We conducted a randomized, double-blind, placebo-controlled trial to explore how zinc gluconate affects migraine symptoms in women. Sixty participants, with an average age of 35, were given either 15 mg of zinc per day or a placebo for 12 weeks, allowing us to measure the impact on headache frequency, duration, and intensity.
The results were quite promising; zinc supplementation significantly reduced how often headaches occurred, shortened their duration, and decreased the severity of the migraines reported. Participants in the zinc group experienced notable improvements, as indicated by their responses to the headache severity scale and a disability assessment questionnaire.
Furthermore, we found that zinc also had a positive effect on certain health markers. The serum levels of low-density lipoprotein (LDL), total cholesterol, and high-sensitivity C-reactive protein (hs-CRP) decreased with zinc supplementation. However, we didn’t observe significant changes in triglycerides or high-density lipoprotein (HDL) levels after adjusting for baseline values.
In conclusion, zinc supplementation appears to hold beneficial effects on migraine severity and frequency, offering a potential alternative for those who seek relief from these debilitating headaches.
Read More
7
Zinc may aid migraine relief
Zinc Administration Favorably Affects Prophylactic Therapy-refractory Migraine Attacks: A Case Series.
We explored the impact of zinc on migraine headaches, particularly looking at its effectiveness for those who haven’t found relief from traditional preventive treatments. Our investigation involved four patients suffering from migraine attacks that were resistant to usual prophylactic therapies.
Each of these patients reported a notable improvement in the frequency and severity of their headaches after incorporating zinc supplements into their regimen. This suggests that zinc might serve as a beneficial alternative for those grappling with stubborn migraines.
While our findings are promising, it's crucial to recognize that further research is needed to firmly establish the efficacy of zinc replacement therapy in this context. Nevertheless, zinc administration could offer hope for individuals facing challenges with typical migraine treatment options.
Read More
8
Zinc intake may reduce migraines
Dietary zinc intake in relation to migraine among adults: a cross sectional study of NHANES 1999-2004.
We explored the connection between zinc intake and migraine through the analysis of cross-sectional data from the National Health and Nutrition Examination Survey conducted between 1999 and 2004. Our aim was to determine if higher dietary zinc could reduce the prevalence of migraines among adults.
In our analysis, we discovered that individuals consuming higher amounts of zinc experienced fewer migraines. Specifically, when comparing participants with the lowest zinc intake to those in higher intake groups, we found significant reductions in migraine occurrence. For example, adjusting for other factors, those in the second and third zinc intake groups had a 27% and 28% lower odds of experiencing migraines, respectively.
We also noted that age plays a role in how zinc intake affects headache prevalence, suggesting that the benefits of dietary zinc may differ depending on age. Interestingly, in adults aged 20 to 50, the relationship between zinc and migraines was not straightforward, indicating a complex interaction.
Overall, this research highlights the potential benefits of increasing zinc in our diets for reducing migraine frequency, and serves as a reminder that dietary choices can have significant health implications.
Read More
Most Useful Reviews
0
Bad headaches experienced
11 people found this helpful
I used this product to enhance my immune system. Unfortunately, every time I took it, I experienced a severe headache lasting several hours. I've since switched to taking this item in my multivitamin daily. Although the dosage is somewhat lower, I consider it a good trade-off for no headache.
Read More
0
Causative headaches
6 people found this helpful
I switched from Citrate to this product for a smaller dose, but it makes me feel sick and gives me bad headaches.
Read More
0
Bad headaches
3 people found this helpful
This product seems effective since I experience bad headaches each time I take it. Perhaps the dosage is too high...
We conducted a randomized, double-blind, placebo-controlled trial to explore how zinc gluconate affects migraine symptoms in women. Sixty participants, with an average age of 35, were given either 15 mg of zinc per day or a placebo for 12 weeks, allowing us to measure the impact on headache frequency, duration, and intensity.
The results were quite promising; zinc supplementation significantly reduced how often headaches occurred, shortened their duration, and decreased the severity of the migraines reported. Participants in the zinc group experienced notable improvements, as indicated by their responses to the headache severity scale and a disability assessment questionnaire.
