We explored how zinc oxide (ZnO), often used as a feed additive, affects diarrhea and gut health in piglets infected with the ETEC K88 strain. Through careful observation, we found that piglets suffering from this infection exhibited significantly increased fecal scores compared to those not affected. The ETEC K88 strain harms the small intestine, leading to a loss of villus height and a decrease in important antioxidant activities.
Our findings revealed that ZnO administration counteracts these negative effects effectively. It not only improved the overall health of the intestine but also enhanced its ability to combat oxidative stress. We also observed a balanced restoration of gut microbiota, as ZnO helped normalize the populations of certain beneficial bacteria altered by the infection.
In summary, our study indicates that ZnO can play a vital role in easing diarrhea in piglets infected with ETEC K88 by reducing intestinal damage, supporting antioxidative defenses, and restoring healthy gut flora.
Read More
Most Useful Reviews
9
Caused diarrhoea
1 people found this helpful
I bought this for folliculitis after stopping antibiotics, hoping to boost my immunity. The tablets are small and easy to take. After a week and taking two daily, I experienced diarrhoea, so now I take one at a time. No other side effects noticed.
Read More
9
Relieves diarrhea
I have irritable bowel syndrome and adrenal fatigue syndrome. If you're suffering from diarrhoea, gas, and bloating, zinc is beneficial. It has helped me significantly.
Read More
9
Stops diarrhea
This is the first zinc supplement that hasn’t irritated my gastrointestinal tract! Unlike others that caused bloating and diarrhoea, this one suits me well. I can now take it to strengthen my immune system.
We explored how zinc oxide (ZnO), often used as a feed additive, affects diarrhea and gut health in piglets infected with the ETEC K88 strain. Through careful observation, we found that piglets suffering from this infection exhibited significantly increased fecal scores compared to those not affected. The ETEC K88 strain harms the small intestine, leading to a loss of villus height and a decrease in important antioxidant activities.
Our findings revealed that ZnO administration counteracts these negative effects effectively. It not only improved the overall health of the intestine but also enhanced its ability to combat oxidative stress. We also observed a balanced restoration of gut microbiota, as ZnO helped normalize the populations of certain beneficial bacteria altered by the infection.
In summary, our study indicates that ZnO can play a vital role in easing diarrhea in piglets infected with ETEC K88 by reducing intestinal damage, supporting antioxidative defenses, and restoring healthy gut flora.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 16 Reviews
7.8
All Reviews
Positive Reviews
Negative Reviews
9
Caused diarrhoea
1 people found this helpful
I bought this for folliculitis after stopping antibiotics, hoping to boost my immunity. The tablets are small and easy to take. After a week and taking two daily, I experienced diarrhoea, so now I take one at a time. No other side effects noticed.
Read More
9
Relieves diarrhea
I have irritable bowel syndrome and adrenal fatigue syndrome. If you're suffering from diarrhoea, gas, and bloating, zinc is beneficial. It has helped me significantly.
Read More
9
Stops diarrhea
This is the first zinc supplement that hasn’t irritated my gastrointestinal tract! Unlike others that caused bloating and diarrhoea, this one suits me well. I can now take it to strengthen my immune system.
Read More
9
Prevents diarrhea
I primarily take zinc during cold seasons, while copper is taken at different times. Zinc has proven effective in healing mucous membranes and alleviating diarrhoea and other ailments. The tablets melt quickly and have no taste.
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9
Effective diarrhoea treatment
Zinc is a vital supplement for everyone. It effectively treats diarrhoea, acts as an antioxidant, and supports immunity, vision, and skin health. The tablets are easy to consume, and I regularly take them for my family. Consulting a doctor is advisable, but 22 mg daily seems beneficial.
Diarrhea is a condition characterized by the frequent passage of loose or watery stools, which can occur due to various factors, including infections, dietary choices, and underlying health conditions. It often results from the body's response to an irritation of the gastrointestinal tract, which can be caused by viruses, bacteria, parasites, or certain medications. While most cases tend to be short-lived and resolve on their own, diarrhea can lead to dehydration, especially in vulnerable populations such as young children and the elderly.
