We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
Read More
9
Zinc effectively suppresses allergies
Zinc treatment prevents IgE-mediated Ca influx and allergic response in RBL-2H3 cells.
We explored the potential of zinc to manage allergic responses by examining its effects on a specific type of immune cell called RBL-2H3. This research highlighted how zinc sulfate (ZnSO) treatment can prevent cell degranulation, which is a process crucial for allergic reactions, triggered by antigens and IgE stimulation.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
Read More
9
Zinc nanoparticles suppress allergic reactions
ZnO Nanoparticles as Potent Inducers of Dermal Immunosuppression in Contact Hypersensitivity in Mice.
We investigated how zinc oxide nanoparticles (nZnO), commonly found in skin products like sunscreens, influence allergic reactions in the skin. Using a specific mouse model that simulates contact allergies, we wanted to understand whether applying nZnO during the sensitization or challenge phases would alter the immune response.
Our research showed that these nanoparticles, when applied during the allergic reaction, were able to suppress the immune response significantly. We noted a reduction in skin inflammation, with the strongest effects observed within 24 hours of exposure, and these effects lasted up to 28 days. Interestingly, while nZnO didn't hinder the initial allergy sensitization process, it did prevent the allergic reaction from fully developing when the allergen was introduced.
We found that the immunosuppressive properties of nZnO are tied to its ability to disrupt certain inflammatory signaling pathways. These findings suggest that nZnO could provide relief for people dealing with contact allergies, especially those using products containing these nanoparticles. Overall, our study sheds light on the potential benefits and mechanisms of nZnO in managing skin allergies.
Read More
Most Useful Reviews
9
No allergic reactions
6 people found this helpful
After trying this zinc supplement for the first time, I was impressed by the results. It is easily absorbed, and I had no allergic reactions. While treating a Covid infection, I noticed that my fatigue and loss of taste improved. Overall, I felt fantastic after taking it.
Read More
9
Reduced allergies
1 people found this helpful
I've been taking Zinc Picolinate daily, and I have noticed significant benefits to my hair, skin, and nails. Additionally, it has helped maintain my immune system and reduced my allergies and instances of colds. Solgar is a favourite brand for me, especially as their products are gluten-free.
Read More
9
No gastrointestinal issues
This product is excellent; it features a good form of zinc and an effective dosage. I experienced no side effects or gastrointestinal issues, and there were no allergies either.
We delved into the effectiveness of zinc treatment in managing allergic rhinitis, aided by a systematic review of clinical studies. Our exploration began with a thorough search of major databases, revealing insights from five clinical reports that met the necessary criteria for inclusion. These studies involved participants ranging from 40 to 180 individuals, providing a balanced mix of genders.
The results spotlighted the positive impact of combining quail egg-based supplements (QES) with zinc. Notably, this combination significantly improved several key measures, such as peak nasal inspiratory flow and mucociliary transport time. We observed that patients experienced relief from troublesome symptoms like nasal congestion, rhinorrhea, and sneezing. Moreover, this combination seemed to reduce the need for standard allergy medications, offering an appealing alternative for those seeking symptom relief.
Importantly, zinc and QES were generally well tolerated, with few reported side effects, which were usually mild and temporary. However, it’s crucial to highlight that individuals with egg allergies should avoid these supplements. As such, while our findings suggest that zinc, particularly in conjunction with QES, can play a role in alleviating allergic rhinitis symptoms, further research is encouraged to solidify these promising results.
Read More
9
Zinc may relieve allergy symptoms
Alleviating effect of intranasal zinc on symptoms of allergic rhinitis.
We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
Read More
9
Zinc effectively suppresses allergies
Zinc treatment prevents IgE-mediated Ca influx and allergic response in RBL-2H3 cells.
We explored the potential of zinc to manage allergic responses by examining its effects on a specific type of immune cell called RBL-2H3. This research highlighted how zinc sulfate (ZnSO) treatment can prevent cell degranulation, which is a process crucial for allergic reactions, triggered by antigens and IgE stimulation.
