We investigated how zinc supplementation impacts chronic gastritis, particularly in the context of oxidative stress and inflammation. By establishing models of inflammatory injury in C57BL/6 mice, we were able to analyze the effects of zinc on the gastric mucosa, which is crucial for maintaining digestive health.
Our findings revealed that when the mice were exposed to a compound known to induce inflammation, there was a noticeable rise in reactive oxygen species (ROS), signaling an increase in oxidative stress. This stress resulted in an uptick in certain harmful factors related to inflammation and cell death. However, when we introduced zinc as a supplement, it effectively reduced these damaging factors, alleviating inflammation and the resulting cell death in both the mouse stomach and cultured cells.
Overall, our study indicates that zinc supplementation can play a significant role in controlling inflammation and protecting against cellular damage caused by oxidative stress in chronic gastritis. By modulating the ROS/NF-κB signaling pathway, zinc demonstrates potential as a protective agent for gastric health.
Read More
8
Zinc shows effectiveness against H. pylori
Comparison of antimicrobial activity of zinc chloride and bismuth subsalicylate against clinical isolates of Helicobacter pylori.
We explored the effectiveness of zinc chloride (ZnCl) in treating Helicobacter pylori (H. pylori) infections, particularly concerning various gastritis conditions. Our study involved testing 116 clinical isolates of H. pylori to see how they responded to ZnCl, bismuth subsalicylate (BSS), and clarithromycin (CLR).
Using a method called agar gel dilution, we found that 95% of the H. pylori strains tested were susceptible to ZnCl at a concentration of 40 μg/ml. This is a promising figure, especially when compared to 98% susceptibility for BSS and 79% for CLR. Interestingly, H. pylori isolates from patients with nonulcer dyspepsia and peptic ulcers showed similar levels of susceptibility to ZnCl.
It's important to note that while ZnCl demonstrated a significant antimicrobial effect against H. pylori, making it a potential candidate for treatment, the study also indicated that its effectiveness was comparable to CLR, but slightly less than BSS. This suggests that while ZnCl may be beneficial in treating H. pylori infections, it should not be viewed as a standalone solution, particularly in gastritis management.
Ultimately, our findings indicate that zinc chloride holds promise in tackling H. pylori, potentially contributing to improved treatment strategies for those suffering from gastritis and related disorders.
Read More
9.5
Zinc Carnosine Enhances Eradication
Zinc carnosine-based modified bismuth quadruple therapy standard triple therapy for eradication: A randomized controlled study.
We conducted a study to explore the effectiveness of a modified bismuth quadruple therapy that included zinc carnosine in treating gastritis, compared to the standard triple therapy. Our participant group consisted of 92 patients who showed symptoms of dyspepsia and tested positive on a urea breath test for the infection.
The study was structured with one group receiving the traditional 14-day standard treatment, which included esomeprazole, amoxicillin, and clarithromycin. The other group was treated with a 10-day regimen that added bismuth subcitrate and zinc carnosine to the same foundational therapies. After completing their courses, we retested the patients to assess the success of the eradication therapy.
Our findings revealed that the modified therapy group achieved a significantly higher eradication rate of 93.5% compared to just 69.6% in the standard treatment group. Besides dizziness, the side effects were similar between the two therapies, indicating that the addition of zinc carnosine did not introduce significant new risks.
This research suggests that zinc carnosine can be beneficial in enhancing the effectiveness of treatments for gastritis while maintaining a favorable safety profile. Therefore, those dealing with difficult-to-treat gastritis might find hope in this innovative approach.
Read More
Most Useful Reviews
10
Beneficial for ulcers
I began taking zinc due to loss of smell, and it proved excellent for my stomach and ulcers. I took it for five months alongside licorice, and it has been tremendously beneficial, confirmed by my colonoscopy results.
Read More
0
Negative side effects
9 people found this helpful
I took this zinc picolinate to help with skin issues but experienced relentless headaches and nausea. After a week, stomach pain felt like gastritis, so I stopped taking it and felt better afterwards.
Read More
7.5
Restores zinc levels
1 people found this helpful
Salvation for zinc deficiency restores my levels without side effects. I take it during illness and find they suit my gastritis perfectly; they are well absorbed.
