Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
3 g
1%*
Magnesium (as magnesium malate trihydrate)
425 mg
101%
Sodium
10 mg
<1%
Magnesium Malate Trihydrate
3.75 g
†
Malic Acid (as magnesium malate trihydrate and malic acid)
2.5 g
†
Top Medical Research Studies
8
We investigated the potential benefits of magnesium in the form of a new compound, magnesium biotin (MgB), on remyelination in rats with induced demyelination. This is particularly relevant for conditions like multiple sclerosis (MS), where demyelination plays a critical role in disease progression. Through our study, we compared MgB's effects to those of standard biotin.
Our findings revealed that MgB significantly enhanced the remyelination process compared to biotin alone. Both treatments showed a dose-dependent improvement in spatial memory, indicating benefits for cognitive functions. Additionally, MgB treatment led to reduced levels of inflammatory proteins, an effect that was more pronounced at higher doses.
Notably, we discovered that MgB helped restore important proteins involved in neuronal function and transmission, such as Synapsin-1 and PSD-95, which are crucial for healthy brain functioning. We also observed an increase in beneficial brain-derived factors and a notable reduction in markers of reactive gliosis, which suggests a reduction in harmful inflammation.
The evidence indicates that combining magnesium with biotin could provide a more effective treatment strategy for promoting myelin repair in demyelination-driven conditions like MS. Our results support the potential for further research into using MgB in clinical settings for MS patients.
Our findings revealed that MgB significantly enhanced the remyelination process compared to biotin alone. Both treatments showed a dose-dependent improvement in spatial memory, indicating benefits for cognitive functions. Additionally, MgB treatment led to reduced levels of inflammatory proteins, an effect that was more pronounced at higher doses.
Notably, we discovered that MgB helped restore important proteins involved in neuronal function and transmission, such as Synapsin-1 and PSD-95, which are crucial for healthy brain functioning. We also observed an increase in beneficial brain-derived factors and a notable reduction in markers of reactive gliosis, which suggests a reduction in harmful inflammation.
The evidence indicates that combining magnesium with biotin could provide a more effective treatment strategy for promoting myelin repair in demyelination-driven conditions like MS. Our results support the potential for further research into using MgB in clinical settings for MS patients.
Read More
Most Useful Reviews
9
Migraine relief
25 people found this helpful
The migraine has resolved! I previously took magnesium aspartate, but due to its neurotoxic effects, I switched to magnesium malate, taking it several times a day. Alongside magnesium chloride baths, transdermal magnesium oil, and sublingual bitter, I suffered from severe migraines for years. Now, I no longer require painkillers. It turns out I was deficient in magnesium.
Read More
7.5
Increased energy
The items arrived punctually and were expertly packed. This product is fantastic; having multiple sclerosis, I am gradually experiencing a boost in energy and reduced headaches.
Read More
7.5
Reduced stiffness
Magnesium is essential for me. Delivery was exceptionally fast, around two weeks. I was very pleasantly surprised. I use magnesium for multiple sclerosis, and I've noticed that when I take magnesium, I feel less stiff and generally a bit better. I currently take Magnesium Chelated (Magnesium Bisglycinate) and have also started trying MALATE due to its malic acid content.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
- All Researches
8
We investigated the potential benefits of magnesium in the form of a new compound, magnesium biotin (MgB), on remyelination in rats with induced demyelination. This is particularly relevant for conditions like multiple sclerosis (MS), where demyelination plays a critical role in disease progression. Through our study, we compared MgB's effects to those of standard biotin.
Our findings revealed that MgB significantly enhanced the remyelination process compared to biotin alone. Both treatments showed a dose-dependent improvement in spatial memory, indicating benefits for cognitive functions. Additionally, MgB treatment led to reduced levels of inflammatory proteins, an effect that was more pronounced at higher doses.
Notably, we discovered that MgB helped restore important proteins involved in neuronal function and transmission, such as Synapsin-1 and PSD-95, which are crucial for healthy brain functioning. We also observed an increase in beneficial brain-derived factors and a notable reduction in markers of reactive gliosis, which suggests a reduction in harmful inflammation.
The evidence indicates that combining magnesium with biotin could provide a more effective treatment strategy for promoting myelin repair in demyelination-driven conditions like MS. Our results support the potential for further research into using MgB in clinical settings for MS patients.
Our findings revealed that MgB significantly enhanced the remyelination process compared to biotin alone. Both treatments showed a dose-dependent improvement in spatial memory, indicating benefits for cognitive functions. Additionally, MgB treatment led to reduced levels of inflammatory proteins, an effect that was more pronounced at higher doses.