Our findings showed that ZnSO not only inhibited cell degranulation but also reduced the expression of certain immune signaling molecules such as IL-4, IL-13, and COX-2. We observed that the increased levels of calcium inside the cells, which usually accompany these allergic reactions, were significantly lowered with zinc treatment.
Interestingly, while zinc did not interfere with the activation of several key proteins in the signaling pathway, it was effective at reducing the overall calcium influx associated with allergic responses. This suggests that zinc might be acting on calcium release-activated channels, offering a preventative advantage in allergic conditions.
Overall, we conclude that treating with zinc sulfate could be a valuable strategy for suppressing allergic responses, making it a topic worth considering for further research and application in allergy management.
Read More
9
Zinc nanoparticles suppress allergic reactions
ZnO Nanoparticles as Potent Inducers of Dermal Immunosuppression in Contact Hypersensitivity in Mice.
We investigated how zinc oxide nanoparticles (nZnO), commonly found in skin products like sunscreens, influence allergic reactions in the skin. Using a specific mouse model that simulates contact allergies, we wanted to understand whether applying nZnO during the sensitization or challenge phases would alter the immune response.
Our research showed that these nanoparticles, when applied during the allergic reaction, were able to suppress the immune response significantly. We noted a reduction in skin inflammation, with the strongest effects observed within 24 hours of exposure, and these effects lasted up to 28 days. Interestingly, while nZnO didn't hinder the initial allergy sensitization process, it did prevent the allergic reaction from fully developing when the allergen was introduced.
We found that the immunosuppressive properties of nZnO are tied to its ability to disrupt certain inflammatory signaling pathways. These findings suggest that nZnO could provide relief for people dealing with contact allergies, especially those using products containing these nanoparticles. Overall, our study sheds light on the potential benefits and mechanisms of nZnO in managing skin allergies.
Read More
8
Zinc supplementation may reduce allergies
Zinc Deficiency and Zinc Supplementation in Allergic Diseases.
We explored how zinc interacts with allergic diseases, which have been rising in prevalence worldwide, affecting both Western and developing nations. The question we aimed to answer was whether zinc deficiency contributes to these allergies and if zinc supplementation can help alleviate symptoms.
Our findings highlight that zinc is an essential trace element crucial for modulating our immune response. This was first noted over 60 years ago, and since then, we have continued to observe the connection between zinc levels and allergic reactions. Allergic conditions like asthma, allergic rhinitis, and skin allergies occur when the immune system overreacts to normally harmless substances, leading to chronic inflammation.
Notably, zinc deficiency can mimic some of the immune responses seen in these allergies, showing how intertwined our nutrition is with our immune health. We noted that while different clinical trials on zinc supplementation yield varied results due to factors like dosage and study design, the overall literature suggests that increasing zinc intake can positively influence immune function and help reduce allergic symptoms.
In conclusion, while further investigation is needed to fully understand the nuances, it appears that maintaining adequate zinc levels could be beneficial for those suffering from allergic diseases.
After trying this zinc supplement for the first time, I was impressed by the results. It is easily absorbed, and I had no allergic reactions. While treating a Covid infection, I noticed that my fatigue and loss of taste improved. Overall, I felt fantastic after taking it.
Read More
9
Reduced allergies
1 people found this helpful
I've been taking Zinc Picolinate daily, and I have noticed significant benefits to my hair, skin, and nails. Additionally, it has helped maintain my immune system and reduced my allergies and instances of colds. Solgar is a favourite brand for me, especially as their products are gluten-free.
Read More
9
No gastrointestinal issues
This product is excellent; it features a good form of zinc and an effective dosage. I experienced no side effects or gastrointestinal issues, and there were no allergies either.
Read More
9
Helpful for allergies
The ingredients were excellent and proved beneficial for my skin allergies.
Read More
9
Helped with allergies
The appropriate zinc form helped my mother manage her allergies effectively.