We conducted a study to explore the effectiveness of a modified bismuth quadruple therapy that included zinc carnosine in treating gastritis, compared to the standard triple therapy. Our participant group consisted of 92 patients who showed symptoms of dyspepsia and tested positive on a urea breath test for the infection.
The study was structured with one group receiving the traditional 14-day standard treatment, which included esomeprazole, amoxicillin, and clarithromycin. The other group was treated with a 10-day regimen that added bismuth subcitrate and zinc carnosine to the same foundational therapies. After completing their courses, we retested the patients to assess the success of the eradication therapy.
Our findings revealed that the modified therapy group achieved a significantly higher eradication rate of 93.5% compared to just 69.6% in the standard treatment group. Besides dizziness, the side effects were similar between the two therapies, indicating that the addition of zinc carnosine did not introduce significant new risks.
This research suggests that zinc carnosine can be beneficial in enhancing the effectiveness of treatments for gastritis while maintaining a favorable safety profile. Therefore, those dealing with difficult-to-treat gastritis might find hope in this innovative approach.
Read More
9.5
Zinc supports recovery in CCS
Case of Cronkhite Canada syndrome shows improvement with enteral supplements.
Our examination focuses on the intriguing case of a 33-year-old man diagnosed with Cronkhite-Canada syndrome (CCS), a rare condition affecting the gastrointestinal tract and skin. During his hospital stay, he presented with severe gastrointestinal symptoms alongside notable skin changes.
To address his condition, the treatment regime included high protein supplements, proton pump inhibitors, and zinc-vitamin supplements. Over the course of five months, we observed a complete improvement in his symptoms. While this particular case emphasizes the role of zinc within a comprehensive treatment plan, it’s important to note that zinc was part of a multi-component strategy that makes it difficult to isolate its individual effects on gastritis directly.
Nonetheless, this case illustrates how early diagnosis and a well-structured treatment approach—integrating nutritional support—can lead to significant recovery in rare syndromes like CCS.
Read More
8
Zinc protects against gastritis damage
Zinc supplementation alleviates oxidative stress to inhibit chronic gastritis the ROS/NF-κB pathway in a mouse model.
We investigated how zinc supplementation impacts chronic gastritis, particularly in the context of oxidative stress and inflammation. By establishing models of inflammatory injury in C57BL/6 mice, we were able to analyze the effects of zinc on the gastric mucosa, which is crucial for maintaining digestive health.
Our findings revealed that when the mice were exposed to a compound known to induce inflammation, there was a noticeable rise in reactive oxygen species (ROS), signaling an increase in oxidative stress. This stress resulted in an uptick in certain harmful factors related to inflammation and cell death. However, when we introduced zinc as a supplement, it effectively reduced these damaging factors, alleviating inflammation and the resulting cell death in both the mouse stomach and cultured cells.
Overall, our study indicates that zinc supplementation can play a significant role in controlling inflammation and protecting against cellular damage caused by oxidative stress in chronic gastritis. By modulating the ROS/NF-κB signaling pathway, zinc demonstrates potential as a protective agent for gastric health.
Read More
8
Polaprezinc shows promise in gastritis
Efficacy and Safety of Polaprezinc-Based Therapy versus the Standard Triple Therapy for Eradication: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
We conducted a systematic review to assess how Polaprezinc, a zinc-l-carnosine complex, might influence the treatment of gastritis. Focusing on its effectiveness when combined with standard triple therapy, which includes antibiotics, we analyzed data from three randomized controlled trials involving 396 participants.
Our findings suggest that adding Polaprezinc to the triple therapy improved the eradication rates of the bacteria responsible for gastritis. Specifically, we observed a significant increase in successful treatment outcomes, indicating a potential advantage of Polaprezinc as a complementary approach.
However, it's important to note that while the combination therapy showed better results, both treatment groups reported similar instances of adverse events. This means that Polaprezinc appears to offer a beneficial effect on treatment outcomes without increasing side effects.
Despite these positive results, we recognize that the evidence is still limited. More extensive trials are needed to confirm these findings and establish Polaprezinc's role in gastritis management firmly. Overall, this treatment could be a promising addition but needs further exploration before becoming a standard approach.