Furthermore, we found that zinc also had a positive effect on certain health markers. The serum levels of low-density lipoprotein (LDL), total cholesterol, and high-sensitivity C-reactive protein (hs-CRP) decreased with zinc supplementation. However, we didn’t observe significant changes in triglycerides or high-density lipoprotein (HDL) levels after adjusting for baseline values.
In conclusion, zinc supplementation appears to hold beneficial effects on migraine severity and frequency, offering a potential alternative for those who seek relief from these debilitating headaches.
Read More
8
Zinc intake may reduce migraines
Dietary zinc intake in relation to migraine among adults: a cross sectional study of NHANES 1999-2004.
We explored the connection between zinc intake and migraine through the analysis of cross-sectional data from the National Health and Nutrition Examination Survey conducted between 1999 and 2004. Our aim was to determine if higher dietary zinc could reduce the prevalence of migraines among adults.
In our analysis, we discovered that individuals consuming higher amounts of zinc experienced fewer migraines. Specifically, when comparing participants with the lowest zinc intake to those in higher intake groups, we found significant reductions in migraine occurrence. For example, adjusting for other factors, those in the second and third zinc intake groups had a 27% and 28% lower odds of experiencing migraines, respectively.
We also noted that age plays a role in how zinc intake affects headache prevalence, suggesting that the benefits of dietary zinc may differ depending on age. Interestingly, in adults aged 20 to 50, the relationship between zinc and migraines was not straightforward, indicating a complex interaction.
Overall, this research highlights the potential benefits of increasing zinc in our diets for reducing migraine frequency, and serves as a reminder that dietary choices can have significant health implications.
Read More
8
Zinc may help reduce migraines
Dietary zinc intake and migraine in adults: a cross-sectional analysis of the National Health and Nutrition Examination Survey 1999-2004.
We explored how dietary zinc intake relates to migraines by analyzing data from the National Health and Nutrition Examination Survey conducted between 1999 and 2004. This cross-sectional study focused on adults who reported experiencing severe headaches or migraines.
Our findings indicated a noteworthy trend: higher intake of dietary zinc was associated with a lower likelihood of having migraines. Specifically, participants with greater zinc consumption—classified into various intake levels—showed a consistent decrease in the odds of experiencing migraine symptoms. For example, those in the highest quintile of zinc intake were 30% less likely to experience migraines compared to those with the lowest intake levels.
This suggests that increasing our zinc intake could be a beneficial strategy for managing migraines. While further research is needed to understand the precise mechanism, the anti-inflammatory and antioxidant properties of zinc may play a crucial role in reducing migraine occurrences.
Read More
8
Zinc chloride may reduce headaches
Epipharyngeal Abrasive Therapy (EAT) Has Potential as a Novel Method for Long COVID Treatment.
We evaluated how zinc chloride, used in epipharyngeal abrasive therapy (EAT), might alleviate headaches among patients with long COVID. EAT involves applying zinc chloride to the lining of the epipharynx, where inflammation can linger after COVID-19.
Our study involved 58 patients who received EAT weekly for a month. Before and after the treatment, we measured the intensity of common long COVID symptoms, including fatigue and headaches, using a visual analog scale.
Interestingly, our findings showed that EAT helped reduce inflammation in the epipharynx and significantly improved not only headaches but also fatigue and attention disorders. This suggests that zinc chloride might play a role in easing headache symptoms associated with long COVID.
Overall, we believe this study highlights the potential of EAT as a new treatment avenue for managing long COVID symptoms, particularly headaches, which can often be debilitating for many.
Read More
8
Zinc improves headache symptoms
Intravenous Calcium-/Zinc-Diethylene Triamine Penta-Acetic Acid in Patients With Presumed Gadolinium Deposition Disease: A Preliminary Report on 25 Patients.