Allergies are the body's immune system responses to substances known as allergens, which can be harmless in most individuals. When a person with allergies encounters these allergens, their immune system mistakenly identifies them as a threat and launches a response. This can lead to symptoms ranging from mild, such as sneezing, itching, and rashes, to severe reactions known as anaphylaxis, which can be life-threatening. Common allergens include pollen, pet dander, certain foods like nuts and shellfish, insect stings, and medications.
Managing allergies often involves avoiding known allergens and using medications such as antihistamines or corticosteroids to alleviate symptoms. In some cases, doctors might recommend allergy shots or immunotherapy to help patients build tolerance over time. If you suspect you have allergies, consulting with a healthcare professional for proper diagnosis and treatment options is crucial. Understanding your triggers and how to live with allergies can significantly improve your quality of life.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
Zinc has been studied for its potential effects on the immune system, and some research suggests that it may play a role in managing allergic responses. While zinc is essential for maintaining overall immune function, a direct link between zinc supplementation and reduction in allergy symptoms has not been firmly established. Some studies indicate that zinc may help modulate inflammation and could potentially benefit those with allergic rhinitis or other allergic conditions, but results can vary widely among individuals.
If you're considering zinc as a supplement for allergies, it’s vital to consult with a healthcare professional first. They can provide personalized advice based on your health status and any medications you might be taking. Additionally, focusing on a balanced diet rich in zinc-containing foods like nuts, seeds, legumes, and whole grains can offer support to your overall health and immune function, which may indirectly influence how your body handles allergens.
Based on user reviews, the time it takes to experience results from this zinc supplement for allergies varies among individuals. Some users have reported significant benefits within a week, noting improvements in their overall condition and reduction in allergy symptoms Read Review. For others, noticeable effects took longer—up to several weeks to a couple of months—indicating that consistent use over time is crucial Read Review.
Several users mention that after about two months of use, they experienced a marked improvement in their immunity and skin conditions, as well as a significant reduction in allergy symptoms Read Review. Therefore, while some may notice results quickly, allowing a month or two for the supplement to take effect seems to be a common experience among users. Overall, patience and consistency appear to be key factors in achieving the desired results with this zinc supplement.
The supplement in question, particularly zinc combined with quail egg supplements, shows promising evidence for managing allergic rhinitis, a common form of allergy. A systematic review that evaluated several clinical studies found that this combination significantly improved symptoms like nasal congestion and sneezing, while also enhancing overall nasal function. Moreover, participants reported a reduced reliance on standard allergy medications, making this supplement an appealing alternative for symptom relief ([1]).
Research further highlights zinc's role in addressing various allergic conditions by modulating immune responses and reducing inflammation. Studies suggest that intranasal zinc can alleviate allergy symptoms, while a broader analysis indicates that adequate zinc levels may decrease the risk of allergic diseases, including allergic rhinitis and atopic dermatitis ([2], [6]). While these findings are encouraging, they also point to the necessity for continued research to firmly establish the effectiveness and mechanisms by which zinc may benefit individuals suffering from allergies.
Based on user reviews, many individuals report significant improvements in their symptoms after taking this zinc supplement. For instance, several users noted enhanced skin, hair, and nail quality, which they attributed to the supplement. One reviewer mentioned that after just a week, they experienced improvements in these areas alongside no side effects such as nausea or allergies Read Review. Others have indicated that their overall health, including immunity and seasonal allergies, improved after using this product for around two months Read Review.
In terms of allergy relief, multiple users reported a decrease in allergic reactions and a general sense of better well-being. Experiences varied, with some noting that they dealt with fewer colds and lighter allergy symptoms compared to previous seasons Read Review. Additionally, one user pointed out a noticeable improvement in their immune response during the cold season Read Review. While many users found success with this supplement, it’s important to note that individual results can vary, and not everyone experienced the same benefits Read Review.