Read More
8
Zinc's role in gastritis improvement
Study of Serum Ferritin, Zinc, and Copper Levels in Children With Helicobacter pylori Gastritis and the Effect of the Treatment.
We conducted a study to understand how zinc influences children suffering from gastritis due to Helicobacter pylori infection. Our investigation included 70 young patients exhibiting symptoms of upper gastrointestinal distress. By dividing the group into H. pylori-positive and H. pylori-negative children, we could directly observe the differences in serum levels of hemoglobin, ferritin, zinc, and copper.
Notably, we found that children with H. pylori had lower levels of serum ferritin and zinc compared to those without the infection. However, the copper levels remained unaffected. Interestingly, after treating the infected children, we observed significant improvements in their hemoglobin, ferritin, and zinc levels. This suggests that while zinc deficiency is often present in these patients, simply providing zinc treatment alone cannot solely isolate its specific impact on gastritis.
Furthermore, we noted that more severe gastritis correlated with lower hemoglobin and zinc levels, and higher transferrin receptor levels. Although zinc appears to play a crucial role in the overall health of these children, our findings indicate that its treatment effect should be viewed alongside other potential factors influencing gastritis recovery.
I began taking zinc due to loss of smell, and it proved excellent for my stomach and ulcers. I took it for five months alongside licorice, and it has been tremendously beneficial, confirmed by my colonoscopy results.
Read More
0
Negative side effects
9 people found this helpful
I took this zinc picolinate to help with skin issues but experienced relentless headaches and nausea. After a week, stomach pain felt like gastritis, so I stopped taking it and felt better afterwards.
Read More
7.5
Restores zinc levels
1 people found this helpful
Salvation for zinc deficiency restores my levels without side effects. I take it during illness and find they suit my gastritis perfectly; they are well absorbed.
Read More
9
Cured my gastritis
This really works! I was surprised my gastritis has disappeared!
Read More
9
Supports hair growth
After suffering from coronavirus, my hair began to fall out significantly. After taking zinc, it started to regrow. I chose this form due to my chronic gastritis, and it has caused no stomach issues.
Gastritis is an inflammation of the stomach lining, which can lead to a range of symptoms including abdominal pain, nausea, vomiting, and indigestion. This condition can be acute, arising suddenly and lasting for a short period, or chronic, developing gradually and persisting over time. Various factors can contribute to gastritis, such as excessive alcohol consumption, prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs), bacterial infections (most notably Helicobacter pylori), and autoimmune disorders.
Treatment for gastritis often focuses on addressing the underlying cause and might include medications to reduce stomach acid, antibiotics for infections, and lifestyle modifications like avoiding irritating foods and beverages. While many people recover from gastritis with adequate care, it's important to consult a healthcare professional for a proper diagnosis and treatment plan. If left untreated, gastritis can lead to more serious complications, such as stomach ulcers or even an increased risk for gastric cancer.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
Zinc is often recognized for its various health benefits, including its role in supporting the immune system and promoting wound healing. In the context of gastritis, which is an inflammation of the stomach lining, zinc may have a supportive role due to its potential anti-inflammatory properties and its involvement in cell regeneration. Some studies indicate that zinc supplements can help in healing gastric mucosal injuries and may alleviate symptoms associated with gastritis. However, the evidence is not definitive and varies based on the individual’s health status and the cause of their gastritis.
That said, it's essential to approach supplementation cautiously. While zinc can be beneficial, taking too much can lead to adverse effects, including nausea, diarrhea, and interference with the absorption of other essential minerals. If you suspect you have gastritis or are considering zinc supplements as part of your treatment plan, it’s always best to consult with a healthcare provider first. They can provide personalized advice and ensure that any supplements or changes in diet won't adversely affect your condition or interact with other medications you might be taking.
Based on user reviews, the timeline for experiencing results from zinc supplementation for gastritis can vary significantly. Some users report incredibly positive outcomes in a relatively short timeframe. For instance, one reviewer stated, "This really works! I was surprised my gastritis has disappeared!" suggesting a potential rapid improvement after initiating use Read Review. Others have taken zinc for extended periods, such as five months, indicating more gradual effects, which seemed beneficial according to their medical evaluations Read Review.