Managing diarrhea typically involves staying hydrated by drinking clear fluids and, when necessary, replenishing lost electrolytes. In some cases, over-the-counter medications may provide relief, although it’s essential to consult a healthcare professional for persistent or severe symptoms. A focus on bland, easy-to-digest foods can also help during recovery. Remember, if diarrhea persists for more than a couple of days or is accompanied by other concerning symptoms—like high fever, severe abdominal pain, or blood in stools—seeking medical attention is crucial.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
Zinc has been recognized for its role in supporting the immune system and maintaining gut health, and research indicates that it may help reduce the duration and severity of diarrhea, particularly in children suffering from acute diarrhea. Several studies have shown that zinc supplementation can effectively shorten the length of an episode and improve recovery. The World Health Organization (WHO) recommends zinc as a complementary treatment alongside rehydration therapy for managing diarrhea, highlighting its importance in treatment protocols.
However, it’s essential to note that while zinc can be beneficial, it should not be seen as a standalone solution for all diarrhea cases. The effectiveness of zinc can vary depending on factors such as the underlying cause of diarrhea, age, and overall health. It's always advisable to consult with a healthcare professional before starting any supplementation, especially in children, to determine the appropriate dosage and ensure safety. In cases of persistent or severe diarrhea, or when accompanied by symptoms like dehydration, medical attention should be sought promptly.
Based on user reviews, the timeline for seeing results when taking zinc supplements for diarrhea varies widely. Some users report experiencing relief fairly quickly, indicating that zinc effectively helps heal mucous membranes and reduces symptoms associated with diarrhea. For example, one user mentioned that zinc can effectively aid conditions like diarrhea and erosive lesions, suggesting its benefits can be felt relatively soon (Read Review). However, others have noted that it may take several days of consistent use before you notice improvements in your symptoms, emphasizing the importance of regular intake (Read Review).
Many users emphasize that maintaining the correct dosage is crucial to avoiding side effects like diarrhea, with reports of needing to adjust their intake downwards to find their optimal balance (Read Review). As such, it might be beneficial to consult with a healthcare provider for personalized recommendations tailored to your situation, ensuring effective results while minimizing unwanted side effects.
Zinc oxide (ZnO) has shown promising results in scientific research specifically for reducing diarrhea, particularly in piglets infected with the ETEC K88 strain. A study highlighted that ZnO administration significantly improved intestinal health and decreased fecal scores in affected piglets, counteracting the damaging effects of the infection on the small intestine as well as restoring gut microbiota balance [1].
While this research provides valuable insights, it focuses on animal models, which means that while the effects of ZnO on diarrhea are clear in this context, further studies are needed to establish its efficacy in humans. Therefore, while there is scientific backing for ZnO in alleviating diarrhea in piglets, more research is necessary to determine its effectiveness in treating diarrhea in people.
Based on user reviews, many individuals have reported significant improvements in symptoms related to gastrointestinal issues, particularly diarrhea. Users with conditions such as irritable bowel syndrome and adrenal fatigue syndrome have noted that zinc effectively alleviates symptoms like gas, bloating, and diarrhea, offering substantial relief overall (Read Review). Additionally, several reviewers have experienced healing of mucous membranes, stating that zinc can be beneficial for conditions like erosive lesions and cold symptoms as well (Read Review)(Read Review).
Users have also expressed satisfaction with the absence of gastrointestinal irritation reported with other supplements. For instance, one reviewer mentioned that this particular zinc supplement did not cause bloating or diarrhea unlike others they had tried (Read Review). While experiences vary, the general consensus suggests that zinc supplementation may support overall gut health and boost immunity effectively, making it a popular choice among users dealing with various health concerns (Read Review).
Based on user reviews, there is a notable discussion surrounding the combination of zinc supplements with other dietary products for managing diarrhea. Many users have reported that when paired with magnesium, zinc not only helps in reducing diarrhea but also enhances the overall effectiveness of their supplementation regimen, particularly during cold seasons or when addressing other health concerns (Read Review). However, some reviews highlight the need for caution, as certain users experienced diarrhea when taking higher doses or when combining it with beverages like dairy, indicating that dietary choices can significantly impact gastrointestinal responses (Read Review).
In contrast, several reviewers praised the zinc formulation for its gentle nature on the stomach, often contrasting it with other supplements that caused bloating or irritation. This suggests that zinc, especially in specific formulations, might help mitigate gastrointestinal side effects, including diarrhea, while still supporting immune health and overall wellness (Read Review). Overall, the feedback indicates that while some users find supplemental combinations valuable and effective, others advise careful management of dosage and timing to avoid adverse effects.