We observed the use of intravenous calcium and zinc in patients diagnosed with gadolinium deposition disease, with a focus on how this treatment affected their headaches. In our preliminary report involving 25 patients, we noted significant improvements in headache symptoms among those receiving treatment, particularly with a regime of calcium-/zinc-diethylene triamine penta-acetic acid (DTPA).
Patients underwent three courses of treatment, and we measured their urinary gadolinium levels and self-reported symptoms before, during, and after these sessions. The findings revealed a noteworthy increase in Gd content in urine, indicating an effective chelation process, as well as moderate symptomatic relief.
Specifically, 13 patients reported a decrease in headache intensity, along with improvements in other symptoms like brain fog and bone pain. For those on a monthly treatment schedule, there were more significant benefits noted compared to the weekly treatment schedule.
Overall, while there was a transient worsening of symptoms in some patients at first—a phenomenon referred to as a "flare-up"—the outcome suggests that the combination therapy shows promise in alleviating headaches among individuals suffering from this perplexing condition.
I used this product to enhance my immune system. Unfortunately, every time I took it, I experienced a severe headache lasting several hours. I've since switched to taking this item in my multivitamin daily. Although the dosage is somewhat lower, I consider it a good trade-off for no headache.
Read More
0
Causative headaches
6 people found this helpful
I switched from Citrate to this product for a smaller dose, but it makes me feel sick and gives me bad headaches.
Read More
0
Bad headaches
3 people found this helpful
This product seems effective since I experience bad headaches each time I take it. Perhaps the dosage is too high...
Read More
7.5
Headache improvement
1 people found this helpful
It is a supplement I take daily without fail. Since I started taking zinc, my headaches have improved significantly, along with the condition of my skin, hair, and nails. I'm particularly pleased that my eyelashes have grown thicker and longer.
Read More
0
Sp stomach pain
1 people found this helpful
It caused me stomach pain and a headache, but I managed to start using the Thorn brand, which suited me better.
A headache is a common condition characterized by pain or discomfort in the head, scalp, or neck. It can vary in intensity, frequency, and duration, and is often classified into two primary categories: primary and secondary headaches. Primary headaches, such as tension-type headaches, migraines, and cluster headaches, are not caused by other medical conditions. Instead, they are conditions in themselves, often resulting from factors like stress, hormonal changes, or environmental triggers. Secondary headaches, on the other hand, are symptoms of an underlying issue, such as an infection, injury, or other medical conditions.
The experience of a headache can differ widely among individuals. Depending on the type, headaches can be throbbing or constant and may be accompanied by other symptoms like nausea, sensitivity to light, or aura effects before the headache strikes. Effective management strategies vary by headache type and may include over-the-counter pain relievers, lifestyle changes, and in some cases, prescription medications. Understanding the specific triggers and patterns related to your headaches can be crucial for prevention and treatment, so maintaining a headache diary may be beneficial for those experiencing frequent or severe episodes.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
Zinc is an essential mineral known for its various health benefits, including immune support and anti-inflammatory properties. Some studies suggest that zinc may have a role in reducing the frequency and severity of headaches, particularly migraines, which can be linked to underlying nutritional deficiencies. Certain research indicates that individuals with lower levels of zinc may experience more frequent headaches, potentially due to its involvement in enzyme functions and neurotransmitter regulation.
However, while zinc supplementation could be beneficial for some, it's important to approach this method with caution. Self-diagnosing and treating headache disorders without professional guidance may lead to unintended side effects, particularly if taken in excessive amounts. If you're considering zinc as a potential remedy for headaches, consulting with a healthcare professional is advisable to determine the appropriateness based on your individual health status and specific headache type. So, while there’s a potential link between zinc and headache relief, more conclusive research is needed to establish zinc as a standardized treatment protocol.
Based on user reviews, the timeline for seeing results from taking zinc supplements for headaches can vary significantly. Several users have noted that they experienced headaches initially after starting the supplement but found that these effects were temporary. For instance, one user mentioned that while they experienced headaches during the first few days, their overall condition improved as they continued the supplement (Read Review). Another user remarked on the improvement of their headaches after consistent use, suggesting a potential period of several days to weeks to notice a positive change (Read Review).
