypothyroidism. I discovered that selenium is concentrated in the thyroid as it is essential for metabolic processes. Various studies have shown that selenium supplementation improves thyroid structure and can lead to quicker remission in certain diseases.
6
Essential for heart
Selenium reduces oxygen deprivation in heart tissue and is essential for the proper functioning of the thyroid gland.
8
We explored the use of selenium-loaded porous silica nanospheres (Se@PSN) as a promising treatment for myocardial infarction (MI). This innovative approach targets harmful reactive oxygen species (ROS), which damage heart cells. By improving antioxidant activity and supporting mitochondrial function, Se@PSN help reduce heart tissue damage and maintain cardiac function after a heart attack. The findings suggest that Se@PSN could be a significant advancement for MI treatments and may offer hope in the clinical realm.
9.5
We looked into how dietary selenium and zinc affect the risk of dilated cardiomyopathy (DCMP) in children. In this case-control study, 36 patients with DCMP were compared to 72 healthy children, assessing their dietary intakes using a food frequency questionnaire.
Our findings revealed that sufficient intake of selenium and zinc significantly lowered the risk of DCMP, suggesting that these nutrients play a protective role. Addressing nutritional deficiencies could improve heart health in affected children, although more research is needed to explore the underlying mechanisms.
Our findings revealed that sufficient intake of selenium and zinc significantly lowered the risk of DCMP, suggesting that these nutrients play a protective role. Addressing nutritional deficiencies could improve heart health in affected children, although more research is needed to explore the underlying mechanisms.
7
We examined how different metals in the blood relate to heart issues in individuals with coronary artery disease (CAD). Our cross-sectional study included 1,555 CAD patients in Southwest China, where we measured the blood concentrations of 14 metals.
Interestingly, we found that lower levels of certain metals, particularly copper and manganese, were linked to poorer cardiac structure and function. On a positive note, higher levels of selenium showed beneficial effects. This suggests that adding selenium or tin might counteract the negative impacts of harmful metals on heart health.
Interestingly, we found that lower levels of certain metals, particularly copper and manganese, were linked to poorer cardiac structure and function. On a positive note, higher levels of selenium showed beneficial effects. This suggests that adding selenium or tin might counteract the negative impacts of harmful metals on heart health.
7
We explored the impact of selenium on heart health, particularly concerning the toxic effects of cadmium. Using zebrafish as a model, we tested various doses and timings of selenium exposure to assess its effectiveness against cadmium-induced heart problems.
Interestingly, we observed that a pre-treatment with 50 µg/L of selenium could reduce heart edema and slow heart rate caused by low levels of cadmium. However, we also found that this benefit diminished with higher cadmium doses.
Our results underline the need for careful selenium dosing and timing for optimal protective effects against heavy metal toxicity in the heart.
Interestingly, we observed that a pre-treatment with 50 µg/L of selenium could reduce heart edema and slow heart rate caused by low levels of cadmium. However, we also found that this benefit diminished with higher cadmium doses.
Our results underline the need for careful selenium dosing and timing for optimal protective effects against heavy metal toxicity in the heart.
9
We investigated the use of a new selenium delivery system to combat radiation-induced heart disease, which is a serious concern for cancer patients undergoing thoracic radiation. Our innovative oral microcarriers showed remarkable effects in protecting heart cells from radiation damage by reducing harmful reactive oxygen species.
Not only did this method improve heart function and reduce signs of damage, but it also supported the immune system by increasing beneficial immune cells after radiation exposure. These promising results suggest that selenium could play a key role in helping to manage and prevent heart complications from radiation therapy.
Not only did this method improve heart function and reduce signs of damage, but it also supported the immune system by increasing beneficial immune cells after radiation exposure. These promising results suggest that selenium could play a key role in helping to manage and prevent heart complications from radiation therapy.
