We explored the relationship between serum zinc levels and chronic fatigue syndrome (CFS) in a study that compared patients with CFS to normal volunteers. By using an atomic absorption method, we measured serum zinc concentrations and found that those suffering from CFS had significantly lower levels of zinc compared to healthy individuals.
Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.
Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.
Read More
9
Zinc may reduce long COVID symptoms
Epipharyngeal Abrasive Therapy (EAT) Has Potential as a Novel Method for Long COVID Treatment.
We evaluated the effects of zinc treatment on individuals with long COVID, focusing on how it relates to chronic fatigue syndrome. Our study involved 58 patients who underwent a unique therapy called Epipharyngeal Abrasive Therapy (EAT), which utilized zinc chloride as an anti-inflammatory agent for the epipharynx.
Participants were treated once a week for a month, and we measured the intensity of their symptoms, specifically fatigue, headaches, and attention disorders, using a visual analog scale (VAS). Remarkably, we found that EAT reduced inflammation in the epipharynx and resulted in significant improvements in the reported intensity of these symptoms.
We believe these findings highlight the potential role of zinc in managing symptoms associated with long COVID and possibly chronic fatigue syndrome. While the evidence is encouraging, it remains essential to conduct more in-depth research to truly understand the specific effects of zinc and ensure these benefits are consistently reproducible.
Read More
8
Oral supplement improves long COVID
Potential Anti-Inflammatory and Anti-Fatigue Effects of an Oral Food Supplement in Long COVID Patients.
We conducted a clinical trial to examine how an oral food supplement (OFS) could impact patients suffering from long COVID, particularly focusing on inflammation and fatigue. This was a robust study design, featuring a double-blind, placebo-controlled setup that included 2 capsules of the supplement daily over two months.
The supplement contained a mix of ingredients like rosehip, propolis, royal jelly, zinc, and vitamin C. While zinc was part of the mix, we observed significant results in inflammation reduction through various parameters, such as a decrease in the neutrophil-to-lymphocyte ratio and C-reactive protein levels. However, we couldn’t isolate zinc's effects individually, as it was evaluated alongside other components.
Importantly, there were also noteworthy improvements in patients’ fatigue levels and overall quality of life, as measured by the fatigue severity scale. We found that vitamin D levels rose significantly in participants during the supplement phase, suggesting that the OFS has potential benefits beyond just zinc.
In conclusion, while this study reveals the OFS improved inflammatory symptoms, fatigue, and quality of life, we must recognize that we did not specifically analyze zinc's isolated effects on chronic fatigue syndrome.
Read More
Most Useful Reviews
9
Boosted energy
328 people found this helpful
I find this zinc very effective as it causes no gastrointestinal side effects, which is crucial for my chronic fatigue syndrome. I take it in the morning after breakfast with vitamin C for absorption and feel it helps prevent illness. The tablets are easy to swallow, and the glass bottle is a bonus.
Read More
9
Health improvement
11 people found this helpful
I've been taking this zinc picolinate for three months, and it has noticeably boosted my immunity, alleviating chronic fatigue syndrome and improving my skin. I’m very satisfied with the results and the quality of this product.
Read More
7.5
Reduced fatigue
8 people found this helpful
When prescribed zinc picolinate for chronic fatigue syndrome, I felt improved energy levels within a week. I usually take it twice daily and have noticed significant relief from my symptoms. The tablet is easy to swallow, and I highly recommend it before cold season.
We evaluated the effects of zinc treatment on individuals with long COVID, focusing on how it relates to chronic fatigue syndrome. Our study involved 58 patients who underwent a unique therapy called Epipharyngeal Abrasive Therapy (EAT), which utilized zinc chloride as an anti-inflammatory agent for the epipharynx.
Participants were treated once a week for a month, and we measured the intensity of their symptoms, specifically fatigue, headaches, and attention disorders, using a visual analog scale (VAS). Remarkably, we found that EAT reduced inflammation in the epipharynx and resulted in significant improvements in the reported intensity of these symptoms.