However, not all experiences are the same. A user shared that after just a week, they experienced increased stomach pain related to gastritis, leading them to discontinue use Read Review. This uncertainty suggests that while some individuals may notice improvements within a short period, others may experience side effects that warrant ceasing use. Overall, individual responses to zinc can vary, and it may require a period of trial and careful observation to gauge its effectiveness for gastritis.
Recent scientific research supports the idea that zinc may be beneficial for those suffering from gastritis, particularly in cases involving Helicobacter pylori infection. A meta-analysis on Polaprezinc, a zinc-l-carnosine complex, demonstrated that this supplement can improve treatment outcomes when used in conjunction with standard triple therapy for gastritis, significantly enhancing rates of bacterial eradication without increasing adverse effects [2]. Furthermore, studies have shown that zinc supplementation can reduce inflammation and cellular damage in chronic gastritis, indicating its protective role in gastric health [1].
In addition, research has highlighted zinc's effect on children with H. pylori-associated gastritis, where zinc levels were notably low in infected individuals, suggesting that zinc treatment correlates with improved nutritional status and potential recovery [3]. However, while these findings indicate a promising role for zinc in managing gastritis, it is important to approach treatment holistically. Zinc should be viewed as a complementary approach rather than a standalone solution, as its effectiveness may depend on various other treatment components and individual patient factors [6]. Overall, incorporating zinc could be a worthwhile consideration in gastritis management, pending future research to further clarify its role.
Based on user reviews, many individuals have reported notable improvements in their symptoms after taking zinc, particularly for issues related to gastritis and overall digestive health. One user mentioned that after five months of taking zinc alongside licorice, they observed tremendous benefits, with their colonoscopy results confirming the positive change Read Review. Another reviewer shared a remarkable experience, stating, "This really works! I was surprised my gastritis has disappeared!" highlighting a complete resolution of symptoms Read Review. Additionally, users indicated that certain formulations appeared gentle on the stomach, providing effective symptom relief without significant side effects Read Review.
However, it’s important to note that individual experiences can vary widely. Some users encountered adverse effects, such as headaches and worsening gastritis symptoms, leading them to discontinue use Read Review. In contrast, others found formulations well-suited to their sensitivities, emphasizing the importance of personal observation and possibly trying different types of zinc Read Review. Overall, while zinc supplementation has shown promise for alleviating gastritis and digestive issues, meticulous consideration of individual tolerance and responses is crucial.
Based on user reviews, the combination of zinc supplementation with other supplements for managing gastritis yields mixed results. One user reported profound success taking zinc alongside licorice, mentioning that it provided significant relief and was confirmed by positive colonoscopy results Read Review. Another reviewer noted that zinc specifically chosen for its absorption worked well without causing any stomach issues, even for those who had chronic gastritis Read Review.
However, not all users have experienced harmony with zinc supplementation. Some reported adverse effects, citing increased stomach pain and other discomforts when combining zinc with their routine Read Review. Another user suggested taking zinc cautiously, noting that while it helped restore their sense of smell, it aggravated their gastritis symptoms at higher doses Read Review. Overall, while users have noted effective combinations, personal tolerance levels and experiences vary widely, reinforcing the need for customized approaches and careful monitoring when integrating zinc with other supplements in treating gastritis.
Based on user reviews, there is some variability in how zinc affects individuals with gastritis, particularly regarding the appropriate dosage. Several users noted that while zinc can be beneficial, caution is needed with dosing. One user reported experiencing stomach pain resembling gastritis after taking a full dose and found that reducing the dose caused their symptoms to worsen (Read Review). This indicates that personal tolerance may vary, suggesting that starting with a lower dose and monitoring symptoms could be prudent.
Conversely, other users reported positive outcomes with zinc without significant side effects, indicating that the right dosage can indeed be effective for managing gastritis symptoms. One user mentioned taking zinc for over a month with great results for their gastritis while avoiding nausea and discomfort (Read Review). Additionally, another shared a helpful tip to avoid taking it on an empty stomach to minimize discomfort while benefiting from its immune-boosting properties (Read Review). Ultimately, users suggest that finding the right dose may require personal adjustment and should consider individual tolerance levels.
