Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.5
USERS' SCORE
Good
Based on 38 Reviews
8.1
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Zinc (as zinc picolinate)
22 mg
200%

Top Medical Research Studies

9
Zinc supplementation benefits MS models
We explored how dietary zinc levels influence spinal cord damage and gene expressions associated with Multiple Sclerosis (MS) using a cuprizone-induced rat model. The study included 46 adult male Wistar rats divided into five groups, with some receiving zinc supplementation while others followed a zinc-deficient diet.

After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.

Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.
Read More
9
Zinc intake benefits RA bone health
We aimed to understand how dietary zinc intake influences the risk of developing osteopenia and osteoporosis in patients with rheumatoid arthritis (RA). Our study relied on data collected from the National Health and Nutrition Examination Survey, spanning several years. Through careful analysis using univariate and multivariate logistic regression models, we were able to uncover significant associations between dietary zinc levels and bone health in this population.

What we found was encouraging: higher zinc intake appeared to lower the chances of these serious bone conditions among RA patients. Our research also went further by examining various factors such as age, body mass index (BMI), and pre-existing health issues like diabetes and hypertension. This comprehensive approach led us to conclude that adequate dietary zinc is crucial for maintaining bone health in individuals with RA, though we noted the need for more extensive long-term studies to corroborate these findings and delve deeper into the underlying mechanisms at play.
Read More
We identified an important link between zinc transport and autoimmune disorders, specifically focusing on the protein SLC39A10 and its role in T cells. Through our study, we discovered that two specific genetic variations in the SLC39A10 gene are associated with inflammatory bowel disease (IBD). To further explore this connection, we created genetically modified mice with a targeted deletion of the Slc39a10 gene in T cells.

Our findings revealed that the loss of SLC39A10 significantly protects against the progression of both IBD and experimental autoimmune encephalomyelitis (EAE). Notably, we also observed that the absence of this transporter led to increased cell death, independent of common pathways usually associated with apoptosis. This indicates that SLC39A10 plays a crucial role in maintaining the health of T cells by facilitating zinc import, which is essential for DNA replication when T cells are activated.

Our research contributes to a deeper understanding of how zinc homeostasis impacts immune function. The insights gained from this study suggest that targeting zinc transport could present new therapeutic options for managing T cell-related autoimmune diseases.
Read More

Most Useful Reviews

9
Significant energy boost
256 people found this helpful
Many thanks to iHerb for the swift delivery and dependable packaging. Solgar's vitamins have truly transformed my health. I used to suffer from frequent colds and felt constantly fatigued, but after taking these vitamins, my energy levels soared, my complexion improved, and I’ve found it easier to manage my autoimmune disorder. My routine includes potassium, magnesium, a B-complex, and zinc in the evening.
Read More
9
Reduced skin rashes
80 people found this helpful
I purchased zinc to combat skin rashes as advised by my doctor since it helps with acne and other skin concerns. After two months of consistent use, I've seen fewer rashes and improved skin elasticity. There were no gastrointestinal issues or allergies, and my hair and nails also appeared healthier. I will continue to buy Solgar zinc.
Read More
9
Family health booster
16 people found this helpful
I consistently order for my family. We appreciate the vitamin's form, size, and effects: clearer skin, improved hair, and better immunity. In spring and autumn, we take one daily. I shared it with a neighbour, and he quickly recovered from a cold. An excellent addition to our health!
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.5
  • All Researches
9
Zinc supplementation benefits MS models
We explored how dietary zinc levels influence spinal cord damage and gene expressions associated with Multiple Sclerosis (MS) using a cuprizone-induced rat model. The study included 46 adult male Wistar rats divided into five groups, with some receiving zinc supplementation while others followed a zinc-deficient diet.

After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.

Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.
Read More
9
Zinc intake benefits RA bone health
We aimed to understand how dietary zinc intake influences the risk of developing osteopenia and osteoporosis in patients with rheumatoid arthritis (RA). Our study relied on data collected from the National Health and Nutrition Examination Survey, spanning several years. Through careful analysis using univariate and multivariate logistic regression models, we were able to uncover significant associations between dietary zinc levels and bone health in this population.

