Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
USERS' SCORE
Moderately Good
Based on 11 Reviews
7
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
3 g
1%*
Magnesium (as magnesium malate trihydrate)
425 mg
101%
Sodium
10 mg
<1%
Magnesium Malate Trihydrate
3.75 g
†
Malic Acid (as magnesium malate trihydrate and malic acid)
2.5 g
†
Top Medical Research Studies
9.5
We explored the impact of magnesium on secretory diarrhea, particularly in the context of cholera, a significant global health issue. The focus was on understanding how magnesium, often overlooked, could serve as an effective treatment option. In our study, we found that increasing levels of magnesium can significantly inhibit chloride secretion in intestinal cells, which is crucial during episodes of diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
Read More
8
We investigated the relationship between magnesium treatment and diarrhea in patients with HNF1B syndrome, where we found that hypomagnesemia is quite common.
A notable case involved a patient with a de novo heterozygous deletion of the HNF1B gene, who suffered from severe diarrhea due to low magnesium levels. After receiving magnesium supplementation, the patient's diarrhea symptoms improved significantly.
Our findings indicate that those with HNF1B deletion are more likely to experience low magnesium levels compared to individuals with intragenic mutations. In fact, among a large group of patients with HNF1B syndrome, over half experienced hypomagnesemia.
This suggests a strong connection between magnesium deficiency and the gastrointestinal issues seen in this condition. It highlights the importance of monitoring magnesium levels in patients, as addressing this deficiency can lead to meaningful relief from diarrhea symptoms.
A notable case involved a patient with a de novo heterozygous deletion of the HNF1B gene, who suffered from severe diarrhea due to low magnesium levels. After receiving magnesium supplementation, the patient's diarrhea symptoms improved significantly.
Our findings indicate that those with HNF1B deletion are more likely to experience low magnesium levels compared to individuals with intragenic mutations. In fact, among a large group of patients with HNF1B syndrome, over half experienced hypomagnesemia.
This suggests a strong connection between magnesium deficiency and the gastrointestinal issues seen in this condition. It highlights the importance of monitoring magnesium levels in patients, as addressing this deficiency can lead to meaningful relief from diarrhea symptoms.
Read More
9
We observed a fascinating case involving a 70-day-old baby girl from Iran who was suffering from severe hypomagnesemia and secondary hypocalcemia. She exhibited signs like seizures and persistent watery diarrhea shortly after birth, leading to significant health challenges, including failure to thrive.
In her treatment, both magnesium and calcium supplementation were used. Despite an initial struggle with response to the magnesium, we noted that over time, her condition improved, and the diarrhea subsided. This suggests that magnesium might play a crucial role in managing diarrhea, especially in cases related to deficiencies.
Additionally, a genetic analysis revealed a novel alteration in her TRPM6 gene, which is notable because such variants are linked to magnesium transport issues. This connection highlights the importance of magnesium not only in treating diarrhea but also in the overall well-being of individuals with genetic predispositions affecting magnesium levels.
Our follow-up with the patient over two years showed no relapses, indicating a positive response to the treatment plan incorporating magnesium. While our findings centered on this specific instance, they contribute to a broader understanding of magnesium's therapeutic effects on diarrhea and related health problems.
In her treatment, both magnesium and calcium supplementation were used. Despite an initial struggle with response to the magnesium, we noted that over time, her condition improved, and the diarrhea subsided. This suggests that magnesium might play a crucial role in managing diarrhea, especially in cases related to deficiencies.
Additionally, a genetic analysis revealed a novel alteration in her TRPM6 gene, which is notable because such variants are linked to magnesium transport issues. This connection highlights the importance of magnesium not only in treating diarrhea but also in the overall well-being of individuals with genetic predispositions affecting magnesium levels.
Our follow-up with the patient over two years showed no relapses, indicating a positive response to the treatment plan incorporating magnesium. While our findings centered on this specific instance, they contribute to a broader understanding of magnesium's therapeutic effects on diarrhea and related health problems.
Read More
Most Useful Reviews
7.5
Improved anxiety significantly
6 people found this helpful
I didn't believe this would work at first. Regular magnesium caused me diarrhoea while I aimed to alleviate anxiety and constipation. After starting with one pill I felt less anxious and gradually increased the dosage. Now, it’s incredible; I've been using the bathroom regularly and my anxiety is improving. This product has made a significant difference for me.