On the other hand, not all experiences were positive. Some users reported consistent headaches after taking the supplement, indicating that it might not work for everyone Read Review. Therefore, while some users did see improvements in their headaches with continued use, it may take several days of consistent supplementation to determine if the product works for you. As with any supplement, individual responses can vary widely, so it might be helpful to monitor your own experience or consult a healthcare professional.
Research indicates that zinc may hold promise in alleviating headache symptoms, particularly migraines. A systematic review analyzing five studies pointed out the potential benefits of zinc for managing migraines, although it emphasized the need for further extensive clinical studies to confirm these findings ([1]). Additionally, other trials have shown that patients resistant to traditional migraine treatments reported significant improvements when zinc was incorporated into their regimen ([2]). Specifically, one randomized, double-blind trial found notable reductions in migraine frequency, duration, and severity after zinc supplementation, suggesting it could serve as an effective alternative for those seeking relief from debilitating headaches ([6]).
Moreover, cross-sectional studies have linked higher dietary zinc intake to a reduced prevalence of migraines, indicating a clear trend where increased zinc consumption correlates with fewer migraine occurrences ([3], [4]). While these findings are encouraging, experts note that more robust clinical research is necessary to establish a definitive understanding of zinc's effectiveness in managing headaches. Nonetheless, the current evidence paints a promising picture for those considering zinc supplements as a potential strategy against migraines.
Based on user reviews, many individuals report notable improvements in various symptoms after taking zinc supplements. Specifically, one user indicated a significant reduction in headaches alongside enhancements in their skin, hair, and nails, with even thicker and longer eyelashes noted (Read Review). Another reviewer mentioned that they experienced headache relief associated with a condition like COVID-19, highlighting the supplement's potential efficacy in such scenarios (Read Review).
However, it's important to note that not all experiences were positive. Some users reported consistent headaches, nausea, and stomach pain when taking zinc, suggesting that while some found relief, others faced adverse effects (Read Review; Read Review). As with any supplement, results can vary widely between individuals; therefore, monitoring personal responses is crucial, and consulting with a healthcare professional may be advisable for tailored advice.
Based on user reviews, there seems to be a mixed response when it comes to combining zinc supplements with other supplements for headache management. Some users reported improved headaches with zinc, while others experienced adverse effects when taking it alongside other supplements. For instance, one user noted that they took zinc with selenium but experienced a headache and nausea, which improved after discontinuing the supplement (Read Review). Conversely, another user found zinc effective in reducing headaches caused by Corona, suggesting that it may work well for certain individuals depending on their specific conditions (Read Review).
However, there were multiple accounts of headaches persisting after taking zinc, both alone and in combination with other supplements. Several reviews highlighted that some users experienced headaches alongside nausea and stomach pain from zinc, indicating a less-than-optimal experience for these individuals (Read Review; Read Review). Additionally, another user mentioned waking up with headaches after taking zinc at night, further emphasizing that while zinc may benefit some, it can also lead to discomfort for others (Read Review). As always, individual responses to supplements can vary greatly, warranting careful self-monitoring and consultation with healthcare professionals.
When it comes to managing migraines with zinc, research suggests that a daily dose of around 15 mg can yield promising results. A randomized, double-blind, placebo-controlled trial found that women taking this dosage experienced a significant reduction in headache frequency, duration, and severity compared to those on a placebo [6]. Furthermore, other studies indicate that patients with resistant migraine symptoms saw notable improvements after incorporating zinc supplements into their regimen, reinforcing the idea that zinc may serve as a valuable alternative for those struggling to find relief from traditional treatments [2].
It's also worth noting that dietary zinc intake appears beneficial, with higher consumption correlated to a lower likelihood of experiencing migraines. For example, participants in the highest quintile of zinc intake were reported to be 30% less likely to have migraines compared to those with the lowest intake levels [4]. However, while the evidence suggests potential, further extensive clinical trials are still needed to confirm the efficacy and establish optimal dosing for zinc in treating headaches.