Based on user reviews, many individuals have successfully combined this zinc supplement with other supplements to manage their allergies. For some, taking additional supplements alongside zinc appeared to enhance their overall efficacy. A user noted that while the zinc itself didn't show notable effects, their allergy symptoms improved possibly due to the other supplements they were taking concurrently Read Review. This suggests that a multi-supplement approach may yield better outcomes for allergy relief for certain individuals.
Several reviewers mention experiencing a reduction in allergy symptoms while exclusively taking this zinc supplement. Users who incorporated it into their routine reported lighter seasonal allergies and fewer colds Read Review. Others also highlighted that they did not experience any allergic reactions during their time on the supplement Read Review. Overall, while individual results vary, many users found that they could integrate this zinc supplement into their regimen effectively, with or without additional products, to better manage their allergy symptoms.
Based on user reviews, the right dose of Zinc for treating allergies appears to vary among individuals, but many report positive effects on their allergy symptoms without experiencing side effects. Users like one reviewer noted that they observed significant improvements in their allergies after using a specific dosage of Zinc Picolinate daily, which ultimately helped reduce their colds and improve overall health Read Review. Another user found that a good form of Zinc at an effective dosage led to no allergic reactions, enhancing their well-being Read Review.
Moreover, individuals attribute their allergy relief to consistent use over a period. For example, one user reported being allergy-free while taking the supplement consistently, particularly in conjunction with the cold season Read Review. Others echoed this sentiment, highlighting that the supplements improved their symptoms significantly without causing any adverse reactions Read Review. However, one reviewer cautioned against potential issues, mentioning that they experienced a flare-up of skin allergies after consuming a product Read Review. Overall, users recommend careful monitoring and consideration of personal tolerance when determining the right dosage for Zinc related to allergies.
9
No side effects
1 people found this helpful
This zinc supplement worked well for me, with improvements in my skin, hair, and nails within a week. Unlike other brands, it didn’t cause any side effects like nausea or dizziness, and I had no allergies. I advise against taking it for more than two months to avoid copper depletion, but it has definitely enhanced my overall well-being.
7.5
No allergies noted
Super Zinc is quite effective. I had no allergies after taking it.
7.5
No allergies experienced
I took these vitamins for two months with positive effects on my immunity and skin. I did not suffer from allergies or side effects during this time.
7.5
Mild allergies experienced
14 people found this helpful
I was initially sceptical about zinc supplements, but I decided to try Solgar after my endocrinologist recommended it. To my surprise, I found that I got ill less severely with mild flu symptoms compared to my colleagues. My usual seasonal allergies were also noticeably lighter, which was unusual for me. Overall, I've been taking it for over a year now, and I feel it has been beneficial for my health.
6
Helpful in relief
It was a good dose during the cold season and seemed to aid with allergy relief.
2
Allergy resolved
The supplement wasn't effective for me, but the allergy did disappear, possibly because I took other supplements alongside it.
9
Helpful for allergies
The ingredients were excellent and proved beneficial for my skin allergies.
9
Reduced allergies
1 people found this helpful
I've been taking Zinc Picolinate daily, and I have noticed significant benefits to my hair, skin, and nails. Additionally, it has helped maintain my immune system and reduced my allergies and instances of colds. Solgar is a favourite brand for me, especially as their products are gluten-free.
9
No gastrointestinal issues
This product is excellent; it features a good form of zinc and an effective dosage. I experienced no side effects or gastrointestinal issues, and there were no allergies either.
7.5
Useful for colds
1 people found this helpful
I began taking this zinc supplement in the autumn, coinciding with the start of the cold season. I have not experienced allergies with this product and have appreciated the combination of quality, dosage, and price.
0
Allergies increased
After consuming this, my skin allergies flared up significantly.
9
Zinc and QES alleviate allergies
Quail Egg-Based Supplements in Allergic Rhinitis: A Systematic Review of Clinical Studies.
We delved into the effectiveness of zinc treatment in managing allergic rhinitis, aided by a systematic review of clinical studies. Our exploration began with a thorough search of major databases, revealing insights from five clinical reports that met the necessary criteria for inclusion. These studies involved participants ranging from 40 to 180 individuals, providing a balanced mix of genders.