Read More
9
No diarrhoea confirmed
Magnesium contributes to normal muscle function and can alleviate cramps. Unlike citrate, magnesium malate does not induce diarrhoea, which makes it a preferable option.
Read More
9
No diarrhoea experienced
This supplement significantly boosts my energy levels each morning and offers good value for money. I take three tablets to stimulate my digestion, and unlike other forms of magnesium, it does not lead to diarrhoea.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
- All Researches
9.5
We explored the impact of magnesium on secretory diarrhea, particularly in the context of cholera, a significant global health issue. The focus was on understanding how magnesium, often overlooked, could serve as an effective treatment option. In our study, we found that increasing levels of magnesium can significantly inhibit chloride secretion in intestinal cells, which is crucial during episodes of diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
Read More
9
We observed a fascinating case involving a 70-day-old baby girl from Iran who was suffering from severe hypomagnesemia and secondary hypocalcemia. She exhibited signs like seizures and persistent watery diarrhea shortly after birth, leading to significant health challenges, including failure to thrive.
In her treatment, both magnesium and calcium supplementation were used. Despite an initial struggle with response to the magnesium, we noted that over time, her condition improved, and the diarrhea subsided. This suggests that magnesium might play a crucial role in managing diarrhea, especially in cases related to deficiencies.
Additionally, a genetic analysis revealed a novel alteration in her TRPM6 gene, which is notable because such variants are linked to magnesium transport issues. This connection highlights the importance of magnesium not only in treating diarrhea but also in the overall well-being of individuals with genetic predispositions affecting magnesium levels.
Our follow-up with the patient over two years showed no relapses, indicating a positive response to the treatment plan incorporating magnesium. While our findings centered on this specific instance, they contribute to a broader understanding of magnesium's therapeutic effects on diarrhea and related health problems.
In her treatment, both magnesium and calcium supplementation were used. Despite an initial struggle with response to the magnesium, we noted that over time, her condition improved, and the diarrhea subsided. This suggests that magnesium might play a crucial role in managing diarrhea, especially in cases related to deficiencies.
Additionally, a genetic analysis revealed a novel alteration in her TRPM6 gene, which is notable because such variants are linked to magnesium transport issues. This connection highlights the importance of magnesium not only in treating diarrhea but also in the overall well-being of individuals with genetic predispositions affecting magnesium levels.
Our follow-up with the patient over two years showed no relapses, indicating a positive response to the treatment plan incorporating magnesium. While our findings centered on this specific instance, they contribute to a broader understanding of magnesium's therapeutic effects on diarrhea and related health problems.
Read More
9
In our exploration of how potassium-magnesium sulfate (PMS) impacts diarrhea in weaned piglets, we set out to understand its effects on growth performance, immunity, and gut health. A total of 216 piglets were divided into six groups, with varying levels of PMS in their diets.
Our findings revealed some compelling results: the addition of PMS significantly reduced the diarrhea rate among the piglets. Notably, when we included 0.3% PMS in their diet, we observed improved antioxidant capacity, which plays a crucial role in maintaining overall gut health.
We also discovered that PMS supplementation positively influenced intestinal immunity by lowering certain inflammatory markers, further suggesting its beneficial role in digestive health. Additionally, the changes in gut bacteria composition indicated that magnesium may help foster a healthier gut environment.
Overall, our study sheds light on magnesium's potential role as a treatment option for reducing diarrhea in weaned piglets, emphasizing its effectiveness in fostering both immunity and gut health.
Our findings revealed some compelling results: the addition of PMS significantly reduced the diarrhea rate among the piglets. Notably, when we included 0.3% PMS in their diet, we observed improved antioxidant capacity, which plays a crucial role in maintaining overall gut health.
We also discovered that PMS supplementation positively influenced intestinal immunity by lowering certain inflammatory markers, further suggesting its beneficial role in digestive health. Additionally, the changes in gut bacteria composition indicated that magnesium may help foster a healthier gut environment.