We believe these findings highlight the potential role of zinc in managing symptoms associated with long COVID and possibly chronic fatigue syndrome. While the evidence is encouraging, it remains essential to conduct more in-depth research to truly understand the specific effects of zinc and ensure these benefits are consistently reproducible.
Read More
8
Synbiotics improve post-COVID fatigue
The effects of 3-month supplementation with synbiotic on patient-reported outcomes, exercise tolerance, and brain and muscle metabolism in adult patients with post-COVID-19 chronic fatigue syndrome (STOP-FATIGUE): a randomized Placebo-controlled clinical trial.
We investigated the impact of a 3-month supplementation with a special synbiotic mixture on adults suffering from post-COVID-19 chronic fatigue syndrome (ME/CFS). This study was thoughtfully designed as a placebo-controlled, double-blind trial involving 26 participants. The intention was to see how this synbiotic, which notably contains zinc among other components, would influence patients' overall experiences, exercise tolerance, and metabolism in tissues affected by fatigue.
The promising findings indicated that taking the synbiotic mixture for three months improved metabolism and helped alleviate some clinical features associated with post-COVID fatigue syndrome. However, it's important to note that because zinc was part of this mixture, the study does not allow us to draw clear conclusions about zinc alone and its effects on chronic fatigue syndrome.
While our research shows that synbiotics may offer a safe and beneficial approach to managing symptoms of ME/CFS following COVID-19, further investigations are needed to fully understand the role of each component, including zinc, before making any strong recommendations for its use in this context.
Read More
8
Oral supplement improves long COVID
Potential Anti-Inflammatory and Anti-Fatigue Effects of an Oral Food Supplement in Long COVID Patients.
We conducted a clinical trial to examine how an oral food supplement (OFS) could impact patients suffering from long COVID, particularly focusing on inflammation and fatigue. This was a robust study design, featuring a double-blind, placebo-controlled setup that included 2 capsules of the supplement daily over two months.
The supplement contained a mix of ingredients like rosehip, propolis, royal jelly, zinc, and vitamin C. While zinc was part of the mix, we observed significant results in inflammation reduction through various parameters, such as a decrease in the neutrophil-to-lymphocyte ratio and C-reactive protein levels. However, we couldn’t isolate zinc's effects individually, as it was evaluated alongside other components.
Importantly, there were also noteworthy improvements in patients’ fatigue levels and overall quality of life, as measured by the fatigue severity scale. We found that vitamin D levels rose significantly in participants during the supplement phase, suggesting that the OFS has potential benefits beyond just zinc.
In conclusion, while this study reveals the OFS improved inflammatory symptoms, fatigue, and quality of life, we must recognize that we did not specifically analyze zinc's isolated effects on chronic fatigue syndrome.
Read More
8
Beta-glucan improves cognitive fatigue
Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
We conducted a study to explore the potential benefits of beta-glucan supplementation in individuals suffering from chronic fatigue syndrome (ME/CFS). Over 36 weeks, we engaged 65 patients in a randomized, double-blind trial where they received either a daily combination of beta-glucan, vitamin D3, vitamin B6, and zinc, or a placebo that contained only microcrystalline cellulose. This approach allowed us to assess the overall impact of this nutritional supplement on fatigue, sleep quality, anxiety, and cognitive performance.
Our findings were particularly encouraging regarding cognitive fatigue; those who received the beta-glucan supplementation showed a significant improvement in cognitive fatigue symptoms over the study period. While zinc was included in the supplement mix, it makes it challenging to pinpoint its isolated contribution to the benefits observed. Therefore, we caution that any conclusions about zinc’s effects on chronic fatigue syndrome should be drawn with care.
This research provides valuable insights into how yeast-derived beta-glucan might serve as a helpful supplement for patients facing cognitive challenges associated with ME/CFS. Moving forward, further investigations are needed to confirm these outcomes and to better understand the immunometabolic mechanisms at play.
Read More
8
Zinc's limited role in fatigue relief
Effect of Melatonin Plus Zinc Supplementation on Fatigue Perception in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
We conducted a study to explore how oral supplementation of melatonin combined with zinc affects fatigue in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The trial lasted 16 weeks, involved 50 participants, and was designed as a randomized, double-blind, placebo-controlled study. Patients were divided to receive either melatonin with zinc or a placebo daily.