Notably, we discovered that MgB helped restore important proteins involved in neuronal function and transmission, such as Synapsin-1 and PSD-95, which are crucial for healthy brain functioning. We also observed an increase in beneficial brain-derived factors and a notable reduction in markers of reactive gliosis, which suggests a reduction in harmful inflammation.
The evidence indicates that combining magnesium with biotin could provide a more effective treatment strategy for promoting myelin repair in demyelination-driven conditions like MS. Our results support the potential for further research into using MgB in clinical settings for MS patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Migraine relief
25 people found this helpful
The migraine has resolved! I previously took magnesium aspartate, but due to its neurotoxic effects, I switched to magnesium malate, taking it several times a day. Alongside magnesium chloride baths, transdermal magnesium oil, and sublingual bitter, I suffered from severe migraines for years. Now, I no longer require painkillers. It turns out I was deficient in magnesium.
Read More
7.5
Increased energy
The items arrived punctually and were expertly packed. This product is fantastic; having multiple sclerosis, I am gradually experiencing a boost in energy and reduced headaches.
Read More
7.5
Reduced stiffness
Magnesium is essential for me. Delivery was exceptionally fast, around two weeks. I was very pleasantly surprised. I use magnesium for multiple sclerosis, and I've noticed that when I take magnesium, I feel less stiff and generally a bit better. I currently take Magnesium Chelated (Magnesium Bisglycinate) and have also started trying MALATE due to its malic acid content.
Read More
Frequently Asked Questions
7.5
Increased energy
The items arrived punctually and were expertly packed. This product is fantastic; having multiple sclerosis, I am gradually experiencing a boost in energy and reduced headaches.
7.5
Reduced stiffness
Magnesium is essential for me. Delivery was exceptionally fast, around two weeks. I was very pleasantly surprised. I use magnesium for multiple sclerosis, and I've noticed that when I take magnesium, I feel less stiff and generally a bit better. I currently take Magnesium Chelated (Magnesium Bisglycinate) and have also started trying MALATE due to its malic acid content.
9
Migraine relief
25 people found this helpful
The migraine has resolved! I previously took magnesium aspartate, but due to its neurotoxic effects, I switched to magnesium malate, taking it several times a day. Alongside magnesium chloride baths, transdermal magnesium oil, and sublingual bitter, I suffered from severe migraines for years. Now, I no longer require painkillers. It turns out I was deficient in magnesium.
8
We investigated the potential benefits of magnesium in the form of a new compound, magnesium biotin (MgB), on remyelination in rats with induced demyelination. This is particularly relevant for conditions like multiple sclerosis (MS), where demyelination plays a critical role in disease progression. Through our study, we compared MgB's effects to those of standard biotin.
Our findings revealed that MgB significantly enhanced the remyelination process compared to biotin alone. Both treatments showed a dose-dependent improvement in spatial memory, indicating benefits for cognitive functions. Additionally, MgB treatment led to reduced levels of inflammatory proteins, an effect that was more pronounced at higher doses.
Notably, we discovered that MgB helped restore important proteins involved in neuronal function and transmission, such as Synapsin-1 and PSD-95, which are crucial for healthy brain functioning. We also observed an increase in beneficial brain-derived factors and a notable reduction in markers of reactive gliosis, which suggests a reduction in harmful inflammation.
The evidence indicates that combining magnesium with biotin could provide a more effective treatment strategy for promoting myelin repair in demyelination-driven conditions like MS. Our results support the potential for further research into using MgB in clinical settings for MS patients.
Our findings revealed that MgB significantly enhanced the remyelination process compared to biotin alone. Both treatments showed a dose-dependent improvement in spatial memory, indicating benefits for cognitive functions. Additionally, MgB treatment led to reduced levels of inflammatory proteins, an effect that was more pronounced at higher doses.
Notably, we discovered that MgB helped restore important proteins involved in neuronal function and transmission, such as Synapsin-1 and PSD-95, which are crucial for healthy brain functioning. We also observed an increase in beneficial brain-derived factors and a notable reduction in markers of reactive gliosis, which suggests a reduction in harmful inflammation.
The evidence indicates that combining magnesium with biotin could provide a more effective treatment strategy for promoting myelin repair in demyelination-driven conditions like MS. Our results support the potential for further research into using MgB in clinical settings for MS patients.
References
- Yulug B, Kilic E, Oğuz T, Orhan C, Er B, et al. Dose-Dependent Effect of a New Biotin Compound in Hippocampal Remyelination in Rats. Mol Neurobiol. 2025. doi:10.1007/s12035-025-04686-y