Overall, our study sheds light on magnesium's potential role as a treatment option for reducing diarrhea in weaned piglets, emphasizing its effectiveness in fostering both immunity and gut health.
Read More
9
We conducted a study to assess the effectiveness of magnesium in treating diarrhea, particularly focusing on its role in extracts from (Wall.) leaves. To evaluate this, we utilized several tests that mimic diarrhea conditions. Our findings showed that while magnesium was mentioned in connection with the extracts, it was administered alongside other treatments. This means we're not entirely sure how much of the anti-diarrheal effect was due to magnesium itself.
In our tests, the methanol extract of (Wall.) leaves was particularly noteworthy, showing significant inhibition of diarrhea at a dose of 400 mg/kg. However, the role of magnesium in this context remains ambiguous since it wasn't given alone. In essence, while the extract worked well against diarrhea, the individual contribution of magnesium to this benefit is unclear.
Overall, we support the traditional use of (Wall.) plants in managing diarrhea and pain, but we need more focused research to isolate the effects of magnesium.
In our tests, the methanol extract of (Wall.) leaves was particularly noteworthy, showing significant inhibition of diarrhea at a dose of 400 mg/kg. However, the role of magnesium in this context remains ambiguous since it wasn't given alone. In essence, while the extract worked well against diarrhea, the individual contribution of magnesium to this benefit is unclear.
Overall, we support the traditional use of (Wall.) plants in managing diarrhea and pain, but we need more focused research to isolate the effects of magnesium.
Read More
8
We investigated the relationship between magnesium treatment and diarrhea in patients with HNF1B syndrome, where we found that hypomagnesemia is quite common.
A notable case involved a patient with a de novo heterozygous deletion of the HNF1B gene, who suffered from severe diarrhea due to low magnesium levels. After receiving magnesium supplementation, the patient's diarrhea symptoms improved significantly.
Our findings indicate that those with HNF1B deletion are more likely to experience low magnesium levels compared to individuals with intragenic mutations. In fact, among a large group of patients with HNF1B syndrome, over half experienced hypomagnesemia.
This suggests a strong connection between magnesium deficiency and the gastrointestinal issues seen in this condition. It highlights the importance of monitoring magnesium levels in patients, as addressing this deficiency can lead to meaningful relief from diarrhea symptoms.
A notable case involved a patient with a de novo heterozygous deletion of the HNF1B gene, who suffered from severe diarrhea due to low magnesium levels. After receiving magnesium supplementation, the patient's diarrhea symptoms improved significantly.
Our findings indicate that those with HNF1B deletion are more likely to experience low magnesium levels compared to individuals with intragenic mutations. In fact, among a large group of patients with HNF1B syndrome, over half experienced hypomagnesemia.
This suggests a strong connection between magnesium deficiency and the gastrointestinal issues seen in this condition. It highlights the importance of monitoring magnesium levels in patients, as addressing this deficiency can lead to meaningful relief from diarrhea symptoms.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 11 Reviews
7
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improved anxiety significantly
6 people found this helpful
I didn't believe this would work at first. Regular magnesium caused me diarrhoea while I aimed to alleviate anxiety and constipation. After starting with one pill I felt less anxious and gradually increased the dosage. Now, it’s incredible; I've been using the bathroom regularly and my anxiety is improving. This product has made a significant difference for me.
Read More
9
No diarrhoea confirmed
Magnesium contributes to normal muscle function and can alleviate cramps. Unlike citrate, magnesium malate does not induce diarrhoea, which makes it a preferable option.
Read More
9
No diarrhoea experienced
This supplement significantly boosts my energy levels each morning and offers good value for money. I take three tablets to stimulate my digestion, and unlike other forms of magnesium, it does not lead to diarrhoea.
Read More
9
No diarrhea experienced
It tastes good and does not cause diarrhoea. It is a very good magnesium supplement form, though it is a bit large and may be challenging for some to swallow.
Read More
0
Severe diarrhea
Even with just one pill, I experience severe diarrhoea.
Read More
Frequently Asked Questions
9
No diarrhoea confirmed
Magnesium contributes to normal muscle function and can alleviate cramps. Unlike citrate, magnesium malate does not induce diarrhoea, which makes it a preferable option.