Throughout the study, we focused on measuring fatigue levels, sleep disturbances, anxiety, and overall quality of life. Our findings highlighted a significant reduction in physical fatigue for those taking the melatonin and zinc combination compared to the placebo group at the end of the treatment period. While the treatment led to an increase in urinary melatonin levels, we did not observe any significant changes in zinc concentrations.
Overall, our results suggest that adding melatonin with zinc could potentially improve the quality of life for those suffering from ME/CFS, primarily by alleviating fatigue symptoms. However, the combination treatment makes it challenging to isolate the specific impact of zinc alone on chronic fatigue syndrome.
I find this zinc very effective as it causes no gastrointestinal side effects, which is crucial for my chronic fatigue syndrome. I take it in the morning after breakfast with vitamin C for absorption and feel it helps prevent illness. The tablets are easy to swallow, and the glass bottle is a bonus.
Read More
9
Health improvement
11 people found this helpful
I've been taking this zinc picolinate for three months, and it has noticeably boosted my immunity, alleviating chronic fatigue syndrome and improving my skin. I’m very satisfied with the results and the quality of this product.
Read More
7.5
Reduced fatigue
8 people found this helpful
When prescribed zinc picolinate for chronic fatigue syndrome, I felt improved energy levels within a week. I usually take it twice daily and have noticed significant relief from my symptoms. The tablet is easy to swallow, and I highly recommend it before cold season.
Read More
9
Restored vitality
6 people found this helpful
I had great results with this zinc, which I used during my Covid treatment. It’s a well-absorbed form that significantly reduced my chronic fatigue syndrome symptoms without side effects, leaving me feeling revitalised and healthy once again. The tablets are simple to take as well.
Read More
7.5
Effective recovery
6 people found this helpful
My doctor suggested zinc during my recovery from a Covid infection to combat chronic fatigue syndrome. I noticed reduced hair loss and improved energy. Taking it with selenium is essential since excess zinc can displace copper. These tablets are easy to swallow and well tolerated.
Chronic Fatigue Syndrome (CFS), also known as Myalgic Encephalomyelitis (ME), is a complex and debilitating condition characterized by profound fatigue that doesn’t improve with rest and worsens with physical or mental activity. This crippling fatigue is often accompanied by a variety of symptoms, including sleep disturbances, cognitive difficulties, muscle pain, and joint pain. Unlike typical tiredness, the fatigue experienced in CFS is long-lasting, and it can significantly hinder everyday activities and overall quality of life.
The precise cause of CFS remains unknown, but it is believed to be influenced by a combination of genetic, environmental, immunological, and psychological factors. Diagnosis primarily relies on a careful assessment of symptoms, as there are no definitive laboratory tests available. Treatment options focus on symptom management and may include lifestyle changes, physical therapy, medication for pain management, and cognitive behavioral therapy. Given the complexity and variability of the condition, individuals with CFS should consult healthcare professionals who specialize in this area to develop personalized management strategies.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
The potential benefits of zinc in managing Chronic Fatigue Syndrome (CFS) are not extensively supported by rigorous scientific evidence. Nonetheless, zinc is an essential mineral involved in numerous biological processes, including immune function and energy metabolism, which may indirectly influence symptoms associated with CFS. Some studies suggest that a deficiency in zinc could exacerbate fatigue or other symptoms, indicating that maintaining adequate levels might be beneficial for overall health and wellbeing.
However, it’s critical to approach zinc supplementation with caution. While some individuals may benefit from taking zinc, especially if they have a documented deficiency, excessive intake can lead to toxicity and adverse effects. Therefore, if you're considering zinc supplements as part of your strategy to manage CFS, it's essential to consult with a healthcare provider. They can help determine appropriate dosage and whether it’s the right move for your health situation, ensuring a balanced approach to your overall care plan.