What we found was encouraging: higher zinc intake appeared to lower the chances of these serious bone conditions among RA patients. Our research also went further by examining various factors such as age, body mass index (BMI), and pre-existing health issues like diabetes and hypertension. This comprehensive approach led us to conclude that adequate dietary zinc is crucial for maintaining bone health in individuals with RA, though we noted the need for more extensive long-term studies to corroborate these findings and delve deeper into the underlying mechanisms at play.
Read More
We identified an important link between zinc transport and autoimmune disorders, specifically focusing on the protein SLC39A10 and its role in T cells. Through our study, we discovered that two specific genetic variations in the SLC39A10 gene are associated with inflammatory bowel disease (IBD). To further explore this connection, we created genetically modified mice with a targeted deletion of the Slc39a10 gene in T cells.

Our findings revealed that the loss of SLC39A10 significantly protects against the progression of both IBD and experimental autoimmune encephalomyelitis (EAE). Notably, we also observed that the absence of this transporter led to increased cell death, independent of common pathways usually associated with apoptosis. This indicates that SLC39A10 plays a crucial role in maintaining the health of T cells by facilitating zinc import, which is essential for DNA replication when T cells are activated.

Our research contributes to a deeper understanding of how zinc homeostasis impacts immune function. The insights gained from this study suggest that targeting zinc transport could present new therapeutic options for managing T cell-related autoimmune diseases.
Read More
8
Zinc's role in alopecia areata
We analyzed how zinc levels in the body relate to alopecia areata (AA), an autoimmune disorder that affects hair loss. Our research involved a systematic review of 34 studies, gathering data from nearly 5,000 participants across 16 countries. By examining various studies, we sought to understand if zinc supplementation could be beneficial for those suffering from AA.

The results were striking. We found that individuals with alopecia areata had significantly lower levels of zinc and vitamin D compared to healthy individuals. Specifically, the data indicated that those with vitamin D deficiency faced a heightened risk of developing AA. This suggests that replenishing these nutrients might help manage the disease.

Importantly, we didn't find a significant difference in copper levels between AA patients and healthy controls, indicating that not all trace elements play the same role in this condition. Overall, our findings highlight the potential of zinc and vitamin D as targeted treatments for alopecia areata, offering new hope for those affected by this condition.
Read More
7
Zinc supplementation eases neutrophil activity
We aimed to explore how zinc supplementation might influence immune responses, particularly focusing on neutrophil activity in the context of autoimmune diseases. To do this, we simulated inflammatory conditions typically seen in such disorders using specific cytokines, interleukin-17 (IL-17) and tumor necrosis factor (TNF)-α.

Our findings indicated that elevating zinc levels significantly reduced the formation of neutrophil extracellular traps (NETs), which are often implicated in tissue damage during autoimmune flare-ups. We also discovered that zinc supplementation lowered the expression of a protein called peptidyl arginine deiminase 4 (PAD4), which is associated with NET formation.

Interestingly, zinc not only decreased harmful neutrophil activity but also boosted the production of beneficial proteins like interleukin-1 receptor antagonist (IL-1RA) and IL-8 in the activated cells. Overall, maintaining adequate zinc levels seems crucial for preserving healthy immune function and preventing the harmful overactivity of neutrophils, suggesting its potential as an adjunct treatment in managing autoimmune conditions.
Read More

User Reviews

USERS' SCORE
Good
Based on 38 Reviews
8.1
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Significant energy boost
256 people found this helpful
Many thanks to iHerb for the swift delivery and dependable packaging. Solgar's vitamins have truly transformed my health. I used to suffer from frequent colds and felt constantly fatigued, but after taking these vitamins, my energy levels soared, my complexion improved, and I’ve found it easier to manage my autoimmune disorder. My routine includes potassium, magnesium, a B-complex, and zinc in the evening.
Read More
9
Reduced skin rashes
80 people found this helpful
I purchased zinc to combat skin rashes as advised by my doctor since it helps with acne and other skin concerns. After two months of consistent use, I've seen fewer rashes and improved skin elasticity. There were no gastrointestinal issues or allergies, and my hair and nails also appeared healthier. I will continue to buy Solgar zinc.
Read More
9
Family health booster
16 people found this helpful
I consistently order for my family. We appreciate the vitamin's form, size, and effects: clearer skin, improved hair, and better immunity. In spring and autumn, we take one daily. I shared it with a neighbour, and he quickly recovered from a cold. An excellent addition to our health!
Read More
9
Acne reduction success
16 people found this helpful
My daughter used to suffer from facial breakouts, but ever since she started taking zinc, her acne has cleared up. Now, she insists I reorder as soon as possible whenever the symptoms return.
Read More
2
Pancreas reaction
10 people found this helpful
Zinc picolinate helped reduce my skin oiliness. However, it caused significant pancreatic reactions, leading to digestive issues despite its benefits for my autoimmune disorder. I had to stop taking it after trying a lower dosage.
Read More