9
No diarrhoea experienced
This supplement significantly boosts my energy levels each morning and offers good value for money. I take three tablets to stimulate my digestion, and unlike other forms of magnesium, it does not lead to diarrhoea.
0
Severe diarrhea
Even with just one pill, I experience severe diarrhoea.
9
No diarrhea experienced
It tastes good and does not cause diarrhoea. It is a very good magnesium supplement form, though it is a bit large and may be challenging for some to swallow.
0
Severe diarrhoea faced
Although I had not tried magnesium malate before, it caused severe diarrhoea for me, whereas other magnesium forms were well tolerated. I also experienced mild heartburn after taking it.
9.5
We explored the impact of magnesium on secretory diarrhea, particularly in the context of cholera, a significant global health issue. The focus was on understanding how magnesium, often overlooked, could serve as an effective treatment option. In our study, we found that increasing levels of magnesium can significantly inhibit chloride secretion in intestinal cells, which is crucial during episodes of diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
We observed that magnesium, at concentrations typically seen in stool, reduced this secretory process by a remarkable 65%. This effect primarily occurs through a specific receptor in the intestinal cells known as the calcium-sensing receptor (CaSR). Interestingly, we noted that magnesium also counteracted Cl- secretion triggered by cholera toxin and other enterotoxins by about 50%.
Using mouse models, we saw that administering magnesium effectively decreased fluid loss associated with cholera by 40%. In a model mimicking the intestinal environment during cholera, adding magnesium not only curbed fluid secretion but also reversed it, promoting absorption instead. Given that patients suffering from cholera often have negligible magnesium levels in their stool, our findings suggest that oral magnesium supplementation could be a simple but effective therapeutic strategy for managing cholera and potentially other forms of secretory diarrhea.
8
We investigated the relationship between magnesium treatment and diarrhea in patients with HNF1B syndrome, where we found that hypomagnesemia is quite common.
A notable case involved a patient with a de novo heterozygous deletion of the HNF1B gene, who suffered from severe diarrhea due to low magnesium levels. After receiving magnesium supplementation, the patient's diarrhea symptoms improved significantly.
Our findings indicate that those with HNF1B deletion are more likely to experience low magnesium levels compared to individuals with intragenic mutations. In fact, among a large group of patients with HNF1B syndrome, over half experienced hypomagnesemia.
This suggests a strong connection between magnesium deficiency and the gastrointestinal issues seen in this condition. It highlights the importance of monitoring magnesium levels in patients, as addressing this deficiency can lead to meaningful relief from diarrhea symptoms.
A notable case involved a patient with a de novo heterozygous deletion of the HNF1B gene, who suffered from severe diarrhea due to low magnesium levels. After receiving magnesium supplementation, the patient's diarrhea symptoms improved significantly.
Our findings indicate that those with HNF1B deletion are more likely to experience low magnesium levels compared to individuals with intragenic mutations. In fact, among a large group of patients with HNF1B syndrome, over half experienced hypomagnesemia.
This suggests a strong connection between magnesium deficiency and the gastrointestinal issues seen in this condition. It highlights the importance of monitoring magnesium levels in patients, as addressing this deficiency can lead to meaningful relief from diarrhea symptoms.
5
We investigated the effects of naldemedine, a medication often used to treat opioid-induced constipation, in combination with magnesium oxide (MgO) and other laxatives during hospital stays. Our study focused on how these treatments affected daily bowel movements and the occurrence of diarrhea.
Analysis of 93 inpatients who received at least four doses of naldemedine revealed that the addition of magnesium or other laxatives significantly increased the average daily defecation counts when compared to naldemedine alone.
However, we also noted that the combination treatments were associated with higher rates of diarrhea. This suggests that while magnesium might enhance bowel movement frequency, it could also lead to more diarrhea, which is an important consideration for treatment.
Therefore, we concluded that introducing naldemedine either alone or with magnesium could be beneficial, but healthcare providers should carefully monitor for signs of diarrhea and adjust treatments as needed.
Analysis of 93 inpatients who received at least four doses of naldemedine revealed that the addition of magnesium or other laxatives significantly increased the average daily defecation counts when compared to naldemedine alone.