Based on user reviews, the timeline for experiencing results from zinc supplements can vary. Many users report noticing improvements in their chronic fatigue syndrome symptoms within as little as one week. For instance, one user shared that they felt improved energy levels after just a week of taking zinc picolinate twice daily Read Review. Another user mentioned a significant boost in concentration and energy after two weeks Read Review.
Conversely, some users indicate that it may take a bit longer for noticeable changes. For example, one user remarked on feeling energized after nearly three years of regular supplementation Read Review. Overall, it seems that while immediate benefits can be experienced within a week or two, longer-term use may also provide substantial health improvements, often related to immunity and energy levels Read Review. As always, individual responses may vary, and it's advisable to consult with a healthcare provider for personalized recommendations.
Scientific research suggests that zinc may have a potential role in managing symptoms associated with Chronic Fatigue Syndrome (CFS), although most studies do not isolate its effects alone. For instance, one study observed that patients with CFS had significantly lower serum zinc levels compared to healthy individuals, hinting at a correlation between zinc deficiency and the severity of CFS symptoms [7]. Additionally, a study involving a combination of beta-glucan and zinc noted significant improvements in cognitive fatigue among participants [3]. However, the inclusion of other components in these studies complicates the ability to link zinc directly to the observed benefits.
Several trials explored combinations of zinc with other substances, yielding positive results for fatigue and overall quality of life among CFS patients. For example, a treatment involving melatonin and zinc showed a significant reduction in physical fatigue [5]. Another research indicated that zinc may help normalize immune responses and improve CFS symptoms when combined with a broader treatment approach [6]. Overall, while emerging evidence suggests that zinc could play a supportive role, further studies are needed to clarify its specific effectiveness as a standalone treatment for Chronic Fatigue Syndrome.
Based on user reviews, many individuals have reported significant improvements in their chronic fatigue syndrome symptoms after incorporating zinc picolinate into their routine. Multiple users cited a noticeable boost in energy levels and overall wellbeing within just a few weeks of starting supplementation. For instance, one reviewer noted an enhancement in their concentration and energy after only two weeks (Read Review), while another claimed to have felt revitalized and healthier during their COVID treatment thanks to zinc's immune-supporting properties (Read Review).
Additionally, longer-term users have shared that consistent use of zinc has led to ongoing improvements in their health. One user mentioned feeling less fatigue upon waking after nearly three years of nightly use (Read Review), while another experienced better mood and reduced tiredness overall (Read Review). Overall, whether you're dealing with chronic fatigue or just looking to boost your immune response, many users have found this supplement beneficial. However, it's important to remember that individual responses can vary, and consulting with a healthcare provider before beginning any new supplement is always a wise decision.
Based on user reviews, many individuals have reported positive experiences when combining zinc picolinate with other supplements for managing chronic fatigue syndrome. For example, one user highlighted the importance of taking zinc alongside vitamin C to enhance absorption, noting that this combination not only aided in preventing illness but also improved their overall health Read Review. Another reviewer shared that taking zinc with selenium was essential for balancing nutrients, particularly to avoid displacing copper from the body Read Review. This indicates that users find success in pairing zinc with complementary supplements to maximize benefits.
Users seem to appreciate the versatility of zinc, using it in conjunction with other vitamins to enhance its effects on chronic fatigue syndrome. For instance, one reviewer mentioned how zinc’s immune-boosting properties, coupled with its anti-inflammatory benefits, significantly reduced fatigue and improved mood Read Review. Overall, while reports on specific combinations vary, there is a consensus that integrating zinc with other supplements can contribute positively to managing symptoms of chronic fatigue. However, individual tolerance and effectiveness can differ, so it may be beneficial to consult with a healthcare provider before starting any new supplement regimen.
Based on user reviews, a range of experiences with Zinc for managing Chronic Fatigue Syndrome suggests that dosages around 22 mg are considered optimal by some users, as higher amounts may be excessive for treating symptoms effectively Read Review. Many users reported improvements in their energy levels and overall well-being after consistent use. For instance, one user noticed a significant increase in energy after taking zinc picolinate for just two weeks, highlighting the quick impact it can have on chronic fatigue symptoms Read Review.