Based on user reviews, the right dose of zinc for treating diarrhea appears to vary among users. Some users report experiencing diarrhea when taking higher doses, such as two tablets daily, as noted by one reviewer who switched to one tablet at a time after suffering from diarrhea with the higher dosage (Read Review). In contrast, other reviewers found success with taking a daily dosage of around 22 mg without gastrointestinal issues (Read Review). Additionally, a user mentioned that splitting the tablet helped them avoid nausea and diarrhea, suggesting that individuals with sensitive stomachs should consider this approach (Read Review).
Most users seem to agree on the importance of monitoring individual reactions to zinc supplements, particularly concerning gastrointestinal side effects. While some found that lower doses worked effectively for them, others had to adjust their intake to halt diarrhea. Therefore, starting at a lower dose and gradually increasing it while observing one's body’s response may be the most prudent approach to finding the right balance for managing diarrhea with zinc (Read Review).
7.5
Helps with diarrhea
6 people found this helpful
Excellent! Solgar's zinc is always in my purchases. It does not cause nausea or bloating and heals mucous membranes effectively. It aids conditions like diarrhoea, erosive lesions, and recurrent rhinitis. I take it before significant events to ensure my skin looks perfect, as it clears acne and oily shine.
9
Effective diarrhoea treatment
Zinc is a vital supplement for everyone. It effectively treats diarrhoea, acts as an antioxidant, and supports immunity, vision, and skin health. The tablets are easy to consume, and I regularly take them for my family. Consulting a doctor is advisable, but 22 mg daily seems beneficial.
9
Caused diarrhoea
1 people found this helpful
I bought this for folliculitis after stopping antibiotics, hoping to boost my immunity. The tablets are small and easy to take. After a week and taking two daily, I experienced diarrhoea, so now I take one at a time. No other side effects noticed.
9
Relieves diarrhea
I have irritable bowel syndrome and adrenal fatigue syndrome. If you're suffering from diarrhoea, gas, and bloating, zinc is beneficial. It has helped me significantly.
7.5
Helps with diarrhea
338 people found this helpful
Mast-style Solgar zinc is now a staple in my purchases. It does not cause nausea or swelling and is best taken at night, 1-1.5 hours after meals. Zinc effectively heals mucous membranes! If you suffer from diarrhoea, erosive lesions or frequent rhinitis, zinc can help. I take it before important events to improve my skin! It clears acne and reduces oily shine.
9
Stops diarrhea
This is the first zinc supplement that hasn’t irritated my gastrointestinal tract! Unlike others that caused bloating and diarrhoea, this one suits me well. I can now take it to strengthen my immune system.
7.5
Reduces diarrhea
9 people found this helpful
This supplement is my number one choice! It has reduced my acne, hair loss, and even improved my mood and sleep quality. The pills are easy to swallow, and I take them at night, two hours after dinner with magnesium. Avoid dairy products as it causes diarrhoea.
0
Diarrhoea concerns
7 people found this helpful
I bought this to improve my immunity. I initially took it for a few days, but as I have a weak stomach, I split the tablet and found no nausea, only diarrhoea. For those with similar issues, it's worth noting!
9
Zinc oxide mitigates diarrhea impacts
Zinc Oxide Administration Relieves the Diarrhea of ETEC K88-Infected Piglets by Reducing Ileal Apoptosis and Maintaining Gut Microbial Balance.
We explored how zinc oxide (ZnO), often used as a feed additive, affects diarrhea and gut health in piglets infected with the ETEC K88 strain. Through careful observation, we found that piglets suffering from this infection exhibited significantly increased fecal scores compared to those not affected. The ETEC K88 strain harms the small intestine, leading to a loss of villus height and a decrease in important antioxidant activities.
Our findings revealed that ZnO administration counteracts these negative effects effectively. It not only improved the overall health of the intestine but also enhanced its ability to combat oxidative stress. We also observed a balanced restoration of gut microbiota, as ZnO helped normalize the populations of certain beneficial bacteria altered by the infection.
In summary, our study indicates that ZnO can play a vital role in easing diarrhea in piglets infected with ETEC K88 by reducing intestinal damage, supporting antioxidative defenses, and restoring healthy gut flora.
References
Zhang Y, Liu J, Li M, Dong Y, Li Z, et al. Zinc Oxide Administration Relieves the Diarrhea of ETEC K88-Infected Piglets by Reducing Ileal Apoptosis and Maintaining Gut Microbial Balance. Vet Sci. 2025;12. doi:10.3390/vetsci12020115