However, we also noted that the combination treatments were associated with higher rates of diarrhea. This suggests that while magnesium might enhance bowel movement frequency, it could also lead to more diarrhea, which is an important consideration for treatment.
Therefore, we concluded that introducing naldemedine either alone or with magnesium could be beneficial, but healthcare providers should carefully monitor for signs of diarrhea and adjust treatments as needed.
4
We explored how magnesium supplementation affects diarrhea, particularly in adults. In recent research, we carefully reviewed data from intervention studies conducted between 1997 and 2022, focusing mainly on single-ingredient magnesium products. Our goal was to determine whether higher doses of magnesium cause significant gastrointestinal issues, especially diarrhea, which had previously shaped the established upper intake limit.
The findings were enlightening. Out of ten studies we analyzed, including five meta-analyses and five randomized controlled trials, seven indicated no significant difference in diarrhea incidents between those receiving magnesium and those given a placebo. It was interesting to note that even at doses as high as 1200 mg per day, participants generally did not report diarrhea.
When reviewing adverse event data reported to the FDA, we found just 40 cases of gastrointestinal issues linked to magnesium supplementation. Quite tellingly, only one-third of these involved complaints about diarrhea. This suggests that the concern regarding magnesium causing significant gastrointestinal problems may be overstated.
Overall, our evaluation indicates that adults can often consume magnesium supplements above the current upper intake level without significant adverse effects related to diarrhea. This opens up opportunities for increasing magnesium intake, which could help address inadequacies in this essential nutrient for many individuals.
The findings were enlightening. Out of ten studies we analyzed, including five meta-analyses and five randomized controlled trials, seven indicated no significant difference in diarrhea incidents between those receiving magnesium and those given a placebo. It was interesting to note that even at doses as high as 1200 mg per day, participants generally did not report diarrhea.
When reviewing adverse event data reported to the FDA, we found just 40 cases of gastrointestinal issues linked to magnesium supplementation. Quite tellingly, only one-third of these involved complaints about diarrhea. This suggests that the concern regarding magnesium causing significant gastrointestinal problems may be overstated.
Overall, our evaluation indicates that adults can often consume magnesium supplements above the current upper intake level without significant adverse effects related to diarrhea. This opens up opportunities for increasing magnesium intake, which could help address inadequacies in this essential nutrient for many individuals.
References
- de Souza Goncalves L, Chu T, Master R, Chhetri PD, Gao Q, et al. Mg2+ supplementation treats secretory diarrhea in mice by activating calcium-sensing receptor in intestinal epithelial cells. J Clin Invest. 2024;134. doi:10.1172/JCI171249
- Wang Y, Xiao X, Lin Q, Song R, Wang X, et al. Hepatocyte nuclear factor 1B deletion, but not intragenic mutation, might be more susceptible to hypomagnesemia. J Diabetes Investig. 2024;15:121. doi:10.1111/jdi.14084
- Costello R, Rosanoff A, Nielsen F, West C. Perspective: Call for Re-evaluation of the Tolerable Upper Intake Level for Magnesium Supplementation in Adults. Adv Nutr. 2023;14:973. doi:10.1016/j.advnut.2023.06.008
- Kamali F, Jamee M, Sayer JA, Sadeghi-Bojd S, Golchehre Z, et al. Intestinal hypomagnesemia in an Iranian patient with a novel TRPM6 variant: a case report and review of the literature. CEN Case Rep. 2023;12:413. doi:10.1007/s13730-023-00785-8
- Cao S, Huang K, Wen X, Gao J, Cui B, et al. Dietary supplementation with potassium-magnesium sulfate modulates the antioxidant capacity, immunity, and gut microbiota in weaned piglets. Front Microbiol. 2022;13:961989. doi:10.3389/fmicb.2022.961989
- Takemura M, Niki K, Miyaguchi S, Ueda M. Naldemedine-laxative combination: retrospective inpatient study. BMJ Support Palliat Care. 2024;13:e816. doi:10.1136/spcare-2022-003685
- Sarkar KK, Mitra T, Rahman MA, Raja IM, Aktaruzzaman M, et al. Bioactivities of (Wall.) and Study against Cyclooxygenase Enzymes. Biomed Res Int. 2022;2022:1331758. doi:10.1155/2022/1331758