7.5
Reduced fatigue
8 people found this helpful
When prescribed zinc picolinate for chronic fatigue syndrome, I felt improved energy levels within a week. I usually take it twice daily and have noticed significant relief from my symptoms. The tablet is easy to swallow, and I highly recommend it before cold season.
7.5
Enhanced focus
6 people found this helpful
I ordered this for my husband due to his chronic fatigue syndrome, and after two weeks his concentration and energy improved significantly. This zinc supports various functions, including skin health and reducing hair loss. The tablets are tasteless and easy to take daily.
9
Reduced fatigue
3 people found this helpful
I found this product to be extremely effective in alleviating my chronic fatigue syndrome upon waking. Following my chiropractor's recommendation, I've been using it nightly for nearly three years. The improvement in my morning fatigue was noticeable, particularly in the beginning. Now, unless I indulge too much the night before, I feel significantly better compared to before.
9
Effective supplement
210 people found this helpful
I ordered this for my husband, who experienced chronic fatigue syndrome and decreased concentration. After taking it for two weeks, his energy levels improved remarkably. This zinc also supports thyroid function and reduces hair loss, further enhancing his overall health.
9
Restored vitality
6 people found this helpful
I had great results with this zinc, which I used during my Covid treatment. It’s a well-absorbed form that significantly reduced my chronic fatigue syndrome symptoms without side effects, leaving me feeling revitalised and healthy once again. The tablets are simple to take as well.
9
Boosted energy
After taking these vitamins for several weeks, I've noticed enhanced energy and reduced tiredness, contributing positively to my chronic fatigue syndrome, especially during autumn and winter. The capsules are easy to swallow and well-absorbed.
9
Boosted energy
328 people found this helpful
I find this zinc very effective as it causes no gastrointestinal side effects, which is crucial for my chronic fatigue syndrome. I take it in the morning after breakfast with vitamin C for absorption and feel it helps prevent illness. The tablets are easy to swallow, and the glass bottle is a bonus.
7.5
Effective recovery
6 people found this helpful
My doctor suggested zinc during my recovery from a Covid infection to combat chronic fatigue syndrome. I noticed reduced hair loss and improved energy. Taking it with selenium is essential since excess zinc can displace copper. These tablets are easy to swallow and well tolerated.
7.5
Mood booster
I had not previously taken zinc but found it remarkably effective for my chronic fatigue syndrome and general well-being. Its anti-inflammatory and antioxidant properties help improve my mood and reduce fatigue during colder months.
6
Effective dosage
1 people found this helpful
The 22mg dosage is perfect for addressing my chronic fatigue syndrome, as higher doses would be excessive. This product supports my recovery from fatigue.
7
Zinc supplementation may benefit CFS
Lower serum zinc in Chronic Fatigue Syndrome (CFS): relationships to immune dysfunctions and relevance for the oxidative stress status in CFS.
We explored the relationship between serum zinc levels and chronic fatigue syndrome (CFS) in a study that compared patients with CFS to normal volunteers. By using an atomic absorption method, we measured serum zinc concentrations and found that those suffering from CFS had significantly lower levels of zinc compared to healthy individuals.
Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.
Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.
8
Beta-glucan improves cognitive fatigue
Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
We conducted a study to explore the potential benefits of beta-glucan supplementation in individuals suffering from chronic fatigue syndrome (ME/CFS). Over 36 weeks, we engaged 65 patients in a randomized, double-blind trial where they received either a daily combination of beta-glucan, vitamin D3, vitamin B6, and zinc, or a placebo that contained only microcrystalline cellulose. This approach allowed us to assess the overall impact of this nutritional supplement on fatigue, sleep quality, anxiety, and cognitive performance.
Our findings were particularly encouraging regarding cognitive fatigue; those who received the beta-glucan supplementation showed a significant improvement in cognitive fatigue symptoms over the study period. While zinc was included in the supplement mix, it makes it challenging to pinpoint its isolated contribution to the benefits observed. Therefore, we caution that any conclusions about zinc’s effects on chronic fatigue syndrome should be drawn with care.