The results spotlighted the positive impact of combining quail egg-based supplements (QES) with zinc. Notably, this combination significantly improved several key measures, such as peak nasal inspiratory flow and mucociliary transport time. We observed that patients experienced relief from troublesome symptoms like nasal congestion, rhinorrhea, and sneezing. Moreover, this combination seemed to reduce the need for standard allergy medications, offering an appealing alternative for those seeking symptom relief.
Importantly, zinc and QES were generally well tolerated, with few reported side effects, which were usually mild and temporary. However, it’s crucial to highlight that individuals with egg allergies should avoid these supplements. As such, while our findings suggest that zinc, particularly in conjunction with QES, can play a role in alleviating allergic rhinitis symptoms, further research is encouraged to solidify these promising results.
9
Zinc may relieve allergy symptoms
Alleviating effect of intranasal zinc on symptoms of allergic rhinitis.
We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.
Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.
The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.
Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.
8
Zinc supplementation may reduce allergies
Zinc Deficiency and Zinc Supplementation in Allergic Diseases.
We explored how zinc interacts with allergic diseases, which have been rising in prevalence worldwide, affecting both Western and developing nations. The question we aimed to answer was whether zinc deficiency contributes to these allergies and if zinc supplementation can help alleviate symptoms.
Our findings highlight that zinc is an essential trace element crucial for modulating our immune response. This was first noted over 60 years ago, and since then, we have continued to observe the connection between zinc levels and allergic reactions. Allergic conditions like asthma, allergic rhinitis, and skin allergies occur when the immune system overreacts to normally harmless substances, leading to chronic inflammation.
Notably, zinc deficiency can mimic some of the immune responses seen in these allergies, showing how intertwined our nutrition is with our immune health. We noted that while different clinical trials on zinc supplementation yield varied results due to factors like dosage and study design, the overall literature suggests that increasing zinc intake can positively influence immune function and help reduce allergic symptoms.
In conclusion, while further investigation is needed to fully understand the nuances, it appears that maintaining adequate zinc levels could be beneficial for those suffering from allergic diseases.
References
Antonelli M, Mazzoleni E, Donelli D. Quail Egg-Based Supplements in Allergic Rhinitis: A Systematic Review of Clinical Studies. Nutrients. 2025;17. 10.3390/nu17040712
Xu H, Tong K, Iwasaki N, Ohgami N, Tazaki A, et al. Alleviating effect of intranasal zinc on symptoms of allergic rhinitis. J Allergy Clin Immunol Glob. 2025;4:100408. 10.1016/j.jacig.2025.100408
Otsuka T, Sato K, Kamiya T, Tanaka H, Hara H. Zinc treatment prevents IgE-mediated Ca influx and allergic response in RBL-2H3 cells. Eur J Pharmacol. 2025;994:177391. 10.1016/j.ejphar.2025.177391
Wang S, Ilves M, Mäenpää K, Zhao L, El-Nezami H, et al. ZnO Nanoparticles as Potent Inducers of Dermal Immunosuppression in Contact Hypersensitivity in Mice. ACS Nano. 2024;18:29479. 10.1021/acsnano.4c04270
Changhai L, Zaichun W, Bo Y, Dan L, Shaohua W. Micronutrients and Allergic Diseases: A Mendelian Randomization Study. Int Arch Allergy Immunol. 2025;186:41. 10.1159/000540376
Maywald M, Rink L. Zinc Deficiency and Zinc Supplementation in Allergic Diseases. Biomolecules. 2024;14. 10.3390/biom14070863
Wei Y, Zhu X, Lin S, Yang W, Wang T, et al. Zinc gluconate improves atopic dermatitis by modulating CXCL10 release of keratinocytes via PPARα activation. Biomed Pharmacother. 2024;177:117129. 10.1016/j.biopha.2024.117129