9
Cured my gastritis
This really works! I was surprised my gastritis has disappeared!
10
Beneficial for ulcers
I began taking zinc due to loss of smell, and it proved excellent for my stomach and ulcers. I took it for five months alongside licorice, and it has been tremendously beneficial, confirmed by my colonoscopy results.
0
Negative side effects
9 people found this helpful
I took this zinc picolinate to help with skin issues but experienced relentless headaches and nausea. After a week, stomach pain felt like gastritis, so I stopped taking it and felt better afterwards.
9
No side effects
This zinc is excellent and easily absorbed. Having gastritis, I previously faced nausea with other brands, but this one posed no issues for me.
9
Effective zinc form
I have stomach issues, so doctors advised against zinc for gastritis. I chose this type and took it for over a month; it helped me regain my sense of smell and works wonderfully for me!
9
Supports hair growth
After suffering from coronavirus, my hair began to fall out significantly. After taking zinc, it started to regrow. I chose this form due to my chronic gastritis, and it has caused no stomach issues.
0
Be cautious
5 people found this helpful
Take caution if you have stomach problems like gastritis. Initially, I took a whole pill and felt dizzy. After reducing to half a tablet, my gastritis worsened. I stopped taking it altogether.
7.5
Gentle on stomach
I found this Solgar zinc great; however, if you have gastritis, avoid taking it on an empty stomach. It supports the immune system and helps against viruses but can cause discomfort on an empty stomach.
8
Polaprezinc shows promise in gastritis
Efficacy and Safety of Polaprezinc-Based Therapy versus the Standard Triple Therapy for Eradication: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
We conducted a systematic review to assess how Polaprezinc, a zinc-l-carnosine complex, might influence the treatment of gastritis. Focusing on its effectiveness when combined with standard triple therapy, which includes antibiotics, we analyzed data from three randomized controlled trials involving 396 participants.
Our findings suggest that adding Polaprezinc to the triple therapy improved the eradication rates of the bacteria responsible for gastritis. Specifically, we observed a significant increase in successful treatment outcomes, indicating a potential advantage of Polaprezinc as a complementary approach.
However, it's important to note that while the combination therapy showed better results, both treatment groups reported similar instances of adverse events. This means that Polaprezinc appears to offer a beneficial effect on treatment outcomes without increasing side effects.
Despite these positive results, we recognize that the evidence is still limited. More extensive trials are needed to confirm these findings and establish Polaprezinc's role in gastritis management firmly. Overall, this treatment could be a promising addition but needs further exploration before becoming a standard approach.
8
Zinc protects against gastritis damage
Zinc supplementation alleviates oxidative stress to inhibit chronic gastritis the ROS/NF-κB pathway in a mouse model.
We investigated how zinc supplementation impacts chronic gastritis, particularly in the context of oxidative stress and inflammation. By establishing models of inflammatory injury in C57BL/6 mice, we were able to analyze the effects of zinc on the gastric mucosa, which is crucial for maintaining digestive health.
Our findings revealed that when the mice were exposed to a compound known to induce inflammation, there was a noticeable rise in reactive oxygen species (ROS), signaling an increase in oxidative stress. This stress resulted in an uptick in certain harmful factors related to inflammation and cell death. However, when we introduced zinc as a supplement, it effectively reduced these damaging factors, alleviating inflammation and the resulting cell death in both the mouse stomach and cultured cells.
Overall, our study indicates that zinc supplementation can play a significant role in controlling inflammation and protecting against cellular damage caused by oxidative stress in chronic gastritis. By modulating the ROS/NF-κB signaling pathway, zinc demonstrates potential as a protective agent for gastric health.
8
Zinc's role in gastritis improvement
Study of Serum Ferritin, Zinc, and Copper Levels in Children With Helicobacter pylori Gastritis and the Effect of the Treatment.
We conducted a study to understand how zinc influences children suffering from gastritis due to Helicobacter pylori infection. Our investigation included 70 young patients exhibiting symptoms of upper gastrointestinal distress. By dividing the group into H. pylori-positive and H. pylori-negative children, we could directly observe the differences in serum levels of hemoglobin, ferritin, zinc, and copper.