This research provides valuable insights into how yeast-derived beta-glucan might serve as a helpful supplement for patients facing cognitive challenges associated with ME/CFS. Moving forward, further investigations are needed to confirm these outcomes and to better understand the immunometabolic mechanisms at play.
8
Zinc's limited role in fatigue relief
Effect of Melatonin Plus Zinc Supplementation on Fatigue Perception in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
We conducted a study to explore how oral supplementation of melatonin combined with zinc affects fatigue in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The trial lasted 16 weeks, involved 50 participants, and was designed as a randomized, double-blind, placebo-controlled study. Patients were divided to receive either melatonin with zinc or a placebo daily.
Throughout the study, we focused on measuring fatigue levels, sleep disturbances, anxiety, and overall quality of life. Our findings highlighted a significant reduction in physical fatigue for those taking the melatonin and zinc combination compared to the placebo group at the end of the treatment period. While the treatment led to an increase in urinary melatonin levels, we did not observe any significant changes in zinc concentrations.
Overall, our results suggest that adding melatonin with zinc could potentially improve the quality of life for those suffering from ME/CFS, primarily by alleviating fatigue symptoms. However, the combination treatment makes it challenging to isolate the specific impact of zinc alone on chronic fatigue syndrome.
7
Zinc's potential benefit in CFS
Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria.
We conducted a study to explore how zinc, along with other natural substances, impacts chronic fatigue syndrome (CFS). Over a period of 10 to 14 months, we analyzed the levels of specific antibodies in the blood of 41 CFS patients before and after they took a combination of natural anti-inflammatory and antioxidant substances, including zinc, while following a leaky gut diet.
Our findings indicate that zinc may help normalize immune responses related to gut health in CFS patients. Specifically, we saw that as the levels of antibodies related to translocated lipopolysaccharides (LPS) from harmful bacteria normalized, many patients reported clinical improvements. This suggests that gut health is an important factor in managing CFS and that treatments like zinc may play a supportive role.
However, it's important to note that the direct effects of zinc alone cannot be clearly separated from those of other substances taken in the study. The combined approach points to a potential pathway in CFS treatment that emphasizes the role of a healthy gut and could open doors for new drug development targeting gut-related inflammation in CFS patients.
References
Ranisavljev M, Stajer V, Todorovic N, Ostojic J, Cvejic JH, et al. The effects of 3-month supplementation with synbiotic on patient-reported outcomes, exercise tolerance, and brain and muscle metabolism in adult patients with post-COVID-19 chronic fatigue syndrome (STOP-FATIGUE): a randomized Placebo-controlled clinical trial. Eur J Nutr. 2024;64:28. doi:10.1007/s00394-024-03546-0
Noce A, Marrone G, Di Lauro M, Vita C, Montalto G, et al. Potential Anti-Inflammatory and Anti-Fatigue Effects of an Oral Food Supplement in Long COVID Patients. Pharmaceuticals (Basel). 2024;17. doi:10.3390/ph17040463
Lacasa M, Alegre-Martin J, Sentañes RS, Varela-Sende L, Jurek J, et al. Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2023;15. doi:10.3390/nu15214504
Imai K, Yamano T, Nishi S, Nishi R, Nishi T, et al. Epipharyngeal Abrasive Therapy (EAT) Has Potential as a Novel Method for Long COVID Treatment. Viruses. 2022;14. doi:10.3390/v14050907
Castro-Marrero J, Zaragozá MC, López-Vílchez I, Galmés JL, Cordobilla B, et al. Effect of Melatonin Plus Zinc Supplementation on Fatigue Perception in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Antioxidants (Basel). 2021;10. doi:10.3390/antiox10071010
Maes M, Leunis JC. Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria. Neuro Endocrinol Lett. 2008;29:902.
Maes M, Mihaylova I, De Ruyter M. Lower serum zinc in Chronic Fatigue Syndrome (CFS): relationships to immune dysfunctions and relevance for the oxidative stress status in CFS. J Affect Disord. 2006;90:141.