6
Initial headaches
This zinc does not cause nausea and headaches, except in the first few days, which is tolerable. I took it due to a confirmed deficiency, so it's best not to stop usage abruptly.
7.5
Headache improvement
1 people found this helpful
It is a supplement I take daily without fail. Since I started taking zinc, my headaches have improved significantly, along with the condition of my skin, hair, and nails. I'm particularly pleased that my eyelashes have grown thicker and longer.
2
Severe headaches
9 people found this helpful
I bought picolinate to cleanse my skin. However, I experienced consistent headaches and nausea after taking it, and severe stomach pain followed. I had to stop due to these adverse effects. My friend helped me eliminate zinc from my body and I felt fine.
10
Headache relief
Excellent! It helped clear my headache caused by Corona.
2
Consistent headaches
9 people found this helpful
I feel a headache every time I take this. I take one tablet at night and wake up with a heavy headache. My skin texture seems better, but I still have blemishes.
0
Headache treatment effects
I took it in the morning after eating. I experienced a headache and nausea, but everything improved after stopping the medication. I took it alongside selenium.
0
Sp stomach pain
1 people found this helpful
It caused me stomach pain and a headache, but I managed to start using the Thorn brand, which suited me better.
7
Zinc's role in migraine management
Zinc as An Emerging Therapy in the Management of Migraine: A Systematic Review.
We explored the impact of zinc in managing migraines, which are often debilitating headaches that many people experience. This research was designed to systematically review the existing literature and gather evidence on how zinc could potentially help alleviate migraine symptoms.
Our investigation led to the analysis of five studies, including two clinical trials and three observational studies. The clinical trials showed a low risk of bias, suggesting that the findings are reliable. Overall, the review indicated a positive role for zinc in managing migraines, yet the evidence currently available is limited.
We noted that while zinc seems to offer some benefits for headache relief, more extensive and robust clinical trials are needed to firmly establish its effectiveness. As of now, the journey toward understanding the full potential of zinc for migraines continues, emphasizing the need for further investigation.
7
Zinc may aid migraine relief
Zinc Administration Favorably Affects Prophylactic Therapy-refractory Migraine Attacks: A Case Series.
We explored the impact of zinc on migraine headaches, particularly looking at its effectiveness for those who haven’t found relief from traditional preventive treatments. Our investigation involved four patients suffering from migraine attacks that were resistant to usual prophylactic therapies.
Each of these patients reported a notable improvement in the frequency and severity of their headaches after incorporating zinc supplements into their regimen. This suggests that zinc might serve as a beneficial alternative for those grappling with stubborn migraines.
While our findings are promising, it's crucial to recognize that further research is needed to firmly establish the efficacy of zinc replacement therapy in this context. Nevertheless, zinc administration could offer hope for individuals facing challenges with typical migraine treatment options.
9
Zinc reduces migraine symptoms
Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women.
We conducted a randomized, double-blind, placebo-controlled trial to explore how zinc gluconate affects migraine symptoms in women. Sixty participants, with an average age of 35, were given either 15 mg of zinc per day or a placebo for 12 weeks, allowing us to measure the impact on headache frequency, duration, and intensity.
The results were quite promising; zinc supplementation significantly reduced how often headaches occurred, shortened their duration, and decreased the severity of the migraines reported. Participants in the zinc group experienced notable improvements, as indicated by their responses to the headache severity scale and a disability assessment questionnaire.
Furthermore, we found that zinc also had a positive effect on certain health markers. The serum levels of low-density lipoprotein (LDL), total cholesterol, and high-sensitivity C-reactive protein (hs-CRP) decreased with zinc supplementation. However, we didn’t observe significant changes in triglycerides or high-density lipoprotein (HDL) levels after adjusting for baseline values.
In conclusion, zinc supplementation appears to hold beneficial effects on migraine severity and frequency, offering a potential alternative for those who seek relief from these debilitating headaches.
8
Zinc intake may reduce migraines
Dietary zinc intake in relation to migraine among adults: a cross sectional study of NHANES 1999-2004.