References
- Li T, Liu X, Yang B, Wang Z, Chen Y, et al. Selenium-loaded porous silica nanospheres improve cardiac repair after myocardial infarction by enhancing antioxidant activity and mitophagy. Free Radic Biol Med. 2025;232:292. 10.1016/j.freeradbiomed.2025.03.004
- He X, Sun H, Zhao Y, Fu X, Wang M, et al. Association of environmental metallic and metalloid contaminants with cardiovascular and all-cause mortality: An umbrella review of systematic reviews and meta-analyses. Eur J Prev Cardiol. 2025. 10.1093/eurjpc/zwaf118
- Li T, Yang B, Liu X, Shi D, Wang Z, et al. Silica Nanoparticles Loaded With Selenium Quantum Dots Reduce Myocardial Ischemia-Reperfusion Injury by Alleviating Ferroptosis and Mitochondrial Dysfunction. Int J Nanomedicine. 2025;20:1843. 10.2147/IJN.S500810
- Chen C, Ma J, Duan S, Xue M, Yang Z, et al. Mitigation of ischemia/reperfusion injury via selenium nanoparticles: Suppression of STAT1 to inhibit cardiomyocyte oxidative stress and inflammation. Biomaterials. 2025;318:123119. 10.1016/j.biomaterials.2025.123119
- Chen Q, Wang WY, Xu QY, Dai YF, Zhu XY, et al. The enhancing effects of selenomethionine on harmine in attenuating pathological cardiac hypertrophy via glycolysis metabolism. J Cell Mol Med. 2024;28:e70124. 10.1111/jcmm.70124
- Heuer RM, Falagan-Lotsch P, Okutsu J, Deperalto M, Koop RR, et al. Therapeutic Efficacy of Selenium Pre-treatment in Mitigating Cadmium-Induced Cardiotoxicity in Zebrafish (Danio rerio). Cardiovasc Toxicol. 2024;24:1287. 10.1007/s12012-024-09910-0
- Bhattarai U, Xu R, He X, Pan L, Niu Z, et al. High selenium diet attenuates pressure overload-induced cardiopulmonary oxidative stress, inflammation, and heart failure. Redox Biol. 2024;76:103325. 10.1016/j.redox.2024.103325
- Sun Y, Mao Q, Zhou D, Tian J, Du H, et al. Associations of multiple blood metals with cardiac structure and function: A cross-sectional study in a CAD population. Environ Pollut. 2024;360:124718. 10.1016/j.envpol.2024.124718
- Marhamati S, Younesian O, Mir SM, Hosseinzadeh S, Joshaghani HR, et al. The effects of high doses of selenium supplementation on mRNA and protein levels of cMLCK levels and total antioxidant capacity in rat heart tissue. Food Chem Toxicol. 2024;191:114886. 10.1016/j.fct.2024.114886
- Masle AM, Kibel A, Jukić I, Čičak P, Selthofer-Relatić K, et al. Enhancing Endothelial Function with Nutrient-Enriched Table Hen Eggs: A Randomized Study in Patients Recovering from Acute Coronary Syndrome. Clin Interv Aging. 2024;19:953. 10.2147/CIA.S461821
- Cheng T, Liu C, Wang Y, Li G, Feng L, et al. A novel histone deacetylase inhibitor Se-SAHA attenuates isoproterenol-induced heart failure via antioxidative stress and autophagy inhibition. Toxicol Appl Pharmacol. 2024;487:116957. 10.1016/j.taap.2024.116957
- Liu C, Wang W, Lai H, Chen Y, Li L, et al. Biosynthesis of fungus-based oral selenium microcarriers for radioprotection and immuno-homeostasis shaping against radiation-induced heart disease. Bioact Mater. 2024;37:393. 10.1016/j.bioactmat.2024.03.034
- Aryafar M, Mahdavi M, Shahzadi H, Ranjbar YR, Sohouli MH, et al. Association between dietary selenium and zinc intake and risk of dilated cardiomyopathy in children: a case-control study. BMC Pediatr. 2024;24:251. 10.1186/s12887-024-04706-1
- Karaye KM, Sa'idu H, Ishaq NA, Balarabe SA, Ahmed BG, et al. Selenium Deficiency as a Risk Factor for Peripartum Cardiomyopathy. West Afr J Med. 2024;41:209.
- Li SJ, Wang AW, Huang KL, Yang Y. Recent Advances on Selenium Nutrition and Keshan Disease. Int Heart J. 2024;65:173. 10.1536/ihj.23-628
- Al-Mubarak AA, Markousis Mavrogenis G, Guo X, De Bruyn M, Nath M, et al. Biomarker and transcriptomics profiles of serum selenium concentrations in patients with heart failure are associated with immunoregulatory processes. Redox Biol. 2024;70:103046. 10.1016/j.redox.2024.103046
