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Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Vitamin B-6 (from pyridoxal-5'-phosphate [Coenzymated™])
335 mcg
20%
Melatonin
5 mg
†
The product is found useful for the following medical conditions
Cancer details
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.8
USERS' SCORE
Good
Based on 1 Review
8.6
9
Vitamin B6 pathway affects cancer survival
Vitamin B6 Pathway Maintains Glioblastoma Cell Survival in 3D Spheroid Cultures.
Most Relevant Research
We explored the role of the vitamin B6 pathway in glioblastoma, a particularly aggressive form of brain cancer. Through a detailed analysis involving various cell cultures, we noted significant changes in vitamin B6-related metabolites when comparing 3D spheroid cultures to traditional 2D monolayers.
This discovery led us to investigate further the implications of these findings for cancer cell survival. We found that using hydralazine, a compound that effectively reduces vitamin B6 levels, triggered cell death in 3D GBM spheroid cultures.
Our results suggest that targeting the vitamin B6 pathway could offer a new avenue for developing treatments for this challenging cancer. This innovative approach highlights the necessity of understanding metabolic processes within tumor environments for creating effective therapies.
This discovery led us to investigate further the implications of these findings for cancer cell survival. We found that using hydralazine, a compound that effectively reduces vitamin B6 levels, triggered cell death in 3D GBM spheroid cultures.
Our results suggest that targeting the vitamin B6 pathway could offer a new avenue for developing treatments for this challenging cancer. This innovative approach highlights the necessity of understanding metabolic processes within tumor environments for creating effective therapies.
9.5
Effective treatment
Most Useful Review
This treatment is both effective and prompt. My doctor prescribed a titration starting at 2.5 mg, increasing daily until I reach 20 mg. It is crucial for anti-cancer protection, especially combined with adequate sleep.
Insomnia details
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 4 Reviews
8.6
9
Melatonin delivery enhances sleep
Silk fibroin microneedles loaded with melatonin for circadian rhythm regulation.
Most Relevant Research
We developed a new way to deliver melatonin for those struggling with insomnia by creating microneedles made from silk fibroin. These tiny needles are designed to improve how the body absorbs melatonin, making it easier for people to get to sleep and stay asleep.
Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.
Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.
We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.
Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.
Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.
We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.
9.5
Restored original formula
Most Useful Review
UPDATE! Source Naturals is reverting to the original formula! I upgraded my review from 1 star to 5 stars after contacting Source Naturals. Their Melatonin had been a lifesaver during my brutal 8-year insomnia battle. After a formula change, I noticed no effect from the new tablets. Thankfully, they plan to return to the previous formula made in-house. It’s a relief, as I depended heavily on melatonin for sleep.
Alzheimer details
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.9
USERS' SCORE
Good
Based on 1 Review
8.5
7
Pyridoxine shows potential in Alzheimer's
Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
Most Relevant Research
We explored the effects of pyridoxine, commonly known as vitamin B6, in a cell model of Alzheimer's disease (AD). This study aimed to understand how pyridoxine works and whether it can help combat the challenges associated with AD.
Using various techniques, including MTT assays, western blotting, and reactive oxygen species (ROS) assays, we observed how pyridoxine can offer protection against AD. The findings showed that vitamin B6 seems to lower ROS levels, which are often elevated in the context of Alzheimer’s. Additionally, it appeared to decrease the presence of cytoplasmic Nrf2 while increasing whole-cell HO-1 expression.
Overall, we suggest that the benefits of pyridoxine in Alzheimer's cases may stem from its ability to act as an antioxidant, particularly by stimulating the Nrf2/HO-1 pathway. This suggests that vitamin B6 could potentially be a useful ally in addressing the oxidative stress associated with Alzheimer’s disease.
Using various techniques, including MTT assays, western blotting, and reactive oxygen species (ROS) assays, we observed how pyridoxine can offer protection against AD. The findings showed that vitamin B6 seems to lower ROS levels, which are often elevated in the context of Alzheimer’s. Additionally, it appeared to decrease the presence of cytoplasmic Nrf2 while increasing whole-cell HO-1 expression.
Overall, we suggest that the benefits of pyridoxine in Alzheimer's cases may stem from its ability to act as an antioxidant, particularly by stimulating the Nrf2/HO-1 pathway. This suggests that vitamin B6 could potentially be a useful ally in addressing the oxidative stress associated with Alzheimer’s disease.
8.8
Cognitive protection
Most Useful Review
Melatonin is not only a sleep aid but has numerous health benefits. It is linked to preventing memory disorders, including Alzheimer's, as it has powerful antioxidant properties. I have used it for years with positive results and feel reassured about its protective effects on my body.