We explored the connection between zinc intake and migraine through the analysis of cross-sectional data from the National Health and Nutrition Examination Survey conducted between 1999 and 2004. Our aim was to determine if higher dietary zinc could reduce the prevalence of migraines among adults.
In our analysis, we discovered that individuals consuming higher amounts of zinc experienced fewer migraines. Specifically, when comparing participants with the lowest zinc intake to those in higher intake groups, we found significant reductions in migraine occurrence. For example, adjusting for other factors, those in the second and third zinc intake groups had a 27% and 28% lower odds of experiencing migraines, respectively.
We also noted that age plays a role in how zinc intake affects headache prevalence, suggesting that the benefits of dietary zinc may differ depending on age. Interestingly, in adults aged 20 to 50, the relationship between zinc and migraines was not straightforward, indicating a complex interaction.
Overall, this research highlights the potential benefits of increasing zinc in our diets for reducing migraine frequency, and serves as a reminder that dietary choices can have significant health implications.
8
Zinc may help reduce migraines
Dietary zinc intake and migraine in adults: a cross-sectional analysis of the National Health and Nutrition Examination Survey 1999-2004.
We explored how dietary zinc intake relates to migraines by analyzing data from the National Health and Nutrition Examination Survey conducted between 1999 and 2004. This cross-sectional study focused on adults who reported experiencing severe headaches or migraines.
Our findings indicated a noteworthy trend: higher intake of dietary zinc was associated with a lower likelihood of having migraines. Specifically, participants with greater zinc consumption—classified into various intake levels—showed a consistent decrease in the odds of experiencing migraine symptoms. For example, those in the highest quintile of zinc intake were 30% less likely to experience migraines compared to those with the lowest intake levels.
This suggests that increasing our zinc intake could be a beneficial strategy for managing migraines. While further research is needed to understand the precise mechanism, the anti-inflammatory and antioxidant properties of zinc may play a crucial role in reducing migraine occurrences.
References
Singhal S, Dutta SB, Bansal S, Dutta S, Shah RB. Zinc as An Emerging Therapy in the Management of Migraine: A Systematic Review. Neurol India. 2024;72:934. 10.4103/neurol-india.Neurol-India-D-23-00337
Fukazawa R, Ishii R, Higashimoto Y, Hanya M, Shimizu Y, et al. Zinc Administration Favorably Affects Prophylactic Therapy-refractory Migraine Attacks: A Case Series. Intern Med. 2024;63:1631. 10.2169/internalmedicine.2111-23
Zheng H, Tian S, Wu L, Zhong X, Liu M, et al. Dietary zinc intake in relation to migraine among adults: a cross sectional study of NHANES 1999-2004. Nutr Neurosci. 2024;27:667. 10.1080/1028415X.2023.2243678
Liu H, Wang Q, Dong Z, Yu S. Dietary zinc intake and migraine in adults: a cross-sectional analysis of the National Health and Nutrition Examination Survey 1999-2004. Headache. 2023;63:127. 10.1111/head.14431
Imai K, Yamano T, Nishi S, Nishi R, Nishi T, et al. Epipharyngeal Abrasive Therapy (EAT) Has Potential as a Novel Method for Long COVID Treatment. Viruses. 2022;14. 10.3390/v14050907
Mazaheri M, Aghdam AM, Heidari M, Zarrin R. Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women. Clin Nutr Res. 2021;10:127. 10.7762/cnr.2021.10.2.127
Ahmadi H, Mazloumi-Kiapey SS, Sadeghi O, Nasiri M, Khorvash F, et al. Zinc supplementation affects favorably the frequency of migraine attacks: a double-blind randomized placebo-controlled clinical trial. Nutr J. 2020;19:101. 10.1186/s12937-020-00618-9
Semelka RC, Ramalho M, Jay M, Hickey L, Hickey J. Intravenous Calcium-/Zinc-Diethylene Triamine Penta-Acetic Acid in Patients With Presumed Gadolinium Deposition Disease: A Preliminary Report on 25 Patients. Invest Radiol. 2018;53:373. 10.1097/RLI.0000000000000453