Notably, we found that children with H. pylori had lower levels of serum ferritin and zinc compared to those without the infection. However, the copper levels remained unaffected. Interestingly, after treating the infected children, we observed significant improvements in their hemoglobin, ferritin, and zinc levels. This suggests that while zinc deficiency is often present in these patients, simply providing zinc treatment alone cannot solely isolate its specific impact on gastritis.
Furthermore, we noted that more severe gastritis correlated with lower hemoglobin and zinc levels, and higher transferrin receptor levels. Although zinc appears to play a crucial role in the overall health of these children, our findings indicate that its treatment effect should be viewed alongside other potential factors influencing gastritis recovery.
8
Zinc enhances H. pylori treatment
Polaprezinc combined with clarithromycin-based triple therapy for Helicobacter pylori-associated gastritis: A prospective, multicenter, randomized clinical trial.
We conducted a study to understand how zinc, specifically through polaprezinc, works alongside traditional treatments for gastritis caused by Helicobacter pylori. In this multicenter trial, participants were divided into different groups to test the effectiveness of polaprezinc when combined with standard triple therapy—omeprazole, amoxicillin, and clarithromycin—versus the triple therapy on its own.
Our findings revealed that patients receiving polaprezinc along with triple therapy had a significantly higher success rate in eradicating H. pylori compared to those who only received the triple therapy. Specifically, those in the group with standard dose polaprezinc achieved an eradication rate of about 77%, dramatically better than the 58.6% seen in the control group.
Additionally, all groups reported improvements in symptoms after treatment. However, it's important to note that the higher dosage of polaprezinc was linked to a slightly increased rate of adverse events. Despite this, there were no serious side effects noted across any group.
Overall, we observed that incorporating standard dose polaprezinc improves H. pylori eradication rates without significantly raising toxicity, suggesting that zinc can be a valuable addition to the treatment regimen for gastritis affected by this bacteria.
References
Sun X, Xu S, Liu T, Wu J, Yang J, et al. Zinc supplementation alleviates oxidative stress to inhibit chronic gastritis the ROS/NF-κB pathway in a mouse model. Food Funct. 2024;15:7136. doi:10.1039/d4fo01142b
Mahmoud A, Abuelazm M, Ahmed AAS, Abdalshafy H, Abdelazeem B, et al. Efficacy and Safety of Polaprezinc-Based Therapy versus the Standard Triple Therapy for Eradication: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2022;14. doi:10.3390/nu14194126
Elsaadany E, Amin S, Abdel-Hafez M, El Amrousy D, Kasem S, et al. Study of Serum Ferritin, Zinc, and Copper Levels in Children With Helicobacter pylori Gastritis and the Effect of the Treatment. J Pediatr Gastroenterol Nutr. 2022;75:e88. doi:10.1097/MPG.0000000000003585
Lenti MV, Facciotti F, Miceli E, Vanoli A, Fornasa G, et al. Mucosal Overexpression of Thymic Stromal Lymphopoietin and Proinflammatory Cytokines in Patients With Autoimmune Atrophic Gastritis. Clin Transl Gastroenterol. 2022;13:e00510. doi:10.14309/ctg.0000000000000510
Ibrahim N, El Said H, Choukair A. Zinc carnosine-based modified bismuth quadruple therapy standard triple therapy for eradication: A randomized controlled study. World J Clin Cases. 2022;10:227. doi:10.12998/wjcc.v10.i1.227
Tan B, Luo HQ, Xu H, Lv NH, Shi RH, et al. Polaprezinc combined with clarithromycin-based triple therapy for Helicobacter pylori-associated gastritis: A prospective, multicenter, randomized clinical trial. PLoS One. 2017;12:e0175625. doi:10.1371/journal.pone.0175625
Yakoob J, Abbas Z, Usman MW, Awan S, Naz S, et al. Comparison of antimicrobial activity of zinc chloride and bismuth subsalicylate against clinical isolates of Helicobacter pylori. Microb Drug Resist. 2014;20:305. doi:10.1089/mdr.2013.0086
Lipin SP, Paul B, Nazimudeen E, Jacob BS. Case of Cronkhite Canada syndrome shows improvement with enteral supplements. J Assoc Physicians India. 2012;60:61.