Frequently Asked Questions

9
Cleared rosacea
6 people found this helpful
I researched the link between rosacea and zinc deficiency, which led me to order Solgar's zinc picolinate tablets. After taking one tablet daily, I noticed a significant improvement in my rosacea within six weeks, going from a 10/10 on the severity scale to about 1.5/10 now. These tablets are well absorbed and have worked wonderfully for me.
7.5
Enhanced well-being
8 people found this helpful
Taking zinc picolinate as prescribed transformed my overall wellbeing. Initially sceptical, I felt a marked improvement in fatigue and low energy after a week. I began with three tablets daily during illness, and my symptoms eased noticeably. I’ll continue taking it to bolster my immune system before winter arrives.
9
Reduced skin rashes
80 people found this helpful
I purchased zinc to combat skin rashes as advised by my doctor since it helps with acne and other skin concerns. After two months of consistent use, I've seen fewer rashes and improved skin elasticity. There were no gastrointestinal issues or allergies, and my hair and nails also appeared healthier. I will continue to buy Solgar zinc.
9
Acne reduction success
16 people found this helpful
My daughter used to suffer from facial breakouts, but ever since she started taking zinc, her acne has cleared up. Now, she insists I reorder as soon as possible whenever the symptoms return.
9
Reduced fatigue impact
6 people found this helpful
I ordered this product for my husband, who suffers from chronic fatigue and drowsiness due to his busy schedule. After two weeks of taking the zinc tablets, he has become much more energised and cheerful, which I attribute to the supplement's effectiveness. It also supports thyroid function and improves skin and nail health, reducing hair loss. Highly recommended!
8
Winter resilience
1 people found this helpful
I ordered zinc to help boost my immune system during the cold and flu season, especially given how rampant illness was in my city. It has certainly strengthened my immunity; I highly recommend it to anyone responsive to colds, particularly through the autumn and spring seasons!
9
Significant energy boost
256 people found this helpful
Many thanks to iHerb for the swift delivery and dependable packaging. Solgar's vitamins have truly transformed my health. I used to suffer from frequent colds and felt constantly fatigued, but after taking these vitamins, my energy levels soared, my complexion improved, and I’ve found it easier to manage my autoimmune disorder. My routine includes potassium, magnesium, a B-complex, and zinc in the evening.
7.5
Supports immunity
1 people found this helpful
Zinc positively affects my hair, nails, skin, and overall immunity while aiding enzyme production. Doctors recommend zinc, vitamin D, and vitamin C during cold seasons to support immunity and fight off illnesses, including issues related to autoimmune disorders. This zinc picolinate is effective and easily absorbed.
2
Panic attacks
1 people found this helpful
I have an autoimmune disorder, and after taking this supplement, I experienced a panic attack and a sensation of warmth in my throat. While it worked, it clearly does not suit everyone.
9
Positive skin effects
1 people found this helpful
I've ordered my second jar of zinc, which has positively impacted my skin, hair, and nails. By taking it regularly, my acne and skin irritations have diminished, and it increases scalp health. I prefer zinc picolinate for its absorption, which is essential for managing my autoimmune disorder effectively.
7.5
Support immune system
6 people found this helpful
The quality and ingredients are excellent, particularly the zinc in picolinate form, which supports the immune system. After experiencing a cold and hair loss during the summer, my doctor prescribed this zinc alongside other treatments. I took one tablet daily, and the improvement in my health has been remarkable. The tablets are small and easy to swallow. I frequently reorder this zinc for overall body health.
7.5
Skin and immunity improvement
31 people found this helpful
For me, this is the best zinc available. It has the right dosage and is well-absorbed with no side effects. I use it to support my immune system during ARVI, enhance my skin, and manage my autoimmune disorder's inflammatory responses. This zinc picolinate delivers excellent results. Five stars!
2
Pancreas reaction
10 people found this helpful
Zinc picolinate helped reduce my skin oiliness. However, it caused significant pancreatic reactions, leading to digestive issues despite its benefits for my autoimmune disorder. I had to stop taking it after trying a lower dosage.
We identified an important link between zinc transport and autoimmune disorders, specifically focusing on the protein SLC39A10 and its role in T cells. Through our study, we discovered that two specific genetic variations in the SLC39A10 gene are associated with inflammatory bowel disease (IBD). To further explore this connection, we created genetically modified mice with a targeted deletion of the Slc39a10 gene in T cells.

Our findings revealed that the loss of SLC39A10 significantly protects against the progression of both IBD and experimental autoimmune encephalomyelitis (EAE). Notably, we also observed that the absence of this transporter led to increased cell death, independent of common pathways usually associated with apoptosis. This indicates that SLC39A10 plays a crucial role in maintaining the health of T cells by facilitating zinc import, which is essential for DNA replication when T cells are activated.

Our research contributes to a deeper understanding of how zinc homeostasis impacts immune function. The insights gained from this study suggest that targeting zinc transport could present new therapeutic options for managing T cell-related autoimmune diseases.
9
Zinc supplementation benefits MS models
We explored how dietary zinc levels influence spinal cord damage and gene expressions associated with Multiple Sclerosis (MS) using a cuprizone-induced rat model. The study included 46 adult male Wistar rats divided into five groups, with some receiving zinc supplementation while others followed a zinc-deficient diet.

After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.

Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.
4
Zinc intake influences autoimmune risk
We examined the connection between dietary zinc intake and the risk of autoimmune thyroiditis (AIT), particularly focusing on Hashimoto's thyroiditis. The study analyzed data from the 2007-2008 National Health and Nutrition Examination Survey, including nearly 5,500 participants—273 with AIT and 5,194 without it.

Our findings revealed that higher dietary zinc intake is associated with an increased risk of AIT, acting as an independent risk factor. This is concerning, as excessive zinc could disrupt our immune balance, potentially leading to other autoimmune disorders.

While it’s clear that zinc plays a role in thyroid health, we must be cautious about how much we consume. The study suggests that dietary zinc should be carefully monitored in those at risk for AIT, and it highlights the need for further research to establish safe consumption levels.
7
Zinc supplementation eases neutrophil activity
We aimed to explore how zinc supplementation might influence immune responses, particularly focusing on neutrophil activity in the context of autoimmune diseases. To do this, we simulated inflammatory conditions typically seen in such disorders using specific cytokines, interleukin-17 (IL-17) and tumor necrosis factor (TNF)-α.

Our findings indicated that elevating zinc levels significantly reduced the formation of neutrophil extracellular traps (NETs), which are often implicated in tissue damage during autoimmune flare-ups. We also discovered that zinc supplementation lowered the expression of a protein called peptidyl arginine deiminase 4 (PAD4), which is associated with NET formation.

Interestingly, zinc not only decreased harmful neutrophil activity but also boosted the production of beneficial proteins like interleukin-1 receptor antagonist (IL-1RA) and IL-8 in the activated cells. Overall, maintaining adequate zinc levels seems crucial for preserving healthy immune function and preventing the harmful overactivity of neutrophils, suggesting its potential as an adjunct treatment in managing autoimmune conditions.

References

  1. Shao Y, Mu Q, Wang R, Luo H, Song Z, et al. SLC39A10 is a key zinc transporter in T cells and its loss mitigates autoimmune disease. Sci China Life Sci. 2025. 10.1007/s11427-024-2817-y
  2. Chen L, Yan C, Huang C, Jiang Z, Lin R, et al. Higher dietary zinc intake increases the risk of autoimmune thyroiditis. Postgrad Med J. 2025. 10.1093/postmj/qgae202
  3. Wu R, Li Y, Peng H, Yang Z, Wang Y, et al. Association Between Serum Trace Elements Level and Alopecia Areata: A Systematic Review and Meta-Analysis. J Cosmet Dermatol. 2025;24:e16740. 10.1111/jocd.16740
  4. Bayiroglu AF, Acar G, Gulbahce-Mutlu E, Baltaci SB, Mogulkoc R, et al. Dietary zinc status is associated with ZnT3 (SLC30A3), IL-6 gene expressions and spinal cord tissue damage in spinal cord tissue in a cuprizone-induced rat Multiple Sclerosis model. J Trace Elem Med Biol. 2024;86:127540. 10.1016/j.jtemb.2024.127540
  5. Fang D, Jiang D, Shi G, Song Y. The association between dietary zinc intake and osteopenia, osteoporosis in patients with rheumatoid arthritis. BMC Musculoskelet Disord. 2024;25:710. 10.1186/s12891-024-07768-5
  6. Cheng J, Rink L, Wessels I. Zinc Supplementation Reduces the Formation of Neutrophil Extracellular Traps by Decreasing the Expression of Peptidyl Arginine Deiminase 4. Mol Nutr Food Res. 2024;68:e2400013. 10.1002/mnfr.202400013
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